LOCUS       NM_001012087            2421 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus membrane associated ring-CH-type finger 7
            (Marchf7), mRNA.
ACCESSION   NM_001012087 XM_229946
VERSION     NM_001012087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Zhao,K., Yang,Y., Zhang,G., Wang,C., Wang,D., Wu,M. and Mei,Y.
  TITLE     Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase
            MARCH7
  JOURNAL   EMBO Rep 19 (2), 305-319 (2018)
   PUBMED   29295817
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Flach,K., Ramminger,E., Hilbrich,I., Arsalan-Werner,A.,
            Albrecht,F., Herrmann,L., Goedert,M., Arendt,T. and Holzer,M.
  TITLE     Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates
            tau protein in vitro impairing microtubule binding
  JOURNAL   Biochim Biophys Acta 1842 (9), 1527-1538 (2014)
   PUBMED   24905733
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Zhao,B., Ito,K., Iyengar,P.V., Hirose,S. and Nakamura,N.
  TITLE     MARCH7 E3 ubiquitin ligase is highly expressed in developing
            spermatids of rats and its possible involvement in head and tail
            formation
  JOURNAL   Histochem Cell Biol 139 (3), 447-460 (2013)
   PUBMED   23104140
  REMARK    GeneRIF: The results suggest that MARCH7 is involved in
            spermiogenesis by regulating the structural and functional
            integrity of the head and tail of developing spermatids.
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Nathan,J.A., Sengupta,S., Wood,S.A., Admon,A., Markson,G.,
            Sanderson,C. and Lehner,P.J.
  TITLE     The ubiquitin E3 ligase MARCH7 is differentially regulated by the
            deubiquitylating enzymes USP7 and USP9X
  JOURNAL   Traffic 9 (7), 1130-1145 (2008)
   PUBMED   18410486
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Metcalfe,S.M., Muthukumarana,P.A., Thompson,H.L., Haendel,M.A. and
            Lyons,G.E.
  TITLE     Leukaemia inhibitory factor (LIF) is functionally linked to
            axotrophin and both LIF and axotrophin are linked to regulatory
            immune tolerance
  JOURNAL   FEBS Lett 579 (3), 609-614 (2005)
   PUBMED   15670816
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083842.1.
            
            On Feb 11, 2005 this sequence version replaced XM_229946.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132280
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2421
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /note="membrane associated ring-CH-type finger 7"
                     /db_xref="GeneID:311059"
                     /db_xref="RGD:1308993"
     exon            1..177
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            178..342
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2268
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH7; MARCH-VII;
                     RING-type E3 ubiquitin transferase MARCHF7;
                     membrane-associated RING-CH protein VII;
                     membrane-associated RING finger protein 7; RING-type E3
                     ubiquitin transferase MARCH7; axotrophin;
                     membrane-associated ring finger (C3HC4) 7, E3 ubiquitin
                     protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF7"
                     /protein_id="NP_001012087.1"
                     /db_xref="GeneID:311059"
                     /db_xref="RGD:1308993"
                     /translation="MESKPSRIPRRISVQPSGSLSARMVSGNRGTSLNDSYHSRDSSF
                     RLDSEYQSASASASASPYQSTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTST
                     SAGRNIGSGLNTLSDSSWRPGQVPRSSSMVLGSFGTDLMRERRDLERRRDSSISSLMD
                     YSHRSGDFTAPAYVQERVPSSYSQGARPKENAANTLQLNSSTNHQLPSEHQTVPSSRD
                     SSRSSFRSHFSPRQSESFRNSSHPAFSYLSSRNETPTISSSERAGSSQRPFQESSDNE
                     GRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRNNGASSS
                     EVNDGRASEASQGFRFLRRRWGLSSLSQNHSSEPDAENFNQESEGRNTGPWLSSSLRN
