LOCUS       NM_017347               1796 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase 3 (Mapk3), mRNA.
ACCESSION   NM_017347 XM_001079997
VERSION     NM_017347.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Rahamim,N., Liran,M., Aronovici,C., Flumin,H., Gordon,T.,
            Urshansky,N. and Barak,S.
  TITLE     Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats
  JOURNAL   Int J Mol Sci 25 (10), 5478 (2024)
   PUBMED   38791516
  REMARK    GeneRIF: Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Jia,X., Song,Y., Li,Z., Yang,N., Liu,T., Han,D., Sun,Z., Shi,C.,
            Zhou,Y., Shi,J., Liu,Y. and Guo,X.
  TITLE     Melatonin regulates the circadian rhythm to ameliorate
            postoperative sleep disorder and neurobehavioral abnormalities in
            aged mice
  JOURNAL   CNS Neurosci Ther 30 (3), e14436 (2024)
   PUBMED   37736695
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Mukhomedzyanov,A.V., Popov,S.V., Maslov,L.N., Diez,E.R. and
            Azev,V.N.
  TITLE     Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective
            Effect of Deltorphin II during Cardiac Reperfusion
  JOURNAL   Bull Exp Biol Med 175 (1), 17-19 (2023)
   PUBMED   37338759
  REMARK    GeneRIF: Role of PI3K, ERK1/2, and JAK2 Kinases in the
            Cardioprotective Effect of Deltorphin II during Cardiac
            Reperfusion.
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Xiao,X., Zou,S. and Chen,J.
  TITLE     Cyclic tensile force modifies calvarial osteoblast function via the
            interplay between ERK1/2 and STAT3
  JOURNAL   BMC Mol Cell Biol 24 (1), 9 (2023)
   PUBMED   36890454
  REMARK    GeneRIF: Cyclic tensile force modifies calvarial osteoblast
            function via the interplay between ERK1/2 and STAT3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Marquardt,B. and Stabel,S.
  TITLE     Sequence of a rat cDNA encoding the ERK1-MAP kinase
  JOURNAL   Gene 120 (2), 297-299 (1992)
   PUBMED   1327976
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   De Miguel,C., Kligman,D., Patel,J. and Detera-Wadleigh,S.D.
  TITLE     Molecular analysis of microtubule-associated protein-2 kinase cDNA
            from mouse and rat brain
  JOURNAL   DNA Cell Biol 10 (7), 505-514 (1991)
   PUBMED   1716439
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Seger,R., Ahn,N.G., Boulton,T.G., Yancopoulos,G.D., Panayotatos,N.,
            Radziejewska,E., Ericsson,L., Bratlien,R.L., Cobb,M.H. and
            Krebs,E.G.
  TITLE     Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo
            autophosphorylation on both tyrosine and threonine residues:
            implications for their mechanism of activation
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6142-6146 (1991)
   PUBMED   1712480
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Boulton,T.G., Gregory,J.S. and Cobb,M.H.
