LOCUS       NM_017212               5149 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus microtubule-associated protein tau (Mapt), mRNA.
ACCESSION   NM_017212 XM_346409
VERSION     NM_017212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Fischer,I., Connors,T., Bouyer,J. and Jin,Y.
  TITLE     The unique properties of Big tau in the visual system
  JOURNAL   Cytoskeleton (Hoboken) 81 (9-10), 488-499 (2024)
   PUBMED   38761116
  REMARK    GeneRIF: The unique properties of Big tau in the visual system.
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Yu,K., Yao,K.R., Aguinaga,M.A., Choquette,J.M., Liu,C., Wang,Y. and
            Liao,D.
  TITLE     G272V and P301L Mutations Induce Isoform Specific Tau
            Mislocalization to Dendritic Spines and Synaptic Dysfunctions in
            Cellular Models of 3R and 4R Tau Frontotemporal Dementia
  JOURNAL   J Neurosci 44 (28), e1215232024 (2024)
   PUBMED   38858079
  REMARK    GeneRIF: G272V and P301L Mutations Induce Isoform Specific Tau
            Mislocalization to Dendritic Spines and Synaptic Dysfunctions in
            Cellular Models of 3R and 4R Tau Frontotemporal Dementia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Chen,J., Xiang,Z., Zhang,Z., Yang,Y., Shu,K. and Lei,T.
  TITLE     Acromegalic Rat Model Presented Cognitive Impairments and Tau
            Hyperphosphorylation in the Hippocampus
  JOURNAL   Neuroendocrinology 114 (6), 577-588 (2024)
   PUBMED   38368872
  REMARK    GeneRIF: Acromegalic Rat Model Presented Cognitive Impairments and
            Tau Hyperphosphorylation in the Hippocampus.
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Christensen,K.R., Combs,B., Richards,C., Grabinski,T.,
            Alhadidy,M.M. and Kanaan,N.M.
  TITLE     Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal
            Transport in Rat Hippocampal Neurons
  JOURNAL   Mol Neurobiol 60 (6), 3423-3438 (2023)
   PUBMED   36859689
  REMARK    GeneRIF: Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs
            Axonal Transport in Rat Hippocampal Neurons.
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Liu,X., Song,W., Yu,Y., Su,J., Shi,X., Yang,X., Wang,H., Liu,P. and
            Zou,L.
  TITLE     Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase
            Kinase-3beta Overactivation-Induced Hyperphosphorylated Tau in Rats
  JOURNAL   Neurotox Res 40 (5), 1163-1173 (2022)
   PUBMED   35951283
  REMARK    GeneRIF: Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen
            Synthase Kinase-3beta Overactivation-Induced Hyperphosphorylated
            Tau in Rats.
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   Kanai,Y., Chen,J. and Hirokawa,N.
  TITLE     Microtubule bundling by tau proteins in vivo: analysis of
            functional domains
  JOURNAL   EMBO J 11 (11), 3953-3961 (1992)
   PUBMED   1396588
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Drechsel,D.N., Hyman,A.A., Cobb,M.H. and Kirschner,M.W.
  TITLE     Modulation of the dynamic instability of tubulin assembly by the
            microtubule-associated protein tau
  JOURNAL   Mol Biol Cell 3 (10), 1141-1154 (1992)
   PUBMED   1421571
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Caceres,A., Mautino,J. and Kosik,K.S.
  TITLE     Suppression of MAP2 in cultured cerebellar macroneurons inhibits
            minor neurite formation
  JOURNAL   Neuron 9 (4), 607-618 (1992)
   PUBMED   1389180
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Goedert,M., Spillantini,M.G. and Crowther,R.A.
  TITLE     Cloning of a big tau microtubule-associated protein characteristic
            of the peripheral nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1983-1987 (1992)
   PUBMED   1542696
REFERENCE   10 (bases 1 to 5149)
  AUTHORS   Weingarten,M.D., Lockwood,A.H., Hwo,S.Y. and Kirschner,M.W.
