LOCUS       NM_001192016            4297 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase
            kinase 5 (Map4k5), mRNA.
ACCESSION   NM_001192016 XM_006240179 XM_578547
VERSION     NM_001192016.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Tung,R.M. and Blenis,J.
  TITLE     A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal
            kinase
  JOURNAL   Oncogene 14 (6), 653-659 (1997)
   PUBMED   9038372
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_006240179.4, NM_001192016.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JAXUCZ010000006.1  94112592-94112943   c
            353-410             JAXUCZ010000006.1  94091718-94091775   c
            411-501             JAXUCZ010000006.1  94074937-94075027   c
            502-566             JAXUCZ010000006.1  94074440-94074504   c
            567-622             JAXUCZ010000006.1  94070737-94070792   c
            623-670             JAXUCZ010000006.1  94068837-94068884   c
            671-713             JAXUCZ010000006.1  94068711-94068753   c
            714-786             JAXUCZ010000006.1  94067566-94067638   c
            787-918             JAXUCZ010000006.1  94065218-94065349   c
            919-981             JAXUCZ010000006.1  94063915-94063977   c
            982-1063            JAXUCZ010000006.1  94062090-94062171   c
            1064-1180           JAXUCZ010000006.1  94061087-94061203   c
            1181-1259           JAXUCZ010000006.1  94057162-94057240   c
            1260-1318           JAXUCZ010000006.1  94050395-94050453   c
            1319-1386           JAXUCZ010000006.1  94049274-94049341   c
            1387-1429           JAXUCZ010000006.1  94046975-94047017   c
            1430-1583           JAXUCZ010000006.1  94046319-94046472   c
            1584-1681           JAXUCZ010000006.1  94045236-94045333   c
            1682-1723           JAXUCZ010000006.1  94044703-94044744   c
            1724-1808           JAXUCZ010000006.1  94043574-94043658   c
            1809-1888           JAXUCZ010000006.1  94042327-94042406   c
            1889-1949           JAXUCZ010000006.1  94041907-94041967   c
            1950-1952           JAXUCZ010000006.1  94038032-94038034   c
            1953-2067           JAXUCZ010000006.1  94037570-94037684   c
            2068-2126           JAXUCZ010000006.1  94036959-94037017   c
            2127-2230           JAXUCZ010000006.1  94035311-94035414   c
            2231-2408           JAXUCZ010000006.1  94034764-94034941   c
            2409-2477           JAXUCZ010000006.1  94029801-94029869   c
            2478-2570           JAXUCZ010000006.1  94027767-94027859   c
            2571-2641           JAXUCZ010000006.1  94024847-94024917   c
            2642-2697           JAXUCZ010000006.1  94023209-94023264   c
            2698-4297           JAXUCZ010000006.1  94020079-94021678   c
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4297
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 5"
                     /db_xref="GeneID:503027"
                     /db_xref="RGD:1562028"
     exon            1..352
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2785
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5"
                     /protein_id="NP_001178945.1"
                     /db_xref="GeneID:503027"
                     /db_xref="RGD:1562028"
                     /translation="MEAPLRPAADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGE
                     LAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL
                     QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG
                     VAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPM
                     FDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF
                     VGQSGLSRALAVELLDKVNNPDNHAHYSEGDDDDFEPHAIIRHTIRSTNRNSRAERTA
                     SEINFDKLQFEPPLRKETEARDEMGLSSEPNFILHWNPFVDGANTGRSTSKRAIPPPL
                     PPKPRINSYPEESLPDEEKSSTVKRCPDPETRAPQVLRRQSSPSCVPIAETSSVGNGN
