LOCUS       NM_001401996            5784 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase
            kinase 4 (Map4k4), transcript variant 2, mRNA.
ACCESSION   NM_001401996
VERSION     NM_001401996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5784)
  AUTHORS   Yang,J., Zheng,X.G., Wu,Y.L., Wang,A.P., Wang,C.H., Chen,W.X.,
            Zhong,S. and Yang,H.
  TITLE     Intestinal epithelial cell-derived exosomes package microRNA-23a-3p
            alleviate gut damage after ischemia/reperfusion via targeting
            MAP4K4
  JOURNAL   Biomed Pharmacother 149, 112810 (2022)
   PUBMED   35303564
  REMARK    GeneRIF: Intestinal epithelial cell-derived exosomes package
            microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via
            targeting MAP4K4.
REFERENCE   2  (bases 1 to 5784)
  AUTHORS   Li,W., Liu,S., Su,S., Chen,Y. and Sun,G.
  TITLE     Construction and validation of a novel prognostic signature of
            microRNAs in lung adenocarcinoma
  JOURNAL   PeerJ 9, e10470 (2021)
   PUBMED   33510968
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5784)
  AUTHORS   Chen,S., Tang,Y., Yang,C., Li,K., Huang,X. and Cao,J.
  TITLE     Silencing CDC25A inhibits the proliferation of liver cancer cells
            by downregulating IL-6 in vitro and in vivo
  JOURNAL   Int J Mol Med 45 (3), 743-752 (2020)
   PUBMED   31922225
REFERENCE   4  (bases 1 to 5784)
  AUTHORS   Lin,J.C., Lee,Y.C., Tan,T.H., Liang,Y.C., Chuang,H.C., Fann,Y.C.,
            Johnson,K.R. and Lin,Y.J.
  TITLE     RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic
            signature of colorectal cancer cell
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (2), 259-272 (2018)
   PUBMED   29138007
REFERENCE   5  (bases 1 to 5784)
  AUTHORS   Gao,X., Chen,G., Gao,C., Zhang,D.H., Kuan,S.F., Stabile,L.P.,
            Liu,G. and Hu,J.
  TITLE     MAP4K4 is a novel MAPK/ERK pathway regulator required for lung
            adenocarcinoma maintenance
  JOURNAL   Mol Oncol 11 (6), 628-639 (2017)
   PUBMED   28306189
REFERENCE   6  (bases 1 to 5784)
  AUTHORS   Bouzakri,K., Ribaux,P. and Halban,P.A.
  TITLE     Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects
            beta cells from tumor necrosis factor-alpha-induced decrease of
            IRS-2 and inhibition of glucose-stimulated insulin secretion
  JOURNAL   J Biol Chem 284 (41), 27892-27898 (2009)
   PUBMED   19690174
  REMARK    GeneRIF: Results identify MAP4K4 as a key upstream mediator of
            TNF-alpha action on the beta cell, preventing tumor necrosis
            factor-alpha-induced decrease of IRS-2 and inhibition of
            glucose-stimulated insulin secretion.
REFERENCE   7  (bases 1 to 5784)
  AUTHORS   Loh,S.H., Francescut,L., Lingor,P., Bahr,M. and Nicotera,P.
  TITLE     Identification of new kinase clusters required for neurite
            outgrowth and retraction by a loss-of-function RNA interference
            screen
  JOURNAL   Cell Death Differ 15 (2), 283-298 (2008)
   PUBMED   18007665
REFERENCE   8  (bases 1 to 5784)
  AUTHORS   Machida,N., Umikawa,M., Takei,K., Sakima,N., Myagmar,B.E.,
            Taira,K., Uezato,H., Ogawa,Y. and Kariya,K.
  TITLE     Mitogen-activated protein kinase kinase kinase kinase 4 as a
            putative effector of Rap2 to activate the c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 279 (16), 15711-15714 (2004)
   PUBMED   14966141
REFERENCE   9  (bases 1 to 5784)
  AUTHORS   Yao,Z., Zhou,G., Wang,X.S., Brown,A., Diener,K., Gan,H. and
            Tan,T.H.
  TITLE     A novel human STE20-related protein kinase, HGK, that specifically
            activates the c-Jun N-terminal kinase signaling pathway
  JOURNAL   J Biol Chem 274 (4), 2118-2125 (1999)
   PUBMED   9890973
REFERENCE   10 (bases 1 to 5784)
  AUTHORS   Su,Y.C., Han,J., Xu,S., Cobb,M. and Skolnik,E.Y.
