LOCUS       NM_053842               5615 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase 1 (Mapk1), mRNA.
ACCESSION   NM_053842
VERSION     NM_053842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5615)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5615)
  AUTHORS   Rahamim,N., Liran,M., Aronovici,C., Flumin,H., Gordon,T.,
            Urshansky,N. and Barak,S.
  TITLE     Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats
  JOURNAL   Int J Mol Sci 25 (10), 5478 (2024)
   PUBMED   38791516
  REMARK    GeneRIF: Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5615)
  AUTHORS   Jia,X., Song,Y., Li,Z., Yang,N., Liu,T., Han,D., Sun,Z., Shi,C.,
            Zhou,Y., Shi,J., Liu,Y. and Guo,X.
  TITLE     Melatonin regulates the circadian rhythm to ameliorate
            postoperative sleep disorder and neurobehavioral abnormalities in
            aged mice
  JOURNAL   CNS Neurosci Ther 30 (3), e14436 (2024)
   PUBMED   37736695
REFERENCE   4  (bases 1 to 5615)
  AUTHORS   Mukhomedzyanov,A.V., Popov,S.V., Maslov,L.N., Diez,E.R. and
            Azev,V.N.
  TITLE     Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective
            Effect of Deltorphin II during Cardiac Reperfusion
  JOURNAL   Bull Exp Biol Med 175 (1), 17-19 (2023)
   PUBMED   37338759
  REMARK    GeneRIF: Role of PI3K, ERK1/2, and JAK2 Kinases in the
            Cardioprotective Effect of Deltorphin II during Cardiac
            Reperfusion.
REFERENCE   5  (bases 1 to 5615)
  AUTHORS   Gu,C., Mo,W., Wang,K., Gao,M., Chen,J., Zhang,F. and Shen,J.
  TITLE     Exosomal miR-370-3p increases the permeability of blood-brain
            barrier in ischemia/reperfusion stroke of brain by targeting MPK1
  JOURNAL   Aging (Albany NY) 15 (6), 1931-1943 (2023)
   PUBMED   37000151
  REMARK    GeneRIF: Exosomal miR-370-3p increases the permeability of
            blood-brain barrier in ischemia/reperfusion stroke of brain by
            targeting MPK1.
REFERENCE   6  (bases 1 to 5615)
  AUTHORS   Taylor,G.A., Thompson,M.J., Lai,W.S. and Blackshear,P.J.
  TITLE     Phosphorylation of tristetraprolin, a potential zinc finger
            transcription factor, by mitogen stimulation in intact cells and by
            mitogen-activated protein kinase in vitro
  JOURNAL   J Biol Chem 270 (22), 13341-13347 (1995)
   PUBMED   7768935
REFERENCE   7  (bases 1 to 5615)
  AUTHORS   Suzuki,T., Okumura-Noji,K. and Nishida,E.
  TITLE     ERK2-type mitogen-activated protein kinase (MAPK) and its
            substrates in postsynaptic density fractions from the rat brain
  JOURNAL   Neurosci Res 22 (3), 277-285 (1995)
   PUBMED   7478291
REFERENCE   8  (bases 1 to 5615)
  AUTHORS   Seger,R., Ahn,N.G., Boulton,T.G., Yancopoulos,G.D., Panayotatos,N.,
            Radziejewska,E., Ericsson,L., Bratlien,R.L., Cobb,M.H. and
            Krebs,E.G.
  TITLE     Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo
            autophosphorylation on both tyrosine and threonine residues:
            implications for their mechanism of activation
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6142-6146 (1991)
   PUBMED   1712480
REFERENCE   9  (bases 1 to 5615)
  AUTHORS   Boulton,T.G., Nye,S.H., Robbins,D.J., Ip,N.Y., Radziejewska,E.,
            Morgenbesser,S.D., DePinho,R.A., Panayotatos,N., Cobb,M.H. and
            Yancopoulos,G.D.
