LOCUS       NM_053947               2945 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1),
            mRNA.
ACCESSION   NM_053947
VERSION     NM_053947.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Bernard,L.P. and Zhang,H.
  TITLE     MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through
            a PKA-Dependent Mechanism
  JOURNAL   PLoS One 10 (5), e0124816 (2015)
   PUBMED   25932647
  REMARK    GeneRIF: MARK/Par1 is activated downstream of NMDA receptors in
            primary hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Gu,G.J., Lund,H., Wu,D., Blokzijl,A., Classon,C., von Euler,G.,
            Landegren,U., Sunnemark,D. and Kamali-Moghaddam,M.
  TITLE     Role of individual MARK isoforms in phosphorylation of tau at
            Ser(2)(2) in Alzheimer's disease
  JOURNAL   Neuromolecular Med 15 (3), 458-469 (2013)
   PUBMED   23666762
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Moravcevic,K., Mendrola,J.M., Schmitz,K.R., Wang,Y.H.,
            Slochower,D., Janmey,P.A. and Lemmon,M.A.
  TITLE     Kinase associated-1 domains drive MARK/PAR1 kinases to membrane
            targets by binding acidic phospholipids
  JOURNAL   Cell 143 (6), 966-977 (2010)
   PUBMED   21145462
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Maussion,G., Carayol,J., Lepagnol-Bestel,A.M., Tores,F.,
            Loe-Mie,Y., Milbreta,U., Rousseau,F., Fontaine,K., Renaud,J.,
            Moalic,J.M., Philippi,A., Chedotal,A., Gorwood,P., Ramoz,N.,
            Hager,J. and Simonneau,M.
  TITLE     Convergent evidence identifying MAP/microtubule affinity-regulating
            kinase 1 (MARK1) as a susceptibility gene for autism
  JOURNAL   Hum Mol Genet 17 (16), 2541-2551 (2008)
   PUBMED   18492799
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Jeon,S., Kim,Y.S., Park,J. and Bae,C.D.
  TITLE     Microtubule affinity-regulating kinase 1 (MARK1) is activated by
            electroconvulsive shock in the rat hippocampus
  JOURNAL   J Neurochem 95 (6), 1608-1618 (2005)
   PUBMED   16238695
  REMARK    GeneRIF: MARK1 was maximally activated between 2 and 5 min after
            electroconvulsive shock
REFERENCE   6  (bases 1 to 2945)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   7  (bases 1 to 2945)
  AUTHORS   Schaar,B.T., Kinoshita,K. and McConnell,S.K.
  TITLE     Doublecortin microtubule affinity is regulated by a balance of
            kinase and phosphatase activity at the leading edge of migrating
            neurons
  JOURNAL   Neuron 41 (2), 203-213 (2004)
   PUBMED   14741102
REFERENCE   8  (bases 1 to 2945)
  AUTHORS   Drewes,G., Ebneth,A., Preuss,U., Mandelkow,E.M. and Mandelkow,E.