                     GISKLISENTEGSAQAPQLPRKKDKRDFPKPTINGLPPTPKVLMGACFSKVFDGCPLK
                     INCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMS
                     LSEGKTFQLYSHNLIALFEQAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHK
                     CCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPE
                     QEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVL
                     VCLDKFVKIVNLQGKLKPSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSD
                     EVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY"
     exon            353..410
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            411..501
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            502..566
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            567..622
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            623..670
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            671..713
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            714..786
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            787..918
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            919..981
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1063
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1180
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1259
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1318
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1386
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1429
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1583
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1681
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1723
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1808
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1888
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1949
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..1952
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2067
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2126
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2230
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2408
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2477
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2570
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2641
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2697
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..4297
                     /gene="Map4k5"
                     /gene_synonym="RGD1562028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcgggtc tccgacccgg cgctcaacaa ggaaggaaca gcctcttcgg tacggcccgc
       61 gcggggcctg gcggggccaa ggaggcccgg aggctgccgg ggtcgcgccc cgtgacgccc
      121 ccgcgctcgc tctcgccggt gcaggcgcag ctgcgggctg aggctccatg ttgggaagcg
      181 ccgcgcaccc tcgttagcgg gatacgggtg ccacaggcag agccccgggc tgggcgcagc
      241 gaagatggag gcccctctga ggcctgccgc cgacatcctg agacggaacc cgcagcacga
      301 ctacgaactg gtgcagaggg tcggcagcgg cacctacggg gacgtgtaca aggccagaaa
      361 tgtacataca ggagaattag ctgcagtaaa aatcatcaaa ttggagcctg gtgatgattt
      421 ttctttgatt caacaagaaa tatttatggt taaagaatgt aaacattgca acatcgtagc
      481 ctactttggg agctatctca gtagggaaaa gctgtggatc tgcatggagt actgcggtgg
      541 cggctcactt caagacatct atcacgttac tggaccacta tctgaactgc aaatagccta
      601 cgtctgcaga gagaccttac agggtcttgc ttatttgcat actaaaggca aaatgcatag
      661 agatatcaaa ggtgcaaata tcttattaac agaccatggt gatgtaaagt tagctgattt
      721 tggtgtggct gcaaagatca cagctaccat tgcaaagagg aagtccttca tcggcacccc
      781 ttactggatg gctccagagg tggcagcggt ggaaaagaat ggcggctaca accagctctg
      841 tgatatctgg gcagtcggga taacagccat cgagcttgga gaacttcagc cgcctatgtt
      901 tgaccttcat ccaatgaggg ctctcttctt aatgtcaaaa agtaatttcc agcctccaaa
      961 gctaaaggac aaaactaaat ggtcatcgac attccataat tttgtcaaaa tagcactaac
     1021 taaaaacccc aagaaaagac caactgctga aaggcttctg actcacactt ttgttgggca
     1081 gtcaggtctg tctcgggccc tcgcggttga actgttggac aaggtgaaca atccagacaa
