LOCUS       NM_001100720            5938 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 8 interacting
            protein 2 (Mapk8ip2), mRNA.
ACCESSION   NM_001100720 XM_001055248 XM_235565
VERSION     NM_001100720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5938)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Schmit,T.L., Biagas,K.V., Sproul,A.A.,
            Gire,S., Maes,M.E., Xu,Z. and Greene,L.A.
  TITLE     Sh3rf2/POSHER protein promotes cell survival by ring-mediated
            proteasomal degradation of the c-Jun N-terminal kinase scaffold
            POSH (Plenty of SH3s) protein
  JOURNAL   J Biol Chem 287 (3), 2247-2256 (2012)
   PUBMED   22128169
REFERENCE   2  (bases 1 to 5938)
  AUTHORS   Giza,J., Urbanski,M.J., Prestori,F., Bandyopadhyay,B., Yam,A.,
            Friedrich,V., Kelley,K., D'Angelo,E. and Goldfarb,M.
  TITLE     Behavioral and cerebellar transmission deficits in mice lacking the
            autism-linked gene islet brain-2
  JOURNAL   J Neurosci 30 (44), 14805-14816 (2010)
   PUBMED   21048139
REFERENCE   3  (bases 1 to 5938)
  AUTHORS   Zhang,Y. and Dong,C.
  TITLE     Regulatory mechanisms of mitogen-activated kinase signaling
  JOURNAL   Cell Mol Life Sci 64 (21), 2771-2789 (2007)
   PUBMED   17726577
  REMARK    Review article
REFERENCE   4  (bases 1 to 5938)
  AUTHORS   Cuenda,A. and Rousseau,S.
  TITLE     p38 MAP-kinases pathway regulation, function and role in human
            diseases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1358-1375 (2007)
   PUBMED   17481747
  REMARK    Review article
REFERENCE   5  (bases 1 to 5938)
  AUTHORS   Muresan,Z. and Muresan,V.
  TITLE     Coordinated transport of phosphorylated amyloid-beta precursor
            protein and c-Jun NH2-terminal kinase-interacting protein-1
  JOURNAL   J Cell Biol 171 (4), 615-625 (2005)
   PUBMED   16301330
REFERENCE   6  (bases 1 to 5938)
  AUTHORS   Buchsbaum,R.J., Connolly,B.A. and Feig,L.A.
  TITLE     Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a
            scaffold for the p38 mitogen-activated protein kinase cascade
  JOURNAL   Mol Cell Biol 22 (12), 4073-4085 (2002)
   PUBMED   12024021
REFERENCE   7  (bases 1 to 5938)
  AUTHORS   Verhey,K.J., Meyer,D., Deehan,R., Blenis,J., Schnapp,B.J.,
            Rapoport,T.A. and Margolis,B.
  TITLE     Cargo of kinesin identified as JIP scaffolding proteins and
            associated signaling molecules
  JOURNAL   J Cell Biol 152 (5), 959-970 (2001)
   PUBMED   11238452
REFERENCE   8  (bases 1 to 5938)
  AUTHORS   Stockinger,W., Brandes,C., Fasching,D., Hermann,M., Gotthardt,M.,
            Herz,J., Schneider,W.J. and Nimpf,J.
  TITLE     The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and
            -2
  JOURNAL   J Biol Chem 275 (33), 25625-25632 (2000)
   PUBMED   10827199
REFERENCE   9  (bases 1 to 5938)
  AUTHORS   Negri,S., Oberson,A., Steinmann,M., Sauser,C., Nicod,P., Waeber,G.,
            Schorderet,D.F. and Bonny,C.
  TITLE     cDNA cloning and mapping of a novel islet-brain/JNK-interacting
            protein
  JOURNAL   Genomics 64 (3), 324-330 (2000)
   PUBMED   10756100
REFERENCE   10 (bases 1 to 5938)
  AUTHORS   Yasuda,J., Whitmarsh,A.J., Cavanagh,J., Sharma,M. and Davis,R.J.
