LOCUS       NM_173331               1888 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 15 (Mapk15),
            mRNA.
ACCESSION   NM_173331
VERSION     NM_173331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Kazatskaya,A., Kuhns,S., Lambacher,N.J., Kennedy,J.E., Brear,A.G.,
            McManus,G.J., Sengupta,P. and Blacque,O.E.
  TITLE     Primary Cilium Formation and Ciliary Protein Trafficking Is
            Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis
            elegans and Human Cells
  JOURNAL   Genetics 207 (4), 1423-1440 (2017)
   PUBMED   29021280
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Bermingham,D.P., Hardaway,J.A., Refai,O., Marks,C.R., Snider,S.L.,
            Sturgeon,S.M., Spencer,W.C., Colbran,R.J., Miller,D.M. 3rd and
            Blakely,R.D.
  TITLE     The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine
            Transporters through a Rho-Dependent Mechanism
  JOURNAL   J Neurosci 37 (38), 9288-9304 (2017)
   PUBMED   28842414
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Liwak-Muir,U., Dobson,C.C., Naing,T., Wylie,Q., Chehade,L.,
            Baird,S.D., Chakraborty,P.K. and Holcik,M.
  TITLE     ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4
            through a miR-21 dependent mechanism
  JOURNAL   Oncotarget 7 (2), 1439-1450 (2016)
   PUBMED   26595526
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Miyatake,K., Kusakabe,M., Takahashi,C. and Nishida,E.
  TITLE     ERK7 regulates ciliogenesis by phosphorylating the actin regulator
            CapZIP in cooperation with Dishevelled
  JOURNAL   Nat Commun 6, 6666 (2015)
   PUBMED   25823377
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Chia,J., Tham,K.M., Gill,D.J., Bard-Chapeau,E.A. and Bard,F.A.
  TITLE     ERK8 is a negative regulator of O-GalNAc glycosylation and cell
            migration
  JOURNAL   Elife 3, e01828 (2014)
   PUBMED   24618899
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Henrich,L.M., Smith,J.A., Kitt,D., Errington,T.M., Nguyen,B.,
            Traish,A.M. and Lannigan,D.A.
  TITLE     Extracellular signal-regulated kinase 7, a regulator of
            hormone-dependent estrogen receptor destruction
  JOURNAL   Mol Cell Biol 23 (17), 5979-5988 (2003)
   PUBMED   12917323
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Abe,M.K., Saelzler,M.P., Espinosa,R. 3rd, Kahle,K.T.,
            Hershenson,M.B., Le Beau,M.M. and Rosner,M.R.
  TITLE     ERK8, a new member of the mitogen-activated protein kinase family
  JOURNAL   J Biol Chem 277 (19), 16733-16743 (2002)
   PUBMED   11875070
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Abe,M.K., Kahle,K.T., Saelzler,M.P., Orth,K., Dixon,J.E. and
            Rosner,M.R.
  TITLE     ERK7 is an autoactivated member of the MAPK family
  JOURNAL   J Biol Chem 276 (24), 21272-21279 (2001)
   PUBMED   11287416
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Abe,M.K., Kuo,W.L., Hershenson,M.B. and Rosner,M.R.
  TITLE     Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a
            C-terminal domain that regulates its activity, its cellular
            localization, and cell growth
  JOURNAL   Mol Cell Biol 19 (2), 1301-1312 (1999)
   PUBMED   9891064
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Qian,Z., Okuhara,D., Abe,M.K. and Rosner,M.R.
  TITLE     Molecular cloning and characterization of a mitogen-activated
            protein kinase-associated intracellular chloride channel
  JOURNAL   J Biol Chem 274 (3), 1621-1627 (1999)
   PUBMED   9880541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF078798.2.
