LOCUS       NM_130749               2700 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus microtubule affinity regulating kinase 3 (Mark3),
            mRNA.
ACCESSION   NM_130749
VERSION     NM_130749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Kwan,J., Sczaniecka,A., Heidary Arash,E., Nguyen,L., Chen,C.C.,
            Ratkovic,S., Klezovitch,O., Attisano,L., McNeill,H., Emili,A. and
            Vasioukhin,V.
  TITLE     DLG5 connects cell polarity and Hippo signaling protein networks by
            linking PAR-1 with MST1/2
  JOURNAL   Genes Dev 30 (24), 2696-2709 (2016)
   PUBMED   28087714
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Gu,G.J., Lund,H., Wu,D., Blokzijl,A., Classon,C., von Euler,G.,
            Landegren,U., Sunnemark,D. and Kamali-Moghaddam,M.
  TITLE     Role of individual MARK isoforms in phosphorylation of tau at
            Ser(2)(2) in Alzheimer's disease
  JOURNAL   Neuromolecular Med 15 (3), 458-469 (2013)
   PUBMED   23666762
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Moravcevic,K., Mendrola,J.M., Schmitz,K.R., Wang,Y.H.,
            Slochower,D., Janmey,P.A. and Lemmon,M.A.
  TITLE     Kinase associated-1 domains drive MARK/PAR1 kinases to membrane
            targets by binding acidic phospholipids
  JOURNAL   Cell 143 (6), 966-977 (2010)
   PUBMED   21145462
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Dequiedt,F., Martin,M., Von Blume,J., Vertommen,D., Lecomte,E.,
            Mari,N., Heinen,M.F., Bachmann,M., Twizere,J.C., Huang,M.C.,
            Rider,M.H., Piwnica-Worms,H., Seufferlein,T. and Kettmann,R.
  TITLE     New role for hPar-1 kinases EMK and C-TAK1 in regulating
            localization and activity of class IIa histone deacetylases
  JOURNAL   Mol Cell Biol 26 (19), 7086-7102 (2006)
   PUBMED   16980613
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Peng,C.Y., Graves,P.R., Ogg,S., Thoma,R.S., Byrnes,M.J. 3rd, Wu,Z.,
            Stephenson,M.T. and Piwnica-Worms,H.
  TITLE     C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and
            promotes 14-3-3 protein binding
  JOURNAL   Cell Growth Differ 9 (3), 197-208 (1998)
   PUBMED   9543386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF465412.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2700
                     /gene="Mark3"
                     /note="microtubule affinity regulating kinase 3"
                     /db_xref="GeneID:170577"
                     /db_xref="RGD:619883"
     exon            1..130
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2473
                     /gene="Mark3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="MAP/microtubule affinity-regulating kinase 3"
                     /protein_id="NP_570105.1"
                     /db_xref="GeneID:170577"
                     /db_xref="RGD:619883"
                     /translation="MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIA
                     SCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFR
                     EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFR
                     QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKITDFGFSNEFTVGSKLDTFCGSPPY
                     AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
                     STDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELDISDQKRIDI
                     MVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPSSD
                     LSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGV
                     PSRKSGSSAVGGKGIAPASPMLGNASNPNKADIPERKKSPAVPSSNAASGGMTRRNTY
                     VCSERCAADRHSVIQNGKESSLTEVFAYAASPASLCATSTCRLRHQRSMSVSASGHPK
                     MVLPPIDSEGDTFKAITTPDQRTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRE
                     RRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGS
                     SRNVSSEQKDENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANTCDYEQRERF
                     LLFCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL"
     exon            131..322
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..376
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..425
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..491