  TITLE     A protein factor essential for microtubule assembly
  JOURNAL   Proc Natl Acad Sci U S A 72 (5), 1858-1862 (1975)
   PUBMED   1057175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 3, 2021 this sequence version replaced NM_017212.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79321.1, SRR26360194.416609.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000010.1  89638625-89638755
            132-244             JAXUCZ010000010.1  89687489-89687601
            245-310             JAXUCZ010000010.1  89698848-89698913
            311-366             JAXUCZ010000010.1  89705907-89705962
            367-499             JAXUCZ010000010.1  89710150-89710282
            500-765             JAXUCZ010000010.1  89713473-89713738
            766-858             JAXUCZ010000010.1  89723750-89723842
            859-940             JAXUCZ010000010.1  89727046-89727127
            941-1053            JAXUCZ010000010.1  89728273-89728385
            1054-5149           JAXUCZ010000010.1  89732013-89736108
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..5149
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /note="microtubule-associated protein tau"
                     /db_xref="GeneID:29477"
                     /db_xref="RGD:69329"
     exon            1..131
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            132..244
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1269
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /note="Tau microtubule-associated protein; PHF-tau; paired
                     helical filament-tau; neurofibrillary tangle protein;
                     microtubule-associated protein tau 0N4R;
                     microtubule-associated protein tau 1N4R;
                     microtubule-associated protein tau 2N4R; MAPT_BigTau;
                     microtubule-associated protein tau BigTau"
                     /codon_start=1
                     /product="microtubule-associated protein tau"
                     /protein_id="NP_058908.2"
                     /db_xref="GeneID:29477"
                     /db_xref="RGD:69329"
                     /translation="MAEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKAEEAGIGDTPN
                     MEDQAAGHVTQARVAGVSKDRTGNDEKKAKGADGKTGAKIATPRGAATPGQKGTSNAT
                     RIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVA
                     VVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLS
                     NVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
                     LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSG
                     DTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL"
     exon            245..310
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            311..366
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            367..499
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            500..765
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            766..858
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            859..940
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1053
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..5149
