LOCUS       NP_001178476             812 aa            linear   ROD 24-JUN-2024
DEFINITION  mitogen-activated protein kinase 7 [Rattus norvegicus].
ACCESSION   NP_001178476 XP_002727763
VERSION     NP_001178476.1
DBSOURCE    REFSEQ: accession NM_001191547.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 812)
  AUTHORS   Devost,D., Zingg,H.H. and Hebert,T.E.
  TITLE     The MAP kinase ERK5/MAPK7 is a downstream effector of oxytocin
            signaling in myometrial cells
  JOURNAL   Cell Signal 90, 110211 (2022)
   PUBMED   34902542
  REMARK    GeneRIF: The MAP kinase ERK5/MAPK7 is a downstream effector of
            oxytocin signaling in myometrial cells.
REFERENCE   2  (residues 1 to 812)
  AUTHORS   Guo,T.M., Xing,Y.L., Zhu,H.Y., Yang,L., Liu,G.X. and Qiao,X.M.
  TITLE     Extracellular regulated kinase 5 mediates osteoporosis through
            modulating viability and apoptosis of osteoblasts in ovariectomized
            rats
  JOURNAL   Biosci Rep 39 (9) (2019)
   PUBMED   31413169
  REMARK    GeneRIF: Extracellular regulated kinase 5 mediates osteoporosis
            through modulating viability and apoptosis of osteoblasts in
            ovariectomized rats.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 812)
  AUTHORS   Kashino,Y., Obara,Y., Okamoto,Y., Saneyoshi,T., Hayashi,Y. and
            Ishii,K.
  TITLE     ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type
            Current in PC12 Cells
  JOURNAL   Int J Mol Sci 19 (7), 2008 (2018)
   PUBMED   29996472
  REMARK    GeneRIF: Study revealed that ERK5 signaling promotes
            phosphorylation of Kv4.2 and inhibits the inactivation of the
            A-type current for the enhancement of membrane excitability in PC12
            cells. ERK5 promotes neurite outgrowth and catecholamine
            biosynthesis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 812)
  AUTHORS   Liu,W., Ruiz-Velasco,A., Wang,S., Khan,S., Zi,M., Jungmann,A.,
            Dolores Camacho-Munoz,M., Guo,J., Du,G., Xie,L., Oceandy,D.,
            Nicolaou,A., Galli,G., Muller,O.J., Cartwright,E.J., Ji,Y. and
            Wang,X.
  TITLE     Metabolic stress-induced cardiomyopathy is caused by mitochondrial
            dysfunction due to attenuated Erk5 signaling
  JOURNAL   Nat Commun 8 (1), 494 (2017)
   PUBMED   28887535
  REMARK    GeneRIF: Erk5 role in the cardiac mitochondria and the Pgc-1alpha
            regulation
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 812)
  AUTHORS   Obara,Y., Nagasawa,R., Nemoto,W., Pellegrino,M.J., Takahashi,M.,
            Habecker,B.A., Stork,P.J.S., Ichiyanagi,O., Ito,H., Tomita,Y.,
            Ishii,K. and Nakahata,N.
  TITLE     ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis
            in adrenal medullary cells
  JOURNAL   Cell Signal 28 (3), 177-189 (2016)
   PUBMED   26739108
  REMARK    GeneRIF: ERK5 signaling is required for catecholamine biosynthesis
            during neural differentiation, in part to induce ankrd1, and to
            maintain appropriate TH levels.
REFERENCE   6  (residues 1 to 812)
  AUTHORS   Grewal,P.K., Holzfeind,P.J., Bittner,R.E. and Hewitt,J.E.
  TITLE     Mutant glycosyltransferase and altered glycosylation of
            alpha-dystroglycan in the myodystrophy mouse
  JOURNAL   Nat Genet 28 (2), 151-154 (2001)
   PUBMED   11381262
REFERENCE   7  (residues 1 to 812)
  AUTHORS   Dalmay,T., Horsefield,R., Braunstein,T.H. and Baulcombe,D.C.
  TITLE     SDE3 encodes an RNA helicase required for post-transcriptional gene
            silencing in Arabidopsis
  JOURNAL   EMBO J 20 (8), 2069-2078 (2001)
   PUBMED   11296239
REFERENCE   8  (residues 1 to 812)
  AUTHORS   Yan,C., Luo,H., Lee,J.D., Abe,J. and Berk,B.C.
