LOCUS       NM_001100673            5465 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 8 interacting
            protein 3 (Mapk8ip3), mRNA.
ACCESSION   NM_001100673 XM_001057684 XM_001057810 XM_001060342 XM_220232
VERSION     NM_001100673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5465)
  AUTHORS   Caswell,P.T. and Dickens,M.
  TITLE     JIP3 localises to exocytic vesicles and focal adhesions in the
            growth cones of differentiated PC12 cells
  JOURNAL   Mol Cell Biochem 444 (1-2), 1-13 (2018)
   PUBMED   29159770
  REMARK    GeneRIF: these observations indicate that JIP3 may be involved in
            transporting vesicular cargoes to the growth cones of PC12 cells,
            possibly targeting JNK to its substrate paxillin, and thus
            facilitating neurite outgrowth.
            Erratum:[Mol Cell Biochem. 2018 Jul;444(1-2):15. doi:
            10.1007/s11010-018-3354-4.. PMID: 29725980]
REFERENCE   2  (bases 1 to 5465)
  AUTHORS   Ma,H., Yu,H., Li,T., Zhao,Y., Hou,M., Chen,Z., Wang,Y. and Sun,T.
  TITLE     JIP3 regulates neuronal radial migration by mediating TrkB axonal
            anterograde transport in the developing cerebral cortex
  JOURNAL   Biochem Biophys Res Commun 485 (4), 790-795 (2017)
   PUBMED   28259553
REFERENCE   3  (bases 1 to 5465)
  AUTHORS   Watt,D., Dixit,R. and Cavalli,V.
  TITLE     JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation
  JOURNAL   J Biol Chem 290 (25), 15512-15525 (2015)
   PUBMED   25944905
REFERENCE   4  (bases 1 to 5465)
  AUTHORS   Rahmati,M., Gharakhanlou,R., Movahedin,M., Mowla,S.J., Khazani,A.,
            Fouladvand,M. and Jahani Golbar,S.
  TITLE     Treadmill training modifies KIF5B motor protein in the STZ-induced
            diabetic rat spinal cord and sciatic nerve
  JOURNAL   Arch Iran Med 18 (2), 94-101 (2015)
   PUBMED   25644797
  REMARK    GeneRIF: Diabetes seems to change spinal cord KIF5B and SYD mRNA
            and sciatic nerves KIF5B content and exercise training modifies it,
            which may be attributable to the training-induced decreased
            hyperglycemia.
REFERENCE   5  (bases 1 to 5465)
  AUTHORS   Sun,T., Yu,N., Zhai,L.K., Li,N., Zhang,C., Zhou,L., Huang,Z.,
            Jiang,X.Y., Shen,Y. and Chen,Z.Y.
  TITLE     c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3)
            regulates neuronal axon elongation in a kinesin- and JNK-dependent
            manner
  JOURNAL   J Biol Chem 288 (20), 14531-14543 (2013)
   PUBMED   23576431
  REMARK    GeneRIF: JIP3 regulates neuronal axon elongation in a kinesin- and
            JNK-dependent manner
REFERENCE   6  (bases 1 to 5465)
  AUTHORS   Sato,S., Ito,M., Ito,T. and Yoshioka,K.
  TITLE     Scaffold protein JSAP1 is transported to growth cones of neurites
            independent of JNK signaling pathways in PC12h cells
  JOURNAL   Gene 329, 51-60 (2004)
   PUBMED   15033528
REFERENCE   7  (bases 1 to 5465)
  AUTHORS   Kelkar,N., Delmotte,M.H., Weston,C.R., Barrett,T., Sheppard,B.J.,
            Flavell,R.A. and Davis,R.J.
  TITLE     Morphogenesis of the telencephalic commissure requires scaffold
            protein JNK-interacting protein 3 (JIP3)
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9843-9848 (2003)
   PUBMED   12897243
REFERENCE   8  (bases 1 to 5465)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
REFERENCE   9  (bases 1 to 5465)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   10 (bases 1 to 5465)
  AUTHORS   Ito,M., Yoshioka,K., Akechi,M., Yamashita,S., Takamatsu,N.,
            Sugiyama,K., Hibi,M., Nakabeppu,Y., Shiba,T. and Yamamoto,K.I.
