LOCUS       NM_001401505            6046 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus membrane associated ring-CH-type finger 1
            (Marchf1), transcript variant 1, mRNA.
ACCESSION   NM_001401505 XM_017600179
VERSION     NM_001401505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6046)
  AUTHORS   Nagarajan,A., Petersen,M.C., Nasiri,A.R., Butrico,G., Fung,A.,
            Ruan,H.B., Kursawe,R., Caprio,S., Thibodeau,J.,
            Bourgeois-Daigneault,M.C., Sun,L., Gao,G., Bhanot,S., Jurczak,M.J.,
            Green,M.R., Shulman,G.I. and Wajapeyee,N.
  TITLE     MARCH1 regulates insulin sensitivity by controlling cell surface
            insulin receptor levels
  JOURNAL   Nat Commun 7, 12639 (2016)
   PUBMED   27577745
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6046)
  AUTHORS   Ohmura-Hoshino,M., Matsuki,Y., Mito-Yoshida,M., Goto,E.,
            Aoki-Kawasumi,M., Nakayama,M., Ohara,O. and Ishido,S.
  TITLE     Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination
            for the maintenance of conventional dendritic cells
  JOURNAL   J Immunol 183 (11), 6893-6897 (2009)
   PUBMED   19917682
REFERENCE   3  (bases 1 to 6046)
  AUTHORS   Jabbour,M., Campbell,E.M., Fares,H. and Lybarger,L.
  TITLE     Discrete domains of MARCH1 mediate its localization, functional
            interactions, and posttranscriptional control of expression
  JOURNAL   J Immunol 183 (10), 6500-6512 (2009)
   PUBMED   19880452
REFERENCE   4  (bases 1 to 6046)
  AUTHORS   Lapaque,N., Jahnke,M., Trowsdale,J. and Kelly,A.P.
  TITLE     The HLA-DRalpha chain is modified by polyubiquitination
  JOURNAL   J Biol Chem 284 (11), 7007-7016 (2009)
   PUBMED   19117940
REFERENCE   5  (bases 1 to 6046)
  AUTHORS   Thibodeau,J., Bourgeois-Daigneault,M.C., Huppe,G., Tremblay,J.,
            Aumont,A., Houde,M., Bartee,E., Brunet,A., Gauvreau,M.E., de
            Gassart,A., Gatti,E., Baril,M., Cloutier,M., Bontron,S., Fruh,K.,
            Lamarre,D. and Steimle,V.
  TITLE     Interleukin-10-induced MARCH1 mediates intracellular sequestration
            of MHC class II in monocytes
  JOURNAL   Eur J Immunol 38 (5), 1225-1230 (2008)
   PUBMED   18389477
REFERENCE   6  (bases 1 to 6046)
  AUTHORS   De Gassart,A., Camosseto,V., Thibodeau,J., Ceppi,M., Catalan,N.,
            Pierre,P. and Gatti,E.
  TITLE     MHC class II stabilization at the surface of human dendritic cells
            is the result of maturation-dependent MARCH I down-regulation
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3491-3496 (2008)
   PUBMED   18305173
REFERENCE   7  (bases 1 to 6046)
  AUTHORS   Matsuki,Y., Ohmura-Hoshino,M., Goto,E., Aoki,M., Mito-Yoshida,M.,
            Uematsu,M., Hasegawa,T., Koseki,H., Ohara,O., Nakayama,M.,
            Toyooka,K., Matsuoka,K., Hotta,H., Yamamoto,A. and Ishido,S.
