LOCUS       NM_019319               3596 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 4 (Mapk4), mRNA.
ACCESSION   NM_019319 XM_001053505 XM_225726
VERSION     NM_019319.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3596)
  AUTHORS   Kant,S., Schumacher,S., Singh,M.K., Kispert,A., Kotlyarov,A. and
            Gaestel,M.
  TITLE     Characterization of the atypical MAPK ERK4 and its activation of
            the MAPK-activated protein kinase MK5
  JOURNAL   J Biol Chem 281 (46), 35511-35519 (2006)
   PUBMED   16973613
REFERENCE   2  (bases 1 to 3596)
  AUTHORS   Xu,H., Dembski,M., Yang,Q., Yang,D., Moriarty,A., Tayber,O.,
            Chen,H., Kapeller,R. and Tartaglia,L.A.
  TITLE     Dual specificity mitogen-activated protein (MAP) kinase
            phosphatase-4 plays a potential role in insulin resistance
  JOURNAL   J Biol Chem 278 (32), 30187-30192 (2003)
   PUBMED   12777378
REFERENCE   3  (bases 1 to 3596)
  AUTHORS   Garcia,J.I., Zalba,G., Detera-Wadleigh,S.D. and de Miguel,C.
  TITLE     Isolation of a cDNA encoding the rat MAP-kinase homolog of human
            p63mapk
  JOURNAL   Mamm Genome 7 (11), 810-814 (1996)
   PUBMED   8875888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Sep 2, 2012 this sequence version replaced
            XM_001053505.2, XM_225726.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2425267.1,
                                           SRR26643298.74664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               JAXUCZ010000018.1  69836293-69836838   c
            547-691             JAXUCZ010000018.1  69799792-69799936   c
            692-853             JAXUCZ010000018.1  69797425-69797586   c
            854-1055            JAXUCZ010000018.1  69793150-69793351   c
            1056-3596           JAXUCZ010000018.1  69788060-69790600   c
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..3596
                     /gene="Mapk4"
                     /note="mitogen-activated protein kinase 4"
                     /db_xref="GeneID:54268"
                     /db_xref="RGD:3047"
     CDS             1..1752
                     /gene="Mapk4"
                     /EC_number="2.7.11.24"
                     /note="MNK2; ERK-4; p63-MAPK; extracellular
                     signal-regulated kinase 4; MAPK 4; MAP kinase 4"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 4"
                     /protein_id="NP_062192.1"
                     /db_xref="GeneID:54268"
                     /db_xref="RGD:3047"
                     /translation="MAEKGDCIASVYGYDLGGRFTDFQPLGFGVNGLVLSATDSRACR
                     KVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAY
                     IVQEYMETDLACLLEQGTLTEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTE
                     DLVLKIGDFGLARIADQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
                     LAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRK
                     LLPDVNREAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEI
                     DDLVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSTPLAEDVQVD
                     PRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEP
                     KLILDLSHWKQAASAPPRAAVAADPVSREDEPASLFLEIAQWVKSTQGGPERASPPPD
                     APEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLCTKPEDLPENKLGDLNGACIS
                     EHPGDLVQTEAFSKERW"
     exon            1..546
                     /gene="Mapk4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..691
                     /gene="Mapk4"
                     /inference="alignment:Splign:2.1.0"
     exon            692..853
                     /gene="Mapk4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1055
                     /gene="Mapk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..3596
                     /gene="Mapk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagaga aaggtgactg catcgccagt gtctacgggt acgaccttgg tgggcgcttc
       61 actgacttcc aacccctcgg cttcggggtc aacgggctgg tgctgtcggc tacggacagc
      121 agggcttgcc ggaaggtagc cgtgaagaag attgtgctga gtgacgcacg aagcatgaag
      181 cacgcgctcc gagagatcaa aatcatccgg cgcctggacc acgacaacat cgtcaaagtg
