LOCUS       NM_001108589            4681 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase binding protein
            1 (Mapkbp1), mRNA.
ACCESSION   NM_001108589 XM_001080877 XM_342498
VERSION     NM_001108589.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Macia,M.S., Halbritter,J., Delous,M., Bredrup,C., Gutter,A.,
            Filhol,E., Mellgren,A.E.C., Leh,S., Bizet,A., Braun,D.A., Gee,H.Y.,
            Silbermann,F., Henry,C., Krug,P., Bole-Feysot,C., Nitschke,P.,
            Joly,D., Nicoud,P., Paget,A., Haugland,H., Brackmann,D., Ahmet,N.,
            Sandford,R., Cengiz,N., Knappskog,P.M., Boman,H., Linghu,B.,
            Yang,F., Oakeley,E.J., Saint Mezard,P., Sailer,A.W., Johansson,S.,
            Rodahl,E., Saunier,S., Hildebrandt,F. and Benmerah,A.
  TITLE     Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent
            Nephronophthisis
  JOURNAL   Am J Hum Genet 100 (2), 323-333 (2017)
   PUBMED   28089251
  REMARK    Erratum:[Am J Hum Genet. 2017 Feb 2;100(2):372. doi:
            10.1016/j.ajhg.2017.01.025. PMID: 28157543]
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Lecat,A., Di Valentin,E., Somja,J., Jourdan,S., Fillet,M.,
            Kufer,T.A., Habraken,Y., Sadzot,C., Louis,E., Delvenne,P.,
            Piette,J. and Legrand-Poels,S.
  TITLE     The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as
            a negative regulator of NOD2 protein signaling by inhibiting its
            oligomerization process
  JOURNAL   J Biol Chem 287 (35), 29213-29226 (2012)
   PUBMED   22700971
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Koyano,S., Ito,M., Takamatsu,N., Shiba,T., Yamamoto,K. and
            Yoshioka,K.
  TITLE     A novel Jun N-terminal kinase (JNK)-binding protein that enhances
            the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase
            1
  JOURNAL   FEBS Lett 457 (3), 385-388 (1999)
   PUBMED   10471813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001108589.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342498.3, XM_001080877.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..4681
                     /gene="Mapkbp1"
                     /note="mitogen activated protein kinase binding protein 1"
                     /db_xref="GeneID:362197"
                     /db_xref="RGD:1307578"
     exon            1..266
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..4673
                     /gene="Mapkbp1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase-binding protein
                     1"
                     /protein_id="NP_001102059.1"
                     /db_xref="GeneID:362197"
                     /db_xref="RGD:1307578"
                     /translation="MMAGEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEK
                     VLGVTVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPD
                     GKYLVTGESGHMPAVRVWDVAERNQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMI
                     VNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATV
                     PLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNT
                     DSFTTTVAHCISVSQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIATITEAS
                     RLFSGGANARYPDTIALTFDPANQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSC
                     VWSVEVYPEIKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSALHRNILSNDLIK
                     IIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHE
                     LQSLSELLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDE
                     HSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMD
                     VEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCS
                     DKNLSIFDFFSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTIS
                     MRQRLAELRQRQRGIKQQGPTSPQKASGAKQHHPPVVPPSGPALSSDSDKEGEDEGTE
                     EEELPALPILGKSTKKELASGSSPALLRSLSHWEMSRAQENMEFLGPAPTANTGPKRR
                     GRWAQPGVELSVRSMLDLRQLETLAPSPRGPSQDSLAVSPTGPGKHSPQAADLSCASQ
                     NERAPRLQASQPCSCPHIIQLLSQEEGVFAQDLESAPIEDGIVYPEPSDSPTMDTSAF
                     QVQAPTGGSLGRVYPGSRGSEKHSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDG
