LOCUS       NM_053829               5796 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 8 (Mapk8), mRNA.
ACCESSION   NM_053829 XM_001056513 XM_341399
VERSION     NM_053829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5796)
  AUTHORS   Zeng,S., Wang,Y., Ai,L., Huang,L., Liu,Z., He,C., Bai,Q. and Li,Y.
  TITLE     Chronic intermittent hypoxia-induced oxidative stress activates
            TRB3 and phosphorylated JNK to mediate insulin resistance and cell
            apoptosis in the pancreas
  JOURNAL   Clin Exp Pharmacol Physiol 51 (3), e13843 (2024)
   PUBMED   38302075
  REMARK    GeneRIF: Chronic intermittent hypoxia-induced oxidative stress
            activates TRB3 and phosphorylated JNK to mediate insulin resistance
            and cell apoptosis in the pancreas.
REFERENCE   2  (bases 1 to 5796)
  AUTHORS   Li,Q., Li,S., Xu,C., Zhao,J., Hou,L., Jiang,F., Zhu,Z., Wang,Y. and
            Tian,L.
  TITLE     microRNA-149-5p mediates the PM2.5-induced inflammatory response by
            targeting TAB2 via MAPK and NF-kappaB signaling pathways in vivo
            and in vitro
  JOURNAL   Cell Biol Toxicol 39 (3), 703-717 (2023)
   PUBMED   34331613
REFERENCE   3  (bases 1 to 5796)
  AUTHORS   Zhang,Y., Zhang,J., Sun,Z., Wang,H., Ning,R., Xu,L., Zhao,Y.,
            Yang,K., Xi,X. and Tian,J.
  TITLE     MAPK8 and CAPN1 as potential biomarkers of intervertebral disc
            degeneration overlapping immune infiltration, autophagy, and ceRNA
  JOURNAL   Front Immunol 14, 1188774 (2023)
   PUBMED   37325630
  REMARK    GeneRIF: MAPK8 and CAPN1 as potential biomarkers of intervertebral
            disc degeneration overlapping immune infiltration, autophagy, and
            ceRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5796)
  AUTHORS   Zhang,B.F., Song,W., Wang,J., Wen,P.F. and Zhang,Y.M.
  TITLE     Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of
            alveolar epithelial cells (AEC) by receptor of advanced glycation
            end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the
            rats of crush injuries
  JOURNAL   J Orthop Surg Res 17 (1), 20 (2022)
   PUBMED   35033142
  REMARK    GeneRIF: Anti-high-mobility group box-1 (HMGB1) mediates the
            apoptosis of alveolar epithelial cells (AEC) by receptor of
            advanced glycation end-products (RAGE)/c-Jun N-terminal kinase
            (JNK) pathway in the rats of crush injuries.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5796)
  AUTHORS   Chen,S., Du,Y., Xu,B., Li,Q., Yang,L., Jiang,Z., Zeng,Z. and
            Chen,L.
  TITLE     Vaccinia-related kinase 2 blunts sorafenib's efficacy against
            hepatocellular carcinoma by disturbing the apoptosis-autophagy
            balance
  JOURNAL   Oncogene 40 (19), 3378-3393 (2021)
   PUBMED   33875785
REFERENCE   6  (bases 1 to 5796)
  AUTHORS   Chaudhary,L.R. and Avioli,L.V.
  TITLE     Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in
            normal human osteoblastic and rat UMR-106 cells
  JOURNAL   J Cell Biochem 69 (1), 87-93 (1998)
   PUBMED   9513050
REFERENCE   7  (bases 1 to 5796)
  AUTHORS   Clerk,A., Fuller,S.J., Michael,A. and Sugden,P.H.
  TITLE     Stimulation of 'stress-regulated' mitogen-activated protein kinases
            (stress-activated protein kinases/c-Jun N-terminal kinases and
            p38-mitogen-activated protein kinases) in perfused rat hearts by
            oxidative and other stresses
  JOURNAL   J Biol Chem 273 (13), 7228-7234 (1998)
   PUBMED   9516415
REFERENCE   8  (bases 1 to 5796)
  AUTHORS   Auer,K.L., Contessa,J., Brenz-Verca,S., Pirola,L., Rusconi,S.,
            Cooper,G., Abo,A., Wymann,M.P., Davis,R.J., Birrer,M. and Dent,P.
  TITLE     The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which
            agonists stimulate DNA synthesis in primary cultures of rat
            hepatocytes
  JOURNAL   Mol Biol Cell 9 (3), 561-573 (1998)
   PUBMED   9487126
REFERENCE   9  (bases 1 to 5796)
  AUTHORS   Gupta,S., Barrett,T., Whitmarsh,A.J., Cavanagh,J., Sluss,H.K.,
            Derijard,B. and Davis,R.J.