                     RCTPLFSRRRREGRDESSRISPSDVPPRSHLFRRESNEVVHLEAQGDSLGAAASRPQA
                     SGASGNASASGSTPDLPQGGRNTGIAGILPGSLFRFAVPPALGSNLTDNVTITVDIIP
                     SGWSSADGKSEKAKSAPSRDPEKLQKIKESLLLEDSDEEEEGDLCRICQMAAASSSNL
                     LIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHEL
                     HRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHM
                     EDLETSEDEF"
     exon            343..538
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            539..706
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1802
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1975
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2085
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2199
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2248
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2384
                     /gene="Marchf7"
                     /gene_synonym="Axot; March7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgcaga gccactctgg gcagcctcat gagacctgtg ccagagcagt aggttttttg
       61 ttttttacac agagtctcca tgtacagctc tgtctggtgt ttagctgtct acatctactg
      121 ctttgagctt gaactcagaa atgagccagc ctttgtctcc tgagtactgg gataaaggaa
      181 accttaagaa tggagtctaa accttccagg attccaagaa gaatttctgt tcaaccctct
      241 ggctctttaa gtgctaggat ggtatctgga aaccgaggaa ccagtttaaa tgattcctat
      301 cattctagag actcttcctt tagactggat tctgaatatc agtctgcctc agcgtcagca
      361 tctgcatcac catatcagtc tacttggtac agtgagtctg agataactca gggagcacgg
      421 tcacggtcac aaaaccagca aagggatcat gattcaaaaa gacctaaact ttcttgtaca
      481 aactgtacgt ctacctcagc tgggagaaat attggaagtg gtttaaatac actgtcagat
      541 tcttcttgga ggcctggtca agttccgaga tcttcttcaa tggtccttgg ttcatttgga
      601 acagacttga tgagagagag gagagatctg gagaggagaa gggactcctc cattagcagt
      661 cttatggact atagtcaccg gagtggggat ttcacagctc cagcatatgt tcaagaaaga
      721 gttccttctt catattcaca gggagcaaga ccaaaagaga atgccgcgaa cactttacag
      781 ttgaattcat ccaccaatca ccaactgcct tctgagcatc agacagtacc aagttctagg
      841 gactctagta gaagttcttt cagatcccat ttttctccaa gacaatcaga atcttttcga
      901 aacagttcac atcctgcatt ttcatatctt tcaagtagaa atgaaactcc aactataagc
      961 agttcagaaa gggctggctc gtctcagaga ccatttcaag aatcttctga caatgaaggt
     1021 aggcgtacaa ctaggagatt gctgtcacgg atagcttcta gcatgtcatc taccttcttt
     1081 tcacgaagat ctagtcaaga ttccttaaat acaaggtcac tgagttccga aaattatatt
     1141 tctccaagaa ccctgacttc acagtctcgg aataatggag catcatcttc tgaagttaat
     1201 gatggcaggg cgtctgaagc gtctcaggga tttaggtttc ttaggcgaag atggggtttg
     1261 tcgtctctta gccagaatca tagctctgaa ccagatgcag aaaactttaa ccaagaatca
     1321 gaaggtagaa atacaggacc atggttgtct tcctcactta gaaatagatg cacacctttg
     1381 ttctctagaa ggaggcgaga gggaagagat gagtcttcaa gaatatctcc atcagatgta
     1441 cctcctagat ctcatctttt cagaagagaa tcaaatgaag tagttcacct tgaagcacag
     1501 ggggactccc ttggggcagc tgccagcaga ccacaagcat ccggagcatc aggcaatgct
     1561 tctgcaagtg gatccacacc agatttgcca cagggtggaa gaaatacagg aatagcaggg
     1621 atccttcctg gctccttatt ccggtttgca gttccgccag cacttggcag taacctgact
     1681 gacaatgtca cgattaccgt agatattatt ccttcaggtt ggagttcagc tgatgggaaa
     1741 agtgaaaaag ctaaaagtgc accttcaaga gacccagaaa aacttcagaa aatcaaagaa
     1801 agcctcctct tagaggactc tgatgaagaa gaagaagggg acttatgtag aatttgccag
     1861 atggcagcag cgtcatcatc taatttattg atagagccat gcaaatgcac tgggagtctg
     1921 cagtatgtcc atcaagagtg tatgaagaag tggttacagg ccaaaattaa ttctggttct
     1981 tcattagagg ctgtaaccac ctgtgaactc tgtaaagaga agttgcaact taacctggag
     2041 gattttgata ttcatgaact acatagagct catgcaaatg aacaagctga gtatgagttt
     2101 atcagctctg gtctctacct agttgtctta ctgcacttgt gtgaacaaag cttttctgat
     2161 atgatgggaa atacaatcga accaagcacg cgcgtccgat ttattaacct tgcaagaact
     2221 cttcaggcac atatggaaga tctcgaaact tcagaggatg agttctgaag atgatggaga
     2281 ccacaacaga aggcttgata ttgcttcact tcatttaaga caaatggatt atctgtgaac
     2341 atgtttgttg aaactggcaa ttaagtatga ataatttcat ggggaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa a
//
