LOCUS       NM_001271090            4180 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus myristoylated alanine rich protein kinase C
            substrate (Marcks), mRNA.
ACCESSION   NM_001271090 XM_002728965 XM_003753491
VERSION     NM_001271090.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Zhang,Z.H., Ma,F.F., Zhang,H. and Xu,X.H.
  TITLE     MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation
  JOURNAL   Neurochem Res 42 (10), 2933-2939 (2017)
   PUBMED   28623606
  REMARK    GeneRIF: that MARCKS is involved in oligodendrocyte precursor cell
            maturation by interacting with Ras-associated protein 10
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Xu,X.H., Deng,C.Y., Liu,Y., He,M., Peng,J., Wang,T., Yuan,L.,
            Zheng,Z.S., Blackshear,P.J. and Luo,Z.G.
  TITLE     MARCKS regulates membrane targeting of Rab10 vesicles to promote
            axon development
  JOURNAL   Cell Res 24 (5), 576-594 (2014)
   PUBMED   24662485
  REMARK    GeneRIF: Either genetic silencing of MARCKS or disruption of its
            interaction with Rab10 inhibited axon growth of cortical neurons.
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Pinner,A.L., Haroutunian,V. and Meador-Woodruff,J.H.
  TITLE     Alterations of the myristoylated, alanine-rich C kinase substrate
            (MARCKS) in prefrontal cortex in schizophrenia
  JOURNAL   Schizophr Res 154 (1-3), 36-41 (2014)
   PUBMED   24568864
  REMARK    GeneRIF: decreased MARCKS and pMARCKS in the frontal cortex in
            schizophrenia was found; results suggest a mechanism other than
            myristoylation was responsible for decreased MARCKS expression in
            schizophrenia
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Mosevitsky,M.I., Snigirevskaya,E.S. and Komissarchik,Y.Y.
  TITLE     Immunoelectron microscopic study of BASP1 and MARCKS location in
            the early and late rat spermatids
  JOURNAL   Acta Histochem 114 (3), 237-243 (2012)
   PUBMED   21764106
  REMARK    GeneRIF: In spermatozoa, as in chromatoid body, BASP1 and MARCKS
            may bind Ca(2+)-calmodulin and therefore contribute to the
            activation of calcium-dependent biochemical processes.
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Ueno,E. and Rosenberg,P.
  TITLE     beta-Bungarotoxin blocks phorbol ester-stimulated phosphorylation
            of MARCKS, GAP-43 and synapsin I in rat brain synaptosomes
  JOURNAL   Toxicon 33 (6), 747-762 (1995)
   PUBMED   7676466
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Herget,T., Brooks,S.F., Broad,S. and Rozengurt,E.
  TITLE     Relationship between the major protein kinase C substrates acidic
            80-kDa protein-kinase-C substrate (80K) and myristoylated
            alanine-rich C-kinase substrate (MARCKS). Members of a gene family
            or equivalent genes in different species
  JOURNAL   Eur J Biochem 209 (1), 7-14 (1992)
   PUBMED   1396720
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Erusalimsky,J.D., Brooks,S.F., Herget,T., Morris,C. and
            Rozengurt,E.
  TITLE     Molecular cloning and characterization of the acidic 80-kDa protein
            kinase C substrate from rat brain. Identification as a glycoprotein
  JOURNAL   J Biol Chem 266 (11), 7073-7080 (1991)
   PUBMED   1707878
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Ouimet,C.C., Wang,J.K., Walaas,S.I., Albert,K.A. and Greengard,P.
  TITLE     Localization of the MARCKS (87 kDa) protein, a major specific
            substrate for protein kinase C, in rat brain
  JOURNAL   J Neurosci 10 (5), 1683-1698 (1990)
   PUBMED   2332803
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Erusalimsky,J.D., Morris,C., Perks,K., Brown,R., Brooks,S. and
            Rozengurt,E.