  TITLE     The JIP group of mitogen-activated protein kinase scaffold proteins
  JOURNAL   Mol Cell Biol 19 (10), 7245-7254 (1999)
   PUBMED   10490659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000187.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001100720.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001100720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               JACYVU010000187.1  7261231-7262018
            789-894             JACYVU010000187.1  7262892-7262997
            895-1173            JACYVU010000187.1  7264226-7264504
            1174-1273           JACYVU010000187.1  7264621-7264720
            1274-2521           JACYVU010000187.1  7264835-7266082
            2522-2597           JACYVU010000187.1  7266460-7266535
            2598-2770           JACYVU010000187.1  7266671-7266843
            2771-2880           JACYVU010000187.1  7266934-7267043
            2881-2988           JACYVU010000187.1  7267788-7267895
            2989-3059           JACYVU010000187.1  7268060-7268130
            3060-3158           JACYVU010000187.1  7268430-7268528
            3159-5938           JACYVU010000187.1  7268702-7271481
FEATURES             Location/Qualifiers
     source          1..5938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5938
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 2"
                     /db_xref="GeneID:315220"
                     /db_xref="RGD:1309727"
     exon            1..788
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             724..3231
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /note="islet-brain-2; JNK-interacting protein 2; JNK MAP
                     kinase scaffold protein 2"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     2"
                     /protein_id="NP_001094190.1"
                     /db_xref="GeneID:315220"
                     /db_xref="RGD:1309727"
                     /translation="MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDC
                     GLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEEDEEEEEEEEEE
                     EDGDGDGRAGGGSGSQELSGESLIPSPSIEESHKLRPTTLHLTTLGAQDSLNNNSNGG
                     FTSAPPSSWQETVLRSPVQEPLKELPAPLLPAEEEHHEVQSLARPGCDCEGNQPPEPP
                     ASGGASPSSDPGIEADLRSHSSGGHEGRRSSQELSSPGSDSEEAGGARLGRMISSISE
                     TELELSSDSGSSSGRSSHLTNSIEEASSPASEPEPEPEPEPLHEPPRRPAFLPVGQDD
                     TNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPPAPRPPEEA
                     ASQANPVPQDCPDPEAVAGPHVELVDMDTLCGPPPPAPAAPRLGPAQSGPCLFLSNPT
                     RDTITPLWAPPGRTARPGRSCSAACSEEEEEDEEEDEEDEEDAEDSVIPPGSRTTGST
                     APLDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLDNDSEEDSSCEASEEEAGATLLG
                     SDQVPEDASPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCVVNGEEREQTHRAVF
                     RFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLL
                     GSKRSPCWVDRFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEI
                     SLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVF
                     VSQESMRPVARSVGRAFLEYYQEHLAFACPTEDIYLE"
     exon            789..894
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1173
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1273
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..2521
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2597
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2770
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2880
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2988
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3059
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3158
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..5938
                     /gene="Mapk8ip2"
