LOCUS       NM_001270556            2759 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase 10 (Mapk10),
            transcript variant 1, mRNA.
ACCESSION   NM_001270556
VERSION     NM_001270556.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Gonzalez-Vazquez,A., Raftery,R.M., Gunbay,S., Chen,G., Murray,D.J.
            and O'Brien,F.J.
  TITLE     Accelerating bone healing in vivo by harnessing the age-altered
            activation of c-Jun N-terminal kinase 3
  JOURNAL   Biomaterials 268, 120540 (2021)
   PUBMED   33307368
  REMARK    GeneRIF: Accelerating bone healing in vivo by harnessing the
            age-altered activation of c-Jun N-terminal kinase 3.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Tenenbaum,M., Plaisance,V., Boutry,R., Pawlowski,V., Jacovetti,C.,
            Sanchez-Parra,C., Ezanno,H., Bourry,J., Beeler,N., Pasquetti,G.,
            Gmyr,V., Dalle,S., Kerr-Conte,J., Pattou,F., Hirai,S.I.,
            Regazzi,R., Bonnefond,A., Froguel,P. and Abderrahmani,A.
  TITLE     The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic
            beta-cell proliferation during postnatal development
  JOURNAL   Cell Mol Life Sci 78 (1), 287-298 (2021)
   PUBMED   32189007
  REMARK    GeneRIF: The Map3k12 (Dlk)/JNK3 signaling pathway is required for
            pancreatic beta-cell proliferation during postnatal development.
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Wei,X., Gong,J., Ma,J., Zhang,T., Li,Y., Lan,T., Guo,P. and Qi,S.
  TITLE     Targeting the Dvl-1/beta-arrestin2/JNK3 interaction disrupts
            Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during
            cerebral ischemia reperfusion
  JOURNAL   Neuropharmacology 135, 11-21 (2018)
   PUBMED   29510185
  REMARK    GeneRIF: results indicate that Wnt5a-mediated JNK3 activation
            participates in Ischemia/Reperfusion brain injury by targeting the
            Dvl-1-beta-arrestin2/JNK3 interaction
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Tonges,L., Planchamp,V., Koch,J.C., Herdegen,T., Bahr,M. and
            Lingor,P.
  TITLE     JNK isoforms differentially regulate neurite growth and
            regeneration in dopaminergic neurons in vitro
  JOURNAL   J Mol Neurosci 45 (2), 284-293 (2011)
   PUBMED   21468718
  REMARK    GeneRIF: Data suggest that JNK isoforms are involved in
            differential regulation of neuronal death and regeneration, and
            that JNK3 appears to be required for regeneration and survival in
            the case of an environment permissive for regeneration.
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Kieran,M.W., Katz,S., Vail,B., Zon,L.I. and Mayer,B.J.
  TITLE     Concentration-dependent positive and negative regulation of a MAP
            kinase by a MAP kinase kinase
  JOURNAL   Oncogene 18 (48), 6647-6657 (1999)
   PUBMED   10597270
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Butterfield,L., Zentrich,E., Beekman,A. and Heasley,L.E.
  TITLE     Stress- and cell type-dependent regulation of transfected c-Jun
            N-terminal kinase and mitogen-activated protein kinase kinase
            isoforms
  JOURNAL   Biochem J 338 (Pt 3) (Pt 3), 681-686 (1999)
   PUBMED   10051439
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Yang,D.D., Kuan,C.Y., Whitmarsh,A.J., Rincon,M., Zheng,T.S.,
            Davis,R.J., Rakic,P. and Flavell,R.A.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Kyriakis,J.M., Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A.,
            Ahmad,M.F., Avruch,J. and Woodgett,J.R.
  TITLE     The stress-activated protein kinase subfamily of c-Jun kinases
  JOURNAL   Nature 369 (6476), 156-160 (1994)
   PUBMED   8177321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FQ084081.1, FQ211777.1 and
            FQ083521.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1) results from translation termination at the upstream
            UGA stop codon, while the longer isoform (1x) results from UGA stop
            codon readthrough to the downstream UGA termination codon. This
            RefSeq represents the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               FQ084081.1         1-262
            263-2043            FQ211777.1         262-2042
            2044-2089           FQ211777.1         2045-2090
            2090-2738           FQ211777.1         2092-2740
            2739-2759           FQ083521.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2759
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /note="mitogen activated protein kinase 10"
                     /db_xref="GeneID:25272"
                     /db_xref="RGD:3663"
     exon            1..391
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..506
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..578
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..1907
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p54-beta; SAPK-beta; c-Jun N-terminal kinase 3;
                     stress-activated protein kinase JNK3; MAPK 10; MAP kinase
                     10; Stress activated protein kinase beta"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /protein_id="NP_001257485.1"
