LOCUS       NM_001398633            4471 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus microtubule affinity regulating kinase 2 (Mark2),
            transcript variant 2, mRNA.
ACCESSION   NM_001398633 XM_006230885
VERSION     NM_001398633.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4471)
  AUTHORS   Tang,E.I. and Cheng,C.Y.
  TITLE     MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through
            Microtubule and Actin Cytoskeletons
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   35971301
  REMARK    GeneRIF: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through
            Microtubule and Actin Cytoskeletons.
REFERENCE   2  (bases 1 to 4471)
  AUTHORS   Zuo,Y.C., Xiong,N.X., Shen,J.Y., Yu,H., Huang,Y.Z. and Zhao,H.Y.
  TITLE     MARK2 Rescues Nogo-66-Induced Inhibition of Neurite Outgrowth via
            Regulating Microtubule-Associated Proteins in Neurons In Vitro
  JOURNAL   Neurochem Res 41 (11), 2958-2968 (2016)
   PUBMED   27465397
  REMARK    GeneRIF: a critical role for MARK2 in overcoming Nogo-66-induced
            inhibition of axon outgrowth in neurons
REFERENCE   3  (bases 1 to 4471)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4471)
  AUTHORS   Schwalbe,M., Biernat,J., Bibow,S., Ozenne,V., Jensen,M.R.,
            Kadavath,H., Blackledge,M., Mandelkow,E. and Zweckstetter,M.
  TITLE     Phosphorylation of human Tau protein by microtubule
            affinity-regulating kinase 2
  JOURNAL   Biochemistry 52 (50), 9068-9079 (2013)
   PUBMED   24251416
REFERENCE   5  (bases 1 to 4471)
  AUTHORS   Sato,Y., Akitsu,M., Amano,Y., Yamashita,K., Ide,M., Shimada,K.,
            Yamashita,A., Hirano,H., Arakawa,N., Maki,T., Hayashi,I., Ohno,S.
            and Suzuki,A.
  TITLE     The novel PAR-1-binding protein MTCL1 has crucial roles in
            organizing microtubules in polarizing epithelial cells
  JOURNAL   J Cell Sci 126 (Pt 20), 4671-4683 (2013)
   PUBMED   23902687
REFERENCE   6  (bases 1 to 4471)
  AUTHORS   Schaar,B.T., Kinoshita,K. and McConnell,S.K.
  TITLE     Doublecortin microtubule affinity is regulated by a balance of
            kinase and phosphatase activity at the leading edge of migrating
            neurons
  JOURNAL   Neuron 41 (2), 203-213 (2004)
   PUBMED   14741102
REFERENCE   7  (bases 1 to 4471)
  AUTHORS   Timm,T., Li,X.Y., Biernat,J., Jiao,J., Mandelkow,E.,
            Vandekerckhove,J. and Mandelkow,E.M.
  TITLE     MARKK, a Ste20-like kinase, activates the polarity-inducing kinase
            MARK/PAR-1
  JOURNAL   EMBO J 22 (19), 5090-5101 (2003)
   PUBMED   14517247
REFERENCE   8  (bases 1 to 4471)
  AUTHORS   Biernat,J., Wu,Y.Z., Timm,T., Zheng-Fischhofer,Q., Mandelkow,E.,
            Meijer,L. and Mandelkow,E.M.
  TITLE     Protein kinase MARK/PAR-1 is required for neurite outgrowth and
            establishment of neuronal polarity
  JOURNAL   Mol Biol Cell 13 (11), 4013-4028 (2002)
   PUBMED   12429843
REFERENCE   9  (bases 1 to 4471)
  AUTHORS   Ebneth,A., Drewes,G., Mandelkow,E.M. and Mandelkow,E.
  TITLE     Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the
            destabilization of microtubules in cells
  JOURNAL   Cell Motil Cytoskeleton 44 (3), 209-224 (1999)
   PUBMED   10542369
REFERENCE   10 (bases 1 to 4471)
  AUTHORS   Drewes,G., Ebneth,A., Preuss,U., Mandelkow,E.M. and Mandelkow,E.
