LOCUS       NM_017322               3711 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 9 (Mapk9),
            transcript variant 1, mRNA.
ACCESSION   NM_017322
VERSION     NM_017322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Ishibashi,R., Itani,M., Kawashima,A., Arakawa,Y. and Aoki,T.
  TITLE     JNK2-MMP-9 axis facilitates the progression of intracranial
            aneurysms
  JOURNAL   Sci Rep 14 (1), 19458 (2024)
   PUBMED   39169203
  REMARK    GeneRIF: JNK2-MMP-9 axis facilitates the progression of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Tan,J., Gao,W., Yang,W., Zeng,X., Wang,L. and Cui,X.
  TITLE     Isoform-specific functions of c-Jun N-terminal kinase 1 and 2 in
            lung ischemia-reperfusion injury through the c-Jun/activator
            protein-1 pathway
  JOURNAL   J Thorac Cardiovasc Surg 162 (2), e143-e156 (2021)
   PUBMED   32414595
  REMARK    GeneRIF: Isoform-specific functions of c-Jun N-terminal kinase 1
            and 2 in lung ischemia-reperfusion injury through the
            c-Jun/activator protein-1 pathway.
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Xie,X.J. and Li,C.Q.
  TITLE     Chrysophanol Protects Against Acute Heart Failure by Inhibiting
            JNK1/2 Pathway in Rats
  JOURNAL   Med Sci Monit 26, e926392 (2020)
   PUBMED   33044948
  REMARK    GeneRIF: Chrysophanol Protects Against Acute Heart Failure by
            Inhibiting JNK1/2 Pathway in Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Bae,K.B., Yu,D.H., Lee,K.Y., Yao,K., Ryu,J., Lim,D.Y., Zykova,T.A.,
            Kim,M.O., Bode,A.M. and Dong,Z.
  TITLE     Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4
            Protein Stability in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cell Reports 9 (6), 2050-2064 (2017)
   PUBMED   29153991
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Lian,S., Xia,Y., Khoi,P.N., Ung,T.T., Yoon,H.J., Kim,N.H., Kim,K.K.
            and Jung,Y.D.
  TITLE     Cadmium induces matrix metalloproteinase-9 expression via
            ROS-dependent EGFR, NF-small ka, CyrillicB, and AP-1 pathways in
            human endothelial cells
  JOURNAL   Toxicology 338, 104-116 (2015)
   PUBMED   26514923
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Chaudhary,L.R. and Avioli,L.V.
  TITLE     Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in
            normal human osteoblastic and rat UMR-106 cells
  JOURNAL   J Cell Biochem 69 (1), 87-93 (1998)
   PUBMED   9513050
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Zhang,P., Hogan,E.L. and Bhat,N.R.
  TITLE     Activation of JNK/SAPK in primary glial cultures: II. Differential
            activation of kinase isoforms corresponds to their differential
            expression
  JOURNAL   Neurochem Res 23 (2), 219-225 (1998)
   PUBMED   9475517
REFERENCE   8  (bases 1 to 3711)
  AUTHORS   Fuchs,S.Y., Dolan,L., Davis,R.J. and Ronai,Z.
  TITLE     Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun
            N-kinase
  JOURNAL   Oncogene 13 (7), 1531-1535 (1996)
   PUBMED   8875991
REFERENCE   9  (bases 1 to 3711)
  AUTHORS   Gupta,S., Barrett,T., Whitmarsh,A.J., Cavanagh,J., Sluss,H.K.,
            Derijard,B. and Davis,R.J.
  TITLE     Selective interaction of JNK protein kinase isoforms with
            transcription factors
  JOURNAL   EMBO J 15 (11), 2760-2770 (1996)
   PUBMED   8654373
REFERENCE   10 (bases 1 to 3711)
  AUTHORS   Kyriakis,J.M., Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A.,
            Ahmad,M.F., Avruch,J. and Woodgett,J.R.
  TITLE     The stress-activated protein kinase subfamily of c-Jun kinases
  JOURNAL   Nature 369 (6476), 156-160 (1994)
   PUBMED   8177321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN948189.1, BC061870.1,
            L27112.1, JAXUCZ010000010.1 and BI282175.1.