  TITLE     ERKs: a family of protein-serine/threonine kinases that are
            activated and tyrosine phosphorylated in response to insulin and
            NGF
  JOURNAL   Cell 65 (4), 663-675 (1991)
   PUBMED   2032290
REFERENCE   10 (bases 1 to 5615)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 9, 2015 this sequence version replaced NM_053842.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1878807.1,
                                           SRR26360172.1960049.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000011.1  97527499-97527825   c
            328-510             JAXUCZ010000011.1  97492966-97493148   c
            511-700             JAXUCZ010000011.1  97491143-97491332   c
            701-817             JAXUCZ010000011.1  97486218-97486334   c
            818-932             JAXUCZ010000011.1  97483294-97483408   c
            933-1064            JAXUCZ010000011.1  97482924-97483055   c
            1065-1174           JAXUCZ010000011.1  97473556-97473665   c
            1175-1300           JAXUCZ010000011.1  97470572-97470697   c
            1301-5615           JAXUCZ010000011.1  97462025-97466339   c
FEATURES             Location/Qualifiers
     source          1..5615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5615
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /note="mitogen activated protein kinase 1"
                     /db_xref="GeneID:116590"
                     /db_xref="RGD:70500"
     exon            1..327
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1291
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /EC_number="2.7.11.24"
                     /note="extracellular-signal-regulated kinase 2; MAPK 2;
                     MAP kinase 2; mitogen-activated protein kinase 2; MAPK 1;
                     MAP kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 1"
                     /protein_id="NP_446294.1"
                     /db_xref="GeneID:116590"
                     /db_xref="RGD:70500"
                     /translation="MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNL
                     NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIV
                     QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD
                     LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE
                     MLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRL
                     FPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELD
                     DLPKEKLKELIFEETARFQPGYRS"
     exon            328..510
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            511..700
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            701..817
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            818..932
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1064
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1174
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1300
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..5615
                     /gene="Mapk1"
                     /gene_synonym="ERK-2; Erk2; ERT1; p42-MAPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactcgct gcccgcccgc ccgtcaggca ggaaggcagg cagtggttct accggcggtt
       61 agttctctct tctgtgttgt cctccctcct cgttcccgat cgccgccagc ggctgctaca
      121 cgggcggcgg cgcggttcct gtgggaagcg cagcacaagt cgagcggtaa ccgcgaagcg
      181 tcgagcccaa cgcggcggag gctgtgcagc caacatggcg gcggcggcgg cggcgggccc
