LOCUS       NM_001398600            3680 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 6 (Map6),
            transcript variant 1, mRNA.
ACCESSION   NM_001398600 XM_006229755
VERSION     NM_001398600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
  REMARK    GeneRIF: MAP6 is present at the Golgi complex and in secretory
            vesicles in unpolarized cells and re-distributed to newly forming
            axons, where it binds and stabilizes axonal microtubules. A
            palmitoylation cycle controls MAP6 membrane-microtubule shuttling
            and is required for its polarized distribution in axons.
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Schwenk,B.M., Lang,C.M., Hogl,S., Tahirovic,S., Orozco,D.,
            Rentzsch,K., Lichtenthaler,S.F., Hoogenraad,C.C., Capell,A.,
            Haass,C. and Edbauer,D.
  TITLE     The FTLD risk factor TMEM106B and MAP6 control dendritic
            trafficking of lysosomes
  JOURNAL   EMBO J 33 (5), 450-467 (2014)
   PUBMED   24357581
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Lefevre,J., Savarin,P., Gans,P., Hamon,L., Clement,M.J.,
            David,M.O., Bosc,C., Andrieux,A. and Curmi,P.A.
  TITLE     Structural basis for the association of MAP6 protein with
            microtubules and its regulation by calmodulin
  JOURNAL   J Biol Chem 288 (34), 24910-24922 (2013)
   PUBMED   23831686
  REMARK    GeneRIF: Structural basis for the association of MAP6 protein with
            microtubules and its regulation by calmodulin.
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Morderer,D., Nikolaienko,O., Skrypkina,I., Cherkas,V., Tsyba,L.,
            Belan,P. and Rynditch,A.
  TITLE     Endocytic adaptor protein intersectin 1 forms a complex with
            microtubule stabilizer STOP in neurons
  JOURNAL   Gene 505 (2), 360-364 (2012)
   PUBMED   22750298
  REMARK    GeneRIF: The neuron-specific isoform of the stable tubule-only
            polypeptide (STOP) interacted with the SH3A domain of ITSN1. STOP
            and ITSN1 were shown to form a complex in vivo.
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Tonami,K., Kurihara,Y., Aburatani,H., Uchijima,Y., Asano,T. and
            Kurihara,H.
  TITLE     Calpain 6 is involved in microtubule stabilization and cytoskeletal
            organization
  JOURNAL   Mol Cell Biol 27 (7), 2548-2561 (2007)
   PUBMED   17210638
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Gory-Faure,S., Windscheid,V., Bosc,C., Peris,L., Proietto,D.,
            Franck,R., Denarier,E., Job,D. and Andrieux,A.
  TITLE     STOP-like protein 21 is a novel member of the STOP family,
            revealing a Golgi localization of STOP proteins
  JOURNAL   J Biol Chem 281 (38), 28387-28396 (2006)
   PUBMED   16837464
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Guillaud,L., Bosc,C., Fourest-Lieuvin,A., Denarier,E., Pirollet,F.,
            Lafanechere,L. and Job,D.
  TITLE     STOP proteins are responsible for the high degree of microtubule
            stabilization observed in neuronal cells
  JOURNAL   J Cell Biol 142 (1), 167-179 (1998)
   PUBMED   9660871
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Bosc,C., Cronk,J.D., Pirollet,F., Watterson,D.M., Haiech,J., Job,D.
            and Margolis,R.L.
  TITLE     Cloning, expression, and properties of the microtubule-stabilizing
            protein STOP
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 2125-2130 (1996)
   PUBMED   8700896
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Adams,M.D., Dubnick,M., Kerlavage,A.R., Moreno,R., Kelley,J.M.,
            Utterback,T.R., Nagle,J.W., Fields,C. and Venter,J.C.