  TITLE     JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein
            that functions as a Scaffold factor in the JNK signaling pathway
  JOURNAL   Mol Cell Biol 19 (11), 7539-7548 (1999)
   PUBMED   10523642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001100673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ377222.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               JAXUCZ010000010.1  14462392-14462812   c
            422-542             JAXUCZ010000010.1  14453304-14453424   c
            543-613             JAXUCZ010000010.1  14450175-14450245   c
            614-705             JAXUCZ010000010.1  14449860-14449951   c
            706-850             JAXUCZ010000010.1  14443586-14443730   c
            851-1097            JAXUCZ010000010.1  14439892-14440138   c
            1098-1200           JAXUCZ010000010.1  14439070-14439172   c
            1201-1319           JAXUCZ010000010.1  14438315-14438433   c
            1320-1331           JAXUCZ010000010.1  14434812-14434823   c
            1332-1389           JAXUCZ010000010.1  14432946-14433003   c
            1390-1542           JAXUCZ010000010.1  14432420-14432572   c
            1543-1597           JAXUCZ010000010.1  14431753-14431807   c
            1598-1728           JAXUCZ010000010.1  14430668-14430798   c
            1729-1785           JAXUCZ010000010.1  14430418-14430474   c
            1786-1956           JAXUCZ010000010.1  14430161-14430331   c
            1957-2083           JAXUCZ010000010.1  14429372-14429498   c
            2084-2179           JAXUCZ010000010.1  14428736-14428831   c
            2180-2338           JAXUCZ010000010.1  14428450-14428608   c
            2339-2504           JAXUCZ010000010.1  14427723-14427888   c
            2505-2687           JAXUCZ010000010.1  14426967-14427149   c
            2688-2877           JAXUCZ010000010.1  14426701-14426890   c
            2878-2997           JAXUCZ010000010.1  14426473-14426592   c
            2998-3078           JAXUCZ010000010.1  14426306-14426386   c
            3079-3146           JAXUCZ010000010.1  14426156-14426223   c
            3147-3295           JAXUCZ010000010.1  14425877-14426025   c
            3296-3467           JAXUCZ010000010.1  14425543-14425714   c
            3468-3581           JAXUCZ010000010.1  14425217-14425330   c
            3582-3620           JAXUCZ010000010.1  14425053-14425091   c
            3621-3800           JAXUCZ010000010.1  14424773-14424952   c
            3801-3950           JAXUCZ010000010.1  14424523-14424672   c
            3951-5465           JAXUCZ010000010.1  14422936-14424450   c
FEATURES             Location/Qualifiers
     source          1..5465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5465
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 3"
                     /db_xref="GeneID:302983"
                     /db_xref="RGD:1563691"
     exon            1..421
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..4072
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /note="JNK/SAPK-associated protein 1; JNK-interacting
                     protein 3; JNK MAP kinase scaffold protein 3"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     3"
                     /protein_id="NP_001094143.2"
                     /db_xref="GeneID:302983"
                     /db_xref="RGD:1563691"
                     /translation="MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLI
                     HCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRK
