LOCUS       NM_001191547            2738 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 7 (Mapk7), mRNA.
ACCESSION   NM_001191547 XM_002727717
VERSION     NM_001191547.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Devost,D., Zingg,H.H. and Hebert,T.E.
  TITLE     The MAP kinase ERK5/MAPK7 is a downstream effector of oxytocin
            signaling in myometrial cells
  JOURNAL   Cell Signal 90, 110211 (2022)
   PUBMED   34902542
  REMARK    GeneRIF: The MAP kinase ERK5/MAPK7 is a downstream effector of
            oxytocin signaling in myometrial cells.
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Guo,T.M., Xing,Y.L., Zhu,H.Y., Yang,L., Liu,G.X. and Qiao,X.M.
  TITLE     Extracellular regulated kinase 5 mediates osteoporosis through
            modulating viability and apoptosis of osteoblasts in ovariectomized
            rats
  JOURNAL   Biosci Rep 39 (9) (2019)
   PUBMED   31413169
  REMARK    GeneRIF: Extracellular regulated kinase 5 mediates osteoporosis
            through modulating viability and apoptosis of osteoblasts in
            ovariectomized rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Kashino,Y., Obara,Y., Okamoto,Y., Saneyoshi,T., Hayashi,Y. and
            Ishii,K.
  TITLE     ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type
            Current in PC12 Cells
  JOURNAL   Int J Mol Sci 19 (7), 2008 (2018)
   PUBMED   29996472
  REMARK    GeneRIF: Study revealed that ERK5 signaling promotes
            phosphorylation of Kv4.2 and inhibits the inactivation of the
            A-type current for the enhancement of membrane excitability in PC12
            cells. ERK5 promotes neurite outgrowth and catecholamine
            biosynthesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Liu,W., Ruiz-Velasco,A., Wang,S., Khan,S., Zi,M., Jungmann,A.,
            Dolores Camacho-Munoz,M., Guo,J., Du,G., Xie,L., Oceandy,D.,
            Nicolaou,A., Galli,G., Muller,O.J., Cartwright,E.J., Ji,Y. and
            Wang,X.
  TITLE     Metabolic stress-induced cardiomyopathy is caused by mitochondrial
            dysfunction due to attenuated Erk5 signaling
  JOURNAL   Nat Commun 8 (1), 494 (2017)
   PUBMED   28887535
  REMARK    GeneRIF: Erk5 role in the cardiac mitochondria and the Pgc-1alpha
            regulation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Obara,Y., Nagasawa,R., Nemoto,W., Pellegrino,M.J., Takahashi,M.,
            Habecker,B.A., Stork,P.J.S., Ichiyanagi,O., Ito,H., Tomita,Y.,
            Ishii,K. and Nakahata,N.
  TITLE     ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis
            in adrenal medullary cells
  JOURNAL   Cell Signal 28 (3), 177-189 (2016)
   PUBMED   26739108
  REMARK    GeneRIF: ERK5 signaling is required for catecholamine biosynthesis
            during neural differentiation, in part to induce ankrd1, and to
            maintain appropriate TH levels.
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Grewal,P.K., Holzfeind,P.J., Bittner,R.E. and Hewitt,J.E.
  TITLE     Mutant glycosyltransferase and altered glycosylation of
            alpha-dystroglycan in the myodystrophy mouse
  JOURNAL   Nat Genet 28 (2), 151-154 (2001)
   PUBMED   11381262
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Dalmay,T., Horsefield,R., Braunstein,T.H. and Baulcombe,D.C.
  TITLE     SDE3 encodes an RNA helicase required for post-transcriptional gene
            silencing in Arabidopsis
  JOURNAL   EMBO J 20 (8), 2069-2078 (2001)
   PUBMED   11296239
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Yan,C., Luo,H., Lee,J.D., Abe,J. and Berk,B.C.