            
            On Jul 18, 2012 this sequence version replaced NM_017322.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases are multifunctional proteins. They are
            involved in a wide variety of cellular processes such as growth,
            proliferation, differentiation, transcription regulation, and
            development. They function in stress responses, apoptosis,
            inflammation and transformation. For example, this kinase plays a
            dominant role in mediating proliferation of lung cancer and
            prostate cancer cells, and in regulation of osmotic stress-induced
            tight junction disruption. Several alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.27423.1,
                                           SRR26643294.38947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DN948189.1         1-33
            34-244              BC061870.1         1-211
            245-1607            L27112.1           1-1363
            1608-3084           JAXUCZ010000010.1  34709192-34710668
            3085-3711           BI282175.1         1-627               c
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..3711
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /note="mitogen-activated protein kinase 9"
                     /db_xref="GeneID:50658"
                     /db_xref="RGD:628847"
     exon            1..211
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            212..382
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1532
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p54-alpha; SAPK-alpha; c-Jun N-terminal kinase 2;
                     stress-activated protein kinase JNK2; MAPK 9; MAP kinase
                     9; stress activated protein kinase alpha II"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 9 isoform 1"
                     /protein_id="NP_059018.1"
                     /db_xref="GeneID:50658"
                     /db_xref="RGD:628847"
                     /translation="MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAF
                     DTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQ
                     DVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
                     SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEL
                     VKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFP
                     DWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPP
                     PQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSI
                     NDISSMSTEHTLASDTDSSLDASTGPLEGCR"
     exon            383..512
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            513..571
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            572..710
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            711..876
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            877..948
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1131
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1256
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1320
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1389
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..3693
                     /gene="Mapk9"
                     /gene_synonym="SAPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg gcggcggcag ctgcggagct gaagggaacc cgaccggaag ggtcgctgcg
       61 ccccgcgccc ctcacaccca ctgcggcggc gacggggcgg agcagagcgg ggcggggcgg
      121 ccgggtccgg gtcctggagc tgggagccgc cagaacgcat cgccgccagc gtgccctccc
      181 tctgcctccg gcgcggcggc gcggagccga gggatctgac aaaggtacca gctctccgga
      241 atcctgtatg acactacatc atgagtgaca gtaaaagcga tggccagttt tacagtgtgc
      301 aagtggcaga ctcaactttc actgttctaa aacgttacca gcagttgaaa ccaattggct
      361 ctggagccca aggaattgtt tgtgctgctt ttgatacagt tcttggaata aatgttgctg
      421 tcaagaagtt aagtcgtcct tttcagaacc aaacgcatgc aaagagagcc taccgtgaac
      481 ttgtcctcct aaagtgtgtc aatcataaaa atataattag cttgttaaat gtgttcacac