  TITLE     MARK, a novel family of protein kinases that phosphorylate
            microtubule-associated proteins and trigger microtubule disruption
  JOURNAL   Cell 89 (2), 297-308 (1997)
   PUBMED   9108484
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053947.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z83868.1, SRR26643287.29631.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000013.1  99086506-99086701   c
            197-400             JAXUCZ010000013.1  99032263-99032466   c
            401-454             JAXUCZ010000013.1  99030727-99030780   c
            455-503             JAXUCZ010000013.1  99018517-99018565   c
            504-569             JAXUCZ010000013.1  99017312-99017377   c
            570-640             JAXUCZ010000013.1  99016182-99016252   c
            641-697             JAXUCZ010000013.1  99010251-99010307   c
            698-934             JAXUCZ010000013.1  99006578-99006814   c
            935-1054            JAXUCZ010000013.1  99006375-99006494   c
            1055-1154           JAXUCZ010000013.1  99002936-99003035   c
            1155-1267           JAXUCZ010000013.1  99001770-99001882   c
            1268-1421           JAXUCZ010000013.1  98998615-98998768   c
            1422-1615           JAXUCZ010000013.1  98998135-98998328   c
            1616-1716           JAXUCZ010000013.1  98994017-98994117   c
            1717-1881           JAXUCZ010000013.1  98992673-98992837   c
            1882-2133           JAXUCZ010000013.1  98991017-98991268   c
            2134-2178           JAXUCZ010000013.1  98985728-98985772   c
            2179-2945           JAXUCZ010000013.1  98983020-98983786   c
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2945
                     /gene="Mark1"
                     /note="microtubule affinity regulating kinase 1"
                     /db_xref="GeneID:117016"
                     /db_xref="RGD:619882"
     exon            1..196
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2527
                     /gene="Mark1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="MAP/microtubule affinity-regulating kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MARK1"
                     /protein_id="NP_446399.1"
                     /db_xref="GeneID:117016"
                     /db_xref="RGD:619882"
                     /translation="MSARTPLPTVNERDTENHTSVDGYTETHIPPTKSSSRQNIPRCR
                     NSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ
                     KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
                     AKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCG
                     SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRV
                     PFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLNDAK
                     RIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRP
                     SSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQK
                     EEWDKDTARRLGSTTVGSKSEVTASPLVGPDRKKSSAGPSNNVYSGGSMTRRNTYVCE
                     RSTDRYAALQNGRDSSLTEMSASSMSSTGSTVASAGPSARPRHQKSMSTSGHPIKVTL
                     PTIKDGSEAYRPGTAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRS
                     AAYSGPPASPSHDTAALAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTARGSSG
                     EPKDKEEGKEAKPRSLRFTWSMKTTSSMDPNDMVREIRKVLDANTCDYEQRERFLLFC
                     VHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL"
     exon            197..400
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..454
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..503
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..569
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..640
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..697
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..934
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1054
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1154
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1267
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1421
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1615