  TITLE     Molecular cloning of mouse ERK5/BMK1 splice variants and
            characterization of ERK5 functional domains
  JOURNAL   J Biol Chem 276 (14), 10870-10878 (2001)
   PUBMED   11139578
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Yang,C.C., Ornatsky,O.I., McDermott,J.C., Cruz,T.F. and Prody,C.A.
  TITLE     Interaction of myocyte enhancer factor 2 (MEF2) with a
            mitogen-activated protein kinase, ERK5/BMK1
  JOURNAL   Nucleic Acids Res 26 (20), 4771-4777 (1998)
   PUBMED   9753748
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   Abe,J., Kusuhara,M., Ulevitch,R.J., Berk,B.C. and Lee,J.D.
  TITLE     Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive
            kinase
  JOURNAL   J Biol Chem 271 (28), 16586-16590 (1996)
   PUBMED   8663194
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002727717.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1173049.1,
                                           SRR26643294.39704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000010.1  46674603-46674834   c
            233-398             JAXUCZ010000010.1  46673879-46674044   c
            399-1477            JAXUCZ010000010.1  46671522-46672600   c
            1478-2151           JAXUCZ010000010.1  46670753-46671426   c
            2152-2285           JAXUCZ010000010.1  46670267-46670400   c
            2286-2738           JAXUCZ010000010.1  46669721-46670173   c
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2738
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /note="mitogen-activated protein kinase 7"
                     /db_xref="GeneID:114509"
                     /db_xref="RGD:621505"
     CDS             1..2439
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /EC_number="2.7.11.24"
                     /note="ERK-5; BMK1 kinase; big MAP kinase 1; extracellular
                     signal-regulated kinase 5; BMK-1; MAPK 7; MAP kinase 7"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 7"
                     /protein_id="NP_001178476.1"
                     /db_xref="GeneID:114509"
                     /db_xref="RGD:621505"
                     /translation="MAEPLKEEDGEDGSGEPPGRVKAEPVHSAASVVAKNLALLKARS
                     FDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRE
                     LKILKHFKHDNIIAIKDILRPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVR
                     YFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM
                     TEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM
                     VLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSA
                     RISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR
                     EGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSGPAPDTVD
                     LTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPV
                     TAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDR
                     SLLERWTRMARPPVPAPAPAPAPTPKPTPTPTQSSAQPTSPPNGPVSQSTAPLQPAGS
                     IPGPASQPVCPPPGPVPQPAGPVPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPY
                     FPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVG
                     FDLEEFLNQSFDMGVADGPQDSQADSASLSASLLADWLEGHGMNPADIESLQREIQMD
                     SPMLLSDLPDLQEP"
     exon            1..232
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
     exon            233..398
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
     exon            399..1477
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2151