  TITLE     Novel regulation of MHC class II function in B cells
  JOURNAL   EMBO J 26 (3), 846-854 (2007)
   PUBMED   17255932
REFERENCE   8  (bases 1 to 6046)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Feb 14, 2022 this sequence version replaced XM_017600179.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMEA5760433
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000016.1  28880694-28880839   c
            147-223             JAXUCZ010000016.1  28628786-28628862   c
            224-432             JAXUCZ010000016.1  28547905-28548113   c
            433-483             JAXUCZ010000016.1  28216581-28216631   c
            484-563             JAXUCZ010000016.1  28110667-28110746   c
            564-1322            JAXUCZ010000016.1  28109641-28110399   c
            1323-1503           JAXUCZ010000016.1  28080441-28080621   c
            1504-1651           JAXUCZ010000016.1  28039203-28039350   c
            1652-6046           JAXUCZ010000016.1  28022159-28026553   c
FEATURES             Location/Qualifiers
     source          1..6046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14-p13"
     gene            1..6046
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /note="membrane associated ring-CH-type finger 1"
                     /db_xref="GeneID:361135"
                     /db_xref="RGD:1305148"
     exon            1..146
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            147..223
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            224..432
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1950
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein
                     ligase MARCH1-like; membrane-associated ring finger
                     (C3HC4) 1, E3 ubiquitin protein ligase; E3
                     ubiquitin-protein ligase MARCHF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF1 isoform 1"
                     /protein_id="NP_001388434.1"
                     /db_xref="GeneID:361135"
                     /db_xref="RGD:1305148"
                     /translation="MPLHQISVIPARETASNGRSSMGRNKEKNKEVENEKSPGRSASR
                     SSNISKASSPTTGTAPRSQSRLSVCPSTQDICRSSILHDMSEDAFEHCTPVMVLRHTR
                     KESGKKPVRQNPRRRRRVSQRYEHAEEQAKERRNDFHLQISSSRWRELDMESSDSSST
                     DESHGIQAKRQAQVKVRLSRRRRNNKPCRNLAGSSIPDRIGLVDLESNGAKHQELTEC
                     GSHTLNICRGKVIRYQECSHPLPSASLVEKTPAGNHSGSKGKYCHRDPQPLHTLRQKE
                     TIKKRFSETDFHTEILAAANGRGCVDGSGLQLNTSTQKSPGADDDGSENFEVCRICHC
                     EGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWE
                     KLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKL
                     VVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTANKLEKNFPCNVNTE
                     GKDAVVVPVPQTGSNTLPTAEGAPPEVIPV"
     exon            433..483
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            484..563
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1322
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1503
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1651
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..6046
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgggt tgcctgccac ccggctgcac gtttgtgagc tgaggagtgc accgccagtc
       61 tctgacaaag gatgggagga tgccactgcc ctgggatgcc ggctgcgcgc agcctgccgg
      121 ctgcctgagc tacttcaccc tccccggaaa tgtacccaaa aagacttctg agagcttgtt
      181 ttctgctgtc ctactgtgac taagcaagac actgccatat tttatccaag tttggcaaag
      241 caaggatatg aacagttctg caggtgggct tctcagggcg agtgaagcca taaggcatcc
      301 aatcagggtt tggccacctg cagcccggcc aatatgcccc tccaccagat ttctgtaatc
