LOCUS       NM_001012127            2634 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MAPK activated protein kinase 3 (Mapkapk3), mRNA.
ACCESSION   NM_001012127 XM_236618
VERSION     NM_001012127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Zaru,R., Ronkina,N., Gaestel,M., Arthur,J.S. and Watts,C.
  TITLE     The MAPK-activated kinase Rsk controls an acute Toll-like receptor
            signaling response in dendritic cells and is activated through two
            distinct pathways
  JOURNAL   Nat Immunol 8 (11), 1227-1235 (2007)
   PUBMED   17906627
  REMARK    Erratum:[Nat Immunol. 2008 Jan;9(1):105]
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Eyers,C.E., McNeill,H., Knebel,A., Morrice,N., Arthur,S.J.,
            Cuenda,A. and Cohen,P.
  TITLE     The phosphorylation of CapZ-interacting protein (CapZIP) by
            stress-activated protein kinases triggers its dissociation from
            CapZ
  JOURNAL   Biochem J 389 (Pt 1), 127-135 (2005)
   PUBMED   15850461
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Clifton,A.D., Young,P.R. and Cohen,P.
  TITLE     A comparison of the substrate specificity of MAPKAP kinase-2 and
            MAPKAP kinase-3 and their activation by cytokines and cellular
            stress
  JOURNAL   FEBS Lett 392 (3), 209-214 (1996)
   PUBMED   8774846
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Lavoie,J.N., Lambert,H., Hickey,E., Weber,L.A. and Landry,J.
  TITLE     Modulation of cellular thermoresistance and actin filament
            stability accompanies phosphorylation-induced changes in the
            oligomeric structure of heat shock protein 27
  JOURNAL   Mol Cell Biol 15 (1), 505-516 (1995)
   PUBMED   7799959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081974.1.
            
            On Feb 11, 2005 this sequence version replaced XM_236618.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081974.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132264,
                                           SAMD00132274 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2634
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /note="MAPK activated protein kinase 3"
                     /db_xref="GeneID:315994"
                     /db_xref="RGD:1304980"
     exon            1..231
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..508
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1438
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /EC_number="2.7.11.1"
                     /note="MAPKAPK-3; MAPKAP kinase 3; mitogen-activated
                     protein kinase-activated protein kinase 3"
                     /codon_start=1
                     /product="MAP kinase-activated protein kinase 3"
                     /protein_id="NP_001012127.1"
                     /db_xref="GeneID:315994"
                     /db_xref="RGD:1304980"
                     /translation="MDGETAGEKGSLVPQPGALGAPALGGAPAPGVRREPKKYAVTDD
                     YQLSKQVLGLGVNGKVLECYHRRSGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRI
                     LDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH
                     SQNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP
                     EKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPKPEWADVS
                     EDAKQLIRLLLKTDPTERLTIMQFMNHPWINQSMEVPQTPLHTARVLEEDKDHWDDVK
                     EEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQGGSSSASPGCNNQ"
     exon            509..648
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            649..713
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..793
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..917
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            918..993
