LOCUS       NM_001106270            4038 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 7 (Map7),
            transcript variant 1, mRNA.
ACCESSION   NM_001106270 XM_001073414 XM_214968
VERSION     NM_001106270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4038)
  AUTHORS   Tymanskyj,S.R., Yang,B.H., Verhey,K.J. and Ma,L.
  TITLE     MAP7 regulates axon morphogenesis by recruiting kinesin-1 to
            microtubules and modulating organelle transport
  JOURNAL   Elife 7, e36374 (2018)
   PUBMED   30132755
  REMARK    GeneRIF: MAP7 recruits kinesin-1 dynamically to microtubules,
            leading to alterations in organelle transport behaviors,
            particularly pause/speed switching.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4038)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   3  (bases 1 to 4038)
  AUTHORS   Tymanskyj,S.R., Yang,B., Falnikar,A., Lepore,A.C. and Ma,L.
  TITLE     MAP7 Regulates Axon Collateral Branch Development in Dorsal Root
            Ganglion Neurons
  JOURNAL   J Neurosci 37 (6), 1648-1661 (2017)
   PUBMED   28069923
  REMARK    GeneRIF: MAP7 promotes axon collateral branch morphogenesis and
            neural circuit function in dorsal root ganglion neurons.
REFERENCE   4  (bases 1 to 4038)
  AUTHORS   Rabionet,M., van der Spoel,A.C., Chuang,C.C., von
            Tumpling-Radosta,B., Litjens,M., Bouwmeester,D., Hellbusch,C.C.,
            Korner,C., Wiegandt,H., Gorgas,K., Platt,F.M., Grone,H.J. and
            Sandhoff,R.
  TITLE     Male germ cells require polyenoic sphingolipids with complex
            glycosylation for completion of meiosis: a link to ceramide
            synthase-3
  JOURNAL   J Biol Chem 283 (19), 13357-13369 (2008)
   PUBMED   18308723
REFERENCE   5  (bases 1 to 4038)
  AUTHORS   Suzuki,M., Hirao,A. and Mizuno,A.
  TITLE     Microtubule-associated [corrected] protein 7 increases the membrane
            expression of transient receptor potential vanilloid 4 (TRPV4)
  JOURNAL   J Biol Chem 278 (51), 51448-51453 (2003)
   PUBMED   14517216
  REMARK    Erratum:[J Biol Chem. 2005 Jul 8;280(27):25948]
REFERENCE   6  (bases 1 to 4038)
  AUTHORS   Komada,M., McLean,D.J., Griswold,M.D., Russell,L.D. and Soriano,P.
  TITLE     E-MAP-115, encoding a microtubule-associated protein, is a retinoic
            acid-inducible gene required for spermatogenesis
  JOURNAL   Genes Dev 14 (11), 1332-1342 (2000)
   PUBMED   10837026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 30, 2010 this sequence version replaced NM_001106270.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760386, SAMEA5760393
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  16751405-16751708
            305-403             JAXUCZ010000001.1  16809413-16809511
            404-481             JAXUCZ010000001.1  16812552-16812629
            482-645             JAXUCZ010000001.1  16824338-16824501
            646-763             JAXUCZ010000001.1  16825492-16825609
            764-874             JAXUCZ010000001.1  16829705-16829815
            875-988             JAXUCZ010000001.1  16833576-16833689
            989-1113            JAXUCZ010000001.1  16840652-16840776
            1114-1223           JAXUCZ010000001.1  16845406-16845515
            1224-1504           JAXUCZ010000001.1  16845788-16846068
            1505-1709           JAXUCZ010000001.1  16847949-16848153
            1710-1884           JAXUCZ010000001.1  16848745-16848919
            1885-1986           JAXUCZ010000001.1  16849053-16849154
            1987-2037           JAXUCZ010000001.1  16849501-16849551
            2038-2095           JAXUCZ010000001.1  16849834-16849891
            2096-2195           JAXUCZ010000001.1  16851777-16851876
            2196-2416           JAXUCZ010000001.1  16853767-16853987
            2417-4038           JAXUCZ010000001.1  16855552-16857173
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..4038