  TITLE     Purification and properties of extracellular signal-regulated
            kinase 1, an insulin-stimulated microtubule-associated protein 2
            kinase
  JOURNAL   Biochemistry 30 (1), 278-286 (1991)
   PUBMED   1846291
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 24, 2020 this sequence version replaced NM_017347.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12008.1, SRR26643287.2264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000001.1  190797194-190797400
            208-390             JAXUCZ010000001.1  190798318-190798500
            391-580             JAXUCZ010000001.1  190800623-190800812
            581-697             JAXUCZ010000001.1  190800985-190801101
            698-812             JAXUCZ010000001.1  190801334-190801448
            813-944             JAXUCZ010000001.1  190801795-190801926
            945-1054            JAXUCZ010000001.1  190802084-190802193
            1055-1209           JAXUCZ010000001.1  190802272-190802426
            1210-1796           JAXUCZ010000001.1  190802825-190803411
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1796
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /note="mitogen activated protein kinase 3"
                     /db_xref="GeneID:50689"
                     /db_xref="RGD:3046"
     exon            1..207
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1177
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /EC_number="2.7.11.24"
                     /note="MAP kinase 1; insulin-stimulated MAP2 kinase;
                     extracellular signal-regulated kinase 1;
                     microtubule-associated protein 2 kinase; MAP kinase 3;
                     mitogen-activated protein kinase 1; MAPK 1; MAPK 3;
                     mitogen-activated 3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 3"
                     /protein_id="NP_059043.2"
                     /db_xref="GeneID:50689"
                     /db_xref="RGD:3046"
                     /translation="MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYT
                     QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI
                     GIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS
                     ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML
                     NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM
                     KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY
                     YDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP"
     exon            208..390
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..580
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..697
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..812
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..944
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1054
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1209
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1796
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; ERK1; ERT2; Esrk1; MAPK1; MNK1; p44;
                     p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggcag cggggggagg cgggaggagt ggagatggcg gcggcggcgg cggctccggg
       61 gggcgggggc ggggagccca ggggaactgc tggggtcgtc ccggtggtcc ccggggaggt
      121 ggaggtggtg aaggggcagc cattcgacgt gggcccacgc tacacgcagc tgcagtacat
      181 cggcgagggc gcgtacggca tggtcagctc agcatatgac cacgtgcgca agaccagagt
      241 ggctatcaag aagatcagcc ccttcgagca tcaaacctac tgtcagcgca cgctgagaga
      301 aatccagatc ttgctgcgat tccgccatga gaatgtcata ggcatccgag acatcctcag
      361 agcacccacc ctggaagcca tgagagatgt ttacattgtt caggacctca tggagacgga
      421 cctgtacaag ctgctaaaga gccagcagct gagcaatgac cacatctgct acttcctcta
      481 ccagatcctc cggggcctca agtacataca ctcggccaat gtgctgcacc gggacctgaa
      541 gccctccaat ctgcttatca acaccacctg cgaccttaag atctgtgatt ttggccttgc
      601 ccggattgct gaccctgagc acgaccacac tggctttctt accgagtatg tggccacacg
      661 ctggtaccga gccccagaga tcatgcttaa ctccaagggc tacaccaaat ccattgacat
      721 ctggtctgtg ggctgcattc tggctgagat gctctccaac cggcctatct tccccggcaa
      781 gcactacctg gaccagctca accacattct aggtatactg ggttccccat cccaagagga
      841 cctaaattgt atcattaaca tgaaggcccg aaactaccta cagtctctgc cctctaaaac
      901 caaggtggct tgggccaagc tttttcccaa atctgactcc aaagctcttg acctgctgga
      961 ccggatgtta acctttaacc caaacaagcg catcacagta gaggaagcac tggctcaccc
     1021 ttacctggaa cagtactatg atccgacaga tgaaccagtg gctgaggagc cattcacctt
     1081 tgacatggag ctggatgatc tccccaagga gcggctgaag gagctgatct tccaagagac
     1141 agcccgcttc cagccagggg caccagaggc cccctaacaa gaacagacac ccctgtcctt
     1201 ttggacctgg tcctgctcct acctgctcct tctctgcaga ttgttagaaa atgaactttg
     1261 ctcaacccgg accccggcag cccaggctgg accaagggtg ggcctggcca ccccctctca
     1321 ctctgctggg gtctcctgct tcaagcaggc ttctcccact ccagtcccct gccccatctc
     1381 cccttgacct gagtgatgag gtggtcccag agctgatctc tgctgctgtg tctttatcta
     1441 tccctgctag ccccagctct ggtagacggt tctggaatgg aagggctatg accgccctag
     1501 gacctgtgct acagaggggt ggagggcact gagtaggcta agctctgccc tactcatcct
     1561 gttggaaccc caccccattt tccctgacag aacattccta aatctcaagg gctagtttcc
     1621 ctgaggagcc aggcctaggc ctaaccctct ccctctcaag ctgccacatg taacgccctt
     1681 gctgcttctg tgtgtgggtg attggatgtg gaggtggggc ccgtggagag cccgtgcccc
     1741 tccccacctc cctgtgcctg tatctaatat ataaatatag agatgtgtat atggat
//
