LOCUS       NM_030862               1540 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus MARCKS-like 1 (Marcksl1), mRNA.
ACCESSION   NM_030862
VERSION     NM_030862.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1540)
  AUTHORS   Bjorkblom,B., Padzik,A., Mohammad,H., Westerlund,N., Komulainen,E.,
            Hollos,P., Parviainen,L., Papageorgiou,A.C., Iljin,K.,
            Kallioniemi,O., Kallajoki,M., Courtney,M.J., Magard,M., James,P.
            and Coffey,E.T.
  TITLE     c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines
            actin stability and migration in neurons and in cancer cells
  JOURNAL   Mol Cell Biol 32 (17), 3513-3526 (2012)
   PUBMED   22751924
  REMARK    GeneRIF: c-Jun N-terminal kinase phosphorylation of MARCKSL1
            enables it to bundle and stabilize F-actin, increase filopodium
            numbers and dynamics, and retard migration in neurons.
REFERENCE   2  (bases 1 to 1540)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1540)
  AUTHORS   Zhao,J., Izumi,T., Nunomura,K., Satoh,S. and Watanabe,S.
  TITLE     MARCKS-like protein, a membrane protein identified for its
            expression in developing neural retina, plays a role in regulating
            retinal cell proliferation
  JOURNAL   Biochem J 408 (1), 51-59 (2007)
   PUBMED   17688421
REFERENCE   4  (bases 1 to 1540)
  AUTHORS   Bertaso,F., Lill,Y., Airas,J.M., Espeut,J., Blahos,J., Bockaert,J.,
            Fagni,L., Betz,H. and El-Far,O.
  TITLE     MacMARCKS interacts with the metabotropic glutamate receptor type 7
            and modulates G protein-mediated constitutive inhibition of calcium
            channels
  JOURNAL   J Neurochem 99 (1), 288-298 (2006)
   PUBMED   16987251
REFERENCE   5  (bases 1 to 1540)
  AUTHORS   Yang,H., Wang,X., Sumners,C. and Raizada,M.K.
  TITLE     Obligatory role of protein kinase Cbeta and MARCKS in vesicular
            trafficking in living neurons
  JOURNAL   Hypertension 39 (2 Pt 2), 567-572 (2002)
   PUBMED   11882609
  REMARK    GeneRIF: PKCbeta-MARCKS signaling may be a general mechanism for
            the stimulation of vesicular trafficking in brain neurons.
REFERENCE   6  (bases 1 to 1540)
  AUTHORS   McNamara,R.K. and Lenox,R.H.
  TITLE     Differential regulation of primary protein kinase C substrate
            (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic
            acid-induced seizures and synaptic reorganization
  JOURNAL   J Neurosci Res 62 (3), 416-426 (2000)
   PUBMED   11054811
REFERENCE   7  (bases 1 to 1540)
  AUTHORS   Chang,S., Hemmings,H.C. Jr. and Aderem,A.
  TITLE     Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C
            substrate, in nerve termini and PC12 cells
  JOURNAL   J Biol Chem 271 (2), 1174-1178 (1996)
   PUBMED   8557647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081789.1.
            
            On Oct 17, 2004 this sequence version replaced NM_030862.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081789.1, AJ301677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1540
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1540
                     /gene="Marcksl1"
                     /gene_synonym="F52; Mlp"
                     /note="MARCKS-like 1"
                     /db_xref="GeneID:81520"
                     /db_xref="RGD:621197"
     exon            1..269
                     /gene="Marcksl1"
                     /gene_synonym="F52; Mlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..782
                     /gene="Marcksl1"
                     /gene_synonym="F52; Mlp"
                     /note="macMARCKS; mac-MARCKS; brain protein F52;
                     MARCKS-like protein 1; macrophage myristoylated
                     alanine-rich C kinase substrate; MARCKS-related
                     protein-like"
                     /codon_start=1
                     /product="MARCKS-related protein"
                     /protein_id="NP_110489.1"
                     /db_xref="GeneID:81520"
                     /db_xref="RGD:621197"
                     /translation="MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLTPKG
                     EGESPPVNGADEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSG
                     LSFKRNRKEGGGDSSASSPTEEEQEQGEISACSDEGTAQEGKAAATPESQEPQAKGAE
                     ASAVSKGGDAEEEAGPQAAEPSTPSGPESGPASASAENE"
     exon            270..1516
                     /gene="Marcksl1"
                     /gene_synonym="F52; Mlp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagcagca gtgggcgcag ctagcgggtc agctgcggag cgggggtgca gcgcgctttg
       61 ccccccgtac ccctccccct cggacgcagc cccacccctc tgcccgccgg gccgtcccag
      121 ccgaactatc ccctgcggcg ccagcgcggg gcggctccgg gcgcccccag cagaccccca
      181 tcatgggcag ccagagctcc aaggctcccc ggggcgacgt gaccgccgag gaggcagcgg
      241 gcgcttcccc cgcgaaggcc aacggacagg agaatggcca cgtgaaaagc aatggagact
      301 taacccccaa gggtgaaggg gagtcaccac ccgtgaacgg agcagatgag gcagctgggg
      361 ctactggtga tgccatcgag ccagcgcccc ctagccagga agctgaggcc aagggggagg
      421 tcgcccccaa ggagaccccc aagaagaaga agaaattctc tttcaagaag cctttcaaat
      481 tgagtggcct gtccttcaag agaaatcgga aggagggtgg gggtgattct tcagcctcct
      541 caccaacaga ggaagagcaa gagcaggggg aaatcagcgc ctgcagtgat gagggcactg
      601 cccaagaagg gaaggctgct gccacccctg agagccaaga gccccaggcc aagggggcag
      661 aggccagtgc tgtctccaag ggaggagacg cggaagaaga ggcagggccc caggctgcag
      721 agccatccac tccctcgggc ccagagagtg gccccgcatc tgccagtgct gagaatgagt
      781 agctgggcgg gggctggtgg gtgatctcta agctgcaaaa actgtgctgt ccttgtgagg
      841 tcaccatctg gaccttgtgc cctggctgcc ttcctgtgcc cagaaaggaa ggggcttgtt
      901 gccccgtccc agccacgctc cctcttctcc ctcctgtgga ttctcccatc agccatttgg
      961 tcttactatt aggccagttg aagatggtcc cttacggttc ccaagttagg ttagtgatgt
     1021 gaaatgctcc tgcctctctc cttcccaagc cccatccccg ctgaaggcaa ctgctgggtt
     1081 tccaattctt ttccaagttc gttttgttta tcctgcttct caagcccctg agccagaagt
     1141 ggggcttaca ctcccaaacc ccgagcgtcc agcctttccc ttgttgaatt cttagtctct
     1201 tgtgctgtgc cctgtggcac ctgggctggg gagggcattg cccctgtctg ggtttttata
     1261 aatgtcttac tcaagttcaa acctccagct tgtgaaatca ccgtgtctct gacttgataa
     1321 gcaagtatta ggcttcaggc gggagggagg tctgtaatgt gaaacaactc cttgttgtct
     1381 ttcccccctc ccattgttgt aaataacttt taatggccaa accccagatt tgtacttttt
     1441 ttttctaact gctaaaacca ttcttccacc tggatttact gtaacatttg gaaaaggaat
     1501 aaatgttgtc cctttaaaaa aaaaaaaaaa aaaaaaaaaa
//