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /note="microtubule-associated protein 7"
                     /db_xref="GeneID:293016"
                     /db_xref="RGD:1308866"
     exon            1..304
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2427
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ensconsin"
                     /codon_start=1
                     /product="ensconsin isoform 1"
                     /protein_id="NP_001099740.2"
                     /db_xref="GeneID:293016"
                     /db_xref="RGD:1308866"
                     /translation="MPGSATAIRQERLKTTHSRTIPLVLFTINEEDELQKNGNSRRPK
                     ASDGYKIQGKRPAPSRPTSTLSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQ
                     LAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKER
                     HEAVVRRTMERSQKPKQKYNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVIS
                     KRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCS
                     PITTPFKTAHSRNPVDRPKLFITPPEGSARRRTIHGISSYKREREHIPFHVSPGVRRT
                     LSPSNLKARSPAPARLWPPSKSMPHLPGTPRPASSLTPGPVRAAASSSSPGNIRPVKR
                     EVKVEPEKKDPEKKVTNDPTIKGRVPLVKVEEGTVEEGTPVKPPDPGKNGPAAVPAPT
                     PATDPAPAPPSPSSVSVGVIPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEK
                     EELERQKIEELARRVAEERSRREEEARRLEAEQARKREELALRLAEEERERWEREEVE
                     RAQKQKEEEARAREEAEKARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKT
                     TGQSNGDMVKGVLAGETEVSALPGVNSPGHVESAGSTHGVALQQSKVTIESSPDLEKQ
                     PNENGMSTQNENFEEIINLPVGSKASRLDVSNENPEIPLKPILAFNDEGTLGPLPQVD
                     GVQTQQTTEVI"
     exon            305..403
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            404..481
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            482..645
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            646..763
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            764..874
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            875..988
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1113
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1223
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1504
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1709
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1884
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1986
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2037
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2095
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2195
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2416
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..4038
                     /gene="Map7"
                     /gene_synonym="Mtap7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttgccaa gtagctggta gtatctgtca gctgcttgca cactgtttac ccacagggga
       61 tctgttacaa gtgctcaaat gaacaggcag cttaggaact agcagcttcc tgggagctgc
      121 aattacataa gcatatatat ttaatataat tgtgggacaa gtagcagcgt tatgcctgga
      181 tcagccacag ctatccgaca agagagattg aagacgaccc actcgaggac tattcccctc
      241 gttctgttca ccattaatga ggaagatgag ctgcaaaaga atggaaattc cagaagaccc
      301 aaagcgtctg atggctataa aatacaagga aagagacctg cccccagccg ccctacttcc
      361 acactttcag gacaaacgag caaccactca ggaaataaac cagatccccc acctgtgcta
      421 cgggttgatg accggcagcg tctggccaga gaacgccgtg aggaacgaga aaaacagcta
      481 gctgcacgag aaaccgtctg gctagagaga gaagagcgag cccggcagca ctatgagagg
      541 cacctggagg cacggaagaa gaagctggag gaccagcggc tgaaggagga gcggaggaga
      601 gctgcggtgg aggagaagcg gagacagagg ctggaggagg acaaggagcg ccatgaagct
      661 gttgttcggc ggacgatgga aaggagccag aagccgaagc agaagtataa ccggtggtcg
      721 tggggaagcc ctctccacgg gagctctagc attcacagtg gagatccaga caggcggtca
      781 gtttccacca tgaatctttc gaaacatgtc gatcctgtca ttagcaagcg gctctcgtcc
      841 tcatctgcaa ctttgctaaa ctctccagat agagctcgcc gcctgcagct cagcccctgg
