LOCUS       NM_019231               1862 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase 13 (Mapk13),
            mRNA.
ACCESSION   NM_019231
VERSION     NM_019231.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Wang,S., Wang,A., Zhang,Y., Zhu,K., Wang,X., Chen,Y. and Wu,J.
  TITLE     The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas
  JOURNAL   BMC Endocr Disord 21 (1), 235 (2021)
   PUBMED   34814904
  REMARK    GeneRIF: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Teng,M., Jiang,X.P., Zhang,Q., Zhang,J.P., Zhang,D.X., Liang,G.P.
            and Huang,Y.S.
  TITLE     Microtubular stability affects pVHL-mediated regulation of
            HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes
  JOURNAL   PLoS One 7 (4), e35017 (2012)
   PUBMED   22506063
  REMARK    GeneRIF: Microtubular structure breakdown activated p38/MAPK
            pathway, accompanied with the upregulation of pVHL.
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Zhong,J., Lardinois,D., Szilard,J., Tamm,M. and Roth,M.
  TITLE     Rat mesothelioma cell proliferation requires p38delta mitogen
            activated protein kinase and C/EBP-alpha
  JOURNAL   Lung Cancer 73 (2), 166-170 (2011)
   PUBMED   21227534
  REMARK    GeneRIF: in pleural mesothelioma, p38 delta and C/EBP-alpha mediate
            proliferation and thus may represent new targets in mesothelioma
            therapy
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Pillai,M.S., Sapna,S. and Shivakumar,K.
  TITLE     p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts
  JOURNAL   Int J Biochem Cell Biol 43 (6), 919-927 (2011)
   PUBMED   21420505
  REMARK    GeneRIF: regulates G1-S transition in hypoxic cardiac fibroblasts
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Leong,D.J., Li,Y.H., Gu,X.I., Sun,L., Zhou,Z., Nasser,P.,
            Laudier,D.M., Iqbal,J., Majeska,R.J., Schaffler,M.B.,
            Goldring,M.B., Cardoso,L., Zaidi,M. and Sun,H.B.
  TITLE     Physiological loading of joints prevents cartilage degradation
            through CITED2
  JOURNAL   FASEB J 25 (1), 182-191 (2011)
   PUBMED   20826544
  REMARK    GeneRIF: Studies identify a novel regulatory pathway involving
            CITED2 and p38delta, which may be critical for the maintenance of
            articular cartilage integrity under normal physical activity
            levels.
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Sabio,G., Arthur,J.S., Kuma,Y., Peggie,M., Carr,J., Murray-Tait,V.,
            Centeno,F., Goedert,M., Morrice,N.A. and Cuenda,A.
  TITLE     p38gamma regulates the localisation of SAP97 in the cytoskeleton by
            modulating its interaction with GKAP
  JOURNAL   EMBO J 24 (6), 1134-1145 (2005)
   PUBMED   15729360
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Schoorlemmer,J. and Goldfarb,M.
  TITLE     Fibroblast growth factor homologous factors and the islet brain-2
            scaffold protein regulate activation of a stress-activated protein
            kinase
  JOURNAL   J Biol Chem 277 (51), 49111-49119 (2002)
   PUBMED   12244047
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Hu,M.C., Wang,Y.P., Mikhail,A., Qiu,W.R. and Tan,T.H.
  TITLE     Murine p38-delta mitogen-activated protein kinase, a
            developmentally regulated protein kinase that is activated by
            stress and proinflammatory cytokines
  JOURNAL   J Biol Chem 274 (11), 7095-7102 (1999)
   PUBMED   10066767
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Parker,C.G., Hunt,J., Diener,K., McGinley,M., Soriano,B.,
            Keesler,G.A., Bray,J., Yao,Z., Wang,X.S., Kohno,T. and
            Lichenstein,H.S.
  TITLE     Identification of stathmin as a novel substrate for p38 delta
  JOURNAL   Biochem Biophys Res Commun 249 (3), 791-796 (1998)
   PUBMED   9731215
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Goedert,M., Cuenda,A., Craxton,M., Jakes,R. and Cohen,P.