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctccgcca cccaccagct ccagcaccag cagcagcgcc ggcgccaccg cccaccttct
       61 gctgtcgccg ccgccacaac caccttcccc tccgctgtcc tcttctgtcc tcgcctcctg
      121 tcgattatca ggctttgaag cagcatggct gaaccccgcc aggagtttga cacaatggaa
      181 gaccaggccg gagattacac tatgctccaa gaccaagaag gagacatgga ccatggctta
      241 aaagctgaag aagcaggcat cggagacacc ccgaacatgg aggaccaagc tgctgggcat
      301 gtgactcaag ctcgagtggc cggcgtaagc aaagacagga caggaaatga cgagaagaaa
      361 gccaagggcg ccgatggcaa aacgggggcg aagatcgcca cacctcgggg agcagccact
      421 ccgggccaga aaggcacatc caatgccacc aggatcccag ccaagaccac acccagccca
      481 aagactcctc caggatcagg tgaaccacca aaatccggag aacgaagcgg ctacagcagc
      541 cccggctcgc ccggaacccc tggcagtcgc tcccgtaccc catccctacc aacgccgccc
      601 acccgagagc ccaaaaaggt ggcagtggtt cgcactcccc ctaagtcacc gtctgccagt
      661 aagagccgcc tacagactgc ccctgtgccc atgccagacc taaagaacgt caggtccaag
      721 attggctcca ctgagaacct gaagcaccag ccgggaggcg gcaaggtgca gataattaat
      781 aagaagctgg atcttagcaa cgtccagtcc aagtgtggct caaaggacaa tatcaaacac
      841 gtcccgggcg gaggcagtgt gcaaatagtc tacaagccag tggacctgag caaggtgacc
      901 tccaagtgtg gttccttagg gaacatccat cacaagccag gaggtggcca ggtagaagta
      961 aaatcagaga agctggactt caaggataga gtccagtcga agattggctc cttggataac
     1021 atcacccatg tccctggagg agggaataag aagattgaaa cccacaagct gaccttcagg
     1081 gagaatgcca aagccaagac agaccatgga gcagaaatcg tgtacaagtc acctgtggtg
     1141 tctggggaca catctccacg gcacctcagc aacgtctcct ccacgggcag catcgacatg
     1201 gtggactctc cacagcttgc cacgttagcc gatgaagtgt ccgcctcttt ggccaagcag
     1261 ggtttgtgat caggcccctg gggccgtcac tgatcatgga gagaagagag agtgagagtg
     1321 tggaaaaaaa aaaaaaaaaa agaatgacct ggcccctcac cctctgccct ccccgctgct
     1381 cctcatagac aggctgacca gcttgtcacc taacctgctt ttgtggctcg ggtttggctc
     1441 gggacttcaa aatcagtgat gggaaaaagt aaatttcatc tttccaaatt gatttgtggg
     1501 ctagtaataa aatattttta aggaaggaaa aaaaaaaaaa cacgtaaaac catggccaaa
     1561 caaaacccaa catttccttg gcaattgtta ttgaccccgc cccccccctc tgagttttag
     1621 agggtgaagg aggctttgga tggaggctgc ttctggggat tggctgaggg actagggcaa
     1681 ctaattgccc acagccccat cttaggggca tcagggacag cggcagcaat gaaagacttg
     1741 ggacttggtg tgtttgtgga gccgtaggca ggtgatgtta actttgtgtg ggtttgaggg
     1801 aggactgtga tagtgaaggc tgagagatgg gtgggctggg agtcagagga gagaggtgag
     1861 gaagacaggt tgggagaggg gacattggct ccttgccaag gagcttggga agcacaggta
     1921 gccctggctg cctgcagcag tcttagctag cacagatgcc tgcctgagaa agcacagtgg
     1981 ggtacagtgg gtgtgtgtgc cccttctgaa gggcagccca tgggagaagg ggtattgggc
     2041 agaaggaagg taggccagaa ggtggcacct tgtagattgg ttctctgaag gctgaccttg
     2101 ccatcccagg gcactggctc ccaccctcca gggagggagg tcctgagctg aggagcttcc
     2161 ctttgctctc acaggaaaac ctgtgttact gagttctgaa gtttggaact acagccatga
     2221 ttttggccac catacagacc tgggacttta gggctaacca gttctttgta aggacttgtg
     2281 cctcttgcgg gaacatctgc ctgttctcaa gcctggtcct ctggcacttc tgcagtgtga
     2341 gggatggggg tggtattctg ggatgtgggt cccaggcctc ccatccctcg cacagccact
     2401 gtatcccctc tacctgtcct atcatgccca cgtctgccat gagagccagt cactgccgtc
     2461 cgtacatcac gtctcaccgt cctgagtgcc cagcctcccc aagccccatc cctggcccct
     2521 gggtagttat ggccaatatc tgctctacac taggggttgg agtccaggga aggcaaagat