      241 tacgaggtac tgggacccaa gggtagcgat ctgcagggcg agctctttaa gttcagcgtg
      301 gcttatattg tccaagagta catggagact gacctggcat gcctgctaga gcagggcacg
      361 ctgaccgagg agcacgctaa gctattcatg taccagctgc tgcgtgggct caagtacatc
      421 cactctgcca acgtgttgca cagggacctg aagcccgcca acattttcat cagcacggag
      481 gacctcgtgc tgaagatcgg ggatttcggg ctggccagaa tcgcggacca gcattactcc
      541 cacaagggtt atctgtcgga agggttggtg acaaagtggt accgctctcc acgactgctc
      601 ctgtccccga acaactacac gaaagccatc gatatgtggg cagctggctg catcctagcg
      661 gagatgctca cggggaaaat gctctttgct ggggctcacg agcttgagca gatgcagctc
      721 atcctagaca ccatccctgt agtgcgggag gaagacaagg aggagctgct cagggtgatg
      781 ccgtcctttg tcagcagcac ttgggaggtg aagaggccac tgcgtaagct actcccggat
      841 gtcaaccgtg aagccattga ctttctggag aagatcctga cctttaaccc catggaccgc
      901 ctaacagctg agatggggct acagcatcct tacatgagcc cgtattcgtg ccccgaggat
      961 gagcccacct cacaacaccc cttccgcatt gaagacgaga tcgacgacct cgtactgatg
     1021 gctgccagtc agagccagct ctccaactgg gacaggtatc ccgtgagcct gtcgtcagat
     1081 ctggaatggc ggcctgaccg ctgtcaggac gcgagcgagg tgcagcgcga cccacgtgct
     1141 ggctctactc cgctggcgga ggatgttcag gtggacccac gcaaggactc acagagcagc
     1201 tccgagcgct tcctggagca gtcgcactcg tccatggagc gcgcctttga ggccgactat
     1261 ggacggtcct gcgactacaa agtggggtct ccgtcctacc tggacaagct gctgtggcgc
     1321 gacaacaagc cccaccacta ctcggaaccc aagctcatcc tggacctgtc gcactggaag
     1381 caggcggcca gcgcaccccc cagggctgca gtagcagcag acccagtgtc acgtgaggat
     1441 gagccagcaa gcctctttct ggagatcgcg cagtgggtca agagcacaca aggtggccct
     1501 gagcgtgcca gtcctccccc tgatgcccca gagccccgtc tctctgcttc acccccggga
     1561 cacccaacac ccattgatgg gggtgccagt ccccaattcg acttagatgt gttcatctcg
     1621 cgtgccctaa agctctgcac caaacctgag gacctaccgg aaaacaaact gggcgacctg
     1681 aatggtgcgt gcatctccga gcaccccggc gacctcgtgc aaacagaggc cttctccaaa
     1741 gaaaggtggt gagcacagaa ggggtgcgtg agaactcccg gagcaagacc ccacccagaa
     1801 agctggaccg cttccttgct ttcctagtac tccttcagcc cctctctgct gcattggggt
     1861 tagcagaaca cacgcgggtc cggggagcaa gaggaatgtc catttcttaa actgccttaa
     1921 taactagcct ttaacctctg ggagcgggtt tgagcagacc ctggctggga gctatcagtt
     1981 tcccatcaaa gggaaaggcc tgttgagtgt acaagggaag aaagggattt cagaccgaag
     2041 tctacagccc tacgaggagt cagaaacagc ttacagacat agtttccaag ccgtgtgacc
     2101 cacctagtcc caaattgaca tttgggccca gtgaagccat taggaccaca agcctggtgg
     2161 tgtcaggata aagcctgtgt cccaagctcc tatccctgga ccagtgtctg accacagtat
     2221 aatgtcttcc tctgctgggg ccactctgac tttttggtca gaaaacggtc ccgagtgctt
     2281 ctcgctttcc cttactgtct gtcccatcct tccctttaat ttagacctgt ggctcctgtt
     2341 ttccgaaacc ggaaacagaa ccggtttctt tttcctagtc gccagacata tttctacgac
     2401 tccccaagtg cttaaatgtc ctcacctgcc acctccctgt attaacccaa cccagctcag
     2461 tctgaagtta ctccttccta gcagaacagt ttgggggctg cttaaactta gtcatctccc
     2521 aggcctgtgc ctacagcctc ctcctgcacg ccctatgcac tttcctgact caacacagcc
     2581 attgttctcc agtggagatc ctacagggat gagtttaaag acggaaattg cgagaatccc
     2641 tcttgtctaa tccccagcat cccacccacc ccacccacac acacacagct cctctccaag
     2701 acgatttcag gaccaaatgt tcttggcaca aatggctcat ttgtaggaga agcaataagg
     2761 tgctttccat aaaaacaaat gagttaggag ggaagactcc gcagaacacc catcatcctt
     2821 cattaatgtc gcccaggatc attttagtcc tagccaggag tagaccctaa agggatggcc
     2881 tgagagatag caaccttcgg gcaagagacc cagaaagata aaccaggagt ttaaagaaag
     2941 gtcctaacct cgggtgtcct caagagccag ctatcaaggt ggagaacccg aggcaaagaa
     3001 agggattcaa agtaatcgca tcctggtggc tcaggttaag agaaacttgg aatcagttcc
     3061 aagcctctgc aggaaaagca tggggcaggg ggttgagggg aataccaaca gtccctggtc
     3121 tgttcctgaa cactccgcca ctggtatcta tcctcccctc cccctgccga catcccaaag
     3181 atacccacga gaggtccagc tgctctgttg agagatctcc ttgggctgtg ttcattctca
     3241 cgacgcagca ccttaaatct cgctgactgt ggtttgtaca ttgaaacgta cagtgcatca
     3301 gaaacatata ttttaaaaca atcatgctga ccgggttttt aagtggaaag tatgtaaata
     3361 taaagggttt aggttttatt cctttttttt ttctttaaga aaaaaatgca atgcacacca
     3421 ccccttatgt gccatttgtc gtcgggggga agctttactt tttgagtaaa gggacatgct
     3481 gctgactgac cgctagctca cggagaattg tgataattag tcatgttctt aaaagaatct
     3541 gttaaatatt attaaacttg atcaggatga gccaaataaa gttttattgg aacata
//