     1141 ccatgctcac tacagtgagg gtgacgatga tgactttgag cctcacgcaa tcattcgtca
     1201 taccattaga tcaacaaaca ggaattccag agctgaacgg acagcttcag aaataaactt
     1261 tgacaaatta cagtttgaac ctcctctaag aaaagaaaca gaagcccggg atgaaatggg
     1321 attatcttca gaaccaaact ttatattaca ttggaatcct tttgtcgatg gtgcaaatac
     1381 aggcagatca acgtctaagc gagccatacc gcctccgcta cctcccaagc caaggataaa
     1441 cagttaccct gaagaaagcc tcccagatga agaaaaatcc tcaaccgtca aacgttgccc
     1501 tgatccggag accagagcac ctcaggtcct cagaagacag agtagcccaa gctgtgttcc
     1561 tatagcggag acatcctctg taggaaacgg caatggaatt tcaaaactga tcagtgagaa
     1621 cacggaggga tcagcacagg ctccacagtt acctcggaaa aaggacaagc gggacttccc
     1681 taaaccaacc atcaatggcc ttcccccaac cccaaaagtg ctgatgggag catgcttttc
     1741 aaaagtattt gatggctgcc ctttgaaaat taattgtgca acatcctgga tacaccctga
     1801 tacaaaagac cagtacatta tttttgggac tgaagatggt atttacacat tgaatctcaa
     1861 tgagctacat gaagcaacta tggaacagtt atttccacgg aaatgcacat ggctctacgt
     1921 catcaataat acactgatgt cattgtcaga aggaaaaacc tttcagctct actctcacaa
     1981 ccttatcgct ttgtttgaac aagccaaaaa gccagggtta gccgcccaca tccagactca
     2041 caggtttcct gaccgcattc tgccaagaaa atttgcctta acaacaaaga ttcctgatac
     2101 aaaaggatgc cacaaatgct gtatagttag aaacccttac acgggacata aatacctctg
     2161 cggagccttg caatctggaa tcgttctgct tcagtggtat gaaccgatgc agaagttcat
     2221 gttgataaag cattttgact ttcctttgcc aagtccactg aatgtgtttg aaatgctggt
     2281 gataccagag caggagtacc ccatggtttg tgtggccatc agcaaaggga cagagtcaaa
     2341 ccaagtagtt cagtttgaga caatcaactt gaactctgca tcgtcctggt ttacagaaat
     2401 tggtgcaggc agccagcagc tggactccat tcacgtgacg cagctggaga gagacactgt
     2461 tctggtgtgt ttggacaaat ttgtaaaaat tgtaaatcta caaggaaagc tgaaacccag
     2521 taagaagctg gcgtctgagc tcagttttga cttccgcatt gagtccgtgg tgtgccttca
     2581 agacagcgtg ttggctttct ggaaacacgg gatgcagggt aaaagcttca aatccgacga
     2641 ggttacccag gaaatttcgg atgaaacaag agttttccgc ctgctaggat cagacagggt
     2701 cgttgttttg gaaagtaggc cgacagaaaa ccctacagct cacagcaatc tctacatcct
     2761 ggctggacat gaaaacagtt actaagcaac agagatgaat tccaagtgac aagacgacga
     2821 atgaatatgt tccattgaca gcgagagcgt tttaagggaa ttcaatacag actgcagtag
     2881 gacttgcttt aatttttgtg ggttttatat caaatgaact gtacattagg atagatttca
     2941 gtattttctg tagctggaaa cagctagtca atctcttgcc actgtgtggt ggttatatca
     3001 agtttgctta ataaaagcta tgagacaaat agccctctag ttccaagaaa cacagtcctt
     3061 ttaaaaaaac aatgtttgta agaaggtgcc atggtgttta agtagctcct gtgattatcc
     3121 tggagggagt ttagtgagca ttctatcatg ttataccatg tctccctcct ccttagtgaa
     3181 cataatttga taagaagtta tcgatcaagc ctttcacttg acattggccg ttctgtatgt
     3241 ttttgtaaga tagaatattt aatccttatt tattaatctc ttgctggagc ggtggaatgt
     3301 ttctaactgt tagcaaaggg aggttgcaca gcagctggaa ttttttataa cgtgtgaaaa
     3361 tgttgtttac ctttccagag tgtgctttag gggtgactgg cagtgtgttt gggggtccag
     3421 cacatgcagt ttcatgtaac aaaatagttt atgacacagt ttcatacagg gttgccttaa
     3481 agggaatttg ttttcaacta cagatggttg taagggctca tgcagaaatt ctgatggtgg
     3541 acaaaaagcc ttagcaggga cgtgatgtcc cggtgtgact accttacttt tgacaagcag
     3601 tgtactacac ctgtgatttt gttttcacat tagggataat gcataaggaa ttaatcttca
     3661 tatatatcat gatccctgat gcttgggaga aaagtattta actgcccata ttatgtattt
     3721 tacttatatt atgcaaaggg ggaaactgca aagtaattgc acgtgtaatc ttggggtttt
     3781 cacattcgta ggtattcatt gtgagtaggt ttaagaaaaa aacactttaa gtgaaattgg
     3841 aatttccgat gggatagtat agatgttgtt tttatatttt ttaaaaagcc agtatactaa
     3901 aattaaaaaa gggtagggct gtcttttagt ttgtttttct tttacaattc ttaatgttcg
     3961 gaattgatgt gttctgttag caccagctgt cttgatgcat ttgttaagac cagttagcat
     4021 tgaggtgaca tgcgggctaa tagtggcaaa ctatagaagt agtctgaaca gacatgacag
     4081 gaaaacaatg tacctatctc atcttgagca gttttataaa gtacatgtta tcatctccat
     4141 tttccaaatg aggaaataaa tagagtttaa caaagttaca caacttatcc gttacgtact
     4201 ggttagttct tgagccagac ctagagtcct cctccgactc tcctcttttc accatgcaat
     4261 atacaagtaa taaaatatta cacaaatgaa ctataaa
//