  TITLE     Sequence identification of 2,375 human brain genes
  JOURNAL   Nature 355 (6361), 632-634 (1992)
   PUBMED   1538749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 20, 2021 this sequence version replaced XM_006229755.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.3228.1,
                                           SRR26643298.4039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2116              JAXUCZ010000001.1  162980339-162982454
            2117-2330           JAXUCZ010000001.1  163026215-163026428
            2331-2527           JAXUCZ010000001.1  163028229-163028425
            2528-3680           JAXUCZ010000001.1  163045396-163046548
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3680
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /note="microtubule-associated protein 6"
                     /db_xref="GeneID:29457"
                     /db_xref="RGD:61804"
     exon            1..2116
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..3545
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /note="isoform 1 is encoded by transcript variant 1; STOP;
                     MAP-6; STOP145; 145-kDa STOP; stable tubule-only
                     polypeptide; microtubule-associated protein 6 homolog"
                     /codon_start=1
                     /product="microtubule-associated protein 6 isoform 1"
                     /protein_id="NP_001385529.1"
                     /db_xref="GeneID:29457"
                     /db_xref="RGD:61804"
                     /translation="MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPP
                     QPPAPPQPGLAPPSRAVAIETQPAQGESDAVARATGPAPGPSGDRETAAAPGRSGLGL
                     GAASGSTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRA
                     WPLPRRGDHPWIPKPVQIPATSQPSPPVLGMPKRRPQSQERGPIQLSADARDPEGAGG
                     AGVPAAGKASGADQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGA
                     DQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPA
                     WMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEET
                     PLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEETPLPPAQSQTQEG
                     GPAAGKASGADERDTRRKAGPAWMVRRSEGHEQTTAAHAQGTGPEGGKGRAVADALNR
                     QIREEVTSTVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEAS
                     KPTTADNKVVDRRRIRSLYSEPFKESPKVEKPSVQSSKPKKTSTSQKPLRKAKDKQVA
                     SGQAAKKKTTESPSATKPDDKEQSKEMNNKLAEAKESRVKPTSDKNQGPVAKEPHKDQ
                     GPVAPGLPKGQGPAVQEPLKDQGPMVPGLPKDQAPVVPGSLKGQSPTAPGPPKDQGAV
                     LLGPMKDLGPVAPASVKDQDHMASELLKNKDSVPLAPAKAQSPLLPEPLKNQSPVVPA
                     RAKDQSFPAPAPTPLKDPGPVIPEPEKDGAPMVPERRKDQNASIMASLKNEAPVASES
                     VKNQGLGGPEPAKDTGTDLKGHGSVFVAPVKSQGPVVPEPTKGQDPIIPALAKDQGPI
                     LPEPPKNQGPPVVLGPIKNQDPVIPVPLKGQDPVVPAPTKDPGPTAPDPLKSQGPRGP
                     QLPTVSPSPPVMIPTVPHAEYIEGSP"
     exon            2117..2330
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2527
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..3680
                     /gene="Map6"
                     /gene_synonym="Mtap6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagacgac ggcggcgtcg gctgcggcat caccaggggt atagatacgg cggaggccgt
       61 tgtgctctct gctctgtctg ggttggaggt gaccgctgcc aagcctcgct aggcggccgg
      121 ctgaaccaga cggaaaggag acagaagcct gtttgcagat cctgcccagc cctctcgctg
      181 cgccatggct taagcccaca gcctccttgc caagcatctc cttgctcggc cggggtctgc
      241 tagacaccgc agtcgcagag agggcgcgcc cagacgccct aggcctggac tctgggacgc
      301 cgagcctcgc tcccattctt cactggtcac agcaggtcct ctgcagaagg cgtttacagc
      361 cggtaatcga gggactttac ggactttcag tggtacctcg tccccgggtg ctttttgagg
      421 gaggaggacg aggcaaaggg cttttaaggg gaggaagcag tgggatccac attggcgggt
      481 ctgggttgga gttaaaggga gatcggaggt ttgatttagg accacaaaaa ggctttgcga