  TITLE     Selective interaction of JNK protein kinase isoforms with
            transcription factors
  JOURNAL   EMBO J 15 (11), 2760-2770 (1996)
   PUBMED   8654373
REFERENCE   10 (bases 1 to 5796)
  AUTHORS   Kyriakis,J.M., Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A.,
            Ahmad,M.F., Avruch,J. and Woodgett,J.R.
  TITLE     The stress-activated protein kinase subfamily of c-Jun kinases
  JOURNAL   Nature 369 (6476), 156-160 (1994)
   PUBMED   8177321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000016.1, CB782828.1,
            L27129.1, FM076271.1, DV724511.1 and AA963835.1.
            
            On Oct 7, 2014 this sequence version replaced NM_053829.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase is activated by various
            cell stimuli, and targets specific transcription factors, and thus
            mediates immediate-early gene expression in response to cell
            stimuli. The activation of this kinase by tumor-necrosis factor
            alpha (TNF-alpha) is found to be required for TNF-alpha induced
            apoptosis. This kinase is also involved in UV radiation induced
            apoptosis, which is thought to be related to cytochrom c-mediated
            cell death pathway. [provided by RefSeq, Jul 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27129.1, SRR26360172.450338.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000016.1  8728171-8728225     c
            56-297              CB782828.1         7-248
            298-1408            L27129.1           298-1408
            1409-4593           JAXUCZ010000016.1  8646360-8649544     c
            4594-5061           FM076271.1         1-468
            5062-5253           DV724511.1         1-192
            5254-5796           AA963835.1         1-543               c
FEATURES             Location/Qualifiers
     source          1..5796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..5796
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /note="mitogen-activated protein kinase 8"
                     /db_xref="GeneID:116554"
                     /db_xref="RGD:621506"
     exon            1..128
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            129..297
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1459
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /EC_number="2.7.11.24"
                     /note="p54 gamma; SAPK gamma; c-Jun N-terminal kinase 1;
                     stress-activated protein kinase JNK1; MAPK 8; MAP kinase
                     8; c-jun NH2-terminal kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8"
                     /protein_id="NP_446281.2"
                     /db_xref="GeneID:116554"
                     /db_xref="RGD:621506"
                     /translation="MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAY
                     DAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQ
                     DVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
                     SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEM
                     VCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFP
                     DVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPP
                     PKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVS
                     SPSVNDMSSMSTDPTLASDTDSSLEASAGPLGCCR"
     exon            298..427
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            428..486
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            487..625
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            626..791
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            792..863
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1046
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1171