                     VSSDLEEQAEGEEEEEEEGGTGLCGLQEGSPHTPDQEQFLKQHFETLANGAAPGGPAR
                     ALERTESRSISSRFLLQVQTSPLREPSLSSSGLALMSRPDQVSQVSGEQLKGSGATPP
                     GAPPEMEPSSGNSGPKQVAPVLLPRRRTNLDNSWASKKTAATRPLAGLQKAQSVHSLV
                     PQDEVPSRPLLFQAEVQGSLGSLPQADGCPSQSHSYWNPTTSSVAKLARSISVGENPG
                     LAAEPQAPAPIRTSPFNKLALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHSETEQ
                     SGPSVSLGKTHTAIEKHSCLGEGTTPKSRTECQAHPGPNHPCAQQLPVSNLLQGPESM
                     QPLSPEKTRNPVESSRPGAALSQDSELALSLQQCEQLVAELRRNVRQAVQLYHSVTSC
                     KTPSAEQSHITRLLRDTFSSVRQELEALDGAVLSSPGGSPGAVGAEQTQALLEQYSEL
                     LLRAVERRMERRL"
     exon            267..358
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..421
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..479
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..650
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..788
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..971
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..989
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1150
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1340
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1487
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1663
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1755
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1881
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1952
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2074
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2150
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2262
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2326
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2461
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2598
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2654
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2891
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3058
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3204
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3399
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3484
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3768
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..4359
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4445
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4681
                     /gene="Mapkbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagacacct actgtgatga taaggttgct tctgccatct caagccagta taagtgacta
       61 tccgaaggcc gtgttgagcg agaaggcagt accgctgttg agacaagtcc taaggccagg
      121 ccagggactg tccttagggg ttcctcgtta tgatggctgg agaaggatca accattacaa
      181 gccgcatcaa gaacttgctg cggtctccat ccatcaaatt acgcagaagt aaagcaggaa
      241 accggagaga ggatctcagc tccaaggtga ccttggagaa ggtactggga gtaactgtat
      301 ctggaggcag aggacttgct tgtgatcccc ggtctggctt agttgcctac ccagctgggt
      361 gtgtggtcgt cctcttcaat ccccggaagc acaaacagca ccacatcctc aacagttcca
      421 ggaaaaccat tactgccctt gcctttagcc ctgatggcaa gtacttggtc actggagaga
      481 gtgggcacat gcctgccgtt cgggtttggg atgtggctga acggaaccag gtggcagagc
      541 tacaagagca taagtatggt gtggcttgtg tggctttctc cccaagtgct aagtacattg
      601 tgtctgtggg ttaccagcat gacatgatag tcaacgtgtg ggcctggaag aaaaacattg
      661 tagtggcctc caacaaagta tctagtcggg tgacagcagt gtccttttct gaagactgta
      721 gctactttgt tactgcaggc aaccggcata tcaaattctg gtacctggat gacagtaaga
      781 cctcaaaggt gaatgccact gtgcccctgc tgggccgctc agggctgctg ggggagttgc
      841 ggaacaacct gtttactgat gtggcctgtg gccgagggaa aaaggctgac agcaccttct
      901 gtatcacgtc gtcagggcta ctgtgcgagt tcagcgatcg aaggcttctg gacaaatggg
      961 tggagctaag aaacacagac agcttcacaa ccactgtggc tcactgcatc tctgtaagcc
     1021 aagaatacat cttctgtggc tgcgctgatg gcacggtgcg ccttttcaat ccttccaacc
     1081 tgcacttcct cagtacccta cccagacccc atgccctggg aacagacatc gccaccatca
     1141 ctgaggccag ccgcctcttt tctggagggg ccaatgcaag gtacccagac accattgcct
     1201 tgacctttga tccagctaat cagtggctgt cttgtgtcta caacgaccac agcatctatg
     1261 tttgggatgt gagggacccc aagaaagtgg ggaaggtgta ctcagctctg tatcattctt
     1321 cctgtgtctg gagtgtggag gtctaccctg agatcaagga cagtaatcag gcctgtctcc