                     /gene_synonym="IB-2; JIP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaaggtct gatcagcacc ctggagtgga cagctccctc ggccaccggt taggcggtct
       61 aacggtttag gaggtctagc gggttagtag gtctggtgtg ttaggaggtc tgaggggctt
      121 cctgaccaac tctgcttttc gaatttaccg ggcatgaatg ctgttcctaa gtcctcgccc
      181 atcaccccac atgagccgtc cacctcccag aagcactgca caccgccgta actagaggcg
      241 cacagacccg ggccgccttg gtcctggctc ctgggtctac cgcacccatt cccccccgca
      301 tctcttcggc tcctgcagaa acctttggtc taccagcgcc tctgcttcca cctatccctt
      361 ctcgccagtt cgtcgcctag aaccacgcaa gccgcacgcc agctttcccg accagaatct
      421 cacgaccacc actaccaccg ctaccaccac cacctcgcat cccgcatccc cccccccccc
      481 cccgcccgac ccccattcct ccgcccccac ctcaggcccc gccctgcgcc actccctccc
      541 ctcacccctg cggcgcggct cgctgccgcg gtgtcctggc agggcgctga ggtgtgtcgc
      601 cgacgggtgt cgcagggcgt gtcacgaggt gagtggggag acagaggccg cgagcctgag
      661 caccaagggc gcgcggtgct cctcacccct ccccctcact gccggcccgc ggttcctggg
      721 aagatggcgg atcgcgcgga gatgttttct ctctcaacct ttcactcgct gtcgcctccg
      781 ggctgcaggc ctccccagga cataagcctg gaagaatttg atgatgaaga cctatctgag
      841 atcacggacg actgtggcct gggccttagc tacgactccg accactgcga gaaggacagt
      901 ctctccctgg gtcgctcaga gcagccgcac cctatctgtt ccttccaaga tgatttccag
      961 gagtttgaga tgatcgatga caatgaggaa gaggaagatg aggaggagga ggaagaggag
     1021 gaagaggagg aagatggaga cggggacggc agagcagggg gaggatctgg ttcacaggaa
     1081 ctttctggag aatcccttat tccctctcct tccatagagg agtcccacaa gctccgaccc
     1141 accaccctcc acctgactac acttggagcc caggactccc tcaacaacaa cagcaatgga
     1201 ggctttacct ctgcgccccc atcttcctgg caggaaacag tgctgcgttc accagtccag
     1261 gagcccctta aagagctacc agcccctctc ttaccagcag aagaggagca ccatgaggta
     1321 cagtcccttg cacgccctgg ttgtgactgt gaagggaacc agccgccaga gccaccagca
     1381 tcaggtgggg cttccccttc ctcggatcct ggtatcgagg ctgacttgag aagccactct
     1441 agtggaggcc atgaaggtcg gcgaagcagc caggagctct catcaccagg ctcggactct
     1501 gaggaggcag gcggcgcacg cctagggcgc atgatctctt ccatttctga gacggagctg
     1561 gagctgagca gtgacagtgg cagcagcagc ggccgctcct cacacctcac caactctatc
     1621 gaggaggctt cgtccccagc ctcagagcct gaacctgagc ccgagcccga gccactacat
     1681 gaacctcccc gccgccctgc cttcctgcct gtgggccagg acgacaccaa cagcgagtat
     1741 gagtccggct ctgagtctga gcctgatctg agtgaggatg ctgactcgcc ctggctactc
     1801 agcaacctgg tgagccgcat gatctccgag ggctcctcgc ctattcgttg ccctggccag
     1861 tgcttgtctc ctcctgcacc acgcccgcca gaagaggctg catcccaggc caacccggta
     1921 ccccaggact gcccagaccc tgaggcagta gcagggcccc acgtggagtt agtggacatg
     1981 gacacccttt gcgggccacc tccgccggcc cctgcagcac ctcggcttgg tccagcgcag
     2041 tctgggccct gccttttcct tagtaaccca acacgtgata ccatcacccc actttgggcc
     2101 ccacctggac gcactgctcg ccctggccgc tcctgctctg ctgcctgctc ggaggaggag
     2161 gaggaggatg aggaagagga cgaggaggat gaggaggatg ctgaggacag cgtgattccc
     2221 cctggctcca ggactacagg ctctactgcg ccgctggatg cctcgctggt gtacgatgcg
     2281 gttaaataca cactagtggt ggatgagcac acgcagctag agctggtgag cctgcggcgc
     2341 tgtgcaggcc tggacaacga cagtgaagag gacagcagct gcgaggccag tgaggaagag
     2401 gcgggagcta cgttactagg cagtgaccag gtgccagaag acgcctctcc tgacagcccc
     2461 gacctcacct tctccaagaa gttcctcaat gtctttgtca acagcacatc tcgatcttcc
     2521 agcactgagt ccttcggtct tttttcctgt gtggtcaatg gagaagagag agagcagaca
     2581 caccgggctg tcttcaggtt catccctcga catccagatg aactagagtt agatgtggac
     2641 gacccggtgt tggtggaagc cgaagaggac gacttttggt tccgtggctt caacatgcgc
     2701 accggcgagc gtggagtgtt ccctgccttc tacgcccatg cagtacctgg tcctgccaag
     2761 gacctgctgg ggagcaagcg gagcccttgc tgggtggatc gcttcgatgt gcagttcttg
     2821 ggctctgtgg aggtaccatg tcaccagggc aatggtatct tgtgtgcagc catgcaaaag
     2881 attgccacag cccggaaact aacggtccac ctgcgccctc ctgcctcttg tgaccttgag
