LOCUS       NM_001164043            1699 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus MAPK activated protein kinase 5 (Mapkapk5),
            transcript variant 1, mRNA.
ACCESSION   NM_001164043
VERSION     NM_001164043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B,
            Britsch S, Meloche S, Gaestel M and Kotlyarov A.
  TITLE     The extracellular signal-regulated kinase 3 (mitogen-activated
            protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling
            complex regulates septin function and dendrite morphology
  JOURNAL   Mol Cell Biol 32 (13), 2467-2478 (2012)
   PUBMED   22508986
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Cerone MA, Burgess DJ, Naceur-Lombardelli C, Lord CJ and Ashworth
            A.
  TITLE     High-throughput RNAi screening reveals novel regulators of
            telomerase
  JOURNAL   Cancer Res 71 (9), 3328-3340 (2011)
   PUBMED   21531765
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin
            SC, Guan KL and Han J.
  TITLE     Inactivation of Rheb by PRAK-mediated phosphorylation is essential
            for energy-depletion-induced suppression of mTORC1
  JOURNAL   Nat Cell Biol 13 (3), 263-272 (2011)
   PUBMED   21336308
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Kress TR, Cannell IG, Brenkman AB, Samans B, Gaestel M, Roepman P,
            Burgering BM, Bushell M, Rosenwald A and Eilers M.
  TITLE     The MK5/PRAK kinase and Myc form a negative feedback loop that is
            disrupted during colorectal tumorigenesis
  JOURNAL   Mol Cell 41 (4), 445-457 (2011)
   PUBMED   21329882
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Kostenko S, Khan MT, Sylte I and Moens U.
  TITLE     The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5
            (MK5/PRAK) inhibitor
  JOURNAL   Cell Mol Life Sci 68 (2), 289-301 (2011)
   PUBMED   20640477
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J,
            Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR 3rd, Wright PE and
            Han J.
  TITLE     PRAK is essential for ras-induced senescence and tumor suppression
  JOURNAL   Cell 128 (2), 295-308 (2007)
   PUBMED   17254968
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A and Gaestel
            M.
  TITLE     Characterization of the atypical MAPK ERK4 and its activation of
            the MAPK-activated protein kinase MK5
  JOURNAL   J Biol Chem 281 (46), 35511-35519 (2006)
   PUBMED   16973613
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Gaestel M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG,
            Morrice NA, Turgeon B, Meloche S, Moens U and Keyse SM.
  TITLE     Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a
            novel signal transduction pathway
  JOURNAL   EMBO J 23 (24), 4780-4791 (2004)
   PUBMED   15577943
  REMARK    Erratum:[EMBO J. 2005 Feb 23;24(4):873]
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov
            A and Gaestel M.
  TITLE     Scaffolding by ERK3 regulates MK5 in development
  JOURNAL   EMBO J 23 (24), 4770-4779 (2004)
   PUBMED   15538386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM032487.1, BC099161.1 and AI715466.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               FM032487.1         1-545
            546-1675            BC099161.1         177-1306
            1676-1699           AI715466.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1699
                     /gene="Mapkapk5"
                     /note="MAPK activated protein kinase 5"
                     /db_xref="GeneID:498183"
                     /db_xref="RGD:1564113"
     exon            1..203
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1589
                     /gene="Mapkapk5"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; MAP
                     kinase-activated protein kinase 5; mitogen-activated
                     protein kinase-activated protein kinase 5"
                     /codon_start=1
                     /product="MAP kinase-activated protein kinase 5 isoform 1"
                     /protein_id="NP_001157515.1"
                     /db_xref="GeneID:498183"
                     /db_xref="RGD:1564113"
                     /translation="MSEDSNMEKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKST
                     QERFALKILLDRPKARNEVRLHMMCATHSNIVEIIEVFANSVQFPHESSPRARLLIVM
                     EMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFKDNS
                     LDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGLIPTSPTPYTY
                     NKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEM
                     AKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHA
                     EQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGSKPKDGVYIHDHENGVEDSNVALEK
                     LRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFTDKV
                     DRLKLAEVVKQVIEEQTLPHEPQ"
     exon            204..277
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            278..353
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            354..451
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            452..560
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..650
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            651..746
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1015
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1136
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1267
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1389
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1494
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1682
                     /gene="Mapkapk5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagccggc acccgggcct tcatctcctc cggtccccag gggcgggcgc tgcccatctc
       61 ccggagtccc ggggacccga gctccgagcc ctctgcttcc tcggctgcca ggggaccgga
      121 cagccgcgca gccttcgccg cttcgggctg tgggagccca ggggagcatg tcggaggata
      181 gcaacatgga gaaagccatc aaggagacct ccattttaga agaatatagt atcaattgga
      241 ctcagaaact gggagctgga attagtggtc cggttagagt ctgtgtaaag aaatctactc
      301 aagaacggtt tgcactgaaa attcttctcg atcgtccaaa agctagaaat gaggtgcgcc
      361 tgcacatgat gtgtgccaca cactccaaca tagttgagat tattgaagtg tttgctaaca
      421 gtgtacagtt ccctcatgag tccagcccca gggctcgact cttaattgta atggagatga
      481 tggaaggggg cgagctgttt cacagaatca gccagcaccg gcactttaca gagaagcaag
      541 ccagccaagt aacaaagcag atagccctgg ctctacagca ctgtcacttg ctaaacattg
      601 cgcacagaga cctcaagcct gaaaatctgc ttttcaagga taactctttg gacgcccctg
      661 tgaagttatg tgactttggg tttgctaaag ttgaccaagg tgatttgatg acgccccagt
      721 ttacccctta ctatgtagca cctcaggtac tggaagcaca gagaaggcac cagaaggaga
      781 agtctggcct catccctacc tcgccaacgc cctacactta caacaagagc tgtgacttgt
      841 ggtccctcgg ggtgataatt tatgtgatgc tatgcggata ccctcctttt tactccaaac
      901 accacagtcg gaccatccca aaggacatgc ggaaaaagat catgacaggg agttttgagt
      961 tcccggagga agagtggagc cagatctcag agatggccaa agacgtggtg aggaagcttc
     1021 taaaggtcaa accagaggaa agactcacaa tcgagggggt gttggaccat ccctggctca
     1081 actcgacaga ggccctggat aatgtgctac cctctgctca gctgatgatg gataaggcag
     1141 tggttgcagg gatccagcag gctcatgccg agcagctggc aaacatgagg atccaggacc
     1201 tcaaagtcag cctcaaaccc ctgcactctg tgaacaaccc cattctgagg aagaggaagc
     1261 tactgggctc caagccaaag gatggtgttt atatccacga ccatgagaat ggagtcgagg
     1321 attcaaatgt tgccttggaa aagcttcgcg atgtcattgc ccagtgcatc cttccccagg
     1381 ctggtaaagg agagaatgaa gatgagaagc tcaatgaggt aatgcaggag gcctggaagt
     1441 acaaccggga gtgcaaactc ctgcgggacg cgctgcagag ttttagctgg aatggtcgtg
     1501 gattcacaga taaagtggac cgattaaagc tggcagaggt tgtgaagcag gtgatcgaag
     1561 agcagaccct tccccacgag ccccagtagg aaccgcttca aactgttttt aacaattgga
     1621 aaaattattc cttaatgtaa aaagtaattt ttatgtaaat taataaatca taatttcatt
     1681 tcaaaaaaaa aaaaaaaaa
//
