LOCUS       NM_001191071            3217 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus microtubule affinity regulating kinase 4 (Mark4),
            mRNA.
ACCESSION   NM_001191071 XM_001057742
VERSION     NM_001191071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Li,Y., Cheng,M., Jin,J., Zhang,D., Zhang,S., Bai,Y. and Xu,J.
  TITLE     Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells
            apoptosis by activating Mark4 in vascular calcification
  JOURNAL   Aging (Albany NY) 16 (3), 2438-2456 (2024)
   PUBMED   38301049
  REMARK    GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth
            muscle cells apoptosis by activating Mark4 in vascular
            calcification.
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Tang,E.I. and Cheng,C.Y.
  TITLE     MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through
            Microtubule and Actin Cytoskeletons
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   35971301
  REMARK    GeneRIF: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through
            Microtubule and Actin Cytoskeletons.
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Sun,W., Lee,S., Huang,X., Liu,S., Inayathullah,M., Kim,K.M.,
            Tang,H., Ashford,J.W. and Rajadas,J.
  TITLE     Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau
            phosphorylation by methylene blue for Alzheimer's disease treatment
  JOURNAL   Sci Rep 6, 34784 (2016)
   PUBMED   27708431
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Rovina,D., Fontana,L., Monti,L., Novielli,C., Panini,N.,
            Sirchia,S.M., Erba,E., Magnani,I. and Larizza,L.
  TITLE     Microtubule-associated protein/microtubule affinity-regulating
            kinase 4 (MARK4) plays a role in cell cycle progression and
            cytoskeletal dynamics
  JOURNAL   Eur J Cell Biol 93 (8-9), 355-365 (2014)
   PUBMED   25123532
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Gu,G.J., Lund,H., Wu,D., Blokzijl,A., Classon,C., von Euler,G.,
            Landegren,U., Sunnemark,D. and Kamali-Moghaddam,M.
  TITLE     Role of individual MARK isoforms in phosphorylation of tau at
            Ser(2)(2) in Alzheimer's disease
  JOURNAL   Neuromolecular Med 15 (3), 458-469 (2013)
   PUBMED   23666762
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Yu,W., Polepalli,J., Wagh,D., Rajadas,J., Malenka,R. and Lu,B.
  TITLE     A critical role for the PAR-1/MARK-tau axis in mediating the toxic
            effects of Abeta on synapses and dendritic spines
  JOURNAL   Hum Mol Genet 21 (6), 1384-1390 (2012)
   PUBMED   22156579
  REMARK    GeneRIF: High MARK4 is associated with Alzheimer's disease.
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Schneider,A., Laage,R., von Ahsen,O., Fischer,A., Rossner,M.,
            Scheek,S., Grunewald,S., Kuner,R., Weber,D., Kruger,C.,
            Klaussner,B., Gotz,B., Hiemisch,H., Newrzella,D.,
            Martin-Villalba,A., Bach,A. and Schwaninger,M.
  TITLE     Identification of regulated genes during permanent focal cerebral
            ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4
  JOURNAL   J Neurochem 88 (5), 1114-1126 (2004)
   PUBMED   15009667
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Trinczek,B., Brajenovic,M., Ebneth,A. and Drewes,G.
  TITLE     MARK4 is a novel microtubule-associated proteins/microtubule
            affinity-regulating kinase that binds to the cellular microtubule
            network and to centrosomes
  JOURNAL   J Biol Chem 279 (7), 5915-5923 (2004)
   PUBMED   14594945
REFERENCE   9  (bases 1 to 3217)
  AUTHORS   Beghini,A., Magnani,I., Roversi,G., Piepoli,T., Di Terlizzi,S.,
            Moroni,R.F., Pollo,B., Fuhrman Conti,A.M., Cowell,J.K.,
            Finocchiaro,G. and Larizza,L.
  TITLE     The neural progenitor-restricted isoform of the MARK4 gene in
            19q13.2 is upregulated in human gliomas and overexpressed in a
            subset of glioblastoma cell lines
  JOURNAL   Oncogene 22 (17), 2581-2591 (2003)
   PUBMED   12735302
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Kato,T., Satoh,S., Okabe,H., Kitahara,O., Ono,K., Kihara,C.,
            Tanaka,T., Tsunoda,T., Yamaoka,Y., Nakamura,Y. and Furukawa,Y.
