LOCUS       NM_053777               3003 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 8 interacting
            protein 1 (Mapk8ip1), mRNA.
ACCESSION   NM_053777
VERSION     NM_053777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Saeed,R., Mohammed,A.K., Saleh,S.E., Aboulwafa,M.M., Aboshanab,K.M.
            and Taneera,J.
  TITLE     Dual Role of Mitogen-Activated Protein Kinase 8 Interacting
            Protein-1 in Inflammasome and Pancreatic beta-Cell Function
  JOURNAL   Int J Mol Sci 24 (5), 4990 (2023)
   PUBMED   36902422
  REMARK    GeneRIF: Dual Role of Mitogen-Activated Protein Kinase 8
            Interacting Protein-1 in Inflammasome and Pancreatic beta-Cell
            Function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Blakeslee,W.W., Lin,Y.H., Stratton,M.S., Tatman,P.D., Hu,T.,
            Ferguson,B.S. and McKinsey,T.A.
  TITLE     Class I HDACs control a JIP1-dependent pathway for
            kinesin-microtubule binding in cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 112, 74-82 (2017)
   PUBMED   28886967
  REMARK    GeneRIF: HDAC-dependent regulatory circuit that promotes formation
            of JIP1:KIF5A:microtubule complexes that regulate intracellular
            transport of cargo such as autophagosomes, is reported.
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Brajkovic,S., Ferdaoussi,M., Pawlowski,V., Ezanno,H., Plaisance,V.,
            Zmuda,E., Hai,T., Annicotte,J.S., Waeber,G. and Abderrahmani,A.
  TITLE     Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity
  JOURNAL   J Diabetes Res 2016, 9158562 (2016)
   PUBMED   26665154
  REMARK    GeneRIF: Suppression of IB1 level mimicked the harmful effects of
            palmitate on the beta cell survival and GSIS. Conversely, ectopic
            expression of IB1 counteracted the deleterious effects of palmitate
            on the beta cell survival and insulin secretion
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Deng,C.Y., Lei,W.L., Xu,X.H., Ju,X.C., Liu,Y. and Luo,Z.G.
  TITLE     JIP1 mediates anterograde transport of Rab10 cargos during neuronal
            polarization
  JOURNAL   J Neurosci 34 (5), 1710-1723 (2014)
   PUBMED   24478353
  REMARK    GeneRIF: this study demonistrated that JIP1 mediates anterograde
            transport of Rab10 cargos during neuronal polarization
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Cunningham,C.A., Knudson,K.M., Peng,B.J., Teixeiro,E. and
            Daniels,M.A.
  TITLE     The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals
            and effector function in CD8(+) T cells
  JOURNAL   Eur J Immunol 43 (12), 3361-3371 (2013)
   PUBMED   23963642
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Pellet,J.B., Haefliger,J.A., Staple,J.K., Widmann,C., Welker,E.,
            Hirling,H., Bonny,C., Nicod,P., Catsicas,S., Waeber,G. and
            Riederer,B.M.
  TITLE     Spatial, temporal and subcellular localization of islet-brain 1
            (IB1), a homologue of JIP-1, in mouse brain
  JOURNAL   Eur J Neurosci 12 (2), 621-632 (2000)
   PUBMED   10712642
REFERENCE   7  (bases 1 to 3003)
  AUTHORS   Meyer,D., Liu,A. and Margolis,B.
  TITLE     Interaction of c-Jun amino-terminal kinase interacting protein-1
            with p190 rhoGEF and its localization in differentiated neurons
  JOURNAL   J Biol Chem 274 (49), 35113-35118 (1999)
   PUBMED   10574993
REFERENCE   8  (bases 1 to 3003)
  AUTHORS   Kim,I.J., Lee,K.W., Park,B.Y., Lee,J.K., Park,J., Choi,I.Y.,
            Eom,S.J., Chang,T.S., Kim,M.J., Yeom,Y.I., Chang,S.K., Lee,Y.D.,
            Choi,E.J. and Han,P.L.