                     QAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE
                     YNALHQRHTEMIQTYVEHIERSKMQQVGGGGQTESSLPGRSRKERPTSLNVFPLADGM
                     VRAQMGGKLVPAGDHWHLSDLGQLQSSSSYQCPNDEMSESGQSSAAATPSTTGTKSNT
                     PTSSVPSAAVTPLNESLQPLGDYGSVTKNNKRAREKRNSRNMEVQVTQEMRNVSIGMG
                     SSDEWSDVQDIIDSTPELDVCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGS
                     EVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQ
                     EVLKGELEAAKQAKVKLENRIKELEEELKRVKSEAVTARREPREEVEDDKIPMAQRRR
                     FTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLF
                     SSSSSPPPAKRSYPSVNIHYKSPTTAGFSQRRNHALCQISAGSRPLEFFPDDDCTSSA
                     RREQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCR
                     PLVEKDPSTKLWCAAGVNLSGWKPNEEDSSNGPKPAPGRDPLTCDREGEGEPKSTHPS
                     PEKKKAKEVPEADATSSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISS
                     IPAASDSDYPPGDMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPV
                     LDKGQGDVAATANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPA
                     PTQSSSTQPASENGSESDGSIVQPQVEPSGESSATTSSAAPTMWLGAQNGWLYVHSAV
                     ANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGH
                     PHHSIRCMAVVDDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVW
                     VSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIAGNRLWVG
                     TGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKTASS
                     FIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEG
                     QKLKNALVLSGGEGYIDFRIGDGEDDETEEGTGDVNQTKPSLSKAERSHIIVWQVSYT
                     PE"
     exon            422..542
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..613
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..705
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..850
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1097
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1200
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1319
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1331
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1389
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1542
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1597
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1728
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1785
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1956
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2083
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2179
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2338
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2504
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2687
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2877
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2997
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3078
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3146
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3295
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3467
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3581
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3620
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3800
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3950
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..5465