  TITLE     Activation of the novel stress-activated protein kinase SAPK4 by
            cytokines and cellular stresses is mediated by SKK3 (MKK6);
            comparison of its substrate specificity with that of other SAP
            kinases
  JOURNAL   EMBO J 16 (12), 3563-3571 (1997)
   PUBMED   9218798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019231.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107849.1, AF092534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000020.1  6837019-6837203
            186-315             JAXUCZ010000020.1  6837639-6837768
            316-374             JAXUCZ010000020.1  6838788-6838846
            375-483             JAXUCZ010000020.1  6842295-6842403
            484-513             JAXUCZ010000020.1  6842538-6842567
            514-561             JAXUCZ010000020.1  6843130-6843177
            562-676             JAXUCZ010000020.1  6843300-6843414
            677-748             JAXUCZ010000020.1  6843500-6843571
            749-828             JAXUCZ010000020.1  6844594-6844673
            829-907             JAXUCZ010000020.1  6844811-6844889
            908-1084            JAXUCZ010000020.1  6844991-6845167
            1085-1862           JAXUCZ010000020.1  6845337-6846114
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1862
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /note="mitogen activated protein kinase 13"
                     /db_xref="GeneID:29513"
                     /db_xref="RGD:3045"
     exon            1..185
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1167
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /EC_number="2.7.11.24"
                     /note="MAP kinase p38 delta; stress-activated protein
                     kinase 4; mitogen-activated protein kinase p38 delta; MAPK
                     13; MAP kinase 13"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 13"
                     /protein_id="NP_062104.3"
                     /db_xref="GeneID:29513"
                     /db_xref="RGD:3045"
                     /translation="MSLIRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAID
                     KRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVYTPATSVRNFQD
                     FYLVMPFMQTDLQKIMGMEFSEEKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNE
                     DCELKILDFGLARHTDAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT
                     GKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPR
                     ASPQAVDLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEREKLS
                     VDEWKQHIYKEIANFSPIARKDSRRRSGMKLQ"
     exon            186..315
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            316..374
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            375..483
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            484..513
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            514..561
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            562..676
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            677..748
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            749..828
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            829..907
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1084
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1862
                     /gene="Mapk13"
                     /gene_synonym="Prkm13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggccgg gagcccgcgg gcagccaccg caacctcctc gcagggccgc caccacgggg
       61 tccgggatga gcctcattcg gaaaaggggc ttctacaagc aggacatcaa caagactgcc
      121 tgggagctgc ccaagaccta cctggcgccc gcgcacgtcg gcagcggggc ctatggcgcg
      181 gtgtgctcgg ccatcgacaa gcggacaggg gagaaggtgg ccatcaagaa gctgagccgg
      241 cccttccagt cggagatctt tgccaagcgc gcttaccgcg aactcctgct gttgaagcac
      301 atgcaccatg agaacgtcat tgggcttctg gatgtctaca cacctgccac ttccgttcga
      361 aacttccaag atttctacct ggtgatgcct ttcatgcaga ccgacctgca gaagataatg
      421 gggatggagt tcagtgagga gaaggtccag tatttggtgt accagatgct caaaggtcta
      481 aagtacatcc actcagctgg tatcgttcac agggacctga agccaggcaa cctggccgtg
      541 aatgaagact gtgagctgaa gatcctggac tttgggctgg cacgccacac ggacgcggag
      601 atgactggct atgtggtgac ccgctggtac cgggctcctg aggtgatcct cagctggatg
      661 cattacaacc agacggtgga tatctggtct gttggctgca tcatggccga gatgctaacc
      721 ggaaagacac tcttcaaggg taaggactac ctggaccagc tgacccagat cctgaaagtg
      781 actggggtgc caggtgccga gttcgtgcag aagctgaaag acaaggcggc caaatcctac
      841 attcagtccc tgccccagag ccccaagaag gatttcacac agcttttccc acgcgccagc
      901 ccgcaagctg tagacctgct ggacaagatg ctggagctgg acgtggacaa gcgtctgacc
      961 gctgctcagg cactcgctca ccccttcttt gaacccttcc gggaccctga ggaggagaca
     1021 gaggcccagc agccatttga tgatgcctta gagcgggaga aactcagcgt ggacgaatgg
     1081 aaacaacaca tctacaaaga gatcgccaac ttcagtccca tagcccggaa ggactcgagg
     1141 cgacgaagtg ggatgaagct gcagtgactg cccgatctaa cctgcggctg agcctgagac
     1201 tgtgacaggg ccaaactctc cctcaggacc aatattattt tgtcactact tctatctcag
     1261 ggtttatagg aatgtagtgt cctgagccga gggaagaatc ttccgatggc ctaaggttca
     1321 ggcctgaggg agaattccag cctgctgttt ggggggtggg ggtggggtgt attaaaacaa
     1381 acatgtgggt gattgcctgg ctgtggggtc ccttccttcc tggagggttg ggaccaagga
     1441 tatgtcagtc aggctgaggg ccttataggg aatgactagg gtctgcttct ggggtggggg
     1501 ggggaggtgc agcacagacc aggatgaggg cttaaagaga tgactgcctt ttaccttttt
     1561 ggaggtcaga atatatatat tcacatgtag cccaggctgt cctccatgta gcccaggctg
     1621 accttgagtc ttcctcttct cctttttttt ttcttttttt tcggagctgg ggaccgaacc
     1681 cagggccttg cgcttcctag gcaagcgctc taccactgag ctaaattccc aacccccctc
     1741 ttctcctttt ttgaaacagc atctcatctg gctatgttgc cctggagcac tgcctggcct
     1801 ggaactcaag agctctacct gcctctgttt ctgggtggtg ggattaaagg cgtgcaccac
     1861 ca
//