      541 ctagcattat ggcgtggccg tgcatcacta gggcctgctg catagcccgc ttctggaacc
      601 agctggacaa ggcggacatt gcggtgccgc tggttttcac caagtactcg gaggccaccg
      661 aacatccagg cgcccctccg cagccaccag cgccgccgca gcccgggtta gcgcccccct
      721 cgcgtgctgt cgccatagag acgcagccag cccagggaga gtcggatgca gttgcccggg
      781 caacagggcc ggcacccggg cccagcggtg accgcgagac tgcagccgcc cccggccgga
      841 gcgggctggg cttgggcgcg gcctccggct ccacttccgg ctcaggcccg gcggactcgg
      901 tgatgcgaca ggactaccgt gcctggaagg tgcagcggcc cgagcccagc tgccggccgc
      961 gaagcgagta ccagccgtcc gacgcgccct tcgagcgcga gacccagtac cagaaggact
     1021 tccgcgcctg gccactgccc cgccgcgggg accacccctg gatccccaag cccgtgcaga
     1081 tccctgcgac ttcgcagcct tccccgcctg ttctcgggat gcccaagcgt cggcctcaaa
     1141 gccaagagcg cgggcccata caactttctg ctgatgcccg ggacccggag ggtgctggag
     1201 gagccggggt gccggcggcc ggaaaggcgt ccggtgcaga ccagcgtgac acacgccgga
     1261 aggcagggcc agcatggatg gtgactcgca ccgaagggca cgaggagaag cctctgcccc
     1321 cggcccagtc ccagacccag gaaggcggtc ctgcagctgg aaaggcgtcc ggtgcagatc
     1381 agcgtgacac acgccggaag gcgggacccg cgtggatggt gactcgcacc gaagggcacg
     1441 aggagaagcc tctgcccccg gcccagtccc agacccagga aggcggtcct gcagctggaa
     1501 aggcgtccgg tgcagatcag cgtgacacac gccggaaggc gggacccgcg tggatggtga
     1561 ctcgcaccga agggcacgag gagaagcctc tgcccccggc ccagtcccag acccaggaag
     1621 gcggtcctgc agctggaaag gcgtccggtg cagatcagcg tgacacacgc cggaaggcgg
     1681 gacccgcgtg gatggtgact cgcaccgaag ggcacgaaga gacgccgctg ccacccgccc
     1741 agtcccagac ccaggagggc ggccctgccg ctggaaaggc gtccggtgca gatcagcgtg
     1801 acacacgccg gaaggcggga cccgcgtgga tggtgactcg caccgaaggg cacgaagaga
     1861 cgccgctgcc acccgcccag tcccagaccc aggagggcgg ccctgccgct ggaaaggcat
     1921 ctggtgcaga tgaacgcgac acgaggagga aggcggggcc ggcctggatg gtgcgtcgct
     1981 ccgaggggca cgagcagacg accgctgccc atgcccaagg cacagggccc gaaggaggca
     2041 aagggcgcgc ggtggctgat gccctcaaca ggcaaattcg ggaggaggtg acgagtacag
     2101 taagcagctc ctacaggaac gaattcagag cgtggacaga catcaagcct gtgaaaccaa
     2161 tcaaagccaa gccccagtac aagcccccag atgacaagat ggttcacgaa accagctaca
     2221 gtgcccagtt caaaggggag gccagtaagc ccaccacagc ggacaacaag gtcgtggatc
     2281 gcagaagaat acgaagcctc tacagtgagc ctttcaagga atccccgaag gtggagaaac
     2341 ctagtgttca gagttccaaa ccaaaaaaga cctcaacgag ccagaagccc ctgaggaagg
     2401 ccaaagacaa gcaggtggcg tcgggccagg ccgccaagaa aaagaccaca gagagcccca
     2461 gtgccaccaa acctgacgac aaggagcaaa gcaaagagat gaacaataaa ctggctgagg
     2521 cgaaagagag ccgggtcaaa cccaccagtg ataagaatca aggtcctgta gccaaagagc
     2581 cacacaagga tcaaggtcct gtggccccag gtcttccgaa aggccaaggt cctgcggtcc
     2641 aagagccttt gaaggatcaa ggccccatgg tgccaggact gccaaaggac caagcccctg
     2701 tagtcccagg gtccttaaag ggtcaaagcc ctacagcccc aggcccgcca aaggatcaag
     2761 gtgctgtgct cttagggccc atgaaggatc taggtccagt ggccccagca tccgtcaagg
     2821 atcaagacca tatggcgtct gagcttctaa agaataaaga ttctgtcccc ttagcaccag
     2881 ccaaagccca aagccctctg ttgccagagc ctctgaagaa tcagagtcct gtggttccag
     2941 caagagctaa ggatcaaagc ttcccagcac cagcaccaac acctctgaag gacccaggtc
     3001 ctgtgatccc tgagcctgag aaagatggag ctcccatggt cccagagcgt aggaaggacc
     3061 agaatgcctc catcatggca tctctgaaga acgaagctcc tgtggcctct gagtctgtga
     3121 agaatcaagg cttaggaggc ccagagccag ccaaagacac aggtacggat ctgaaaggac
     3181 atggttctgt gtttgtagca cctgtgaaga gccaaggtcc agtggttcct gagccaacta
     3241 agggccaaga ccccattatc ccagcactag ccaaggacca aggtcccata ctcccagagc
     3301 ctccaaagaa tcaaggaccc cctgtggtcc ttgggcctat aaagaatcaa gaccctgtaa
     3361 ttccagtacc tctgaagggt caggatcccg tggtgccagc cccaaccaag gacccaggtc
     3421 ctacagcccc tgaccctctg aagtctcaag gtcccagagg ccctcaactg cccacggtct
     3481 caccttcacc cccagtcatg atcccaacag tcccccatgc ggaatatatt gagggatccc
     3541 cttgattccc ttgaaatgcc atggaggagc tggcagtgga agtgcttccc tcctggggag
     3601 gcaaagacat atatttaatc tgcatgaaac cgtgctgtat agtcttgctg gaatctaata
     3661 aaactggttc ctctggctca
//