  TITLE     Internal amino acid sequence analysis of the 80 kDa protein kinase
            C substrate from rat brain: relationship to the 87 kDa substrate
            from bovine brain
  JOURNAL   FEBS Lett 255 (1), 149-153 (1989)
   PUBMED   2676596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001271090.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M59859.1, BF281934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               JAXUCZ010000020.1  42245399-42245882   c
            485-4180            JAXUCZ010000020.1  42240185-42243880   c
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..4180
                     /gene="Marcks"
                     /gene_synonym="KINC; Macs"
                     /note="myristoylated alanine rich protein kinase C
                     substrate"
                     /db_xref="GeneID:25603"
                     /db_xref="RGD:3028"
     exon            1..484
                     /gene="Marcks"
                     /gene_synonym="KINC; Macs"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1312
                     /gene="Marcks"
                     /gene_synonym="KINC; Macs"
                     /note="protein kinase C substrate 80 kDa protein;
                     Myristoylated alanine-rich protein kinase C substrate"
                     /codon_start=1
                     /product="myristoylated alanine-rich C-kinase substrate"
                     /protein_id="NP_001258019.2"
                     /db_xref="GeneID:25603"
                     /db_xref="RGD:3028"
                     /translation="MGAQFSKTAAKGEAAAERPGEAAVASSPSKANGQENGHVKVNGD
                     ASPAAAEPGAKEELQANGSAPAADKEEPASGGAATPAAADKDEAAAAPESGAATADKE
                     AAEAEPAEPGSPSAETEGASASSTSSPKAEDGAAPSPSSETPKKKKKRFSFKKSFKLS
                     GFSFKKSKKEAGEGAEAEGATADGAKDEAAAAAGGDAAAAPGEQAGGAGAEGAEGGES
                     REAEAAEPEQPEQPEQPAAEEPRAEEPSEAVGEKAEEPAPGATADDAPSAAGPEQEAP
                     AATDEPAASAAPSASPEPQPECSPEAPPAPVAE"
     exon            485..4180
                     /gene="Marcks"
                     /gene_synonym="KINC; Macs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcatctta ttagcaacca gggagatttc tccattttcc tcttgtctac agtgcggcta
       61 caaatctggg attttttttt attacttctt tttttaaaaa actacacttg ggctcctttt
      121 ttgtgctcga cttttccacc tttttccctc cttcctgcgc tgctgctttt tgatctcttc
      181 gactaaaaat tttttatccg gagtgtattt aatcgggtct cttctgtcct cctcgtcacc
      241 cccaccccct ccctccggtg tgtgtgccgc cgccgctgtt gctgctgccg ccgctgctgc
      301 tgctcgcccc gtcgttacac caacccaagg ctctttgttt cctctcttgg atctgttgag
      361 tttctttgtt gaagaagcca gcatgggtgc acagttctcc aagaccgcag cgaagggaga
      421 agccgccgct gagaggcccg gggaggcggc tgtggcctcg tcgccttcca aagcaaatgg
      481 gcaggagaat ggccacgtaa aagtgaacgg ggacgcgtcg cccgccgccg ccgagccggg
      541 cgccaaggag gagctgcagg ccaacggcag cgccccggcc gccgacaagg aggagcctgc
      601 gagcggcggc gccgcgaccc ccgccgcggc cgataaggat gaggcagccg cggcccccga
      661 gtcgggcgcc gccacggccg acaaggaggc tgcggaggcc gagcccgccg agcccggctc
      721 cccctccgcg gagaccgagg gcgcgtctgc ctcctccacg tcgtccccca aggcggagga
      781 cggggccgcg ccgtctccca gcagcgagac cccgaaaaaa aaaaagaagc gcttttcctt
      841 caagaagtcc ttcaagctga gcggcttctc cttcaagaag agcaagaagg aggccggcga
      901 gggcgctgag gcggaaggcg cgaccgccga cggcgccaag gacgaggccg cagctgcagc
      961 cggcggcgac gcggccgcgg ccccggggga gcaggcgggc ggggcgggcg ccgagggcgc
     1021 ggagggcgga gagtcccggg aggccgaggc ggcggagccg gagcagccgg agcagcctga
     1081 gcagcccgcg gcggaagagc caagggccga ggagccgtcg gaggccgtgg gggagaaggc
     1141 cgaggagccc gcgccgggcg ccaccgcaga tgacgcgccc tccgctgcgg ggcccgagca
     1201 ggaggcgccc gccgccaccg acgagcccgc ggcgtccgca gctccctccg cgtcaccgga
