LOCUS       NM_021746               1666 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12),
            mRNA.
ACCESSION   NM_021746
VERSION     NM_021746.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Wang,S., Wang,A., Zhang,Y., Zhu,K., Wang,X., Chen,Y. and Wu,J.
  TITLE     The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas
  JOURNAL   BMC Endocr Disord 21 (1), 235 (2021)
   PUBMED   34814904
  REMARK    GeneRIF: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Zheng,A., Cao,L., Qin,S., Chen,Y., Li,Y. and Zhang,D.
  TITLE     Exenatide Regulates Substrate Preferences Through the p38gamma MAPK
            Pathway After Ischaemia/Reperfusion Injury in a Rat Heart
  JOURNAL   Heart Lung Circ 26 (4), 404-412 (2017)
   PUBMED   27574735
  REMARK    GeneRIF: These results demonstrated that Exenatide improved cardiac
            function, increased translocation of GLUTs, and suppressed
            translocation of FAT/CD36 after myocardial I/R injury. This
            protective effect was mediated, at least in part, through
            modulation of the cardiac p38gamma MAPK.
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Cuenda,A. and Rousseau,S.
  TITLE     p38 MAP-kinases pathway regulation, function and role in human
            diseases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1358-1375 (2007)
   PUBMED   17481747
  REMARK    Review article
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Yin,J., Liu,Y.H., Xu,Y.F., Zhang,Y.J., Chen,J.G., Shu,B.H. and
            Wang,J.Z.
  TITLE     Melatonin arrests peroxynitrite-induced tau hyperphosphorylation
            and the overactivation of protein kinases in rat brain
  JOURNAL   J Pineal Res 41 (2), 124-129 (2006)
   PUBMED   16879317
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Court,N.W., Ingley,E., Klinken,S.P. and Bogoyevitch,M.A.
  TITLE     Outer membrane protein 25-a mitochondrial anchor and inhibitor of
            stress-activated protein kinase-3
  JOURNAL   Biochim Biophys Acta 1744 (1), 68-75 (2005)
   PUBMED   15878399
  REMARK    GeneRIF: SAPK3 activity towards PDZ domain-containing substrates
            such as alpha1-Syntrophin is inhibited by outer membrane protein
            25.
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Bellon,S., Fitzgibbon,M.J., Fox,T., Hsiao,H.M. and Wilson,K.P.
  TITLE     The structure of phosphorylated p38gamma is monomeric and reveals a
            conserved activation-loop conformation
  JOURNAL   Structure 7 (9), 1057-1065 (1999)
   PUBMED   10508788
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Conrad,P.W., Rust,R.T., Han,J., Millhorn,D.E. and
            Beitner-Johnson,D.
  TITLE     Selective activation of p38alpha and p38gamma by hypoxia. Role in
            regulation of cyclin D1 by hypoxia in PC12 cells
  JOURNAL   J Biol Chem 274 (33), 23570-23576 (1999)
   PUBMED   10438538
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Hasegawa,M., Cuenda,A., Spillantini,M.G., Thomas,G.M.,
            Buee-Scherrer,V., Cohen,P. and Goedert,M.
  TITLE     Stress-activated protein kinase-3 interacts with the PDZ domain of
            alpha1-syntrophin. A mechanism for specific substrate recognition
  JOURNAL   J Biol Chem 274 (18), 12626-12631 (1999)
   PUBMED   10212242
REFERENCE   9  (bases 1 to 1666)
  AUTHORS   Lechner,C., Zahalka,M.A., Giot,J.F., Moller,N.P. and Ullrich,A.
  TITLE     ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4355-4359 (1996)
   PUBMED   8633070
REFERENCE   10 (bases 1 to 1666)
  AUTHORS   Mertens,S., Craxton,M. and Goedert,M.