  TITLE     Molecular cloning of mouse ERK5/BMK1 splice variants and
            characterization of ERK5 functional domains
  JOURNAL   J Biol Chem 276 (14), 10870-10878 (2001)
   PUBMED   11139578
REFERENCE   9  (residues 1 to 812)
  AUTHORS   Yang,C.C., Ornatsky,O.I., McDermott,J.C., Cruz,T.F. and Prody,C.A.
  TITLE     Interaction of myocyte enhancer factor 2 (MEF2) with a
            mitogen-activated protein kinase, ERK5/BMK1
  JOURNAL   Nucleic Acids Res 26 (20), 4771-4777 (1998)
   PUBMED   9753748
REFERENCE   10 (residues 1 to 812)
  AUTHORS   Abe,J., Kusuhara,M., Ulevitch,R.J., Berk,B.C. and Lee,J.D.
  TITLE     Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive
            kinase
  JOURNAL   J Biol Chem 271 (28), 16586-16590 (1996)
   PUBMED   8663194
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XP_002727763.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1173049.1,
                                           SRR26643294.39704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     Protein         1..812
                     /product="mitogen-activated protein kinase 7"
                     /EC_number="2.7.11.24"
                     /note="ERK-5; BMK1 kinase; big MAP kinase 1; extracellular
                     signal-regulated kinase 5; BMK-1; MAPK 7; MAP kinase 7"
                     /calculated_mol_wt=88338
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Region          2..77
                     /region_name="Required for cytoplasmic targeting.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13164; propagated from
                     UniProtKB/Swiss-Prot (P0C865.1)"
     Region          49..384
                     /region_name="STKc_ERK5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Extracellular signal-Regulated Kinase 5; cd07855"
                     /db_xref="CDD:270842"
     Site            order(61..64,66..67,69,82,84,101,115,137..140,143,
                     145..146,182,184,186..187,189,199..200,203,219,221..224,
                     226,264)
                     /site_type="active"
                     /db_xref="CDD:270842"
     Site            order(61..64,66..67,69,82,84,115,137..140,143,146,184,
                     186..187,189,199..200)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270842"
     Region          78..139
                     /region_name="Required for binding to MAP2K5.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Site            order(101,145,182,184,203,219,221..224,226,264)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270842"
     Site            order(112,141..142,147,158,161,168,190..194,350,352,355)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270842"
     Region          140..406
                     /region_name="Necessary for oligomerization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Site            199..226
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270842"
     Region          219..221
                     /region_name="TXY. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Region          424..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Region          505..539
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C865.1)"
     Site            716
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13164; propagated from
                     UniProtKB/Swiss-Prot (P0C865.1)"
     Site            729
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13164; propagated from
                     UniProtKB/Swiss-Prot (P0C865.1)"
     CDS             1..812
                     /gene="Mapk7"
                     /gene_synonym="Bmk1; Erk5; Prkm7"
                     /coded_by="NM_001191547.1:1..2439"
                     /db_xref="GeneID:114509"
                     /db_xref="RGD:621505"
ORIGIN      
        1 maeplkeedg edgsgeppgr vkaepvhsaa svvaknlall karsfdvtfd vgdeyeiiet
       61 igngaygvvs sarrrltgqq vaikkipnaf dvvtnakrtl relkilkhfk hdniiaikdi
      121 lrptvpygef rsvyvvldlm esdlhqiihs sqpltlehvr yflyqllrgl kymhsaqvih
      181 rdlkpsnllv nencelkigd fgmarglcts paehqyfmte yvatrwyrap elmlslheyt
      241 qaidlwsvgc ifgemlarrq lfpgknyvhq lqlimmvlgt pspaviqavg aervrayiqs
      301 lpprqpvpwe tvypgadrqa lsllgrmlrf epsarisaaa alrhpflaky hdpddepdca
      361 ppfdfafdre altrerikea ivaeiedfha rregirqqir fqpslqpvas epvcpdvemp
      421 spwapsgdca mespppalpp csgpapdtvd ltlqpappas elappkrega isdntkaalk
      481 aallkslrsr lrdgpsaple apeprkpvta qerqrereek rrrrqerake rekrrqerer
      541 kergagtlgg pstdplaglv lsdndrslle rwtrmarppv papapapapt pkptptptqs
      601 saqptsppng pvsqstaplq pagsipgpas qpvcpppgpv pqpagpvpap lqtapstsll
      661 asqslvppsg lpgsgapevl pyfpsgpppp dpgltpqpst sespdvnlvt qqlsksqved
      721 plppvfsgtp kgsgagygvg fdleeflnqs fdmgvadgpq dsqadsasls aslladwleg
      781 hgmnpadies lqreiqmdsp mllsdlpdlq ep
//