  TITLE     MARK, a novel family of protein kinases that phosphorylate
            microtubule-associated proteins and trigger microtubule disruption
  JOURNAL   Cell 89 (2), 297-308 (1997)
   PUBMED   9108484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006230885.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4469.1,
                                           SRR26643429.4749.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               JAXUCZ010000001.1  213954699-213955149 c
            452-631             JAXUCZ010000001.1  213905156-213905335 c
            632-685             JAXUCZ010000001.1  213904875-213904928 c
            686-734             JAXUCZ010000001.1  213902087-213902135 c
            735-800             JAXUCZ010000001.1  213901758-213901823 c
            801-871             JAXUCZ010000001.1  213901569-213901639 c
            872-928             JAXUCZ010000001.1  213901298-213901354 c
            929-1165            JAXUCZ010000001.1  213900454-213900690 c
            1166-1285           JAXUCZ010000001.1  213899718-213899837 c
            1286-1385           JAXUCZ010000001.1  213899509-213899608 c
            1386-1498           JAXUCZ010000001.1  213899312-213899424 c
            1499-1631           JAXUCZ010000001.1  213898308-213898440 c
            1632-1804           JAXUCZ010000001.1  213897900-213898072 c
            1805-1902           JAXUCZ010000001.1  213897594-213897691 c
            1903-2064           JAXUCZ010000001.1  213896644-213896805 c
            2065-2322           JAXUCZ010000001.1  213895859-213896116 c
            2323-2367           JAXUCZ010000001.1  213892911-213892955 c
            2368-4471           JAXUCZ010000001.1  213890213-213892316 c
FEATURES             Location/Qualifiers
     source          1..4471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4471
                     /gene="Mark2"
                     /note="microtubule affinity regulating kinase 2"
                     /db_xref="GeneID:60328"
                     /db_xref="RGD:708483"
     exon            1..451
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..2728
                     /gene="Mark2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase MARK2; EMK1; EMK-1; ELKL
                     motif kinase 1; MAP/microtubule affinity-regulating kinase
                     2; serine/threonine kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MARK2 isoform 2"
                     /protein_id="NP_001385562.1"
                     /db_xref="GeneID:60328"
                     /db_xref="RGD:708483"
                     /translation="MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSA
                     DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR
                     IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV
                     SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP
                     ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD
                     CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS
                     MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS
                     HKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKV
                     PASPLPGLDRKKTTPTPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMPGS
                     RASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVAS
                     PSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPFGVTPASPSGHSQGR
                     RGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGGGGTDKEKEEFREAKPRSLR
                     FTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEV
                     CKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL"
     exon            452..631
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..685
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..734
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..800
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..871
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..928
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1165
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1285
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1385
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1498
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1631
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1804
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1902
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2064
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2322
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2367
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..4471
                     /gene="Mark2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggtggtg gcggccatgt tgggagcagc aggtccggca gcggctgcct gtgtgtcggg
       61 cgcggagcag tgcggctgag ggcaggggag gagcgaggca ggcggccggc tgcggcggtt
      121 gagagtaggc ggagcggcgc ggccgggccg aaaggcggca caacccagcc gggggtcggg
      181 ggggtgcggt ccggagccgc tcggagccgg cgaggcctag cccgagcggc gcatcaccgg
      241 gctggcgtga gccatcgccc ggcctccccg cacccccggc cggggcccat gcagcgggtg
      301 ctcctgctgt gagaagcccc gcccggccgg gctcctagcc ttccctttcc tcccttcctc