      541 cacaaaaaac gctagaagaa ttccaagatg tgtacttggt tatggagtta atggacgcta
      601 acttatgtca ggttattcat atggagctgg accatgaaag aatgtcatac ctcctctacc
      661 agatgctttg tggcattaag cacctgcatt cagctggcat aattcatagg gatttgaagc
      721 ctagcaacat tgtagtaaaa tcagactgta ctctcaagat ccttgacttt ggcctggcac
      781 ggacagcctg taccaacttt atgatgactc cctatgtggt aactcgctac tatcgggctc
      841 cagaagtcat cctgggcatg ggctacaagg agaatgttga tatctggtca gtgggttgca
      901 tcatgggaga gctggtgaaa ggttgtgtga tattccaagg tactgaccat attgatcaat
      961 ggaataaagt tattgaacag ctaggaacac catccgcaga gttcatgaag aaacttcagc
     1021 caactgtaag gaattatgtg gaaaacagac caaagtaccc tggaatcaaa tttgaagagc
     1081 tctttccaga ttggatattt ccgtcagaat ccgaacgaga caaaataaaa acaagtcaag
     1141 ccagagatct gttatcgaaa atgttagtga ttgatccgga caagcggatc tctgtggacg
     1201 aagccttgcg ccacccgtat attactgttt ggtatgaccc cgctgaagca gaagcgccac
     1261 cacctcaaat ttatgatgcc cagttggaag aaagagagca tgcgattgaa gagtggaaag
     1321 aactaattta caaagaagtg atggactggg aagaaagaag caagaatggg gtgaaagacc
     1381 agccttcaga tgcagcagta agcagcaagg ctactccttc tcagtcgtca tccatcaatg
     1441 acatctcatc catgtccact gagcacaccc tggcctcaga cacagacagc agtctcgatg
     1501 cctcaaccgg acccctggaa ggctgccgat gaaacctcgc agatggcgca cttgtctgtg
     1561 aaggactctg gcttccatgg ccctgagcac atgggagctg gtggaaccaa atcaagaagc
     1621 tccatgttct gcatgtaaga aacacgacgc cttgccccca ctcagttcca gtaggattgc
     1681 ctgcgtagac tgtaacatga ggcagacgat gtctggagaa aaagtacaaa ccacactgtt
     1741 agaaattttg ttcaagatca tttcaggtga gcaattagaa tagccgagtt tctttttcca
     1801 gtcgtgtggt gtccttggtg acagatcatg tgtaactgtg gggactcgta tgcatgtgac
     1861 cacaaatgct tgcttgaact tgcccatgta gcactttggg aatcagtatt taaatgccaa
     1921 ataatcttcc aggtagttct gcttctagaa taatctctta atcctcttta gtaatttggt
     1981 gtctgtccac aaaaaaatag atcatgtgta tgaattggcc actatcatat tatcatattt
     2041 tacccacttt tatggtatga tttattctgt cttttgtatt tcagaaggaa tataattaaa
     2101 tttatttaat aaataaaact acagcttttc ttaaatttgt gatgttttag gctgagaatt
     2161 accactgctt tatatcgaca ctctgtgtcc tttaaactgc ccactatggg aaactttacg
     2221 tacagctttc tgcatgacaa agttccaagt tgtatttcac tctgcttaac gacttatgtc
     2281 accttgaatc ctgaccacac atttcctttt tcttggtcct ctgaacttgg atctagaatc
     2341 cctcacagaa cttcaccttc tttatcacaa agcaccccat ctcagtagaa tgaatcggca
     2401 gattcctgag ccccgctgcc taatgtagag ctgacagggt ggcttcccca gaacggtggg
     2461 tgggtgcctc cttccctgag cccacccatc ctttgctccc ctctctttat ttaaggtgaa
     2521 aggtgattgg gtctcatagc ctttcctttt gtagcattgc ctaacttgtc tttctcactg
     2581 acagaagcca ccacgtccag ccagagcaca tggtctctta ggagaccggg cttacttacc
     2641 atgcatgttt gctgctgtcc ttttccattt tgtggaggca tttccttttt ctaagggaat
     2701 tcctcagatg ttctagaaac attcagaaga acgcagaaga aatattctag agaattaggg
     2761 gttcattctt gaatattttc tgatttaaaa ctgctcacct gaaattgata ctttcagatc
     2821 ctgatctgta aattactcga gatttggtaa gatgctgagt tctctgtgtt gttgcagaat
     2881 tggagttggg atgatcatac cttggctacc tgcgctcaga gcatttcctt cttgagctta
     2941 ttttgttaac aattcatatc ttgtgttcag ttactttggg agctatggag tgtgttatag
     3001 aaggaaattt gataagaact tttatggaaa gtaccatcta atacgtgatt ctgtctgcac
     3061 cagttgtatc ctaatggttg gtctgatcat tggaaccttt aatgaacaat gttaatctga
     3121 agtaaggatt agctttatat cacatgtgga cactttcagt tacaaatgct agtgcgggtg
     3181 agggcagaga cacctgccta tggcttcagg ttattgggcc ctgggaggct gaagtttcac
     3241 agcgtcatac tgtgctcttc cctcggatgc acattcttga aatgacttcc ctgaaactta
     3301 aggaggaaat cagaaaggca ctgcattatc tgccctacac tgtaagggga gcatgctgtg
     3361 atagaggctc gccctggtcc cacagacagg aggcagctgt gagtggatcc aggcgccctc
     3421 aaagagtggc tttctccccc cttactctgc ctatctatca acactgtttt ggatggagcc
     3481 tgtgctggtg tggacagggt ctcatgccaa gactctcctc catcaggcaa gtgcacctag
     3541 gactggccac agcgccccaa agaaatacct caccccagtt tcagggtcct ccctcctgag
     3601 cctagctttg ccagggtcct gggacaatgc gaatggtttt gagctgacct ctgtaggcaa
     3661 atgctgatgt tggataaaga actgaaaaat gtgaaaaaaa aaaaaaaaaa a
//