  TITLE     Isolation of a novel human gene, MARKL1, homologous to MARK3 and
            its involvement in hepatocellular carcinogenesis
  JOURNAL   Neoplasia 3 (1), 4-9 (2001)
   PUBMED   11326310
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001057742.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.1487.1,
                                           SRR26643297.987.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000001.1  88236479-88236553   c
            76-276              JAXUCZ010000001.1  88230011-88230211   c
            277-330             JAXUCZ010000001.1  88227030-88227083   c
            331-379             JAXUCZ010000001.1  88226847-88226895   c
            380-445             JAXUCZ010000001.1  88226352-88226417   c
            446-516             JAXUCZ010000001.1  88223088-88223158   c
            517-573             JAXUCZ010000001.1  88221110-88221166   c
            574-810             JAXUCZ010000001.1  88218778-88219014   c
            811-930             JAXUCZ010000001.1  88214131-88214250   c
            931-1030            JAXUCZ010000001.1  88213672-88213771   c
            1031-1140           JAXUCZ010000001.1  88212923-88213032   c
            1141-1300           JAXUCZ010000001.1  88212663-88212822   c
            1301-1518           JAXUCZ010000001.1  88211462-88211679   c
            1519-1622           JAXUCZ010000001.1  88210140-88210243   c
            1623-1901           JAXUCZ010000001.1  88207443-88207721   c
            1902-1946           JAXUCZ010000001.1  88206234-88206278   c
            1947-3217           JAXUCZ010000001.1  88203393-88204663   c
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3217
                     /gene="Mark4"
                     /note="microtubule affinity regulating kinase 4"
                     /db_xref="GeneID:680407"
                     /db_xref="RGD:1591792"
     exon            1..75
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2283
                     /gene="Mark4"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="MAP/microtubule affinity-regulating kinase 4"
                     /protein_id="NP_001178000.1"
                     /db_xref="GeneID:680407"
                     /db_xref="RGD:1591792"
                     /translation="MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRN
                     SIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK
                     LFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARA
                     KFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGS
                     PPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVP
                     FYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKR
                     IEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSD
                     TTNGTSSSKGSSHNKGQRTSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEE
                     RLPGRKASCSAAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTR
                     RNTYVCTERPGSERQSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIR
                     STFHGGQVRDRRAGGGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLT
                     RRVTDEPERIGGPEVTSCHLPWDKAETAPRLLRFPWSVKLTSSRPPEALMAALRQATA
                     AARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR
                     TLVTRISNDLEL"
     exon            76..276
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            277..330
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            331..379
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            380..445
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            446..516
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            517..573
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..810
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            811..930
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1030
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1140
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1300
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1518
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1622
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1901