      241 ggagatggtc cgcgggcagg tgttcgacgt ggggccgcgc tacactaatc tctcgtacat
      301 cggagaaggc gcctacggca tggtttgttc tgcttatgat aatctcaaca aagttcgagt
      361 tgctatcaag aaaatcagtc cttttgagca ccagacctac tgtcagagaa ccctgagaga
      421 gataaaaatc ctactgcgct tcagacatga gaacatcatc ggcatcaatg acatcatccg
      481 ggcaccaacc attgagcaga tgaaagatgt atatatagta caggacctca tggagacaga
      541 tctttacaag ctcttgaaga cacagcacct cagcaatgat catatctgct attttcttta
      601 tcagatcctg agaggattaa agtatataca ttcagctaat gttctgcacc gtgacctcaa
      661 gccttccaac ctcctgctga acaccacttg tgatctcaag atctgtgact ttggccttgc
      721 ccgtgttgca gatccagacc atgatcatac agggttcttg acagagtatg tagccacgcg
      781 ttggtacaga gctccagaaa ttatgttgaa ttccaagggt tataccaagt ccattgatat
      841 ttggtctgtg ggctgcatcc tggcagagat gctatccaac aggcctatct tcccaggaaa
      901 gcattacctt gaccagctga atcacatcct gggtattctt ggatctccat cacaggaaga
      961 tctgaattgt ataataaatt taaaagctag aaactatttg ctttctctcc cgcacaaaaa
     1021 taaggtgccg tggaacaggt tgttcccaaa cgctgactcc aaagctctgg atttactgga
     1081 taaaatgttg acatttaacc ctcacaagag gattgaagtt gaacaggctc tggcccaccc
     1141 gtacctggag cagtattatg acccaagtga tgagcccatt gctgaagcac cattcaagtt
     1201 tgacatggag ctggacgact tacctaagga gaagctcaaa gaactcattt ttgaagagac
     1261 tgctcgattc cagccaggat acagatctta aattggtcag gacaagggct cagaggactg
     1321 gacgcgttca gatgtcggtg tccccccagt tcttgaccct ggtcctgtct ccagcccgtc
     1381 tcagcttacc cactcttgac tcctttgagc cgttccgagg ggcagttctg gtcgtagtgg
     1441 cttttatact ttcacggaat tcttcagtcc agagagttct cctgcaccag gccctgcaca
     1501 gttgcactca gtgcactcaa gtgctcactg ttgtttagtc agtaactgct ttctggtttg
     1561 aaagatgcag tggttcctcc ctgccctgaa tccttcctac atgtcaccta ctgaactgtc
     1621 agcctcctca gagcaagtct taacagactt gttccagtta tgcccaccca ccttacatta
     1681 gggaaggcta agacataagg caccttaagt cagtgacagc tccaaactta cacgccatct
     1741 gttggctgta gctgtctgct cagatcggag ctttcgggcg gccctggatg gtggtgcagg
     1801 ctgcaggggc aggcgcttct gttgcaggag tcctttgggg catttttctg ggtatcgtgt
     1861 aagtcccaaa tttaaactat gtggtatttt cccagctttt taagaatgtg gtcattgttt
     1921 aaatgaaata gagaggaagc attgcaccag caatgatatt cttcaggttt ctatggttac
     1981 tctattgtaa tggaggtgtg gtgcttgcca aaatgttaca cactatcctt agccagagat
     2041 tgaaagtaac agctgtgctt gtcattcgct gcaagatgga catgcacaaa gctgtggaag
     2101 tttccagaaa agtagagagc aggctgacct agatgttcag ggtggagcgc catacagcct
     2161 tgaactgtcc cacacagaag gctgctttgt aaccatgctc actgcctggg gatttagtta
     2221 aagggaacac tgcatctttg agtgagaaag tgtacagttc ttctcctgca gcatgtcagc
     2281 accgcgagct catctttcag cagtgtaatg acttgtatgt aataaagcct tcatgagctc
     2341 tcctcacgaa gctgttgcca agttagagat gtttctggta ctgctgagtt aacgtcataa
     2401 aaggctagca gtaactgttg aagctctctt tttctttcct tctctcctat attttgttcc
     2461 tgcactgtgt gctgtggagt tgatggtgtt atcccagtgc agtgcctccc aacccctcac
     2521 tgctctctga tgagaaattt gccttgttca atacttactg tgctattgca tgactgttaa
     2581 ggtctctgtg cagagaccaa tgtccaagtg tcacatcctt tggttgagtg aaatctgttg
     2641 tgacctctga gttgtattcc atgaagagaa tgctacccag aagataatat aggaaagata
     2701 attatattat taacttttca tttctcaact gtccttttat tttcttggtt tttattttat
     2761 tttattttat tttgatagca atggaaaatg ggttctatag actgcctgtt agtatgaaca
     2821 gcagtgcaat gcacttgtaa ctcatggaaa taaatgtaca tctttatctt tacaccgatg
     2881 ataagatgca gtgttgattt cctctggatc ggtgtgtcct aatcaattta taacttgtgc