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2285
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2738
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccgaac cgttgaagga ggaggacggc gaagatggct ctggggaacc ccctgggcgg
       61 gtgaaggcag aacccgtcca ctccgctgca tctgtcgtgg ccaagaacct ggccctgctc
      121 aaagcccgct ccttcgacgt gacctttgac gtgggggacg agtacgagat catcgagacc
      181 ataggcaatg gggcctacgg ggtggtgtcc tcggcgcgcc gccgcctcac gggtcagcag
      241 gtggccatca agaagatacc taatgctttt gatgtggtga ccaatgccaa acggaccctc
      301 agggaactga agatcctcaa acacttcaaa cacgacaata tcatcgccat caaggacatc
      361 ctgaggccca ctgtgcccta tggagaattc agatctgtct acgtggtact ggacctcatg
      421 gaaagtgacc tacaccagat cattcactct tcacagccgc tcacactaga acatgtgaga
      481 tacttcctat accagctgct tcggggcctc aaatacatgc actctgctca ggtcatccac
      541 cgcgatctta aaccctctaa ccttttggtc aatgagaact gtgagctcaa gattggtgac
      601 tttggaatgg cccgtggcct gtgtacatcc cctgccgagc accagtactt catgactgag
      661 tatgtggcca ctcgctggta ccgtgctcct gaactcatgc tttcgctgca tgagtacaca
      721 caggctattg acctctggtc tgtgggctgc atctttggtg agatgctggc tcggcgacag
      781 ctcttcccag gcaaaaacta tgtgcatcag ttacagctga tcatgatggt gttgggaact
      841 ccatcaccag ctgtgattca ggctgtgggg gctgaaaggg tgcgagccta tatccagagc
      901 ctgccaccaa ggcagcctgt accttgggag acagtatacc cgggtgctga ccgccaggcc
      961 ctctcactgc tgggacgcat gttgcgattt gaacccagtg cccgaatctc agctgctgct
     1021 gcccttcgcc accccttcct ggctaagtac cacgaccctg acgatgagcc tgattgcgcc
     1081 ccaccttttg actttgcttt tgaccgtgaa gcccttacca gggagcgcat taaggaggcc
     1141 attgtggctg agattgagga cttccatgca cgacgggagg gcatccgcca acaaattcgc
     1201 ttccagccct ctttgcagcc tgtggctagt gagcctgtgt gtccagatgt cgagatgccc
     1261 agcccctggg ctccaagtgg agactgtgcc atggagtcac ctcctccagc actaccacca
     1321 tgctctggcc ctgcccctga cactgttgat ctgactctgc agcctgcccc gcccgccagt
     1381 gagcttgctc cgccaaaaag agagggtgcc atctccgaca ataccaaagc agccctcaaa
     1441 gctgctctgc tcaagtccct gaggagccgg cttcgagatg ggcccagtgc acccttggag
     1501 gcccctgaac ctcgaaagcc tgtgacagct caggaacgtc agcgagagcg agaagagaag
     1561 cgcaggaggc gacaagagag agccaaggag agggagaagc gacgacaaga gcgggagcgc
     1621 aaggagaggg gggctggcac cttggggggc ccctctactg accctttggc tggattggtg
     1681 ctcagtgaca atgaccgaag cctgctagag cggtggactc gcatggctag gcctcctgtc
     1741 cctgcaccag caccagcacc agcaccaaca ccaaaaccaa caccaacacc aacacagtcc
     1801 tctgctcaac ccactagtcc tcccaatggc cctgtatctc agtctactgc tcctctacag
     1861 cctgcaggct ctattcctgg tcctgcctcc cagcctgttt gcccaccccc tgggcctgtt
     1921 ccccagcctg ctggccctgt ccctgcccct ctccagactg ccccttccac tagccttttg
     1981 gcctcccagt cacttgtgcc acctagtggg ttgcctggtt ctggtgcccc agaagttctg
     2041 ccttacttcc catctggccc accacctcca gatcctgggc tcacccctca gccttctaca
     2101 tcagagtcac ctgatgtcaa cctggtgacc cagcaactgt ccaagtctca ggtggaggac
     2161 cccctgcctc ccgtgttctc aggcactcca aagggcagtg gggctggcta cggtgttggc
     2221 tttgacctgg aggaattctt aaaccaatct tttgacatgg gtgtggctga tgggccacag
     2281 gatagccagg cagactcagc ctcactctca gcctccctcc ttgctgactg gcttgagggc
     2341 cacggcatga accccgctga cattgagtct ctgcagcgtg agatccagat ggactcccca
     2401 atgttgctgt ctgacctgcc tgacctccaa gaaccctgag acccacagct tgtgccttgc
     2461 tgccaggaca gacccagctt caaggtccag gggtgcagtc cagagggctg cagccttgag
     2521 cctggcaggt gaggctcagc ttgagttact ctgcaggttc atctcagacc caccgttcag
     2581 ccttaagcag ccgcctgagc caccaccgag ccataacagg atgggaggct ctactccttc
     2641 ctgcgcagtc ttctccagtg ttgtattttt attactgttg taatatgcat ttgttttgcc
     2701 atcgaaatga ggcctgtgaa atacaaggtt tcctttaa
//