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1235
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1313
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..5782
                     /gene="Mapk8"
                     /gene_synonym="JNK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgagg ccggacgttg cggccgaaac gcggagccgc gagcaggatt aagtagcggc
       61 cgcggccacc gcgggacggc gccgctctcc gctacgggct tccaggtctc cgttggctgc
      121 actgccggcc gtggtgaata tttggatgaa gccattagac taattgcttg ccatcatgag
      181 cagaagtaaa cgtgacaaca atttttatag tgtagagatc ggagattcta cattcacagt
      241 cctaaaacga taccagaact taaagcctat aggctcagga gctcaaggaa tagtgtgtgc
      301 agcttatgat gctattcttg aaagaaatgt tgcaatcaag aagctcagcc ggccatttca
      361 gaatcagacc catgctaagc gagcctaccg agaactagtt cttatgaagt gtgttaatca
      421 caaaaatata attggccttt tgaatgtttt cacaccacag aaatccctag aagaatttca
      481 agatgtttac atagtcatgg agctcatgga tgcaaatctt tgccaagtga ttcagatgga
      541 gttagatcat gaaagaatgt cctaccttct ctatcaaatg ctgtgtggaa tcaagcacct
      601 tcactctgct ggaattattc atcgggactt aaagcctagt aatatagtag tcaaatcaga
      661 ctgcactttg aagattcttg attttggact ggcaaggact gcaggaacga gttttatgat
      721 gacgccttac gtggtaactc gttactacag agcaccagag gtcattctcg gcatgggcta
      781 caaggagaac gtggatttat ggtctgtggg gtgcattatg ggagaaatgg tttgcctcaa
      841 aatcctcttt ccaggaaggg actatattga tcagtggaat aaagttattg aacagctcgg
      901 aacaccttgt cctgaattca tgaagaaact acaaccaaca gtaaggactt acgttgaaaa
      961 cagacctaag tacgctggct atagctttga gaaactgttt cctgatgtgc ttttcccagc
     1021 tgactcagaa cataacaaac ttaaagccag tcaggcgaga gatttgttat ctaaaatgct
     1081 ggtgatagat gcgtccaaaa ggatctccgt agacgaagct ctccagcacc cgtacatcaa
     1141 cgtctggtat gatccttcag aagcagaggc cccaccacca aagatccctg acaagcagtt
     1201 agatgaaagg gagcacacaa tagaggagtg gaaagaactg atatacaagg aggtcatgga
     1261 tttggaggag cgaactaaga atggcgtcat aagagggcag ccgtctcctt taggtgcagc
     1321 agtgatcaat ggctctcagc atccggtctc ttcgccgtct gtcaatgaca tgtcttcaat
     1381 gtccacagat ccgactctgg cctcggatac agacagcagt ctagaagcat cagctggacc
     1441 tctgggctgc tgtagatgac tacttgggcc ttgggtgggt gggagggatg gggaattggt
     1501 tagtcattga tagaactgct ttaaaaacaa ttcagtggtc atatttttga gtgatttttc
     1561 agaaaatgta gaattcattt tgtagtaaag tagtttattt tttttaattt cgagtgttgt
     1621 aatttaaaac ctaagttgtg tttttaaaca gcaacaaaac tgtattgtat ttttgctgta
     1681 attaactgta taatgtaaac ctaattattt tatcatggtt taaattttgc atatttgctt
     1741 tatcttatgc tgctgatttt tttactgaat ttgtaagatt tttgtttatc aaagcaacta
     1801 ttatgtggtg acttgcatat atcatgaatt atttaagatg tttataagtt tttttattag
     1861 aatttatttc agatgtttgt tcatgatgct atccttcagg gttatgtgct tatcaatgaa
     1921 ataaccccag aggagtaagg gaaaataacc tgtagccagt tatattcagg aataactact
     1981 gtaaatgatg aacgtgtcaa gaaacctcca atatttgcta cttgccaatc ccatcttagt
     2041 taaaacaatt ggtaggcaac cttacctaaa ttttagcgga caccctgtta tctaaatgac
     2101 agagtaacag agcatgtctt taaagatgct ggggacctcc ttctacattt gagtctccct
     2161 acaccaacct aacaaaactt aaattaagaa atgtggcata ttctgaacac ttgtggcatg
     2221 cttgaagctt ttgatcacac aaagtcaaga ggatccttca tgaatctaca tttcagtgga
     2281 gctcagcaga cgcttcccct gtcctagcgc tgagcctgct tctgtataca ctgaggtatc
     2341 tcctcagcct gtaggtcctg gcattggtcc aagagcctga actttcccat ttgttcagtt
     2401 cctgggcgct ggacctttcc caaatcctgc tcacttagca gtcagtctgt tgagcaccag
     2461 ttggtggtgt tcctggccat ttgattctac ctgtagcata gtcctgtttc tactagctgt
     2521 caggaggtcc caaagcctac ttaaacttgt gtaggtgaca tttaaatgag caatataccg
     2581 ttcatctgaa aatagtagca cacagccata tgtaggatgt cattttctaa ggactgtttc
     2641 ttcacagtga gcagagcagg catagtggtg gctctttagt ctgagtcttt ggtttgtttt
     2701 atgtctgatt tccagtgtgg acgttgagta gtgtaagaat ggtgctgctc ctgacaagtg