            
            On May 3, 2007 this sequence version replaced NM_173331.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF078798.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1888              AF078798.2         117-2004
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1888
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /note="mitogen-activated protein kinase 15"
                     /db_xref="GeneID:286997"
                     /db_xref="RGD:628675"
     exon            1..109
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1684
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /EC_number="2.7.11.24"
                     /note="ERK-7; MAPK 15; MAP kinase 15; extracellular
                     signal-regulated kinase 7; extracellular signal-regulated
                     kinase 8"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 15"
                     /protein_id="NP_775453.1"
                     /db_xref="GeneID:286997"
                     /db_xref="RGD:628675"
                     /translation="MCAAEVDRHVSQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKK
                     IFDAFRDQTDAQRTFREIMLLREFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNA
                     VIQKGRLLEDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDAACRVKLCDFGLA
                     RSLSDFPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPL
                     FPGTSTFHQLELILETIPLPSMEELQGLGSDYSALILQNLGSRPRQTLDALLPPDTPP
                     EALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWTRGSDVRLPVHEGDQLSAP
                     EYRNRLYQMILERRRNSRSPREEDLGVVASRAELRASQRQSLKPGVLPQVLAETPARK
                     RGPKPQNGHGHDPEHVEVRRQSSDPLYQLPPPGSGERPPGATGEPPSAPSGVKTHVRA
                     VAPSLTSQAAAQAANQPLIRSDPARGGGPRAVGARRVPSRLPREAPEPRPGRRMFGIS
                     VSQGAQGAARAALGGYSQAYGTVCRSALGRLPLLPGPRA"
     exon            110..208
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            209..238
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            239..329
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            330..460
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            461..624
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..764
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            765..822
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            823..960
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1066
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1265
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1369
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1498
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1872
                     /gene="Mapk15"
                     /gene_synonym="ERK-8; Erk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaatcgg tggacaaaga gccagcgtct gcctctcacc atgtgtgctg ccgaggtgga
       61 ccgtcatgta tcccagagat acctgatcaa gcggaggctt gggaaggggg cctacggcat
      121 tgtatggaag gccatggacc ggaggactgg tgaggtagtg gccatcaaga aaatctttga
      181 tgcctttagg gaccagacag atgctcagag gaccttccgt gaaatcatgc ttctccggga
      241 gtttgggggc catcccaaca tcatccgcct gcttgatgta atcccagcaa agaatgacag
      301 ggatatttac ctggtgtttg agtccatgga caccgacctg aacgcggtca tccagaaggg
      361 cagactgttg gaggacatcc acaaacgttg catcttttac cagctcctga gagccaccaa
      421 gtttatccat tcagggcgcg tcattcaccg ggaccagaag ccagccaacg ttctattgga
      481 tgctgcttgc cgggtgaaac tatgtgactt tggcctggca cgctccctca gtgacttccc
      541 tgaagggcct gggggccagg ccctgacaga atatgtggcc acacgctggt accgagctcc
      601 agaggtgctt ctgtcttccc gatggtatac ccctggggtg gacatgtgga gcctgggctg
      661 catactggga gagatgcttc gagggcagcc actgtttccg ggtacatcta ctttccacca
      721 gctggagctg atcctggaga ccattccatt gccctccatg gaggagctcc agggccttgg
      781 atcagactac agtgctttga ttctgcagaa tcttggatcc aggccacggc agacgctgga
      841 cgccctcctg ccgccagaca cccccccaga agccctggac ctcctcaagc gactcttggc
      901 atttgctccg gacaaacggc ttagtgcaga gcaggctctt caacaccctt acgtgcagag
      961 attccattgc cccgaccgcg agtggacacg ggggtccgat gtgcggctcc cggtacacga
     1021 aggagaccag ctctctgcac cagagtatcg caaccgcctg taccagatga tcctggagcg
     1081 gagacggaac agccgcagcc ctcgagagga agacttgggg gttgtggcct cgcgggcaga
     1141 gctcagggct tcccagaggc aatcgctcaa gcccggagtc ctcccccagg tcttggcgga
     1201 gacgcctgcg cggaaacgcg gacccaaacc tcagaatggc catggtcacg atcccgagca
     1261 tgtggaagtt cgcaggcaga gttcagaccc cctgtaccaa cttccgccgc caggcagcgg
     1321 ggaaaggccc ccaggggcca caggggagcc accctccgca ccctcagggg tgaagactca
     1381 cgttagggcg gtggcgccct ccctgacttc acaggccgcg gctcaggcgg ccaatcagcc
     1441 tctgatccgc agtgatccgg cccggggcgg tgggccaagg gctgtcggcg cgcgacgggt
     1501 cccttcccgc ctgccccggg aggccccgga accccgaccc ggccgaagga tgtttggcat
     1561 ctcggtctcg cagggggccc agggtgcagc cagagctgct cttggcggct actcccaggc
     1621 ctacgggacc gtgtgccgct ccgcgctggg ccgcctgcct ctgctccccg gaccgcgtgc
     1681 gtgagccgcc caccaacctc cttgcggcaa actggcgccg gcccccagac cccagcgcat
     1741 catctccctt ctctgcctcc ccgccttcga gttccaggag ggttctctga gcctctctcc
     1801 cctaaggggg agtagatgga ggtttccact ccacccccaa caatttattc caataaagtt
     1861 ttatctttct taaaaaaaaa aaaaaaaa
//
