LOCUS       NM_001106372            1472 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus membrane associated ring-CH-type finger 5
            (Marchf5), mRNA.
ACCESSION   NM_001106372 XM_001080178 XM_215286
VERSION     NM_001106372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Matsuno K, Nagashima S, Shiiba I, Taniwaka K, Takeda K, Tokuyama T,
            Ito N, Matsushita N, Fukuda T, Ishido S, Inatome R and Yanagi S.
  TITLE     MITOL dysfunction causes dwarfism with anterior pituitary
            hypoplasia
  JOURNAL   J Biochem 168 (3), 305-312 (2020)
   PUBMED   32302394
  REMARK    GeneRIF: MITOL dysfunction causes dwarfism with anterior pituitary
            hypoplasia.
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Wang J, Aung LH, Prabhakar BS and Li P.
  TITLE     The mitochondrial ubiquitin ligase plays an anti-apoptotic role in
            cardiomyocytes by regulating mitochondrial fission
  JOURNAL   J Cell Mol Med 20 (12), 2278-2288 (2016)
   PUBMED   27444773
  REMARK    GeneRIF: These findings suggest that MITOL plays a protective role
            against apoptosis in cardiomyocytes.
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Park YY, Lee S, Karbowski M, Neutzner A, Youle RJ and Cho H.
  TITLE     Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular
            senescence through dynamin-related protein 1 and mitofusin 1
  JOURNAL   J Cell Sci 123 (Pt 4), 619-626 (2010)
   PUBMED   20103533
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Karbowski M, Neutzner A and Youle RJ.
  TITLE     The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1
            dependent mitochondrial division
  JOURNAL   J Cell Biol 178 (1), 71-84 (2007)
   PUBMED   17606867
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Nakamura N, Kimura Y, Tokuda M, Honda S and Hirose S.
  TITLE     MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to
            change mitochondrial morphology
  JOURNAL   EMBO Rep 7 (10), 1019-1022 (2006)
   PUBMED   16936636
REFERENCE   7  (bases 1 to 1472)
  AUTHORS   Yonashiro R, Ishido S, Kyo S, Fukuda T, Goto E, Matsuki Y,
            Ohmura-Hoshino M, Sada K, Hotta H, Yamamura H, Inatome R and Yanagi
            S.
  TITLE     A novel mitochondrial ubiquitin ligase plays a critical role in
            mitochondrial dynamics
  JOURNAL   EMBO J 25 (15), 3618-3626 (2006)
   PUBMED   16874301
REFERENCE   8  (bases 1 to 1472)
  AUTHORS   Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K and Fruh K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158801.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001106372.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158801.1, SRR8487227.64742.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1472
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /note="membrane associated ring-CH-type finger 5"
                     /db_xref="GeneID:294079"
                     /db_xref="RGD:1305617"
     exon            1..321
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1123
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 153; E3 ubiquitin-protein
                     ligase MARCH5; membrane-associated ring finger (C3HC4) 5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF5"
                     /protein_id="NP_001099842.1"
                     /db_xref="GeneID:294079"
                     /db_xref="RGD:1305617"
                     /translation="MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQ
                     ACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAA
                     GIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIR
                     WEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPT
                     IATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQE
                     EA"
     exon            322..524
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            525..655
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            656..839
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1006
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1448
                     /gene="Marchf5"
                     /gene_synonym="March5; Rnf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggtccat ggaccggaac cctgggcgga ccggcaggaa cccgggccgc gaccgccgcc
       61 tcccggcccc aggctcctcc tcctcgctcc ccgccgccct ctgcggtcgc ccgcgggctg
      121 cgcatcgccg ccgcgggcct ctgggagccg cgccgggagg ctgtgtggcg gggccgaggc
      181 cgccgcggga ctgaggccta ctccgccgcc tctcagtgct attgtcccgg ggcctggccc
      241 tgagcggagc tgcgggcgag ggccgagctc gccggctccg cagaagatgc cggaccaagc
      301 ccttcaacag atgctggaca gaagttgctg ggtgtgtttt gccaccgatg aagacgatag
      361 aacagctgaa tgggtgagac catgcaggtg cagaggatct actaagtggg ttcaccaggc
      421 ttgtctacaa cgctgggtag atgagaagca acgaggaaac agcacagcca gagtggcctg
      481 ccctcagtgc aatgccgagt acttaatagt gtttccaaag ctgggtccag ttgtttatgt
      541 cttggatctt gcagatagac tgatctcaaa agcttgcccc tttgctgcag caggaataat
      601 ggttggatct atctactgga cagctgtgac ttatggagca gtgacagtga tgcaggttgt
      661 aggccataaa gaagggctgg atgttatgga gcgagctgac cctttatttc ttttgattgg
      721 acttcctact attcctgtca tgctgatact aggcaaaatg attcgctggg aggactatgt
      781 gcttagacta tggcgcaaat actcaaataa actacaaatt ttgaacagta tatttccagg
      841 gattggttgt cctgttcctc gaattccagc tgaagctaat cctttagcag atcatgtctc
      901 tgctactaga attttgtgtg gagcccttgt ctttcctact attgcgacaa tagttggtaa
      961 actgatgttc agtagcgtta actcaaattt acagaggaca atcttgggcg gaattgcttt
     1021 tgttgccata aaaggagcat ttaaggttta cttcaaacag cagcaatatt tacgtcaggc
     1081 acaccgcaaa atcctaaatt atccagagca agaagaagca taaaactgac ttctggttgt
     1141 tctgaggcct ctcatcctga cgagtctgtt gtgttctgat tccatcacta atgcgctagt
     1201 ggagactggt gataagctac tgctcctata ttctaagaga tacaataaag cacgcagggc
     1261 gggggaaagc ctctcagtaa tcacggaacc taaggacatg agtcagctct gtaatttgta
     1321 tgtactactt ttacggcagt cggctaaacc attattttag catggtaaat ctgggtttgt
     1381 tcatattttt ccagacaaga atgtaaagat aaaactgtac aaatattaaa agtggacatg
     1441 ttgtttcaaa aaaaaaaaaa aaaaaaaaaa aa
//