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1118
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1204
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1285
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2604
                     /gene="Mapkapk3"
                     /gene_synonym="MAPKAP-K3; MK-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactctgggt ccagggctcc cctccgcagc ggactccagg cctcactatc tcttgcccct
       61 ctcgcctaca acatgacttc cgtctagtgc tttgccatca agtgcgcctt cgcctggcac
      121 gcctttcctg ggcccctata tggccgtttc tcaagacctg gctgcttcac tgcgccggac
      181 tcctcaactc cacatgtgcc tgggctgagg gatcacctcc ccctgctgta cgtgcctctg
      241 gacgtgccag gctggggcta cctacaagcg ccccgtgggg gccatggatg gcgagacggc
      301 gggggagaag gggagtcttg tgccccagcc aggtgcgctc ggtgcgcccg ccttgggcgg
      361 tgctccggcc ccaggtgtgc gacgggaacc caagaagtac gcggtgactg atgactacca
      421 gttgtccaag caagtgctgg gtctgggtgt gaacggcaag gtactagagt gctaccatcg
      481 gcgctctggg cagaagtgtg ccttgaagct cctgtatgac agccccaagg cccggcagga
      541 ggtggaccac cactggcagg cctcaggcgg cccccacatt gtgcgcatcc tggacgtgta
      601 cgagaacatg catcacggca agcgctgcct cctcatcgtc atggaatgca tggagggtgg
      661 tgagctgttc agcaggattc aggagcgcgg tgatcaggct ttcactgaga gagaggccgc
      721 agagataatg cgggacattg gcactgccat ccagttcttg cacagccaga acattgccca
      781 ccgagatgtc aagcctgaaa acctactcta tacatccaag gagaaggatg ctgtacttaa
      841 actcactgat tttggctttg ccaaggaaac cacccaaaat gccctccaga caccctgtta
      901 cactccctat tatgtggctc ctgaggtcct gggtccagag aagtatgaca agtcgtgcga
      961 tatgtggtcc ctgggggtca tcatgtacat ccttttgtgt ggattcccac ccttctactc
     1021 caacacgggc caggccatct ctccaggaat gaagagaagg attcgcttgg gccagtatgg
     1081 cttccctaaa cctgaatggg cagacgtctc tgaggatgcc aagcagctaa tccgtctgct
     1141 cctgaagaca gatcccaccg agaggctgac catcatgcag tttatgaacc atccttggat
     1201 caatcaatcg atggaggtcc cacagacccc actccataca gcccgagtgc tggaggaaga
     1261 caaagaccac tgggatgacg tcaaggaaga gatgaccagt gccctggcca cgatgagggt
     1321 agactacgac caggtgaaaa tcaaggacct gaagacctct aacaaccgac tcctcaacaa
     1381 gcggaggaaa aagcaggggg gcagctcctc agcctcaccg ggatgcaaca accagtaact
     1441 cgtggtgcct tggaggagcc agactgacag actctaacgt cctgaggctc tggccaggag
     1501 gggctggagt cattcttaaa acaaaaggag aattttgttg tcttaatgtg tcacattgaa
     1561 cttgaggata aagagcttgg cccaagagtc ccggcctaag tctcaggctc tagaaagctg
     1621 tgggtcctcg gggatgggag ctctctgcta cagctgaggc aactttgtac actggcttga
     1681 ctgaggccac agctctgttt tgccttagga catagcctta cttctaggcc actgggagtt
     1741 gtggtggatc tacccttttt ctataaagga tgtatcctgc tgtgtgggca gatgggtctg
     1801 gccttgagga aagtattggg ccattggttg ctatggtgac cagaggccat gttgctgtct
     1861 gagaatactg aacaaaggcg gaaggaggga cagtcaaggg tctaccttct tggggaggtt
     1921 tgtctctctc acactggctg tccttcccca ggctcactcc tctgtggtct gccagaggct
     1981 acagagtcct gcttgcttat tttcctggat ggtccagccc tggcttacta tagcatgagc
     2041 ccatgtaaca ctcagagaga cactagggtc cctggcacca agcatcctgt cattaccccc
     2101 tgatctaaaa ggtaacttct catctcaact ggagaacttc cctgtgacaa acgctcccat
     2161 ctcttcctac tcaccagatc tcaggtagga aagcctgtct ctgcggctag cactggctac
     2221 ccttgggttt acttttgtga aagggagtgc ttggctccct gtgacccagg accttttcct
     2281 gtactctgga tcagacctgg gtggtgaaga gctgctgagc cacgccttca aggggtctgg
     2341 tcctggctgt agcctgagtg gagcagagag ggttttcctt ggcggagccc agacttagcc
     2401 agctctgccc tgtcctgcgc agggtaacat ccaggtgctg agtggttgat tggtgaccta
     2461 acaagtgcct ggcacccagt ctccttccta gatgatccta gatcctggcc tttctcactg
     2521 gctgggaaac cttagatctt gtcagccaca acagtgctgc tgggttttat attcagatat
     2581 taataaacac atttttaacg ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
