LOCUS       NP_001388434             538 aa            linear   ROD 01-APR-2024
DEFINITION  E3 ubiquitin-protein ligase MARCHF1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001388434 XP_017455668
VERSION     NP_001388434.1
DBSOURCE    REFSEQ: accession NM_001401505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Nagarajan,A., Petersen,M.C., Nasiri,A.R., Butrico,G., Fung,A.,
            Ruan,H.B., Kursawe,R., Caprio,S., Thibodeau,J.,
            Bourgeois-Daigneault,M.C., Sun,L., Gao,G., Bhanot,S., Jurczak,M.J.,
            Green,M.R., Shulman,G.I. and Wajapeyee,N.
  TITLE     MARCH1 regulates insulin sensitivity by controlling cell surface
            insulin receptor levels
  JOURNAL   Nat Commun 7, 12639 (2016)
   PUBMED   27577745
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Ohmura-Hoshino,M., Matsuki,Y., Mito-Yoshida,M., Goto,E.,
            Aoki-Kawasumi,M., Nakayama,M., Ohara,O. and Ishido,S.
  TITLE     Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination
            for the maintenance of conventional dendritic cells
  JOURNAL   J Immunol 183 (11), 6893-6897 (2009)
   PUBMED   19917682
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Jabbour,M., Campbell,E.M., Fares,H. and Lybarger,L.
  TITLE     Discrete domains of MARCH1 mediate its localization, functional
            interactions, and posttranscriptional control of expression
  JOURNAL   J Immunol 183 (10), 6500-6512 (2009)
   PUBMED   19880452
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Lapaque,N., Jahnke,M., Trowsdale,J. and Kelly,A.P.
  TITLE     The HLA-DRalpha chain is modified by polyubiquitination
  JOURNAL   J Biol Chem 284 (11), 7007-7016 (2009)
   PUBMED   19117940
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Thibodeau,J., Bourgeois-Daigneault,M.C., Huppe,G., Tremblay,J.,
            Aumont,A., Houde,M., Bartee,E., Brunet,A., Gauvreau,M.E., de
            Gassart,A., Gatti,E., Baril,M., Cloutier,M., Bontron,S., Fruh,K.,
            Lamarre,D. and Steimle,V.
  TITLE     Interleukin-10-induced MARCH1 mediates intracellular sequestration
            of MHC class II in monocytes
  JOURNAL   Eur J Immunol 38 (5), 1225-1230 (2008)
   PUBMED   18389477
REFERENCE   6  (residues 1 to 538)
  AUTHORS   De Gassart,A., Camosseto,V., Thibodeau,J., Ceppi,M., Catalan,N.,
            Pierre,P. and Gatti,E.
  TITLE     MHC class II stabilization at the surface of human dendritic cells
            is the result of maturation-dependent MARCH I down-regulation
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3491-3496 (2008)
   PUBMED   18305173
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Matsuki,Y., Ohmura-Hoshino,M., Goto,E., Aoki,M., Mito-Yoshida,M.,
            Uematsu,M., Hasegawa,T., Koseki,H., Ohara,O., Nakayama,M.,
            Toyooka,K., Matsuoka,K., Hotta,H., Yamamoto,A. and Ishido,S.
  TITLE     Novel regulation of MHC class II function in B cells
  JOURNAL   EMBO J 26 (3), 846-854 (2007)
   PUBMED   17255932
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Feb 14, 2022 this sequence version replaced XP_017455668.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMEA5760433
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14-p13"
     Protein         1..538
                     /product="E3 ubiquitin-protein ligase MARCHF1 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH1; E3
                     ubiquitin-protein ligase MARCH1-like; membrane-associated
                     ring finger (C3HC4) 1, E3 ubiquitin protein ligase; E3
                     ubiquitin-protein ligase MARCHF1"
                     /calculated_mol_wt=60485
     Region          327..392
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Site            order(329,332,348,353,356,359,372,375)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438111"
     CDS             1..538
                     /gene="Marchf1"
                     /gene_synonym="March1; RGD1305148"
                     /coded_by="NM_001401505.1:334..1950"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:361135"
                     /db_xref="RGD:1305148"
ORIGIN      
        1 mplhqisvip aretasngrs smgrnkeknk evenekspgr sasrssnisk asspttgtap
       61 rsqsrlsvcp stqdicrssi lhdmsedafe hctpvmvlrh trkesgkkpv rqnprrrrrv
      121 sqryehaeeq akerrndfhl qisssrwrel dmessdssst deshgiqakr qaqvkvrlsr
      181 rrrnnkpcrn lagssipdri glvdlesnga khqeltecgs htlnicrgkv iryqecshpl
      241 psaslvektp agnhsgskgk ychrdpqplh tlrqketikk rfsetdfhte ilaaangrgc
      301 vdgsglqlnt stqkspgadd dgsenfevcr ichcegdees plitpcrctg tlrfvhqscl
      361 hqwikssdtr ccelckydfi metklkplrk weklqmttse rrkifcsvtf hviavtcvvw
      421 slyvlidrta eeikqgndng vlewpfwtkl vvvaigftgg lvfmyvqckv yvqlwrrlka
      481 ynrvifvqnc pdtanklekn fpcnvntegk davvvpvpqt gsntlptaeg appevipv
//