      361 caagcttctc cgttccctcc cctgagatac cggcgccatg tccagcgctc ggacccccct
      421 acccacgctg aacgaaaggg acacggagca gcccaccttg ggacaccttg attccaagcc
      481 cagcagtaag tccaacatgc tgcggggccg caactcagcc acctctgctg acgagcagcc
      541 ccatattggc aactacagac tccttaagac cattggcaag ggtaactttg ccaaagtgaa
      601 gttggcccgg cacatcctga cggggaaaga ggtagctgtg aagatcattg acaagactca
      661 gctgaattcc tccagcctgc agaaactctt ccgagaagta agaataatga aggttttgaa
      721 tcatcccaac atagttaagt tatttgaagt gatcgagact gagaagacgc tctaccttgt
      781 catggagtat gccagtggcg gagaggtatt tgattaccta gtggcccatg gcaggatgaa
      841 agaaaaagaa gctcgagcca aatttcgcca gatagtgtct gctgtgcagt actgtcacca
      901 gaagtttatt gttcatagag atctaaaggc agaaaacctg ctcctggatg ctgatatgaa
      961 catcaagatt gcagactttg gctttagtaa cgaattcacc tttgggaaca agctggatac
     1021 tttctgtggt agtcctcctt atgctgcccc agaactcttc cagggcaaaa agtatgacgg
     1081 tcctgaagtg gatgtctgga gcctgggcgt catcctctat acactggtca gcgggtccct
     1141 gccttttgat ggacagaacc tcaaggagct acgggaaagg gtactgaggg ggaaataccg
     1201 tattccattc tacatgtcca cggactgtga aaatctgctt aagaaatttc tcatacttaa
     1261 tcctagtaag agaggcactt tggagcaaat tatgaaagat cggtggatga atgtgggcca
     1321 tgaggatgac gagctaaagc cttacgtgga gccactccct gactacaagg atccccggcg
     1381 gacagagttg atggtgtcaa tgggttacac acgggaagag atccaggact cgctggtagg
     1441 ccagaggtac aacgaagtga tggctaccta tctgctcctt ggctacaaga gctctgagct
     1501 ggaaggtgac accatcactt taaagccccg gccttcagct gatctaacca acagcagtgc
     1561 cccatctcca tcccacaaag ttcagcgcag cgtctctgcc aaccccaagc agcggcgctc
     1621 cagtgaccag gccgtccccg ccattcccac ctcgaattcc tactctaaga agactcagag
     1681 taacaacgca gaaaataagc ggcctgagga agagacaggg cggaaagcca gcagcaccgc
     1741 caaagtgcct gccagccctc tgcctggcct ggacaggaag aagaccactc ctaccccctc
     1801 cacaaacagc gtcctctcca ccagcacaaa cagaagcagg aactccccac ttttggacag
     1861 ggccagcctt ggccaggcct ccatccagaa tggtaaagac agcctaacca tgccagggtc
     1921 ccgggcctcc acggcttctg cttctgccgc agtctctgcg gcccggcccc gccagcacca
     1981 gaaatccatg tctgcctccg tacaccccaa caaggcctct gggttgcccc ccacggagag
     2041 taactgtgag gtgcctcggc ccagcacagc cccccagcgt gtccctgtcg cctccccctc
     2101 cgcccacaac atcagcagca gtagtggagc cccagaccga actaatttcc cacggggtgt
     2161 gtccagtcga agcaccttcc atgctgggca gctccgacag gtgcgggacc agcagaatct
     2221 gcccttcggt gtgaccccag cctcaccctc tggccatagc cagggccggc ggggggcctc
     2281 tggcagcatc ttcagcaagt tcacctccaa gtttgtccgc aggaacctga atgaacctga
     2341 aagcaaagac cgagtggaga cgctcagacc tcacgtggta ggcggtggag gcactgacaa
     2401 ggaaaaggaa gaatttcggg aggccaagcc tcgttccctg cgcttcactt ggagcatgaa
     2461 gaccacgagc tctatggagc ccaatgagat gatgcgggag atccgcaagg tgctggacgc
     2521 caacagctgc caaagcgagc tgcacgagcg atacatgctg ctgtgcgtgc atggcacacc
     2581 cggccacgag aactttgtgc agtgggagat ggaggtgtgc aaactgcccc ggctgtctct
     2641 caacggtgtt cggtttaagc ggatatcggg cacttccatg gccttcaaaa acattgcctc
     2701 caaaatagcc aatgagctga agctttaaca ggctgtcagg aggggcggca gaggcccacc
     2761 agtggacttg gctgcttggg ccaaacctgc atccccctgg gagaaaaact gcaggatgaa
     2821 ttggtgtgtc tcccctgctg gcacttgtcc ccttccaggc ccttctcagt tttttcttcc
     2881 atgtttgtgg gggatgggaa gtggtggttc ctcctcccac attcacccct gcccagaagt
     2941 ctctcccttc ccctctaccc ccgtacagga ggcaaaggaa ggggaagggg ttgggggggc
     3001 agggctcccc ctcggtactg cggttgcaca gagtatttcg cctaaaccaa gaaaattttt
     3061 attaccaaaa agaaaaaaag aaaaaaaaaa agaaaaaaaa tcccagcggc cacctttcct
     3121 ccctgcccca ttgggacagt caagactgga tctgtggggc tcctgggagg atggctcagg
     3181 gctggaacac tctcaggcaa gagtggtggg gttccctgca ggccctccgc caggcccact
     3241 ttgggcttcc cctctcccca ctgctttccc ctccaagcga cccaccagag gtggccttcc
     3301 cctgccccca ggcccttggg ctatgggcct tatactgggg cccagtgggg gtactgcaca
     3361 gccctggaga gggtgagcag tgggaccctg gctccctcca taccatgtcc tctgcccgcc
     3421 ttccccagag ctgggcactt cctcccatga gctgctgtgg ggacattcgc tccccttctc
     3481 agaagtctgt gccatcttcc cccacctctc cgggtggaag gcggggctga cccccagttc
     3541 tggtaaaggg gagtggaatg cgccatgggc tctcagcccc cagggggccg cttgggaaca
     3601 gggacacagc ttctccgttc tgggcgtctt tgtctgaaag cacagcccct caccatcccc
     3661 ctaccgcttc cccttccttg gcattaatct gggcaccgtt ctcatctctc agccttgcct
     3721 tttcttcctg gcattgccgc ccctcctctc aggagactgt ccagggcctc catggctgcc
     3781 tggcggaagg ctggattggg cggcagggcc aggagcctct tgtcctccac tgggtggggc
     3841 aaagtaactc ctgcttgcta acctctgagg ccagtgtgtg aatgggtgac tgtaggcgct
     3901 tggctggtgg tggccactgc atcccttaat ttatttctct gctgtttcag ttcttgagaa
     3961 attggggaag tcctacagag gctgcccctg ccctcacctg agttgtacat tttttttgtg
     4021 atgggttatt ttttattttt tattattatt attattgttt ttttttggtt tttttttttt
     4081 tttttgattt atgatgactc cactctttgc cccagttgtc gtcttgtcac tcccacccct
     4141 gttcatcacc ctggctccca agccaggtca ggctcaccaa cacgttgagt cttgggttcc
     4201 aggaagaaac cttgccaacc tcaaccctcc agccccgtgc tccactggct atggctcaga
     4261 ccaagggctt ctcctttccc ctcttgccct acggaacagc ccgggtgctc caaagggggc
     4321 caggagggca tggcttggct cccaagataa ggggtggggg ccaggacacc caggcaaggt
     4381 ggcccctccc tgcctagccc cctcttcccc accctgcact tagtttctcc tctggatcaa
     4441 acacgtaata aagagaatgt ttggaatctg a
//