     2581 ttgggccttg gtctctagtc ctacgttgca cgaatccaac cagtgtgcct cccacaagga
     2641 accttacaac cttgtttggt ttgctccatc atttcccatc gtggatggga gtccgtgtgt
     2701 gcctggagat taccctggac acctctgctt tttttttttt actttagcgg ttgcctccta
     2761 ggcctgactc cttcccatgt tgaactggag gcagccacgt taggtgtcaa tgtcctggca
     2821 tcagtatgaa cagtcagtag tcccagggca gggccacact tctcccatct tctgcttcca
     2881 ccccagcttg tgattgctag cctcccagag ctcagccgcc attaagtccc catgcacgta
     2941 atcagccctt cataccccaa tttggggaac ataccccttg attgaaatgt tttccctcca
     3001 gtcctatgga agcggtgctg cctgccctgc tggagcagcc agccatctcc agagacgcag
     3061 ccctttctct cctgtccgca ccctgttgcg ctgtagtcgg attcgtctgt ttgtctgggt
     3121 tcaccagagt gactatgata gtgaaaagaa aaagaaaaag aaaaaagaaa aaagaaaaaa
     3181 aaaaaaggac gcatgttatc ttgaaatatt tgtcaaaagg ttgtagccca ccgcagggat
     3241 tggagggcct ggatattcct tgtcttcttc gtgacttagg tccaggccgg tgcagtgcta
     3301 ccctgctggg acatcccatg ttttgaaggg tttcttcttc atctgggacc ctgcagacac
     3361 tggattgtga cattggaggt ctatgacatt ggccaaggcc tgaagcacag gacccgttag
     3421 aggcagcagg ctccgactgt cagggagagc ttgtggctgg cctgtttctc tgagtgaaga
     3481 tggtcctctc taatcacaac ttcaagtccc acagcagccc tggcagacat ctaagaactc
     3541 ctgcatcaca agagaaaagg acactagtac cagcagggag agctgtggcc ctagaaattc
     3601 catgactctc cactacatat ccgtgggtcc tttccaagcc ttggcctcgt caccaagggc
     3661 ttgggatgga ctgccccact gatgaaaggg acatctttgg agaccccctt ggtttccaag
     3721 gcgtcagccc cctgaccttg catgacctcc tacagctgta aggatgaggc ctttaaagat
     3781 taggaacctc aggcccaggt cggccacttt gggcttgggt acagttaggg acgatgcggt
     3841 agaaggaggt ggccaacctt tcccatataa gagttctgtg tgcccagagc taccctattg
     3901 tgagctcccc actgctgatg gactttagct gtccttagaa gtgaagagtc caacggagga
     3961 aaaggaagtg tggtttgatg gtctgtggtc ccttcatcat ggttacctgt tgtggttttc
     4021 tctcgtatac ccatttaccc atcctgcagt tcctgtcctt gaataggggt gggggtactc
     4081 tgccatatct cttgtagggc agtcagcccc caagtcatag tttggagtga tctggtcagt
     4141 gctaataggc agtttacaaa ggaattctgg cttgttactt cagtgaggac aatcccccaa
     4201 gggccctggc acctgtcctg tctttccatg gctctccact gcagagccaa tgtctttggg
     4261 tgggctagat agggtgtaca atttgcctgg ttcctccaag ctcttaatcc actttatcaa
     4321 tagttccatt taaattgact tcaatgataa gagtgtatcc catttgagat tgcttgtgtt
     4381 gtggggtaaa ggggggagga ggaacatgtt aagataattg acatgggcaa ggggaagtct
     4441 tgaagtgtag cagttaaacc atcttgtagc cccattcatg atgttgacca cttgctagag
     4501 agaagaggtg ccataaggct agaacctaga ggcttggctg tcccaccaac aggcaggctt
     4561 ttgcaaggca gaggcagcca gctaggtccc tgacttccca gccaggtgca gctctaagaa
     4621 ctgctcttgc ctgctgcctt cttgtggtgt ccagagccca cagccaatgc ctcctcaaaa
     4681 ccctggcttc cttccttcta atccactggc acatcagcat cacctccgga ttgacttcag
     4741 atccacagcc tacactacta gcagtgggta agaccacttc ctttgtcctt gtctgttctc
     4801 cagaaaagtg ggcatggagg cggtgttaat aactataggt ctgtggcttt atgagccttc
     4861 aaacttctct ctagcttctg aaagggttac ttttgggcag tattgcagtc tcaccctccc
     4921 gatgggctgt agcctgtgca gttgctgtac tgggcatgat ctccagtgct tgcaagtccc
     4981 atgatttctt tggtgatttt gagggtgggg ggagggacat gaatcatctt agcttagctt
     5041 cctgtctgtg aatgtccata tagtgtactg tgttttaaca aacgatttac actgactgtt
     5101 gctgtacaag tgaatttgga aataaagtta ttactctgat taaacaaaa
//