      901 gagagcagcg ttgttagcag acttctgacg cccacacatt cgttcctggc cagaagcaaa
      961 agcacggccg ccttgtctgg agacacagca tcttgcagcc ccatcaccac gcccttcaaa
     1021 actgcacact ctagaaaccc agtggatcga ccaaaactct ttataacgcc gcccgagggc
     1081 tctgctcgga ggaggaccat tcacgggata tcgagctata aaagagaacg agaacacatt
     1141 cccttccacg tttcccctgg tgtccgaagg actctgtctc catctaatct caaggcgaga
     1201 tccccagctc cagcccgcct ttggccccca tccaagtcca tgcctcatct gcccgggaca
     1261 ccccgaccgg catcctcctt gactcctggc cccgtcagag ctgctgcttc ttcctcgtct
     1321 cctggcaaca tccgccctgt caagagagaa gtgaaagtgg agcctgagaa aaaagacccc
     1381 gagaagaaag tgaccaatga ccccacaata aagggcaggg tgccattagt gaaggtggag
     1441 gagggcacag ttgaagaggg gacacccgtg aagccacctg accctggtaa gaatggacca
     1501 gctgctgttc cagcccccac tccagcgacg gacccagccc cagcaccacc atcaccatcc
     1561 tctgtgagtg tcggtgtaat tcctaagact tctgcaggca ccactgaccc agaagaggct
     1621 acgaggctgc tggctgagaa gaggcgtcta gccagagagc aaagggagaa ggaagaaagg
     1681 gagaggaagg agaaggaaga gctggagaga caaaagatag aggaattggc gcgaagggtg
     1741 gctgaagagc gaagtcgcag ggaagaggaa gcgcgcaggc tggaagctga gcaggcgcgc
     1801 aagagagagg agctggcgct gcgtctggct gaagaggagc gggagcggtg ggagagggag
     1861 gaggtggagc gcgcacagaa gcagaaagaa gaagaagccc gagcccggga ggaggcagag
     1921 aaggctcggc aggaacgaga gaaacatttt cagaaagaag agcaggagcg cctggagagg
     1981 aagaagcgac ttgaagagat catgagaaga accagaagga cagagacagc ggataagaaa
     2041 accactgggc aaagcaatgg cgacatggtc aaaggagttc tcgccggaga gacagaggta
     2101 tctgccctgc caggtgtgaa ctctccagga catgtcgagt ctgcaggcag cacacatgga
     2161 gtggctttgc agcaatcaaa agtgaccata gagagttctc cagatttgga gaagcagcca
     2221 aatgaaaatg gaatgtccac acaaaatgaa aattttgaag aaattataaa cttacctgtt
     2281 ggatcaaaag catccagatt agacgtctcc aatgagaacc cagaaattcc cttgaaacca
     2341 attttggcct ttaatgatga agggacactt gggcccctac ctcaggtgga tggtgtgcag
     2401 acacaacaga ccacagaagt tatatgagcg tttcctctga agaaccaaag caaacatttt
     2461 ctacgacgaa tggaatttca ggctccaaag agcccctccc tccagtttcc tagagttctt
     2521 gaccatcatt tttaaaagac gtattaaagt cagctcaaga caacagactc agtagctttt
     2581 ctaaccattt tcgccaatag gaagaaatgc tccttaatgc tccttaatct gataccctga
     2641 ggtggcattt tccagaatgt ccctccttag taaataaatc aatatttttc tgaactcttt
     2701 caaaaaacaa aaagagcatt tcattataaa aagaaacggg catggttatc acagggatct
     2761 tttttttttt ttttcacttt taaacttcaa tacataagat tggcaaaaat aaaatacctt
     2821 ttacaacgta ctacttgaca atgggtacct ctttgccctc cgggtggagc gagtggaggg
     2881 tagtcaaaca aacctgtttg tttaaatatt actgcaaagg cagtttgtag aggcagaagg
     2941 tggccaggtt acctggccgt cataaacaca gctcgtaaac acgggcatcc tgcagaccca
     3001 gctgccactg tcttcctgag actccattta cagaaccaca atgacaactc tgaaaatgtg
     3061 aagacatttt tttcagagca agaaaataat tcgctgtcct ttttgttttt gtttttccta
     3121 ctttttttgg agaatgggtt tctctgtgta gccctggctg tcctaaaact ggctctggag
     3181 accagactga cctcgaaccc cacctgcctc tgcttcctgg gtgctgagat cagaggcgcg
     3241 cgacagcccc gcctggctca gctgtcctcc taagcgatgt atttataaga gcttttttcc
     3301 agatagatga actagaacgg gacagagtgc agacacgctc cagcagatgc actccgcctg
     3361 ccgccctggg agcctggatg atgatgtggg gctctctgat gtctgtatgc tgctgccacc
     3421 cccagggatg gtgggacttc tctctctttg ccttacgtga ttgcagatga tgtgggggaa
     3481 atgtttaata ttcctttaga tcaatgaatt tggcttctgc tcgtttcaga gcaatgagaa
     3541 aaaatggtgt cgatgtcggg ggacacggac cgtcgcaaat gtcctcagtg tatagcgacc
     3601 ctccgctttt cctgtgtcct ccttcttccc tcttgctgct cagcccagct gtacaaacct
     3661 gcactttgat ttgctaatat aaattcagtt ttattttccc acttaagaga caaccaatga
     3721 gaaatggaga agggagtgcc gaggccatgg cgtctccctc ccactgtgat atattggttt
     3781 tatacaaaga gcgattggtt aatctacaag atttaatgtg gaactattca tctattgggg
     3841 ttcttttaaa tccaggcata caatctttac caacagtttg taaaacattg ttaagacatc
     3901 aatttgtggg gtctccccat ttggttgtcc atgtacatct agatattgta ttaaaaaaaa
     3961 tctgttcaac aaatttgttc tatttattta aatctaccaa acataaaata caaataaaat
     4021 gtttgacata gttttgcc
//