  TITLE     NIK is a new Ste20-related kinase that binds NCK and MEKK1 and
            activates the SAPK/JNK cascade via a conserved regulatory domain
  JOURNAL   EMBO J 16 (6), 1279-1290 (1997)
   PUBMED   9135144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               JAXUCZ010000009.1  49696700-49697069
            371-436             JAXUCZ010000009.1  49697292-49697357
            437-493             JAXUCZ010000009.1  49757176-49757232
            494-619             JAXUCZ010000009.1  49769595-49769720
            620-730             JAXUCZ010000009.1  49772429-49772539
            731-821             JAXUCZ010000009.1  49776143-49776233
            822-952             JAXUCZ010000009.1  49778846-49778976
            953-1007            JAXUCZ010000009.1  49779626-49779680
            1008-1086           JAXUCZ010000009.1  49781456-49781534
            1087-1262           JAXUCZ010000009.1  49784543-49784718
            1263-1335           JAXUCZ010000009.1  49786963-49787035
            1336-1546           JAXUCZ010000009.1  49788129-49788339
            1547-1708           JAXUCZ010000009.1  49791732-49791893
            1709-1795           JAXUCZ010000009.1  49795070-49795156
            1796-1918           JAXUCZ010000009.1  49795805-49795927
            1919-2080           JAXUCZ010000009.1  49796679-49796840
            2081-2311           JAXUCZ010000009.1  49798980-49799210
            2312-2418           JAXUCZ010000009.1  49800019-49800125
            2419-2570           JAXUCZ010000009.1  49802206-49802357
            2571-2668           JAXUCZ010000009.1  49802939-49803036
            2669-2677           JAXUCZ010000009.1  49803841-49803849
            2678-2853           JAXUCZ010000009.1  49805130-49805305
            2854-2974           JAXUCZ010000009.1  49805939-49806059
            2975-3092           JAXUCZ010000009.1  49809457-49809574
            3093-3263           JAXUCZ010000009.1  49809881-49810051
            3264-3407           JAXUCZ010000009.1  49813188-49813331
            3408-3542           JAXUCZ010000009.1  49815656-49815790
            3543-3643           JAXUCZ010000009.1  49817167-49817267
            3644-3793           JAXUCZ010000009.1  49818759-49818908
            3794-3953           JAXUCZ010000009.1  49819432-49819591
            3954-4093           JAXUCZ010000009.1  49820323-49820462
            4094-5784           JAXUCZ010000009.1  49820663-49822353
FEATURES             Location/Qualifiers
     source          1..5784
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..5784
                     /gene="Map4k4"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 4"
                     /db_xref="GeneID:301363"
                     /db_xref="RGD:1305322"
     exon            1..370
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..4177
                     /gene="Map4k4"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 4 isoform 2"
                     /protein_id="NP_001388925.1"
                     /db_xref="GeneID:301363"
                     /db_xref="RGD:1305322"
                     /translation="MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLW
                     LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS
                     CGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQ
                     RPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVP
                     EQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL
                     AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE
                     RRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLHDHRRPHAQQPPPP
                     QQQDRSKPSYHAPEPKPHYDPADRAREVEDRFRKTNHSSPEAQAKQTGRGLEPPVPSR
                     SESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLR
                     SQDPCPPSRSEGLSQSSDSKSEVPEPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRD
                     SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPG
                     SQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPAGEVDLTALAKELR
                     AVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGE
                     TESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQ
                     ISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKR
                     FNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTI
                     SGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIA
                     LKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVD
                     VDSGSVYDIYLPTHIQCTIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVL
                     QWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
                     FASVRSGGSSQVYFMTLGRTSLLSW"
     exon            371..436
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            437..493