  TITLE     Molecular cloning of multiple splicing variants of JIP-1
            preferentially expressed in brain
  JOURNAL   J Neurochem 72 (4), 1335-1343 (1999)
   PUBMED   10098834
REFERENCE   9  (bases 1 to 3003)
  AUTHORS   Bonny,C., Nicod,P. and Waeber,G.
  TITLE     IB1, a JIP-1-related nuclear protein present in insulin-secreting
            cells
  JOURNAL   J Biol Chem 273 (4), 1843-1846 (1998)
   PUBMED   9442013
REFERENCE   10 (bases 1 to 3003)
  AUTHORS   Dickens,M., Rogers,J.S., Cavanagh,J., Raitano,A., Xia,Z.,
            Halpern,J.R., Greenberg,M.E., Sawyers,C.L. and Davis,R.J.
  TITLE     A cytoplasmic inhibitor of the JNK signal transduction pathway
  JOURNAL   Science 277 (5326), 693-696 (1997)
   PUBMED   9235893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF109774.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_053777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF109774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3003
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 1"
                     /db_xref="GeneID:116457"
                     /db_xref="RGD:70937"
     exon            1..288
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2317
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /note="mitogen activated protein kinase 8 interacting
                     protein; JRP; IB-1; islet-brain-1; JIP-1-related protein;
                     JNK-interacting protein 1; JNK MAP kinase scaffold protein
                     1"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     1"
                     /protein_id="NP_446229.1"
                     /db_xref="GeneID:116457"
                     /db_xref="RGD:70937"
                     /translation="MQLVLKMDSSPDNDSWLEDQWERWLTHDISLEEFEDEDLSEITD
                     ECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAASDTPGAEDDEE
                     DDDELAAQRPGVGPSKAESGQEPASRSQGQGQGPGTGSGDTYRPKRPTTLNLFPQVPR
                     SQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRG
                     TSTDSPCRRTAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQR
                     PPDPAEPTSTFLPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPEQAE
                     PPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYS
                     DESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLN
                     VFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQ
                     AEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVP
                     YHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADEAQEAKGNKCS
                     HFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQF
                     YKQFVEYTCPTEDIYLE"
     exon            289..394
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            395..703
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            704..785
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1598
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1674
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1847
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1957
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2074
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2145
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2244
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2992
                     /gene="Mapk8ip1"
                     /gene_synonym="Jip-1; JIP1; Mapk8ip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctggggc ctgggtcggc agctgcggcc tcctctctgg cccatctatt tttaatgagc
       61 tccccgggct tctgcagccg gcagaatgca gaaaggcagg cccagtctgt ggaggccaga