                     /gene="Mapk8ip3"
                     /gene_synonym="JIP-3; JIP3; JSAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggcggcg gcgcatccta aggtggtggc tgcctgaggt gacagcggcc cgtggactcg
       61 ggcaccagag cgagccgcgc tggcggcggc ggcggtagcc gcgatgatgg agatccagat
      121 ggacgaggga ggcggtgtgg tggtgtacca agatgactac tgctccggct cggtgatgtc
      181 ggagcgtgtg tcgggcctgg cgggctccat ctaccgcgag ttcgagcgcc tcattcactg
      241 ctatgatgag gaggtggtca aggagctcat gccgctggtg gtgaacgtgc tggagaacct
      301 tgactcggtg ctgagcgaga accaggagca cgaggtggag ctggagctcc tacgcgagga
      361 caacgagcag ctgctcacgc aatacgagcg cgagaaggcg ctgcgcaaac aggccgagga
      421 gaaattcatc gaatttgaag atgccttgga acaagagaag aaagaactcc agatccaggt
      481 agaacattat gagtttcaga cgcgccagct ggagctaaag gccaaaaact atgcagatca
      541 gatttcccga ctggaggagc gggagtcgga gatgaagaag gaatacaacg cgctgcacca
      601 gcggcacacg gagatgatcc agacctatgt ggaacacatc gaaagatcga agatgcagca
      661 ggttggggga ggcggccaaa cagaaagcag cctgcccggg cggagcagga aggagcgtcc
      721 cacctctctg aatgtcttcc ccctggctga tggaatggta cgtgcacaga tggggggcaa
      781 gctcgtgcct gcgggggacc actggcacct gagtgacctc ggccaactac agtccagctc
      841 cagctaccag tgtccaaacg atgagatgtc tgagtcaggc cagtcctcag cagctgcaac
      901 acccagtacc acaggtacca aatccaacac acccacatcc tccgtgccct cagcagctgt
      961 cacaccactc aacgagagcc tacagcccct gggggactat ggcagtgtca caaagaacaa
     1021 caaacgggcc cgagagaagc gcaacagccg taacatggag gtccaggtca cccaagagat
     1081 gcggaacgtc agtattggta tgggtagcag tgacgagtgg tccgatgttc aggacattat
     1141 cgactccacc ccagagctgg atgtgtgtcc ggaaacccgt ctggaccgca caggaagcag
     1201 cccaacccag gggatcgtaa acaaagcttt tggaatcaac accgattccc tgtaccatga
     1261 actatctaca gcggggtctg aggtcatcgg ggatgtggac gagggagctg accttctagg
     1321 ggagttctca ggaatgggca aagaagtggg gaacctgctg ctggagaact cacagcttct
     1381 agagacaaaa aatgctttga atgtggtgaa gaatgacctc attgccaagg ttgaccaact
     1441 gtcaggagag caggaggtac tgaagggtga attggaagca gccaagcaag ccaaagtcaa
     1501 gctggagaac cgaatcaaag agcttgaaga agaactgaaa agagtcaagt cagaggcagt
     1561 aaccgcccgc cgtgagccca gagaagaggt ggaggatgac aaaatcccca tggcccaacg
     1621 ccgacgcttc acaagagtgg agatggcccg agtgctcatg gaacgtaacc agtacaagga
     1681 acgcctcatg gagctgcagg aggctgtgcg gtggactgaa atgatcagag catccaggga
     1741 acacccatct gtccaggaaa agaagaaatc cactatctgg cagttcttta gccgcctctt
     1801 cagctcctca tccagccccc ctccggccaa acggtcctac ccgtctgtga acattcacta
     1861 caagtcaccc actacagctg gctttagcca gcgtcgcaac catgctttgt gccagatctc
     1921 agccggcagc cgacccctgg agttcttccc tgatgatgac tgcacctctt ctgcccggcg
     1981 tgagcagaag cgggagcagt accgccaggt ccgtgaacac gtgcgcaatg atgacgggag
     2041 gctgcaggcc tgtgggtgga gcctgcctgc caagtacaag cagctgagcc ccaatggagg
     2101 ccaggaagat acccggatga aaaatgtgcc tgtccctgtg tactgccgcc ctctggtgga
     2161 gaaggacccc tcaacaaagc tgtggtgtgc tgctggtgtc aacctgagtg ggtggaaacc
     2221 aaacgaggag gactctagca atggacccaa gcctgcacca ggtcgagacc ctctgacctg
     2281 cgaccgggaa ggagaaggcg aacccaagag cacccaccca tcacctgaga agaagaaggc
     2341 aaaggaggtc cctgaggcgg atgctacctc cagtcgggta tggatcctca ccagcaccct
     2401 gactaccagc aaggtggtga tcattgatgc caaccaacca ggcacagttg tggatcagtt
     2461 cacagtctgc aatgcccacg tcctgtgtat ctccagcatt cctgcggcca gcgacagtga
     2521 ttatccccct ggagacatgt tcctagacag tgatgtgaac cccgaagact caggtgctga
     2581 cggtgtgctg gctggcatca ccctggtggg atgtgctacc cgctgcaatg taccacgtag
     2641 caactgttcc tcccgaggag acaccccagt actggacaag gggcaggggg atgtggcagc
