LOCUS       NP_058908                374 aa            linear   ROD 13-FEB-2025
DEFINITION  microtubule-associated protein tau [Rattus norvegicus].
ACCESSION   NP_058908 XP_346410
VERSION     NP_058908.2
DBSOURCE    REFSEQ: accession NM_017212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Fischer,I., Connors,T., Bouyer,J. and Jin,Y.
  TITLE     The unique properties of Big tau in the visual system
  JOURNAL   Cytoskeleton (Hoboken) 81 (9-10), 488-499 (2024)
   PUBMED   38761116
  REMARK    GeneRIF: The unique properties of Big tau in the visual system.
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Yu,K., Yao,K.R., Aguinaga,M.A., Choquette,J.M., Liu,C., Wang,Y. and
            Liao,D.
  TITLE     G272V and P301L Mutations Induce Isoform Specific Tau
            Mislocalization to Dendritic Spines and Synaptic Dysfunctions in
            Cellular Models of 3R and 4R Tau Frontotemporal Dementia
  JOURNAL   J Neurosci 44 (28), e1215232024 (2024)
   PUBMED   38858079
  REMARK    GeneRIF: G272V and P301L Mutations Induce Isoform Specific Tau
            Mislocalization to Dendritic Spines and Synaptic Dysfunctions in
            Cellular Models of 3R and 4R Tau Frontotemporal Dementia.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Chen,J., Xiang,Z., Zhang,Z., Yang,Y., Shu,K. and Lei,T.
  TITLE     Acromegalic Rat Model Presented Cognitive Impairments and Tau
            Hyperphosphorylation in the Hippocampus
  JOURNAL   Neuroendocrinology 114 (6), 577-588 (2024)
   PUBMED   38368872
  REMARK    GeneRIF: Acromegalic Rat Model Presented Cognitive Impairments and
            Tau Hyperphosphorylation in the Hippocampus.
REFERENCE   4  (residues 1 to 374)
  AUTHORS   Christensen,K.R., Combs,B., Richards,C., Grabinski,T.,
            Alhadidy,M.M. and Kanaan,N.M.
  TITLE     Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal
            Transport in Rat Hippocampal Neurons
  JOURNAL   Mol Neurobiol 60 (6), 3423-3438 (2023)
   PUBMED   36859689
  REMARK    GeneRIF: Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs
            Axonal Transport in Rat Hippocampal Neurons.
REFERENCE   5  (residues 1 to 374)
  AUTHORS   Liu,X., Song,W., Yu,Y., Su,J., Shi,X., Yang,X., Wang,H., Liu,P. and
            Zou,L.
  TITLE     Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase
            Kinase-3beta Overactivation-Induced Hyperphosphorylated Tau in Rats
  JOURNAL   Neurotox Res 40 (5), 1163-1173 (2022)
   PUBMED   35951283
  REMARK    GeneRIF: Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen
            Synthase Kinase-3beta Overactivation-Induced Hyperphosphorylated
            Tau in Rats.
REFERENCE   6  (residues 1 to 374)
  AUTHORS   Kanai,Y., Chen,J. and Hirokawa,N.
  TITLE     Microtubule bundling by tau proteins in vivo: analysis of
            functional domains
  JOURNAL   EMBO J 11 (11), 3953-3961 (1992)
   PUBMED   1396588
REFERENCE   7  (residues 1 to 374)
  AUTHORS   Drechsel,D.N., Hyman,A.A., Cobb,M.H. and Kirschner,M.W.
  TITLE     Modulation of the dynamic instability of tubulin assembly by the
            microtubule-associated protein tau
  JOURNAL   Mol Biol Cell 3 (10), 1141-1154 (1992)
   PUBMED   1421571
REFERENCE   8  (residues 1 to 374)
  AUTHORS   Caceres,A., Mautino,J. and Kosik,K.S.
  TITLE     Suppression of MAP2 in cultured cerebellar macroneurons inhibits
            minor neurite formation
  JOURNAL   Neuron 9 (4), 607-618 (1992)
   PUBMED   1389180
REFERENCE   9  (residues 1 to 374)
  AUTHORS   Goedert,M., Spillantini,M.G. and Crowther,R.A.
  TITLE     Cloning of a big tau microtubule-associated protein characteristic
            of the peripheral nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1983-1987 (1992)
   PUBMED   1542696
REFERENCE   10 (residues 1 to 374)
  AUTHORS   Weingarten,M.D., Lockwood,A.H., Hwo,S.Y. and Kirschner,M.W.
  TITLE     A protein factor essential for microtubule assembly
  JOURNAL   Proc Natl Acad Sci U S A 72 (5), 1858-1862 (1975)
   PUBMED   1057175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 16, 2007 this sequence version replaced NP_058908.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79321.1, SRR26360194.416609.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..374
                     /product="microtubule-associated protein tau"
                     /note="Tau microtubule-associated protein; PHF-tau; paired
                     helical filament-tau; neurofibrillary tangle protein;
                     microtubule-associated protein tau 0N4R;
                     microtubule-associated protein tau 1N4R;
                     microtubule-associated protein tau 2N4R; MAPT_BigTau;
                     microtubule-associated protein tau BigTau"
                     /calculated_mol_wt=39012
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P10636; propagated from
                     UniProtKB/Swiss-Prot (P19332.3)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10637; propagated from
                     UniProtKB/Swiss-Prot (P19332.3)"
     Region          <85..186
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <185..206
                     /region_name="Tubulin-binding"
                     /note="Tau and MAP protein, tubulin-binding repeat;
                     pfam00418"
                     /db_xref="CDD:459807"
     Region          208..237
                     /region_name="Tubulin-binding"
                     /note="Tau and MAP protein, tubulin-binding repeat;
                     pfam00418"
                     /db_xref="CDD:459807"
     Region          239..268
                     /region_name="Tubulin-binding"
                     /note="Tau and MAP protein, tubulin-binding repeat;
                     pfam00418"
                     /db_xref="CDD:459807"
     Region          270..300
                     /region_name="Tubulin-binding"
                     /note="Tau and MAP protein, tubulin-binding repeat;
                     pfam00418"
                     /db_xref="CDD:459807"
     CDS             1..374
                     /gene="Mapt"
                     /gene_synonym="MAPT_0N4R; MAPT_1N4R; MAPT_2N4R; Mtapt;
                     pTau; RNPTAU; Tau"
                     /coded_by="NM_017212.3:145..1269"
                     /db_xref="GeneID:29477"
                     /db_xref="RGD:69329"
ORIGIN      
        1 maeprqefdt medqagdytm lqdqegdmdh glkaeeagig dtpnmedqaa ghvtqarvag
       61 vskdrtgnde kkakgadgkt gakiatprga atpgqkgtsn atripakttp spktppgsge
      121 ppksgersgy sspgspgtpg srsrtpslpt pptrepkkva vvrtppksps asksrlqtap
      181 vpmpdlknvr skigstenlk hqpgggkvqi inkkldlsnv qskcgskdni khvpgggsvq
      241 ivykpvdlsk vtskcgslgn ihhkpgggqv evksekldfk drvqskigsl dnithvpggg
      301 nkkiethklt frenakaktd hgaeivyksp vvsgdtsprh lsnvsstgsi dmvdspqlat
      361 ladevsasla kqgl
//