      121 agtcccagcc ctgccttgag ctctggcccc cctacccttc tgggcatgaa agggcagctc
      181 tggagccccg cagccccctg gccgggcagg gctctccatg cagctggtac tgaagatgga
      241 ttcgagccca gacaatgaca gctggttgga ggatcagtgg gaacgctggc tcacccatga
      301 tatcagcctg gaggagtttg aggatgaaga cctttcggag atcactgatg agtgtggcat
      361 cagcctgcag tgcaaagaca ccttgtctct ccggcccccg cgcgccgggc tactgtctgc
      421 gggtagcagc ggtagcgcgg ggagccggct gcaggcggag atgctgcaga tggacctgat
      481 cgacgcggca agtgacactc cgggcgccga ggacgacgaa gaggacgacg acgagctcgc
      541 tgcccaacgg ccaggagtgg ggccttccaa agccgagtct ggccaggagc cggcgtctcg
      601 cagccagggt cagggccagg gccccggcac aggcagcgga gacacctacc ggcccaagag
      661 gcctaccacg ctcaaccttt tcccgcaggt gccgcggtct caggacacgc tgaataataa
      721 ctctttaggc aaaaagcaca gttggcagga ccgtgtgtct cgatcatcct cccctctgaa
      781 gacaggggag cagacgcctc cacatgaaca tatctgcctg agtgatgagc tgccgcccca
      841 gggcagtcct gttcccaccc aggatcgtgg cacttccacc gacagccctt gtcgccgtac
      901 tgcagccacc cagatggcac ctccaagtgg tccccctgcc actgcacctg gtggccgggg
      961 ccactcccat cgagatcgaa tccactatca ggcagatgtg cggctcgagg cgactgagga
     1021 gatctacctg accccagtgc agaggccccc agaccctgca gaacccacct ccaccttctt
     1081 gccacccact gagagccgga tgtctgtcag ctcggatcct gaccctgccg cttactctgt
     1141 aactgcaggg cgaccgcacc cttccatcag tgaagaggat gagggcttcg actgtctgtc
     1201 atccccagag caagctgagc caccaggtgg agggtggcgg ggaagcctcg gggagccacc
     1261 accgcctcca cgggcctcac tgagctcgga caccagcgca ctgtcctacg actctgtcaa
     1321 gtacacactg gtggtggatg agcatgccca gcttgagttg gtgagcctgc ggccatgttt
     1381 tggagattac agtgacgaaa gcgactctgc cactgtctat gacaactgtg cctctgcctc
     1441 ctcgccctac gagtcagcca ttggtgagga atatgaggag gcccctcaac cccggcctcc
     1501 cacctgcctg tcagaggact ccacaccgga tgagcctgac gtccacttct ctaagaagtt
     1561 tctgaatgtc ttcatgagtg gccgctctcg ttcctccagt gccgagtcct ttgggctgtt
     1621 ctcctgtgtc atcaatgggg aggagcatga gcaaacccat cgggctatat tcaggtttgt
     1681 gcctcggcat gaagatgaac ttgagctgga agtggacgac cctctgctgg tggagctgca
     1741 ggcagaagac tattggtatg aggcctataa catgcgcact ggagcccgtg gtgtctttcc
     1801 tgcctactat gccattgagg tcaccaagga gcctgagcac atggcagccc ttgccaaaaa
     1861 cagcgactgg attgaccagt tccgggtgaa gttcctgggc tctgtccagg ttccttatca
     1921 caagggcaat gatgtcctct gtgctgctat gcaaaagatc gccaccaccc gccggctcac
     1981 cgtgcacttt aacccgccct ccagctgtgt ccttgaaatc agcgttaggg gtgtcaagat
     2041 aggtgtcaaa gctgatgaag ctcaggaggc caagggaaat aaatgtagcc actttttcca
     2101 gctaaaaaac atctctttct gtgggtacca tccaaagaac aacaagtact ttgggtttat
     2161 cactaagcac cctgctgacc accggtttgc ctgccatgtc tttgtgtctg aagattccac
     2221 caaagccctg gcagagtctg tggggcgtgc atttcagcag ttctacaagc aatttgtgga
     2281 atatacctgt cctacagaag atatctactt ggagtagcag caacccccct ctctgcagcc
     2341 cctcagcccc aggccagtac taggacagct gactgctgac aggatgttgt actgccacga
     2401 gagaatgggg gagtgagggc tgttggggtc ggggggcagg ggtttgggga gaggcagatg
     2461 cagtttattg taatatatgg ggttagatta atctatggag gacagtacag gctctctcgg
     2521 ggctggggaa gggcagggct ggggtggggg tcaggcatct ggccacaaag ggatccccta
     2581 gggacagagg cgctgcacca tcctgggcct tgtttcatac tagaggccct ggctttctgg
     2641 ctcttgggtc ctgccttgac aaagcccatg ccacctggaa gtgtcacctt cccttgtcca
     2701 cctcacccag agccctgagc tcatgctgag cccaagcacc tccgaaggac tttccagtaa
     2761 ggaaatggca acatgtgaca gtgaggaccc tgttctcatc tgtggggcct ccggcagctc
     2821 cgacctccag cctggccagc acgctgaccc tggcaagctt gtgtgttcaa agaaggagag
     2881 ggccacagca agccctgcct gccagggaag gttccctctc agctggcccc agccaactgg
     2941 tcactgtctt gtcacctggc tactactatt aaagtgccat ttcttgtctg gaaaaaaaaa
     3001 aaa
//