     1261 gccgcagccc gagtgcagtc cggaggcgcc ccccgcgccg gtggccgagt aagctccggg
     1321 cgccctcttg taattcaaga acttttcccc ccaagtttgt ttgttggagt ggtgccaggt
     1381 actggttttg gagaacttgt ctacaaccag ggattgattt taaagatttt ttttttaatt
     1441 ttacattttt tttttaaagc agcaaatttt gttttctttt aaagccccct tccccacaga
     1501 tcccatctca aatcattgtt accaccattc cgacaggccg aggacggttt agacagcttc
     1561 ctctgccttc ttttgttttt gtttttgttt tttttttctt tacttttact cttttttttt
     1621 tgcatcagta ttaatgtttt ttgcatactt tgcatcttta ttaaaaaaat gtaaactttc
     1681 tttgtcaaat ctatggacgt acccatatat gaaggagatg ggtgggtcaa aaaggaatat
     1741 caaatgaagt gataggggcc actatgggaa attgaaacag tgcataacat tgccaagata
     1801 atatgccact aaaaacgacg gtgtaaaggc ttaggggttt ccttctttcc tttttttttt
     1861 ttttaaagaa agttattacg atgtattttg tgaggcaggt ttacaacact acacgttttg
     1921 aataagaagg aaaaagaaaa gaattaaaaa caccaatacc cagatttaaa aaaaaaaaat
     1981 catagtctta ggagttcatc taaaccatag gaacttcctg cttatctcat gttagctgta
     2041 ccagtcagta attatgtaga actacaagtt gtataggctt tattgtttat tgctggttta
     2101 tgaccttaat aaagtgtaat tatgtattac cagcagggtg tttttaactg tgattattgt
     2161 ataaaaacaa atcttgatat ccttcagaag cacatgaagt ttgcaagtct ccaccctgcc
     2221 catctttttg taaaactgca gtcatcttgg accttttaaa cacaaatttt aaacccaacc
     2281 aagctgtgat acgtggaatg gttactgttt atactgtggt atgttttttt ttttcttttt
     2341 tctttttttt tttttttttt tgattacagc agacaatgct ttcttttcca gttgtctttg
     2401 agaataaagg aaaaacaaat cttcagatgc agtggttttg cgtagcacct cgtctctcgt
     2461 gttttgtaaa tactggagga tctttgacca atttgacata gagctggaat gtaacgttgc
     2521 ttacaaacat tgctattcaa ctcctgctta aggtgttcta attttctgtg agcacactaa
     2581 aagcaaaaaa taaatgtgaa taaaatgtac aaatttgttg tgttttttta tgttctgagg
     2641 ctgacttcta ggtcttaggt taacttttag ggaggccttg catgccatca aaagtacatt
     2701 tggctgtggt ttttgataag aagttttcaa gctctggaat tcataatcag tgtcaaatta
     2761 catatgtggg aagatcttat actgtgtcga ttgttatcat ttatctgctt ttaatttgca
     2821 tttaaaactg aaaattactt ttactgtagt tatgtagcat gccaaattaa gccacttaag
     2881 acagaagtgg ctggacccta agactatttc ataaactgtt ttcttgtcat tgcaggtcca
     2941 gaagcaagag tgttgagttc agactgcaca taagtcatga aaagatggcc aaacatgttt
     3001 aaatgttgat ggtttatatg gtataagcct tagcgtttgg ctcacttcca aattattgtc
     3061 gaaatgtgct atactttacg gacaggtttc cataaggaag taatggtgtt caatggacat
     3121 attgttagtt ttggaccatt agcatagctt cgaccttttt tttttttctt ttgaatcaaa
     3181 gtgttagcat cttgttactc aaatgaaaag ataatccttt atatattaat ccttactagt
     3241 ttactttctg cttattttcc agcttataac tggatttttt ttactggacc ctaaactgat
     3301 tcttttttta actattgctt tattaaatgc aaaatagtcc acctgttgtg atttgagcag
     3361 agtgccgggt ggagttcagg gtaaagttga gccacatctg tggtggcctc tcaatattcc
     3421 atcatattaa gaataacagc attagctttt ggataatgct ccctaattga aataatggat
     3481 cagaactaat ggttcctttc ctttctaaac agtctccctg ctaatgatac caagtaacat
     3541 ttgaaagagt aaacttgatc ctgagtttct tgagttcttg gaagattaaa gtcaaacctg
     3601 gtaaccaaag gactgatttg tgggtctttc ccactttaac caacttgttc gaaaacccct
     3661 agttggccaa atatggtgcc tggtatgtag tagcactcaa ctgaaatggg tttttaaaaa
     3721 agaaaaaaaa aataactcct gaactgagta gttaaaaata ctgtgtagaa aagtattcta
     3781 tattgctagg tttgttcttt taacagctga gatttattaa gatgcattat tttgatttta
     3841 atcactgcct aaaaacactt tgggtggtac tgatggagtg gtggattttc ctccaaatgg
     3901 ctaaatgcaa tttgacatac ttttcatcca aagttttgta catcctgttg ttttctaatg
     3961 gaaaaaaaat gttaatatgg cttttttgta ctactaaaaa tagctttgag attaaggaaa
     4021 ataaataact cttgtacagt tcagaatcgt gttattaagt ctgtattggc agtgtgtaca
     4081 gtgacatttg ctgtggttat gaacacttat ctggattata aaaagcattt ggtccaattc
     4141 ctatttcttg taaaataaag ttttaccagt tgatataatc
//