     2761 tgtgttcact gtttacattt tatatctgca gaatccttct ctgtaactga atctttccta
     2821 agtaaaatgt catcaaggcc tcattatttc tgaaatgatg tctgcaatac ccaggcacct
     2881 ttggtattat ctggagtaag aggggcttca tggaatgaac tgggaaatgc atgctgtatg
     2941 agctgcaggg ttgtaggaag aagccccttg gagcttccag ccagcagcaa gagcaggcac
     3001 agcctagact aacgaaaggt tgcttagcag gttttcattt gtttgttttg gttctatttt
     3061 gtttggggag gatttttttt tttaatattt agtgtagaat tacttttaaa tagagtattt
     3121 taagtcattg tttatgtgca atacttaaga ctaagataca ttaattacct ttttatatac
     3181 tttgaaatat agcaagttag tttattatga tttctagcct ctcacctttt agtgattcct
     3241 tttctatatg tacaacatgg tgcattaatt ttgttagaca agtgtgaatt tgagactgtc
     3301 gtgcctcttg ggttatagaa atagatggtt ggagtcagga ttttagccga gatcggagca
     3361 tgagcgtgtt cttattttat actagtttta caactaactg gttttatttt ccctatgata
     3421 aaatgtgtca ctattgcact taacagctga catgctttag ttagttttcg gtgttttgta
     3481 cttgatcgct gagaagccgt ctttcttggt tcagatttcg gttaagtaag gaataccagt
     3541 tgttctgatt gtatcattta ttgtaattgc cagctcccac ttgccagcct tcgtgtttca
     3601 gttgaattaa aagaaaacaa gctttcagtg cttaatgtaa gctgaaatac ttaacaaaat
     3661 tataccctaa aagcaaggtc tgtttgttaa acacgtggtc cagcttttta agatccactg
     3721 tacacgcgcg cgcgcacaca cacacacaca cacacacaca cacacacaca cacacacacc
     3781 tttgtttata tctgttaaca taaaccctgc tggtactttt taagagtctt aaagcatctt
     3841 aagtattttt ttaaggaatt acaaataaca tttctgtctc tcagtacttg ttaaaccacc
     3901 ctatcatttg acttttcaat gacatgtatt taagatgccg attgtcttac tgtctgaaag
     3961 ttgtttaact tagaattagc attccacttc atggtttagg aaagagagcc ttattctttc
     4021 tacatgtctt cctggttcca gttctcgtac ccgctaatat gtagtggtca tccataagat
     4081 ggccatgttg ttgggattgc tttgttacaa atagagcatc ccagtcttcg atgctctttg
     4141 ctaagcggtc tttactgtgt cacgccatgc tgctgatcgc cagatctcag aagagtacac
     4201 accagaaaca gcggcccagt gcgttcacac ctggcttgta agagaagcag tagccccgcc
     4261 agtacagaga agctcaattg tgtacaaagc agcagcctgc ctgtcacctg tgtccctcag
     4321 ttctgagctc atctcacttt gtcaccctaa gacttggagg tgggaaggac actgacagga
     4381 caggacgagc agtaggccag ggaagctgct tcctgagtca cagtgggact tggtttacat
     4441 cattggtcag tttctgccac acacccacac acgaagacag ccatgagtgc tgcctaagcg
     4501 ctagcctgca cagcattttg agacttaaaa gaaaaacaac atagtatatt ttcaggaatc
     4561 ctgttgtagt ttgtgagtgt tgttcattag tcacacatta gtgtagagtg gatgcatgat
     4621 gccccatgac cccagcaatt cttaccagtg agtaggtacc cagcaccgtc tctcacccgt
     4681 agccctcttc agcattgccc tgtggcctgt tgcattctag ttagtgtgca tcgtgtttta
     4741 ctgatctctt gggtgcttct tgtaaaccac aggaagcaca tttgtcttag tcgcacaaaa
     4801 gatgaaagag ataaagggca ttgaagcaga aatgtgtggt ttggggtaag ataggaaaac
     4861 ttgtgtccaa gttaatttca aagtaactgc tcttaggcag agtgctctta aggggagtct
     4921 agtaagcaac tttctgggca cttctggttt cgattctctt cgttactgaa actcctgaga
     4981 actattacct gtggattagt tttgcacaat gtcctattct cacagtgact taaaattaga
     5041 ctaggttttt aattgaacta cctcacaccg attttctatg ctttcccaag taagctgttg
     5101 cccttactgt tagaccttta ctcagtgtaa attttaaatg tgcgttgaat actttatagc
     5161 cactgttgac aaaataccag taagtgtgtg aagtgcaagc cttgcatcag taagagacag
     5221 tcccgtgcag tcttccactg cgtctgggga attgtgctgc atatgcttat tgacatcatc
     5281 actgttttgt aagaaacctg ctcaagatat cagtccacgc tttacatttt acaaaaggag
     5341 gaaatcttag taaattttac gaagaaataa attacttttg taggcccaat atttggtata
     5401 tttttgagaa gctgttaatc ttatagccga atgatgaagt taaactgaag tagctgtctg
     5461 cctggactgt gacgtctatt ttctcattac gttttaccct gttaataagg ttttaaacct
     5521 caaaacatag gataataatt agattttttt tctctctccc tgtgtgtgtc attccttctt
     5581 cctccctcct cttccctgtg ctctcctctc ttctctctag acaaaacaaa atggggcact
     5641 ttgtagggaa tgctgagatc attattgtgg tttactcgtt catgccctag tcattaaaca
     5701 tgcaccactg gatgtaaaca gtgttatcta gtatgtcaat tggttataat attttaaata
     5761 aaaaagaaaa agtggtatga aaaaaaaaaa aaaaaa
//
