LOCUS       NM_138509               2310 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus microtubule-associated protein, RP/EB family,
            member 1 (Mapre1), mRNA.
ACCESSION   NM_138509 XM_346667
VERSION     NM_138509.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Liu,S., Li,H., Wu,S., Li,L., Ge,R. and Cheng,C.Y.
  TITLE     NC1-peptide regulates spermatogenesis through changes in
            cytoskeletal organization mediated by EB1
  JOURNAL   FASEB J 34 (2), 3105-3128 (2020)
   PUBMED   31909540
  REMARK    GeneRIF: NC1-peptide regulates spermatogenesis through changes in
            cytoskeletal organization mediated by EB1.
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2310)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   4  (bases 1 to 2310)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2310)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   6  (bases 1 to 2310)
  AUTHORS   Nakamura,M., Zhou,X.Z., Kishi,S. and Lu,K.P.
  TITLE     Involvement of the telomeric protein Pin2/TRF1 in the regulation of
            the mitotic spindle
  JOURNAL   FEBS Lett 514 (2-3), 193-198 (2002)
   PUBMED   11943150
REFERENCE   7  (bases 1 to 2310)
  AUTHORS   Morrison,E.E. and Askham,J.M.
  TITLE     EB 1 immunofluorescence reveals an increase in growing astral
            microtubule length and number during anaphase in NRK-52E cells
  JOURNAL   Eur J Cell Biol 80 (12), 749-753 (2001)
   PUBMED   11831388
  REMARK    GeneRIF: In this study we used EB1 immunostaining in mitotic
            NRK-52E cells to quantitatively analyse the length and number of
            growing astral microtubules during metaphase and anaphase
REFERENCE   8  (bases 1 to 2310)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
REFERENCE   9  (bases 1 to 2310)
  AUTHORS   Askham,J.M., Moncur,P., Markham,A.F. and Morrison,E.E.
  TITLE     Regulation and function of the interaction between the APC tumour
            suppressor protein and EB1
  JOURNAL   Oncogene 19 (15), 1950-1958 (2000)
   PUBMED   10773885
REFERENCE   10 (bases 1 to 2310)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081726.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_138509.4.
            
            On Oct 25, 2005 this sequence version replaced NM_138509.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081726.1, CF110918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2310
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /note="microtubule-associated protein, RP/EB family,
                     member 1"
                     /db_xref="GeneID:114764"
                     /db_xref="RGD:621781"
     exon            1..77
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..201
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..887
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /note="adenomatosis polyposis coli binding protein Eb1;
                     end-binding protein 1; APC-binding protein EB1"
                     /codon_start=1
                     /product="microtubule-associated protein RP/EB family
                     member 1"
                     /protein_id="NP_612518.2"
                     /db_xref="GeneID:114764"
                     /db_xref="RGD:621781"
                     /translation="MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAY
                     CQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQ
                     DNFEFVQWFKKFFDANYDGKEYDPVAARQGQETAVAPSLVAPALSKPKKPLGSGSAAP
                     QRPIATQRTTAAPKAGPGMVRKNPGMGNGDDEAAELMQQVKVLKLTVEDLEKERDFYF
                     GKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY"
     exon            202..347
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..555
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..677
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..830
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..2307
                     /gene="Mapre1"
                     /gene_synonym="Eb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgacggt ttgaacgaga cgaagacaga accggagccg ggcgcgcgga ctgcggacgc
       61 gggtcctgtg agagccgaag atggcagtga atgtgtactc gacgtcagtc accagtgata
      121 acctcagtcg acatgacatg ctggcttgga tcaatgaatc tctgcagttg aatctgacaa
      181 agatagaaca gctatgttca ggggctgcat actgtcagtt catggacatg ctcttccccg
      241 gctccattgc cttgaagaaa gtgaaattcc aggctaagct agaacatgaa tatatccaga
      301 acttcaaaat actacaagcc ggcttcaaga ggatgggcgt tgacaaaata attcctgtgg
      361 ataaattagt aaaaggaaaa tttcaggaca attttgaatt cgttcaatgg ttcaagaagt
      421 tttttgatgc aaattatgat ggaaaagaat atgatcctgt cgctgccaga caaggtcaag
      481 aaacggcagt ggctccttct cttgtcgctc cagctttgag taaaccgaag aaacctctcg
      541 gctccggtag tgcagcccca cagagaccca ttgcaacaca gaggactact gcagctccta
      601 aggctggccc cgggatggtg cgaaagaatc ctggcatggg caatggagat gacgaagctg
      661 ctgaattgat gcagcaggtc aaagtattga agcttactgt tgaagacttg gagaaggaga
      721 gagatttcta cttcggcaag ctaaggaaca ttgaattgat ttgccaggag aatgaggggg
      781 aaaatgaccc tgtactgcag aggattgtag atattcttta tgccacagat gaaggctttg
      841 tgatacctga cgaggggggc ccacaggagg aacaagaaga gtattaagca gtctggacca
      901 gcagagcaac atccgacgtc ttcactccaa atcatgtgct tacctgttaa atactccctt
      961 ttattaatct tagaggattc actggtttct tttcataagc aaaaagtacc tcttctcaaa
     1021 gtgcactttg cagaagtctc accttttccg atgagtttga gttaggagcc tttgccttgt
     1081 agcagagcag tgttaacatc tagttggtcc accaggggaa cgagaggcca accatggggc
     1141 ccttcaatgt ggatgctggt cacactgact gatggagaag ggagggggtt ataatacacg
     1201 aggtgacaac ctcagaagtg taaagactga attgaattct aagctaatgt gaaattctgg
     1261 cagagaacgt tttaataaat aaatgcctta agagtattta aaaatatgct tccatatttc
     1321 aaaatataaa gtgtaacatg acaggagatt ttatgtgtct gacattgtgt ctgggaagga
     1381 agggccagac tttagatcct ttggaacctg ctgtcgtagg cctttcagtg cagcttgaat
     1441 cttacggttg tagactttgg cccagaagta aagtttggaa agttctgtaa agccattttg
     1501 tgtcactgac cagttgcatc cctgctataa aagcaagcag catggttgct tgggtgaaga
     1561 gagggcgtct gggccctgca gtgcctgagg cgaagagctc agctttccct tgggcgttcc
     1621 tctcatcttt tcaaactgtc ccccaggtcc agtgggacct gcccacatct ctgggatttg
     1681 aatgggtgct gagtcccagc atactgtctt ttaagtttac atttaacacg ttctcttctc
     1741 tgctcccttt gacctctgac tccttaagtt tgctgctgag ggttgtaaat acagcaggca
     1801 ggtgaccggg ctgcaagttc ttgctggacc tctggcaaag gagtgatcag tgaaggccag
     1861 tgccaccttg ggctctgtga ggccagggtg ctcgctgtct gctgtcacag ctcccactgt
     1921 cacctgagaa ctttgccagt gcactaatct ctttggagat aaaattctct agtgtgttac
     1981 taatgttaaa atgttttttt taagaatata cagtaccatg actgaaatat taatatttaa
     2041 aatagttcat tccttaattc tccctcattt gctttaccca cagcctattc atttcctttg
     2101 gcagaactct gcacaatgtg ttacccacta ctgagattgt tccgcccctg acgtgtttgt
     2161 gttgatttgt ttctggtggt agagtgtctt atgctgtgtg tagaaacagg cattttatga
     2221 cagattgtta tgtagtgcat gctctgtgga attcagagga aaatccagat tcagtgatta
     2281 acaatgccaa aaaaaaaaaa aaaaaaaaaa
//