                     /db_xref="GeneID:25272"
                     /db_xref="RGD:3663"
                     /translation="MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVAKHYNMSKSKV
                     DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ
                     THAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME
                     LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
                     MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI
                     EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD
                     LLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE
                     LIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTD
                     SSLEASAGPLGCCR"
     exon            579..748
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..878
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..937
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1076
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1242
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1314
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1497
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1622
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1686
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1764
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2743
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
     polyA_site      2743
                     /gene="Mapk10"
                     /gene_synonym="Jnk3; SAPb; SAPKC; Serk2"
ORIGIN      
        1 cacaatggta caggcagcct cccgctgcac aatggtttcc aggcagtgag agggtgattc
       61 agcaagccgc tctctcttct cttaagcctc ctcgtctccg tttattttta tgggggtggg
      121 tggtgcttct tatatgctta cccttttttt ttctattttc atttttacat atttcccttt
      181 tcttcctcac tcctcaattc ctaggggctt gagtgagcta aagattgggt cttcttggaa
      241 atcacctgtc tgttattatt tttaaacaat ctctgcacct ccaaagactc tcctccttat
      301 tccggtttgg aatgtggcta atgaaagccc agtagggagg atttctgggg caaacaggcg
      361 gaccaggatc ctggttctca ggcacggaat ggctattgtg agagcgccac cagcaggacc
      421 atcgcagatc ttggttatgg ctgctcacgc aagaggctgt tgatgtagac cccctttccc
      481 gtagatgaga aatcacacga gcagtggtat ttatgagcct ccatttctta tactactgca
      541 gtgaaccaac cttggatgtg aaaattgcct tttgtcaggg attcgacaaa cacgtggatg
      601 tgtcttctgt tgccaaacat tacaacatga gcaaaagcaa ggtagataac cagttctaca
      661 gtgtggaagt gggagactca accttcacag ttctaaagcg ctaccagaac ctgaagccga
      721 tcggctctgg ggctcaggga atagtttgtg ctgcgtatga cgctgtcctc gacagaaatg
      781 tggccattaa gaagctcagc agacccttcc agaaccaaac tcatgccaag agggcttacc
      841 gggagctggt cctcatgaag tgtgtgaacc ataaaaacat tattagctta ttaaatgtct
      901 ttacacccca gaaaacactg gaggagttcc aagatgttta cttagtgatg gaactgatgg
      961 acgccaactt gtgtcaggtg attcagatgg agctggacca cgagcggatg tcgtacttgc
     1021 tgtaccagat gctgtgcggc atcaaacacc tccactccgc tgggatcatc cacagggact
     1081 taaaacccag taacatcgta gtcaagtctg attgcacact gaaaatcctg gactttggac
     1141 tggccaggac agcgggcaca agcttcatga tgactccgta tgtggtgacg agatattaca
     1201 gagcccccga ggtcatcctg ggcatgggct acaaggagaa cgtggacata tggtctgtgg
     1261 gctgcatcat gggagaaatg gttcgtcaca aaatcctctt tcccggaagg gactatattg
     1321 accagtggaa caaagtcata gagcagctag gaactccgtg tccagaattc atgaagaaat
     1381 tgcagcccac cgtcagaaac tacgtggaga accggcccaa gtatgcaggc ctcaccttcc
     1441 ccaagctctt tccagattcc ctcttcccag cggattccga gcacaataaa cttaaagcca
     1501 gccaagccag ggacttgttg tcaaagatgt tagtgattga cccagcgaag aggatatcgg
     1561 tggatgacgc attgcagcat ccgtacatca acgtttggta cgaccctgct gaagtggagg
     1621 cgcctccgcc tcagatatat gacaagcaac tggatgaaag ggagcacacc atcgaagaat
     1681 ggaaagaact catctacaag gaagtaatga actcagaaga gaagactaag aacggcgtag
     1741 tcaaaggcca gccctcacct tcaggtgcag cagtgaacag cagtgagagt ctccctccat
     1801 cctcgtctgt caacgacatc tcctccatgt ccaccgacca gaccctcgca tccgacactg
     1861 acagcagcct ggaagcctcg gcgggaccgc tgggttgttg caggtgacta gccgcctgcc
     1921 tgcgaaaccc agcgttcttc aggagatgac gccatgatag aacacagcgc acatgcacac
     1981 acacagagct tgtacacaca cacacacaca cacacacacg cacgcacgca cacacacaca
     2041 cacgaacgca cgcaagcacg cacgcacaaa tgcactcacg caatgtcaag aaaaaaaaag
     2101 tagcgagaga gagcgagaga gccaacgtaa aactaagtta aatctttctg cgtgcttctc
     2161 cagagttctg tatcgcagct gagctgaaat gtatacttaa cttctagtcg cgctcgcgcg
     2221 ctcgcgcgct cgctttggtc tccctccggc agtgcttact acacaagaca aaccagacac
     2281 aattagagaa gcctttccct aaagtgtaac ttaagtggct gcagaaccag caacctgtaa
     2341 ccgcccttca aatggcatga ggaggtgggc accggccccg cccagcatgt gtgtgtctct
     2401 atctcgcgtc tacctgctcc tttcggccta gtcagatggg tgtagataca gacccgcatg
     2461 tgtctgtatt caaacggcac ctagagatgc tcctgtcagt gtcctcaagg ctccaccaag
     2521 acgcgcaccg ggctaccaca tggtccctgt catgtgacct attactctga cataaatcca
     2581 tctgtaatat attgccagta tataagccgt ttagtttgtc aattgattaa gctgtatgtc
     2641 ttataagaga ctatgtaaag ggggaatatg gaggagtgaa ctctcagacc cttgaagatg
     2701 tagcttctgg atttgaaccg attaaatggc acctgtatac cgaaaaaaaa aaaaaaaaa
//
