LOCUS       NM_001109532            1379 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase 11 (Mapk11),
            mRNA.
ACCESSION   NM_001109532 XM_001073684 XM_001073721
VERSION     NM_001109532.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y and Wu J.
  TITLE     The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas
  JOURNAL   BMC Endocr Disord 21 (1), 235 (2021)
   PUBMED   34814904
  REMARK    GeneRIF: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine
            agonist-resistant prolactinomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Hsu YL, Wang MY, Ho LJ, Huang CY and Lai JH.
  TITLE     Up-regulation of galectin-9 induces cell migration in human
            dendritic cells infected with dengue virus
  JOURNAL   J Cell Mol Med 19 (5), 1065-1076 (2015)
   PUBMED   25754930
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Liu H, Yanamandala M, Lee TC and Kim JK.
  TITLE     Mitochondrial p38beta and manganese superoxide dismutase
            interaction mediated by estrogen in cardiomyocytes
  JOURNAL   PLoS One 9 (1), e85272 (2014)
   PUBMED   24465521
  REMARK    GeneRIF: Data indicate a functionally active mitochondrial pool of
            p38beta mitogen activated protein kinase (p38beta MAPK), and that
            this kinase phosphorylates manganese superoxide dismutase (MnSOD)
            in an 17beta-estradiol (E2)-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Hua WK, Chang YI, Yao CL, Hwang SM, Chang CY and Lin WJ.
  TITLE     Protein arginine methyltransferase 1 interacts with and activates
            p38alpha to facilitate erythroid differentiation
  JOURNAL   PLoS One 8 (3), e56715 (2013)
   PUBMED   23483889
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Kogai T, Liu YY, Mody K, Shamsian DV and Brent GA.
  TITLE     Regulation of sodium iodide symporter gene expression by
            Rac1/p38beta mitogen-activated protein kinase signaling pathway in
            MCF-7 breast cancer cells
  JOURNAL   J Biol Chem 287 (5), 3292-3300 (2012)
   PUBMED   22157753
  REMARK    GeneRIF: Overexpression of p38beta or Rac1 significantly enhanced
            (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS
            expression in MCF-7 cells.
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Das M, Cui J and Das DK.
  TITLE     Generation of survival signal by differential interaction of
            p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the
            adapted heart
  JOURNAL   J Mol Cell Cardiol 42 (1), 206-213 (2007)
   PUBMED   17069850
  REMARK    GeneRIF: unique ceramide signaling in ischemic and preconditioned
            hearts involving lipid rafts, which generated a survival signal by
            differentially associating the p38MAPKalpha and p38MAPKbeta with
            the caveolin-1 and caveoli-3
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Yin J, Liu YH, Xu YF, Zhang YJ, Chen JG, Shu BH and Wang JZ.
  TITLE     Melatonin arrests peroxynitrite-induced tau hyperphosphorylation
            and the overactivation of protein kinases in rat brain
  JOURNAL   J Pineal Res 41 (2), 124-129 (2006)
   PUBMED   16879317
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri
            PL and Gherzi R.
  TITLE     p38-dependent phosphorylation of the mRNA decay-promoting factor
            KSRP controls the stability of select myogenic transcripts
  JOURNAL   Mol Cell 20 (6), 891-903 (2005)
   PUBMED   16364914
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Yang SH, Galanis A and Sharrocks AD.
  TITLE     Targeting of p38 mitogen-activated protein kinases to MEF2
            transcription factors
  JOURNAL   Mol Cell Biol 19 (6), 4028-4038 (1999)
   PUBMED   10330143
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S and Han J.
  TITLE     Characterization of the structure and function of a new
            mitogen-activated protein kinase (p38beta)
  JOURNAL   J Biol Chem 271 (30), 17920-17926 (1996)
   PUBMED   8663524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474027.1.
            
            On Sep 13, 2008 this sequence version replaced NM_001109532.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1379
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /note="mitogen-activated protein kinase 11"
                     /db_xref="GeneID:689314"
                     /db_xref="RGD:1309340"
     exon            1..187
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1166
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 11"
                     /protein_id="NP_001103002.2"
                     /db_xref="GeneID:689314"
                     /db_xref="RGD:1309340"
                     /translation="MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA
                     RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEV
                     YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE
                     DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
                     GKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHG
                     ANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTL
                     EEWKELTYQEVLSFKPLETSQLPGTHEIEQ"
     exon            188..317
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            318..376
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            377..488
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            489..518
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            519..566
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            567..681
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            682..753
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            754..833
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            834..912
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1086
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1379
                     /gene="Mapk11"
                     /gene_synonym="p38beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgggcgt ggggcgcggg ccgggtgctg cgtggggatc cggggcgctc gctccagctg
       61 cctctgcgga tatgtcgggt ccgcgcgcgg gattctaccg gcaagagctg aacaaaacag
      121 tatgggaggt gccgcagcgg ctgcagggcc tacgcccggt gggctccggc gcctacggct
      181 cggtctgttc ggcctacgac gcacggctgc gccagaaggt ggctgtgaag aagctgtctc
      241 gccctttcca atcgctgatc cacgcgagga ggacataccg tgagctacgc ctactcaaac
      301 acctgaagca cgagaacgtc ataggacttt tggacgtctt cacgccggcc acatccatcg
      361 aggatttcag cgaagtgtac ctcgtgacca ccctgatggg cgctgacctg aataacatcg
      421 tcaagtgtca ggccctgagc gatgagcatg ttcagttcct tgtctaccag ctgctgcgtg
      481 ggctgaagta tatccactcg gcgggcatca tccaccggga cctgaagccc agcaatgtag
      541 cagtgaatga ggactgcgag ctgaggatcc tggactttgg gctggcacgc caggctgatg
      601 aggagatgac tggatatgtg gccacacggt ggtaccgggc tccagagatc atgctgaact
      661 ggatgcacta caaccagaca gtggacatct ggtctgtggg ctgcatcatg gctgagctgc
      721 tccaaggaaa ggccctcttt cctggaaatg actacatcga ccagctgaag cggatcatgg
      781 aggtggtggg cacacccagc cctgaggttc tggcaaagat atcctcggag catgcccgga
      841 catacatcca gtctctgcct cccatgcccc agaaggacct cagcagtgtc ttccatgggg
      901 ccaaccctct ggctgtagac ctccttggaa gaatgctggt gctagacagt gaccagagag
      961 tcagtgcggc cgaagccttg gcccatgcat acttcagcca gtaccatgac cctgacgacg
     1021 agccagaggc cgagccctat gatgaaagtg ttgaggccaa ggagcgcacc ctggaggagt
     1081 ggaaggagct tacttaccag gaagtcctta gcttcaagcc cctggaaaca tcgcagctcc
     1141 ctggcaccca tgaaattgag cagtgaggca ttgcctgagg ggggagacct aagcctgtcc
     1201 cctttcctca gcttgctggc tttcctcaag aggtgcctct caggcagccc tgacacttaa
     1261 cctgggaccc cctagccttg agaagctcta cacctataca cacgaatgca cggatgtgtc
     1321 tgtaaccctg ctgttatgtg tcggagtctg ggcagtagtg gacctacctt ggtccaccc
//