      361 ccagcccggg agacagccag caatgggaga agttcaatgg gcagaaacaa agagaagaac
      421 aaggaagttg agaatgaaaa gtccccaggg cgatctgcaa gtcgatcaag taacatatca
      481 aaagcaagca gcccaacgac agggacagct cccaggagcc agtcaaggtt gtctgtctgt
      541 ccatctactc aagacatctg cagatcttcc atcttgcatg acatgtcaga agatgcattt
      601 gagcactgca cccctgtcat ggtgctgagg cacactagaa aagaatctgg taagaaacca
      661 gtaagacaaa atcctaggag gaggagaagg gtctctcaga gatatgagca tgcagaagag
      721 caagccaagg agagaagaaa cgactttcac ctccagatct caagttcaag gtggagagaa
      781 cttgatatgg agtcttcaga ttcatcttcc acagatgaga gtcacgggat tcaggcaaaa
      841 agacaagccc aggttaaagt cagactgtct cggcgaagga gaaataataa gccatgtaga
      901 aacttggctg ggtcttccat tcctgacaga attggccttg ttgatctgga atccaatggt
      961 gcaaagcacc aagagctgac agaatgtggg agtcacactt taaacatctg tagaggaaaa
     1021 gtcataaggt accaagaatg cagtcatcca ctgccaagcg catccttggt ggagaagaca
     1081 cccgcaggga accactcagg gagtaaaggc aaatactgtc acagagatcc tcagcccttg
     1141 catacactta ggcaaaaaga aacaatcaag aaaagatttt cagaaactga tttccatact
     1201 gaaatcctgg cagctgcaaa tgggagaggt tgtgtggatg gctcagggct ccagctgaat
     1261 acctctaccc agaagtctcc tggtgctgat gatgatggct ctgaaaattt cgaagtgtgc
     1321 aggatctgtc actgcgaagg agatgaagag agcccactca tcacaccctg tcgctgcaca
     1381 ggaaccttgc gctttgtcca ccagtcctgt ctccaccagt ggatcaagag ctcagacaca
     1441 cggtgctgtg agctctgcaa gtatgacttc ataatggaaa ccaagctcaa gcccctgcgg
     1501 aagtgggaaa agctccagat gaccacgagc gaaaggagga aaatattctg ctctgtcacg
     1561 ttccacgtca tcgccgtcac ctgcgtggtg tggtccttgt atgtgttgat agaccggaca
     1621 gcggaggaaa tcaagcaagg taacgacaat ggtgtgctgg agtggccatt ttggacaaaa
     1681 ctggttgtgg tggccatcgg cttcacagga ggtctcgtct tcatgtatgt acagtgtaaa
     1741 gtctacgtcc agctgtggcg caggctgaag gcctacaacc gtgtgatctt tgtgcagaat
     1801 tgcccagaca ctgccaacaa actggagaag aacttcccgt gtaatgtgaa cacggaaggc
     1861 aaggatgctg tggttgtgcc tgtgccacag acaggttcga atacactgcc aactgcagag
     1921 ggggccccgc ctgaagttat accagtctga tggaactgga cgggaacttc ttcacggaag
     1981 gatctctgca acccccagcc actacgaaca gaagtgcgtc tgcgctggtg gcttcttgag
     2041 cttctcgttt cccttactga cttgtttgtc ctgacttgga gcaaaaagga aatgagaaga
     2101 aaataacacg tgaccaggat ctcaagaagc agagcctgca gtgggacctg gaaaggtgaa
     2161 gaatcttagg gaaggagttc ataaggaatg gttggtacga gccagtcttc caaggggatg
     2221 gacacgtgat actccgagta gtgcagagga aattcctgaa cagacttcaa ttgcaatgta
     2281 tgcttctttg tagggttctg taacgttagc cttctccact ggaaacgaca cccacccaca
     2341 catttggtct taagcctgaa attgtgtgca tcatccctaa gtcacaccag aagtaaactt
     2401 ggaggacctg agaggttttt ttaaaaaata cttttgacag ctgttttttc tggctattgt
     2461 gaagtctggt tattttgaca gatgcatgtt tttaagtgga tgcaatacac atttggggat
     2521 agaaatgttt ggaattttgt ttcaatgatg aagagatttt cagagcatcg tgaagtttag
     2581 ctagaactgt tttttgagca actatcatgc tgtggggttc tttcttgttg ttgttgttgc
     2641 tgttgttgtt ttttctggtc cctcttacac agtgctcaac aatagacata taacatgagc
     2701 tacaaataca accacagttg taaatcttaa atctcctagt gtgccccatt aggaaaagta
     2761 aaaataaata ggtcaatcaa tttttataat ttacttaaca ctatttatac aagttacttt
     2821 atgtcatcaa tggaaacaat tataaaaata gctttcatta ttttcttgaa ccaattcttc
     2881 aaaattctgc atggacacct caatatgaat gaagtgtgtt ggacaggacc taattaagaa
     2941 tatcagctgc cagagccctt ggattagaaa ctgcatctct gtttcattta agttatttta
     3001 aaacagcagt ttaatccatc tttctgtttt gcagtttcat ctaaaggtta cgatttacaa
     3061 gcaccaaact caccaaatta agtaacctgg tttgatttca accaagtttc aaaggggcga
     3121 aaaaatctaa ggtataggaa gtcagtaaaa tgtgtagcaa tgttatgaag gtaacttctg