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1946
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..3217
                     /gene="Mark4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccctcctg ggaccccaaa gaagatgtct tcgaggacgg cgctggcccc gggcaacgat
       61 cggaactcgg acacgcatgg caccttgggc agcggacgat cttcggacaa aggaccgtcc
      121 tggtccagcc gttccctggg tgctcgttgc cggaactcta tcgcttcctg ccctgaggag
      181 caaccccatg tgggcaacta caggctgctc aggaccatcg ggaagggcaa ctttgctaaa
      241 gtcaagctgg ctcggcatat cctcacgggc cgggaggtcg ctatcaagat cattgataaa
      301 acccagctga accccagtag cttacagaag ctgttcagag aagttcgaat tatgaaggga
      361 ctcaatcacc ccaacatcgt gaagcttttt gaggtgatag agacggagaa gacgttatac
      421 ctggtgatgg aatatgctag cgcaggagaa gtgtttgact acctcgtgtc gcacggccgc
      481 atgaaggaga aggaggctcg agccaagttt cggcagatcg tgtcagccgt gcactactgt
      541 caccagaaga acattgtaca cagggatctg aaggctgaga acctgttgct ggatgccgag
      601 gccaacatca aaatcgccga cttcggcttc agcaacgagt tcacgctcgg ctccaagctg
      661 gacaccttct gtgggagccc cccgtacgcc gccccggaac tgttccaggg caagaagtat
      721 gatgggccag aggtggacat ctggagcctg ggcgttatcc tgtacacact ggtcagcggc
      781 tccctgccct tcgacgggca caacctcaag gagctgcggg agcgagtcct caggggcaag
      841 taccgagtcc ccttctacat gtctacagac tgcgagagca ttctgcggag atttctggtg
      901 ctgaaccccg caaaacgctg taccctggag caaatcatga aagacaaatg gatcaacatt
      961 ggctatgagg gtgaggagct gaagccatac acggaacccg aggaggactt cggggacacc
     1021 aagagaattg aggtgatggt gggtatgggc tacacacggg aagaaatcaa agaggccttg
     1081 accaaccaga agtacaacga ggtgaccgcc acctacctcc tgctgggcag gaagactgag
     1141 gagggtgggg accggggtgc cccagggctg gccctggcac gggtgcgggc gcccagcgac
     1201 accaccaatg ggacaagctc cagcaaaggc agcagccaca acaaagggca gcggacttct
     1261 tcctccacct accaccgcca gcgtcggcac agcgacttct gtggcccgtc ccctgccccg
     1321 ctgcacccga agcgcagccc aaccagcacg ggggacacgg agctcaaaga agagcggctg
     1381 ccgggtcgga aagcaagctg cagtgcagcg ggcagcggga gtcgaggctt gcccccctcc
     1441 agccccatgg tcagcagtgc ccacaacccc aacaaggcag agatccccga gcggcggaag
     1501 gacagcacta gtaccccaaa caacctcccc cccagcatga tgacccgaag aaacacctac
     1561 gtgtgcacag agcggccagg gtctgagcgc cagtccttgt tgccaaatgg caaagaaaat
     1621 agctctggta cctcgcgggt gccccctgcc tcaccctcca gtcacagcct ggctccccca
     1681 tcgggagagc ggagccgcct ggctcggggc tccaccatcc gcagcacctt ccatgggggc
     1741 caggtccgag accggcgggc agggggcggg agtggcgggg gtgtgcagaa tggacccccg
     1801 gcctcaccca cgctggccca tgaggccgca cccctgccct ccgggcggcc ccgccccacc
     1861 accaacctct tcaccaagct gacctccaaa ctgacccgaa gggtcacaga cgaacctgag
     1921 agaatcgggg gacctgaggt cacaagttgc catctacctt gggataaagc ggaaaccgcc
     1981 cccaggctgc tcagattccc ctggagtgtg aaactgacca gctctcgacc tcctgaggcc
     2041 ctgatggctg ccctgcgaca ggccacagcg gccgcccgct gccggtgccg ccagccgcag
     2101 ccgttcctgc tggcctgcct gcacgggggt gcgggcgggc ccgagcccct gtcccatttc
     2161 gaagtagagg tgtgccagct gccccggccc ggcctcaggg gcgtcctctt ccgccgcgtg
     2221 gcgggcaccg ccctggcctt ccgaaccctt gtcacccgca tttccaacga cctcgaactc
     2281 tgagccaccg ccaccgccac caccaccacc accaccacca ccatcaccac cacagccacc
     2341 atcacacccc gggtcccttc ttttctctgg ttcctttcac ttccccaaaa ggggaacagg
     2401 acagaggagg gggttccccg tatcatgact gaagcttccc tggattagat tggtggacag
     2461 tgtggggaca catgacacga taagagggct cagcaggggg gagctggcac cctcctaggg
     2521 cctctagtgg ggaccccccc atcttgctct gctgcagggc acttgaggag actttgggga
     2581 caggagtgag aagggaaact gaggaaattc tcccatttgg ggagaacttc caggcataat
     2641 gactggagac agaactcggg gggttcaggg agttgggggt cacaggcaga aaccttcccc
     2701 tccctcctcc ttatgctcga acctccttca tgccccaggc tggcgcgggg cactttgtac
     2761 aaatccgtgt atatactcct gtccctctgc agaggtctct cggggagcta ccgctgtcgc
     2821 ctcaagtttt taagttattg cccccccttc tgtcagctcc tcacctgcag cctgttactc
     2881 aataaacagt aggagtccct ccagccccca accccctggc cgacctgggg tcttccttcc
     2941 cagcccttgg cctgcaggtg agcagggagc tggggacttg accccaacct gtggttctgc
     3001 ttgctgagcc tccgttatct catctgcaga atgggaacag tggggttgga gggtgggtcc
     3061 aggatgatca tggaagaggg caaaacagaa ttcggcctct tccgtgaggc cccagccttc
     3121 tgtgacaccc tcctcttggc cacttactcc cctctgccgt attacactgg acccagagcc
     3181 tcttcctatt ccaataatac atgtattcaa taaacaa
//