     2941 ttcagacaga actgttcatg ggccttactc tatttctctc caccccactc cccatgcact
     3001 gccccacaca tcagtttaca taagatggca tgcaccttta atcccagcat tcagaagtca
     3061 gaggcaggtg ggtctctgaa ttggaagcaa gcctggtttg catagggagg tccaagacag
     3121 ttgggacttt ctaggccctg tctcagaaac caaaagaaag gtcctcccct tctgccctga
     3181 agagcaaatg aatctgacat ggtcctctct taaaaccagg tctcaagtag tcagaacaaa
     3241 cataccgagg tggagtctgg ttccctctga aaagggcctt cttgccccca ggagtggggg
     3301 gaggggcgca ggtgtctgtt cagcgtccca tggcacccgc caccaccacc ccccccatgg
     3361 cacctgccac cagattcagg ggacactcac acctcatacg gctcatccca ggaaccagat
     3421 ctcagttctt ggtgtaaagc cccgctattc acatccacac atgaacccta cctggcactg
     3481 aaggagggga ggttcagctt tcattgatag agtagtggtc agttttcctt tttctttttg
     3541 tctttttttt taaagccctg acagttctcc tacttgtttc ttcttcatat ttttaatccc
     3601 atgagattaa tttgcagtct tctgagtaag ggaaccgtag cctcatcttg ttgaagactg
     3661 aactcttcct ggtactgtgg gggctggggt tggcatgaga gcactcactg catccgaatg
     3721 cctgtaccac aggtggtgtg gctttcctct agccattgta actgacagct catagctgtc
     3781 gggtatagga acactccgtt attttgattc tcacatttct aaaaatgtct ggtgtcattg
     3841 agtgcctctg ctattcatat gcatagataa gctgtctggt gggtggactt tttgtccaag
     3901 tcttaaaatg tgagcaaaaa taaaagaaaa tcaaaaacat gaagacactt ggcatgaaga
     3961 ggaaagctat ccaaccatcc cagagagcac atgctgatag cagcactcag agctgatact
     4021 aacctgctgt gtggtgcatc catactgccc tcaccctcac cctcttatga gtacgagcga
     4081 tggctgggct gggcgtgact gttagtttgg gaagctgtga attaacagca gctatctgag
     4141 gaatcacaaa ggtagacact gcatgccaca tagtattcag accacttaga ggaaacttca
     4201 tctgcttagg ataatactta cattattaat agttatgttt gaacttttgg tgacttatat
     4261 aatatggtaa cacattcaaa tatgcatatg ctttgggcct tcatactact tttatatttg
     4321 taaatcagtg ttttggagca attccaagtt taagggaaat atttttgtaa atgtgatggt
     4381 tttgaaaatc tgagcaattc ttttgcttac aagttttttt taaagcattt gtgctttaaa
     4441 aattgtagtg ctagtgtttg aaatatggca ccctataacc cagataagaa atataagaat
     4501 ggagtaaatg ctgtcatttg tcatgctgtg tccaccttgg cctgctgggt caacagtggg
     4561 gatccagagt ccctaggtta ccccagcttg tctgacgctt gctgcctttc tgtaccattt
     4621 aacccttcag agcactccag acagttctga cacggctttg tatccgcttt gtgctgtgga
     4681 tgcctttttg gtattgtatc ccaaactgca tagatgattt aggataatgg tgagtttaaa
     4741 aaatgaatgt tgaagcaaga ttttattaag aatttaaatg ttttttcatt atattgttaa
     4801 acttgaacat ttatctgtgg cttatgtgat ttggttaata tgtataaaaa ttgtaagagg
     4861 tttatatttc accttaattc ttttgatgtt gtaaacatgc cttttaattc attatttgaa
     4921 tgtttatggc acctgacttg taaaaagaat taccaaaaaa aaaaagtcct tagaatcatg
     4981 acattgtctc actgtgttgc cagggtaact gcgctgctca gaaggctgag tcactccatg
     5041 tagctagagt gccttctgac tttcctgggt gctgctgaca gtaagatcac agactgatgc
     5101 tctgggtgac tggggccgtc gtctccatca ggtcttccag gtggtccttc agaccctggg
     5161 tacagggaag ggaaggcggc ctcacaccct ccccaccact agccttcagt agctccagtg
     5221 caggacagat gtccaaggca gacttttcac agcaagaact gacaactgtt agccaaactt
     5281 gtgtttcttg tcagtattgg aggcagtaca gtgattattt acccatcaga aatactggga
     5341 aatgtttaaa taaggagaga caggctttag gtcactaaag ccaaacgttg accaccttcc
     5401 ctctgttctc agctgtagct ggctctgctc agactgtctc ctgtgaaagg cagttggtgt
     5461 cctttgccat gcatgcagaa gatagaaaaa tacatttcgg gtcataccac ataacatgta
     5521 ccaagcgaat atcaatcacg tcttcctaaa agttttttat gtcattgcat gtgtcagtaa
     5581 atccctatta actaaagacc ctgcttctgc ccttc
//