     2701 cactgccaat gggaaggtca acccatccca atccacagaa gaagccacag aagccacgga
     2761 ggtgccagat cctggtccca gtgagtcaga agcaacaaca gtccggcctg ggcctctcac
     2821 agagcatgtc tttactgacc cagcacccac ccaatcctcc agcacccagc ctgccagtga
     2881 gaatgggtca gagtcggatg gcagcattgt acagcctcag gtggagccca gtggggagtc
     2941 ctcagcaacc accagtagtg ctgcacccac catgtggcta ggagcccaga atggctggct
     3001 ctatgtgcac tcagcggtag ccaactggaa gaagtgtctg cactccatca aactaaaaga
     3061 ctctgtgctg agcctggtgc atgtcaaagg ccgagtgctg gtagctcttg cagatggaac
     3121 cctggctatc ttccatcgtg gagaggatgg ccagtgggac ctgagcaact accacctaat
     3181 ggacctgggc cacccacacc actccatccg ctgcatggct gttgtggatg accgagtttg
     3241 gtgtggctac aagaacaagg tgcatgtcat ccagcccaag acaatgcaaa ttgagaaatc
     3301 atttgatgcc cacccacggc gggaaagcca ggtacgacag ctagcctgga tcggtgatgg
     3361 agtatgggtc tctattcgct tggattctac acttcggctg taccacgctc acacgcacca
     3421 gcacctgcag gatgtggaca ttgagcccta tgttagcaag atgctgggta ccggcaagct
     3481 gggcttctcc ttcgtgcgca tcacagccct actcattgca ggcaaccgtc tgtgggtggg
     3541 cactggcaat ggggttgtca tctccatccc cttgactgag actgtggtcc tgcatcgagg
     3601 ccagctctta ggtctccgag ccaacaagac atccccaacg tctggggagg ggacccgccc
     3661 agggggcatc atccatgtgt atggggatga cagcagtgac aagactgcca gtagtttcat
     3721 cccctactgc tccatggccc aggctcagct ctgcttccac gggcaccgtg atgctgtcaa
     3781 attctttgtc tctgtaccag gaaatgtgct ggccacgctc aatggcagtg tgctagacag
     3841 cccatcagag ggccctgggc ctgctgcacc tgctgcagat gctgagggcc agaagttgaa
     3901 gaatgcactg gtgctgagtg gtggtgaagg ttacattgac ttccgcatcg gggatggaga
     3961 ggatgatgaa actgaggaag gtaccgggga tgtgaaccag acgaagccct cgttgtccaa
     4021 ggctgagcgc agccacatca tcgtgtggca ggtgtcctac acccctgagt gagaccctgt
     4081 cctgcctgat gccaactgta cataggaccc tgcctgcctg cccccccgcc tgttccctgg
     4141 ggcagccagg ttcgtccatc cccttttaac ctctcaactt gcagcttttg cctgaggtcc
     4201 agcccccagc tgttagagag gggtgaagca gggtttggga agtgaggcag gaacagatgt
     4261 ctttcccatc agggaggaga gagcctctga gatactctcc agcagcccct ggccttggcc
     4321 caacacctag ctcaacatga agtcccaggg ggccctcagg gcaagacagg accaaaatgg
     4381 ctatgggcgg cccctacagg tggccctggc tccactccat cctcaccagt cctggcagga
     4441 gcaagagcct cacactgcca gggtcttccc caagtctact tgctttgcat gcagccccga
     4501 ggaagggatt cctgatttcc aaccctttgg ctttctctga gggacccagg cctggccacc
     4561 atcatctgcc cagaagcaag gttagggctg ccctgattcc tgggcccccc agtctaggtc
     4621 ttacctgggt acctggcatg accgctcagg gccggcctta gggtagctgc ttcaaaagat
     4681 gacaataccc attaacccag gggagcccaa gattgtccac cccacacaga ccagtgtccc
     4741 ctaagctctt tcctgggcac aagattcacc ttggaggagc aagaccctag tgccctgccc
     4801 ctcccagaag ccccaagggt agaatttctc aggctgccag ggcaggcaca ggcctcagga
     4861 aaaagggtgg ccctggtctc cccagagtca gtcctaggat gcaggcttag cctcaggtta
     4921 atggaggatg gtgtgctcca agggcctgcc tcctgtacag ggctccaagg agcccagctc
     4981 ccggacacgt actaagtgcc tagggttgcc ggctgtggcc tgctcccttg gagagcaact
     5041 gacaagaggc tttcaggcag aggccagaag agctgaggac cagccaggat gggcacaatt
     5101 ctaagcaagt gtgtggaagc aggtgctgcc ctggccctgg ccttactctt caggggcact
     5161 gattagagtc agtggcctct actgcactct tcccaccaga gaagcacaga tccaggggca
     5221 ctgcccctga gcctatctgg ccacaacaag ctgcagcaat gtgcagctgc aagcttcccc
     5281 ccaccaccct gccacctctc cactgtgatg tatgtccctt gtctgttccc acaggcgtgt
     5341 gaagtgaccg gggttagctg ggtgggtgcg actggaggga aggggccagt gcagctctcc
     5401 tcaggctttg gccttgcaag tgaactcaca tatctgctct gtatgtaata aatgtcttaa
     5461 cacta
//