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1716
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1881
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2133
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2178
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2945
                     /gene="Mark1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcctcgc ccgccttccc gccccgcggc ctgcgggagc cgcgcgctcc ccggcgcggc
       61 ctgctcgcgc gcgcccgccc tcgccgaagc cctcctcggc ccgcgacccg ccggaccccc
      121 ggcccgaccc cgccgcccgc gcaagatgtc ggcgcggacg ccattgccca cggtgaacga
      181 gcgggacacg gagaaccata catctgtgga tggatatact gaaacgcata tcccgcctac
      241 caaatcaagt agcagacaaa acattccccg gtgtagaaac tccattacgt cagcgacaga
      301 tgaacagcct cacatcggaa attaccgttt acagaaaaca atagggaagg ggaattttgc
      361 caaagtgaaa ttggcaaggc atgtcctaac aggtagagag gtagctgtga aaataataga
      421 caaaactcag ctaaacccta ccagtctaca aaagttgttc cgagaagtac gaataatgaa
      481 gatactgaac catcctaaca tagtgaaact gtttgaagtt attgaaacag agaagacgct
      541 ctacctggtc atggaatacg caagtggggg tgaagtcttt gattacttag ttgcccacgg
      601 aagaatgaaa gagaaagagg cccgggccaa attcaggcag attgtatctg ctgtacagta
      661 ttgtcatcaa aaatgcattg tccaccgtga tcttaaggct gaaaaccttc tccttgatgc
      721 tgatatgaat attaaaattg ctgactttgg ttttagcaat gaattcacag tggggaacaa
      781 attggacaca ttctgtggaa gcccgcctta tgctgcccct gagcttttcc aaggcaagaa
      841 gtacgacggg ccggaagtgg atgtgtggag tctaggcgtc attctctaca cgctggtcag
      901 tggctccctg cctttcgatg gccagaatct aaaggagctc cgggagcggg tcctgcgagg
      961 gaagtaccgt gttcctttct acatgtccac ggactgcgag aacctcctga agaaactgct
     1021 agtgctgaac cccataaaga ggggcagcct ggagcaaata atgaaagacc gatggatgaa
     1081 cgttggtcat gaagaggaag agctaaaacc atattctgag cctgagcttg atctcaatga
     1141 tgcaaaaaga atagacatta tggtcaccat gggttttgca cgagatgaaa tcaatgatgc
     1201 cttagtaagc cagaaatatg atgaggttat ggctacttat attcttctag gtagaaaacc
     1261 acctgagttc gaaggtggtg agtcactgtc cagtggaaac ctttgtcagc gatcccggcc
     1321 gagcagtgac ctgaacaaca gcacgcttca gtcacctgct cacctgaagg tccagcgaag
     1381 catctcagcc aaccagaagc agaggcgctt cagtgaccat gccggtccct ccatcccccc
     1441 tgctgtctca tacaccaaaa ggcctcaggc caacagcgtg gagagtgaac agaaagagga
     1501 gtgggacaaa gacacagccc gcagacttgg cagcaccacc gtgggctcga agagcgaagt
     1561 cacagccagc cccttggtgg ggccagacag gaaaaagtcc tcagctggcc caagtaacaa
     1621 cgtatattct ggcggtagca tgacgaggag aaatacatat gtgtgtgaga ggagcacgga
     1681 ccggtacgct gccttgcaga atggaagaga cagcagcctt acagagatgt ctgccagcag
     1741 catgtcctcc acaggttcca ctgtggcctc tgctggcccc tcagcacgtc cccgccacca
     1801 gaagtctatg tcaacctctg gccaccctat taaagttaca ctgccaacca ttaaagatgg
     1861 ctctgaagct tatcggcctg gtacagctca gagagtgcct gctgcttccc cgtctgctca
     1921 cagcattagt gccagtactc ctgacaggac ccgcttcccc cgagggagct ccagccgaag
     1981 cactttccac ggggagcagc tccgagagcg gcgcagtgct gcttatagcg gaccacctgc
     2041 ctccccgtcc catgacacag ctgcacttgc acatgccaga agggggacgt caactgggat
     2101 aatcagcaaa atcacctcca agttcgtccg cagggaccca agtgaaggcg aagccagtgg
     2161 cagaaccgac acagccagag gttcatcggg ggagccgaaa gacaaggaag agggtaagga
     2221 ggccaagccg aggtcgctgc gcttcacgtg gagcatgaag accactagtt caatggaccc
     2281 caatgacatg gtgagagaga tccgcaaggt gctggatgcc aacacctgtg actatgaaca
     2341 gagagagagg ttcctgctct tctgcgttca cggagacgct cggcaggaca gcctcgtaca
     2401 gtgggagatg gaggtctgca agttgcctcg gctctcactc aatggggtcc gcttcaagcg
     2461 aatatccggg acatctattg cctttaagaa cattgcatcc aaaatagcaa atgagcttaa
     2521 gctgtagaga tgtgtaggct tcgggatcag ggaagatgca cccacatctg aggtaccgtc
     2581 tctgagtgta ctggcgacag ctgatgtggt ccagctgtga atctcccatg cagaaatcgt
     2641 ccttaatgca ataaggttat acatagttat gagctgtaaa attcaagtca gtacgagcta
     2701 taataagaac cgtagcttca aaagtaggtt cacatgtaca ggtaagtata ttgtgtattt
     2761 ctgttcattt tctgttcata gagttgtata ataaaatata attgctttaa aacctgtata
     2821 gttgtctaga tctccacaca gaaatgtacg tttaatgctg tgagttgaaa aggatttccc
     2881 tgttacttac atctggtgtg tttttaaaac tcttacctcc gtcatgctat tttgaaaatt
     2941 gtgtc
//
