LOCUS       NM_001034108            1306 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus membrane associated ring-CH-type finger 2
            (Marchf2), mRNA.
ACCESSION   NM_001034108 XM_576195
VERSION     NM_001034108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Fukuda,H., Nakamura,N. and Hirose,S.
  TITLE     MARCH-III Is a novel component of endosomes with properties similar
            to those of MARCH-II
  JOURNAL   J Biochem 139 (1), 137-145 (2006)
   PUBMED   16428329
REFERENCE   2  (bases 1 to 1306)
  AUTHORS   Nakamura,N., Fukuda,H., Kato,A. and Hirose,S.
  TITLE     MARCH-II is a syntaxin-6-binding protein involved in endosomal
            trafficking
  JOURNAL   Mol Biol Cell 16 (4), 1696-1710 (2005)
   PUBMED   15689499
  REMARK    GeneRIF: Depletion of MARCH-II by small interfering RNA perturbed
            the trans-Golgi network (TGN) localization of syntaxin 6 and
            TGN38/46
REFERENCE   3  (bases 1 to 1306)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI578941.1 and BC088286.1.
            
            On Oct 14, 2005 this sequence version replaced XM_576195.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC088286.1, AB048838.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5756307, SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AI578941.1         1-41
            42-1306             BC088286.1         1-1265
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1306
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /note="membrane associated ring-CH-type finger 2"
                     /db_xref="GeneID:362849"
                     /db_xref="RGD:1306395"
     exon            1..27
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            28..255
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..820
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH2;
                     syntaxin-6-binding protein; membrane associated RING-CH
                     finger protein II; membrane-associated RING-CH protein II;
                     membrane-associated RING finger protein 2;
                     membrane-associated ring finger (C3HC4) 2, E3 ubiquitin
                     protein ligase; RING-type E3 ubiquitin transferase MARCH2;
                     RING-type E3 ubiquitin transferase MARCHF2; RING finger
                     protein 172"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF2"
                     /protein_id="NP_001029280.1"
                     /db_xref="GeneID:362849"
                     /db_xref="RGD:1306395"
                     /translation="MTTGDCCHLPGSLCDCSSSPAFSKVVEATGLGPPQYVAQVTSRD
                     GRLLSTVIRALDTPSDCPFCRICHEGANGENLLSPCGCTGTLGAVHKSCLEKWLSSSN
                     TSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFVFITPLAAISGWLCL
                     RGAQDHLRLHSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKI
                     READGSEDPHHSLLATGLLKKVAEETPV"
     exon            256..451
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            452..661
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1296
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1266..1271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
     polyA_site      1296
                     /gene="Marchf2"
                     /gene_synonym="MARCH-II; March2; RGD1306395; RNF172"
ORIGIN      
        1 cggccgcccg gcccggccgc ggaacaggct cctgggacca tgggcctcag gccctgagga
       61 caggaggctc cctgtggcca tgacgacagg tgactgttgc cacctccctg gctccctatg
      121 tgactgctct agcagccctg ccttttccaa ggttgtggag gccacagggc ttggaccacc
      181 tcagtatgta gctcaagtga cttcaaggga tggccggctg ctctcaactg tcatccgggc
      241 tttggataca ccgagtgact gtcccttctg ccgaatctgc catgagggag caaatgggga
      301 gaacttgctg tccccatgtg gctgtactgg caccctggga gctgtgcaca agagctgcct
      361 ggagaaatgg ctgtcttcct ccaacaccag ctactgtgag ctgtgtcaca ctgagtttgc
      421 agtggaaaag cggccccgac ctctcacaga gtggctaaag gacccagggc cgcgcaccga
      481 gaagcggaca ctgtgctgtg acatggtgtg ctttgtgttt atcacaccac tggccgccat
      541 ctcaggctgg ctgtgcctgc gaggggccca ggaccacctc cgtctgcata gccggctgga
      601 ggctgtaggg ctcattgccc tcaccatcgc cctcttcacc atctatgtgc tctggacact
      661 ggtctctttc cgataccatt gccagctgta ctcggaatgg aggaagacca atcagaaagt
      721 ccggctgaag atccgggaag cagatggctc cgaggaccct caccactcct tgctggctac
      781 tggactttta aaaaaggtgg cagaggagac ccctgtgtga aggcctggct ggcaggactc
      841 tgaggtagtg gacagacccg agtcagatgg cagtgcacgg catttggaaa gatggagtct
      901 gcctgacttt tcatgcacag ctatgatgct tctcaggcca atagccacag caaacagagc
      961 ctgctctgtg accctgtgtg aacatatttt taagggtttt gttttgcaca ttattgtata
     1021 tggcaagcac agatggacag atttgagctt tggatggagt aggcacccct atctcactct
     1081 gagatctgtt tgacaccctt tggacagcag ctttagctgc tggtgtcaag ggtgcgtgcc
     1141 cattgggcta gaaggttcca gcaggcttct tgcattactc tgcacctagc tggcttgctt
     1201 tactggcact cttgacttat aaacttataa agttgcactg catttcaaaa acctactcct
     1261 aaatgaataa aaggagccct tgttggctaa tatggaaaaa aaaaaa
//