  TITLE     SAP kinase-3, a new member of the family of mammalian
            stress-activated protein kinases
  JOURNAL   FEBS Lett 383 (3), 273-276 (1996)
   PUBMED   8925912
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_021746.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X96488.1, SRR26643295.29765.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000007.1  122096003-122096307 c
            306-435             JAXUCZ010000007.1  122095783-122095912 c
            436-494             JAXUCZ010000007.1  122092967-122093025 c
            495-606             JAXUCZ010000007.1  122090564-122090675 c
            607-636             JAXUCZ010000007.1  122090421-122090450 c
            637-684             JAXUCZ010000007.1  122090113-122090160 c
            685-799             JAXUCZ010000007.1  122089645-122089759 c
            800-871             JAXUCZ010000007.1  122088496-122088567 c
            872-951             JAXUCZ010000007.1  122088318-122088397 c
            952-1030            JAXUCZ010000007.1  122088169-122088247 c
            1031-1204           JAXUCZ010000007.1  122087912-122088085 c
            1205-1666           JAXUCZ010000007.1  122085913-122086374 c
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1666
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /note="mitogen-activated protein kinase 12"
                     /db_xref="GeneID:60352"
                     /db_xref="RGD:70975"
     exon            1..305
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1284
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /EC_number="2.7.11.24"
                     /note="ERK-6; MAP kinase p38 gamma; stress-activated
                     protein kinase 3; extracellular signal-regulated kinase 6;
                     mitogen-activated protein kinase p38 gamma; MAPK 12; MAP
                     kinase 12; SAP kinase-3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 12"
                     /protein_id="NP_068514.1"
                     /db_xref="GeneID:60352"
                     /db_xref="RGD:70975"
                     /translation="MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSA
                     VDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDF
                     TDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLA
                     VNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE
                     MITGKILFKGNDHLDQLKEIMKVTGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASV
                     LTNASPQAVNLLEKMLVLDAEQRVTAAEALAHPYFESLRDTEDEPKAQKYDDSFDDVD
                     RTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL"
     exon            306..435
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..494
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..606
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..636
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..684
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..799
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..871
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..951
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1030
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1204
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1666
                     /gene="Mapk12"
                     /gene_synonym="Sapk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggcggct atacagagtt cagggtggcg accccgagag aagagcccgc aaaggaaagc
       61 cccagaggcg ggcaggcggg tggccggcgc ggagccggcc ctgccacgca gtgacccggg
      121 gcgcacgggc ggagcccctg atcccaagtc cggtcctaga gcgcggtgct ccggccgggg
      181 atgagctccc cgccacccgc ccgcaagggc ttttaccgcc aggaggtgac caaaacggcc
      241 tgggaggtgc gcgccgtgta ccaggacctg cagcccgttg gctctggtgc ctatggtgca
      301 gtgtgctctg cagtagacag ccgcactggc aacaaggtgg ccatcaagaa gttgtaccgg
      361 cccttccagt cggagctgtt tgccaagcgc gcctacagag agttgcgcct cctcaaacac
      421 atgcgccacg agaacgtcat tgggctgctg gatgtgttca ctcccgatga gactctggat
      481 gacttcacag acttctacct ggtgatgcca ttcatgggca ctgacctggg caagctcatg
      541 aagcacgaga ctctgagtga agacagaatc cagtttcttg tgtatcagat gctgaagggg
      601 ctgaagtata tccacgctgc cggcgtcatc cacagggact tgaaacctgg aaacctggct
      661 gtgaacgagg actgtgagct gaagatccta gattttggcc ttgccaggca ggcggacagt
      721 gagatgacag gatatgtggt aacccggtgg tatcgggcac cagaggtcat cttgaattgg
      781 atgcgttaca cacagacagt ggacatttgg tctgttggct gcatcatggc agagatgatt
      841 actggaaaga tcctgttcaa aggcaatgac cacctggacc agctgaagga gatcatgaaa
      901 gtcacaggga caccccctcc tgagtttgta cagaagctac agagtgctga ggccaagaac
      961 tacatggaag gcctccctga gttggaaaag aaggattttg cttctgtcct gaccaatgca
     1021 agccctcagg ccgtgaatct cctggaaaag atgctggtgt tggatgcgga acagcgggtg
     1081 acagcagctg aggcattagc ccacccatac tttgagtccc ttcgggacac tgaggatgag
     1141 cccaaggccc agaaatatga tgactccttt gatgacgtag accgcaccct tgaggaatgg
     1201 aagcgtgtta cgtataagga agtgctcagc ttcaagcctc ccaggcagct aggagccaga
     1261 gttccaaagg agacagctct gtgaagacct ccgggtggtt tggggggtat cctaaggagg
     1321 ctgtctggga gcttcgcaga caccttggct tcccttctcc ggaagaggaa tcctggttgg
     1381 caccagtgcc tggtgctttt atcccaagtc atccacctgg aaaggctgtg tagacccctt
     1441 gaatcacgaa ccctccatct ccaagccagt tcttcagatt ttgagcgccc gagatgaccc
     1501 tggcagaaca tctaagcttt tttttttttc ttttttcttt ttttcggagc tggggaccga
     1561 acccagggcc ttgcacttgc taggcaagcg ctctactact gagctaaatc cccaacccca
     1621 catctaagct ttctgtccaa gacccctacc caacatggga ctagcc
//