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..562
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..619
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..856
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            857..976
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1076
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1189
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1343
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1561
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1665
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1824
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2082
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2127
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2700
                     /gene="Mark3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctgc tcatcggccg cccagagctg ggcggttttg ttttcgcctt ggcgttgtgc
       61 agaatcaaag cgcaataaga tgtccactag gacccctttg ccaacggtga atgaacgaga
      121 cactgaaaac cacatttcac atggagatgg gaggcaagaa gtcacctccc gcaccgggcg
      181 ctctggagct cggtgtagaa actcaatagc ttcctgtgca gatgaacagc ctcatattgg
      241 aaactacaga ctattgaaaa caatcggcaa ggggaacttt gcaaaagtga aattggcgag
      301 acacatcctc acaggcagag aggttgcaat aaagataatt gacaaaactc agttgaatcc
      361 aacaagtcta cagaagctct tcagagaagt aagaataatg aagattttaa atcacccaaa
      421 catagtgaaa ttgttcgagg tcattgaaac ggaaaaaaca ctctacttaa tcatggaata
      481 tgcaagtgga ggtgaagtat ttgactattt ggttgcacat ggaagaatga aggaaaaaga
      541 agcaagagct aagtttagac agattgtgtc cgcagtacag tattgccacc aaaaacggat
      601 cgttcacaga gacctcaagg ctgaaaatct gttattagat gcggatatga acattaaaat
      661 aacagatttt ggttttagca atgaatttac tgttggcagt aaactagaca cgttttgtgg
      721 tagtccacca tatgcagccc ctgagctctt ccagggcaag aagtatgacg ggccggaagt
      781 ggacgtgtgg agtctcggcg tcattctgta caccctagtc agtgggtcac ttccctttga
      841 tggtcagaac ctgaaggaac tgagagagag agtactccga gggaagtaca gaatcccttt
      901 ctacatgtcc acagactgtg agaaccttct caagcgcttc ctggtgctga acccagttaa
      961 acgcggcact ctggagcaaa tcatgaagga caggtggatc aatgcaggtc atgaggaaga
     1021 ggagcttaag ccatttgtcg aaccagaact agacatctca gaccagaaga gaatagatat
     1081 tatggtggga atgggatatt cccaagaaga aatacaagaa tctcttagta aaatgaaata
     1141 cgatgaaatc acagcgacgt acttgttact ggggaggaag tctgcagagc tggacgctag
     1201 tgactccagt tctagcagca acctttcact tgctaaggtg cggccaagca gtgacctcag
     1261 caatagcact ggccagtctc ctcatcacaa agggcagagg agtgtgtctt caagtcagaa
     1321 gcagagacgg tacagtgacc acgctggacc agctattcct tcagttgtgg catatccgaa
     1381 gaggagtcag accagcactg cagatagtga cctcaaagaa gatggagttc cctcccgaaa
     1441 atcaggcagc agtgctgtag gaggaaaggg gattgcccct gccagtccca tgcttgggaa
     1501 tgcaagcaat cccaataaag ctgatattcc cgagcgcaag aaaagccctg ctgtccccag
     1561 tagtaatgca gcatctggtg ggatgactcg gaggaacact tacgtgtgca gtgagagatg
     1621 tgcagcggac agacattcag tgattcagaa cggcaaagaa agcagcctga cagaagtgtt
     1681 cgcttacgca gctagccctg cctcactctg tgccacatct acctgtcggc tgagacatca
     1741 gaggtcgatg tccgtgtcag cctctgggca ccccaagatg gtgttacctc caatagacag
     1801 tgaaggagat accttcaagg ctatcaccac tccagatcag aggactccag ttgcttctac
     1861 acacagtatt agcagtgcga caaccccaga tcgcatccgc ttcccaaggg gcacagccag
     1921 ccgtagcact ttccacgggc agcctcgaga gcggcgaacc gcaacatata atggcccccc
     1981 agcctcaccc agcttgtccc atgaagccac accgctgtcc cagacgcgaa gcagaggctc
     2041 cactaatctt tttagcaaac ttacttctaa actcaccaga agacttccaa ctgaatatga
     2101 gaggaacggg agatatgagg gctcaagtcg caatgtatct tcggaacaaa aggatgagaa
     2161 cagagaggcc aaacctcggt ccctgcgctt cacctggagc atgaaaacca ctagttccat
     2221 ggatcccagt gacatgatgc gggagatccg caaagtgctg gacgccaata cctgcgacta
     2281 tgagcagagg gagcgcttcc tgctcttctg tgtccatggc gacgggcacg ctgagagcct
     2341 ggtgcagtgg gagatggaag tctgtaagct gccaagactg tctctgaatg gggtccggtt
     2401 taagcggata tcagggacat ccatcgcttt caaaaacatt gcttccaaaa ttgccaacga
     2461 gctaaagctg taacccagta attatggtgt aaattaagta gcaagcaaag gtgtttccag
     2521 agcactgatg gaaatgtgta gagtaatatt taggcaataa cgtgcatctt ctaaatcatg
     2581 acattaaagt ctgaggacga gagcgggcct gggagcgaag gctggccttc cctgcgaatg
     2641 cactacatta aagtctgtga ccccgggcct ttgttttgtt tccattgccc tgggggtcag
//