     3181 catagaaact ataaagtaac tatgataggg aaataaacat ttattttgct actaaatcag
     3241 gtgttaagga ttttaaatcc acatgaagta tcaacgtgac acgggtatct taaggacctc
     3301 aaccccacgt ttgaacctga cagtattttc ctcactcagc tcattcaata cattccatgg
     3361 tgagtgataa gctgcgttgt gggcccaaca cctgattaca gctctacaca gattccaata
     3421 aactgatatg agaactacca tgagtgggtg aatactcaca aaccgtgacc tgtcaaaacc
     3481 agacagccac cttgttttaa agtgactttt gttgtcgttg ttagctgtca ttatttatta
     3541 tcctgaaaag gcagagatgg ccataaaaac caaagcatgg gcatcatgtt gcacaactct
     3601 gggttccata tccatgcact ttgtaataat cagtgtttgt tcttcgtgga tgataaagga
     3661 aaaggaaaaa caaaaggatc cttcaatgag aagagtattt gtggtgattg acactggatc
     3721 caaatagtcc cacccttaga aatagacata gtaaacaatg tcaagtgtgt gtgtgtgtgt
     3781 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gacatgtata ttcatgtata tatgcaagag
     3841 aaatgttaag gtcaagccaa gaaacaaagg gttaatactc atcttcctta aaagtgtgca
     3901 ggagggacat ggcgtcaata gacacagaca aagcaatgga catgactgat gtagaccagg
     3961 ccttcagcac aaataagcag aaccttgcat taacttcctg aaaggttcca ttctaaagat
     4021 ttaagaacag gaagagcaga ggaagggcgg gtgctctgta agttcacaca aaggcattaa
     4081 ccatcgttta gtttctctgt atagttctcc gcgcgcttcc taggatggca atttgttgtg
     4141 gaccaggact gcacaagaag aggtctacat cttcttgcaa gtaaagtgca aagtaaaact
     4201 gatttatctt ttccccgcag aaaatatacc ttacttacca cagaaaaaac tatctaaaag
     4261 caagatggtt atttgaatag cttgtttcac agaggaagga gattggctcc atcatatttt
     4321 tcaaggtgta taccaccact aaactaaaca gaaaagagac aagctttgct acaatgggga
     4381 aagacagcat gctgctttaa aagtgacagc tacatgctgc aggttaacta ctgtaagctt
     4441 tgcctttaaa tgagaatgat ggaattctac agtgtatgca ccactcagtg attatgctga
     4501 tatcctctga tgctttaaaa ctcacaaaag ttttttcctc taaattatta cctgaattta
     4561 ctatttatga ttcaaacaat ctgccctaac tattcatgta tataatagag atgtaggacc
     4621 cgtactccta atatttgaga agtttaggac ttcaggggta tcccaaatta aagccagccc
     4681 agactacatg agacctttct ccaaaagtaa aacaaagatt ttaaactcaa tgaataaagc
     4741 cagtattaaa aacatctctt catattgtgt ggtaatggtg ttttctccta ataaccatga
     4801 aaaggtttgg cattgatggc ctgacatact gctcaaagag aaaaaagaat ggcattatct
     4861 tgaagtgtgt ttacctgctt tcatgtaaaa aataaagtga aattgaaaca aaattatcac
     4921 tgagtttaga ttattaaact ggatttttag aaacacaaca tgaagctgtg ctatgagaaa
     4981 tgccataaac cagacttcaa aaatgttttc tatcatgagc agacattttc actaaggtgt
     5041 aattatttca acagaaatga attaaaacac ttaaggtaga gcccaggacg gaagaggtac
     5101 attagtggtc agaccctttc tgtcctcaga ctcctggttg agctctaagc acacgtacca
     5161 gctcacaacc acctgtagct tcaactccac cacaatgacc tcttctggtc tctgatctct
     5221 ctctctctcc tctgtctctc tctgtctctg tctctgtctc tctctctcac acacacacac
     5281 acacacacac acatgggggt ggggggtgga tctttaaaaa gtgacatgac tcaaaagcac
     5341 ataaaattaa gtataaaaca gtaagaaaac cctacaaaaa tcgagaaaag ggcgtaagag
     5401 taccaattac acaggatatt acaatgcagg catcagtgtc tcttgtaatg tcccaggatc
     5461 aaatcctcac tttggcctgc tgctgctgtc actgatgata tcccacaaag aatcctcatt
     5521 catacctgta gttttctttt gttaggacat gggttacccc catttattct tcaagctcaa
     5581 aattaagacc attaatacaa tgacatcatt aagagaaatc acaaaggtgg ggggtgggag
     5641 ggaggccgtt cattccatct gtcagatata atttttcttg ccttgccaat ggatgttttg
     5701 gagcaaatac taagtgtaga cagtaaaacc tactgtcgct attgtgactg gtccttccat
     5761 cagctcaatg gtgctatttt acataacaat acaactaaaa ggaagctgtc cagttgggct
     5821 gcagtgtttc tcccatatct gaagaaagcc cttgttggaa aatcagatat aacattcaac
     5881 aaaggaaaaa gtattatttt aactgtgtac aatttttgag attgggcact ggtacatttt
     5941 agttctacct aatgtctttc attaacaatt tactgtttgt gagtaatgtg tgcttaacaa
     6001 actaactatc tgtgaaagac tttgtatatt aaacaaatgc tccaaa
//