     1381 cccccagttc ctttattact tgctcctcag acaacaccat ccgcctgtgg aacacggaga
     1441 gctctggggt acatggctct gcgctgcacc ggaacatcct cagcaatgat ctcattaaga
     1501 tcatctatgt ggatgggaac actcaggctt tgttggacac tgagcttcct ggaggggaca
     1561 aagctgatgg gtccctgatg gatccccgag taggcatccg ttctgtgtgt atcagcccca
     1621 acggacaaca cctagcttca ggagaccgca tggggacact tagggtccat gagctgcagt
     1681 ccctgagtga gctgctgaaa gttgaggccc acgactctga gatcctgtgc ctggagtact
     1741 ctaagccaga cacgggtctg aaactgctag catcagcgag ccgggaccgt ctgatccatg
     1801 tgctggatgc tgggcgggaa tatagtctac agcagacact ggacgagcat tcatcctcca
     1861 tcactgctgt caagtttgca gccagcgatg ggcaggtgcg aatgatcagc tgtggtgcag
     1921 acaagagcat ttacttccgg actgcacaga agtctggaga aggagtgcag tttacacgaa
     1981 cacaccacgt ggtacggaag acaaccctct atgacatgga tgtagaaccc agctggaagt
     2041 acacggccat cggctgccaa gaccgaaata tccggatctt taacattagc agcgggaagc
     2101 agaaaaagct gtttaaaggg tcacagggtg aggatggcac tctcattaag gtgcagacag
     2161 acccctcagg gatctacatt gccactagct gttccgataa gaatctctcc atttttgact
     2221 tcttctcagg cgagtgtgtg gccaccatgt ttggtcattc agagattgtc actggcatga
     2281 aatttagtaa cgactgcaaa catctcatct cggtgtcagg ggacagctgc atatttgtgt
     2341 ggcgtctgag ctcagagatg accatcagca tgaggcagcg cctggctgag ttgcgccagc
     2401 gccagcgagg gatcaagcag caaggaccaa cttctcccca aaaggcatct ggagccaaac
     2461 agcaccaccc tccagtggta cccccttctg gaccagctct ttcctcagac agtgacaagg
     2521 agggagaaga tgagggtact gaagaggaag aacttccagc tctgcccatc ctgggcaaga
     2581 gcaccaagaa ggaactagcc tcaggctcta gtccagcttt gctccgaagc ctgtcccact
     2641 gggaaatgag tcgggcacaa gagaacatgg agttcctggg cccagctcct acagctaaca
     2701 ccgggcctaa acgaagaggg cgctgggccc aaccaggtgt ggagctgagt gttcgctcca
     2761 tgctggacct gcgacagcta gagactttgg ccccaagtcc tcgaggcccc agccaggact
     2821 cactggctgt gtccccaact ggtcctggga agcatagccc acaggccgct gacctgtcgt
     2881 gtgctagcca gaatgaaagg gcccctcggc ttcaggcctc ccaaccctgc tcctgccccc
     2941 acattatcca attgttgtca caagaggaag gagtctttgc tcaagatctg gagtctgcac
     3001 ccattgaaga tggtattgtc tacccggaac ccagtgacag ccctaccatg gataccagtg
     3061 cgtttcaggt gcaggctcca accggaggat ccctagggag agtttaccca ggcagcaggg
     3121 gctcagaaaa gcacagtccc gacagcgcgt gctctgtgga ttacagcagc agccggcttt
     3181 ccagcccgga acacccgaat gaagactctg agagcacaga gcccctaagt gtggatggcg
     3241 tctcctcaga cctggaagag caagccgagg gcgaggaaga agaggaagaa gagggaggca
     3301 ctggcctctg tgggctacag gaaggcagcc ctcatacacc ggatcaggaa cagtttctaa
     3361 aacagcactt tgagactctg gccaatgggg ctgctccagg aggtccagca cgggctctag
     3421 agaggacaga gtctcggagc atctcatcac gattcctcct gcaagtgcag acctccccac
     3481 tcagggaacc atccctatcc tcctcaggct tggccctgat gtccagacct gaccaggtat
     3541 cacaggtatc tggtgagcag ctgaaaggca gtggtgccac tcccccagga gcacccccag
     3601 aaatggaacc ctcttctggc aactctggcc ccaagcaggt ggctcctgtg ctgttgccac
     3661 gacggcgtac caacctggac aacagctggg cctccaagaa aacggctgca acccggcctt
     3721 tagctggact ccagaaagcc cagtctgtgc atagtttggt accacaggat gaggtgcctt
     3781 cacgtccact gctcttccag gcagaggttc agggcagctt aggatccctg ccacaagctg
     3841 atggctgccc atctcagtcc cactcctact ggaaccccac caccagttct gtggccaagc
     3901 tggctcggag catttctgtt ggcgagaatc caggcctggc agccgaacct caagctcctg
     3961 caccgatccg aacctcacca ttcaacaaac tagctctgcc tagccgggct caccttgtcc
     4021 tggacatccc caaaccactt cctgaccgtc ccactctgac cacattctca cccgtatcta
     4081 agggcctggc ccacagtgaa accgaacagt cgggcccctc agtgagcctt ggaaagactc
     4141 acactgcaat tgaaaagcac tcctgcttag gggagggaac tactcctaaa tctaggacag
     4201 aatgccaggc tcatcctggc cccaaccacc cctgtgccca gcaactgccg gtcagcaacc
     4261 tcctccaagg ccctgagagc atgcagcccc tgtcccctga gaagactcgt aaccctgtgg
     4321 aaagcagcag gccaggggca gccctgagcc aggactcaga actggccttg agcctacaac
     4381 aatgtgaaca gcttgtggca gagctccgga ggaatgtacg ccaggcagtg cagctctacc
     4441 actcggtgac cagctgtaag acaccttcag cagagcaaag tcacatcacc cgtctcttga
     4501 gagacacctt ctcttcagtg cggcaggagc tagaggccct ggatggggct gtgctgtcca
     4561 gcccaggggg cagccccggg gctgtggggg ctgagcaaac gcaggccctg ttggagcagt
     4621 actcagagct cttgctccga gctgtggaac ggcgcatgga gcgcagactc tgagtccctg
     4681 a
//