     2941 atctctctgc ggggggtcaa gctgagtctg agtggaggag gacctgagtt ccagcgttgc
     3001 agccactttt tccagatgaa gaacatctcc ttctgtggct gtcatccccg aaacagctgc
     3061 tattttggct tcattaccaa acacccgctg ctaagccgct ttgcctgcca cgtctttgtg
     3121 tcccaggagt ctatgaggcc agtggcaagg agcgtgggcc gggccttcct ggagtactac
     3181 caggagcacc tggcattcgc ctgccccaca gaagatatct acctggagta gcactcgcct
     3241 ccctcagctc ccatccacac agctctgagt atctcaaggc ccgccatggc ttgagcaagg
     3301 accggatcgg ggacatttgg aaccttacct tgtaggagtc tctgggctgg gaacttttct
     3361 cctttatccc caggtcatgg ctttcgggag ctgttgggga gaggagcctc agcagccata
     3421 cttttcttcc gatgcatctt tttcctctct cgtcccgttc ttccgactgc ctttcctctg
     3481 tctctcgccc ctttctgtgc ctgtagacct agctctttgc tctctctttt ggagttagaa
     3541 cctgagggag gggagtaggc tcaaggtaac cgatgaagtc aggtttcccc ggtgttccct
     3601 cctgcccttc tcttgtgatt tataaatgaa ttttaatttt tatagtgaat ctcaagggat
     3661 catcccacct ttgatcacag gaagggatcc tagcccccaa ctcacaagga gctcgggaag
     3721 gagggggagg ggcttccaag agaaccttag ggtgactagg tggttcttga tgctcaccca
     3781 aagcccccaa tgctgctagg aggagggcac cccccaaagg gtgctcccca caggtcatct
     3841 gcttttgccg ctgctaacac ccctgcagtc cagccagtga gtatctgccc tgcgtgcgcc
     3901 acctgctgtg tacgtgggcc ccgcccacgg catcaataaa ctctgcttgg tgtgaccctg
     3961 gctgttttta aggtggtgcc caggtggggt ccaggtctca ggtgctgcct gtggttatga
     4021 aaagggagga cccagggtga aggggtaacg ggaggggtct tcagtgcttc ctgaagtcct
     4081 gttgagggcg gatcactgca tgctatgcta gagccctgct gaaggtgttg tctggaggtg
     4141 ctcacaggat ttactccgaa cgcacttgat ttccggcaga gatagcccag gtctgaaagt
     4201 actggccacg gacgctgtgt ctttcccatg tgaggtatgg ggagagttgt ggctcagatc
     4261 gtggtggtag tggtgatgat ggtggtgggg tgtatgtgtg tgcgcgcgtg tgtgtgtatg
     4321 ccacgaacaa cttgagaaat aatgtctttg ggtctcacaa attggtattt tttcaaagtc
     4381 ttacacagta agccagcaga aaataagtaa cttaaaaaca aagcaaaaac aaaaaactgt
     4441 gcctgtaggg gactttagat cctcaccaag attctttcct ggggcccccg aatgactgga
     4501 acctcggggg aatgatcctt tgacagtagg tggcccctga ccttaggcag caccacagaa
     4561 agagaacagg tgatggctgt gagtcacaca gtgaacaaag gaatgatttg acagtttgct
     4621 acataaaaat aaaaaacatc ttcttagcct ggtgtggtag cacacattta acagaagaac
     4681 attggaggct gagacaggat ggctgtgacc ttaaggccaa cctaggctct atgatgtgat
     4741 cctccccctc ccactccaga atagtaacta taaaaatcat ctttacttaa aggtctcttc
     4801 agtgtgccaa caaacaaaaa tattcacgat atgtgcgaat atcagggacg aagaccagtt
     4861 gctgtggagt tgtcattttt tagctcatgt gccagggaca tcccaagtgt ccaggagaat
     4921 ctgtaaatat ctttctgcta cttagcagag gccggaaaga ggcaggcagc cacttggggg
     4981 cagcatgaaa cccgcacccc tgtgctgggt ggtggaggca tggcctccag gcctacacag
     5041 ctcagcagca gagaccgccc cacctccaga tacgtatcct ttctgccctg tgtcccttcc
     5101 agggcccagg cttcctcccc tgaccctctc tgtctctttg gcttttcaga tggttagcat
     5161 ttttcctcct gcctggcaat taggacagct gtgggacatg cttggtggcc tttccttgct
     5221 gctttcttcc tacctctctg gttgccccac aagccctgtc ctgtccttac tggcttcaag
     5281 gcaggcaagc atagggaata gcttagtaac ttgggactcc acttagtctg ggctacaccc
     5341 ctcttctggc atccttacct gcatgcacat gcacataaca cccctctcca gtgtgcctag
     5401 caaacctgtt ggcaacctag gactcccacc tgcactgaga tgcacaagat tccactctgg
     5461 aaagtgggat gagtttctct tcctcttaag gatttactac actttagatc ttattcagtc
     5521 atattgcagt tatgtccaga atcagaacag ggagactggc ttggtgtgaa ctggactggg
     5581 gtgcattgtg cattaaggca aaatgttctg taggcaaact tttaggggag aattccctat
     5641 ttaccacttt acacctatga gtagttggac gtgcatatga ttaaaacaag atgcgttacg
     5701 ggaagagacc tgtgcactgg acggagggct tctgtattcc aagcctgccc ctcaaaatag
     5761 agaaccaccc aaactctgcc aacagtgtct cctccttcct ctgctctcca tagaagaagc
     5821 ctccaggcat caacctggag tccgtgcgca tcttcactca tacggccccg gtcactcgtg
     5881 atatcatagt tgacctgtac tatcgctttg ctttgaataa aactaacctg gctcatga
//