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..619
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            620..730
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            731..821
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..952
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1007
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1086
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1262
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1335
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1546
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1708
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1795
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1918
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2080
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2311
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2418
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2570
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2668
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2677
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2853
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2974
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3092
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3263
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3407
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3542
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3643
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3793
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3953
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4093
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..5784
                     /gene="Map4k4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttcgcggc ctcgcgttcg cttgctcgct cgccgcgctc tccggcccca gctccgggcg
       61 gctcgtgcag gcgcgcgcgc gcggggcgcc ggggcctgag gcggcgggcg acgcccgggg
      121 ggtgggtggg ggccgaggga gggccgccgc gccatggtgt gagccccgtg gcccgcgctc
      181 gccgcgctcc gctcagacca gacgacacgc cgcgccggcg gcggcctgct tgtgcggccc
      241 gagccccggc gccgccgagc ccctgcccgt cgctcgctcg ctcgcctgct cttggggcgg
      301 cgacccgggg aagatggcga acgactctcc ggctaaaagc ttggtggaca tcgacctgtc
      361 gtccctgcgg gaccctgctg ggatttttga gctggtggaa gtggttggaa atggcaccta
      421 tggacaagtc tataagggtc gacatgttaa aacgggtcag ctggcggcca tcaaggttat
      481 ggatgtcacc gaggatgaag aggaagaaat caaactggag ataaatatgc tgaagaaata
      541 ttctcatcat agaaatattg caacatacta tggtgctttc attaagaaga gccctccagg
      601 acacgatgac cagctctggc tcgttatgga gttttgcggg gctggttcca tcacagacct
      661 tgtgaagaac accaaaggga acacgctcaa agaagactgg attgcttaca tctcccggga
      721 aatcctcagg gggttggccc atctccacat tcaccatgtc attcaccgag acatcaaggg
      781 gcagaacgtg ctgctgactg agaacgcgga ggtgaaactt gttgattttg gtgtaagcgc
      841 tcagctggac aggacggttg gacggagaaa tacattcata ggcacaccat actggatggc
      901 tccggaggtc atcgcctgcg acgagaatcc agatgccact tacgactaca gaagtgacct
      961 ctggtcttgt ggcatcacgg ccatcgagat ggcagaagga gccccccctc tctgtgacat
     1021 gcatccaatg agagcgctgt ttctcatccc cagaaaccct cctcccaggc tgaagtcaaa
     1081 aaaatggtca aagaaatttt tcagcttcat agaaggctgc ctggtgaaga attacatgca
     1141 gcggccctct acagagcagc ttttaaaaca ccctttcata agggatcagc ccaatgaaag
     1201 gcaggttcga atccagctta aggatcacat agaccggacc aggaagaaga gaggcgagaa
     1261 agatgagacg gagtacgagt acagtggcag tgaggaggag gaggaggaag tgcctgagca
     1321 ggagggagag ccaagttcca tcgtcaatgt gcctggagag tcgactctgc gacgtgattt
     1381 cctgaggctg cagcaagaga acaaggaacg gtctgaggct ctgcggagac agcagcttct
     1441 gcaggagcag cagctccggg agcaggagga gtataagagg cagctgctgg ctgagaggca
     1501 gaagcggatt gaacagcaga aagaacagag gaggcggctg gaagagcaac aaaggagaga
     1561 gcgtgaagcc aggaggcagc aggaacgtga gcagcggcgg cgagaacagg aggagaagag
     1621 gcgtctggag gaactggaaa ggcggcgtaa ggaagaggaa gagaggagac gggcagaaga
     1681 cgagaagagg cgagtggagc gggagcagga gtacatcagg cggcagctag aggaagagca
     1741 gcggcacctg gagatcctgc agcagcagct gctccaggag caggctatgt tactgcacga
     1801 ccacaggagg ccacacgcac aacagccgcc acccccgcag cagcaggaca ggagcaaacc
     1861 cagctatcac gctccagagc ccaagcctca ctacgaccct gctgacagag ctcgggaggt
     1921 ggaagataga tttagaaaga ctaaccacag ctcccctgag gcccaggcta agcagacagg
     1981 cagaggactg gagccacccg tgccttcccg gtcagaatct ttttccaatg gcaactcaga
     2041 gtctgtgcac cctgccctgc agagaccagc ggagccacag gtacagtggt cccacctggc
     2101 atctctcaag aacaatgtct cccctgtctc gagatcccat tccttcagtg acccttctcc
     2161 caaattcgca caccaccatc tccgctctca ggacccatgt ccaccttccc gcagtgaggg
     2221 gctcagtcag agctctgact ctaagtcgga ggtacctgag cccacccaaa aggcttggtc
     2281 tagatcagac agtgacgagg tgcctccaag ggttcctgtg agaacgacat ctcgttcccc
     2341 tgtcctgtcc cgtcgagatt ctccactgca gggcagtggg cagcaaaata gccaagcagg
     2401 acagagaaat tccaccagca gtattgagcc ccggcttcta tgggagagag tggaaaagct
     2461 ggtccccagg ccaggcagtg gcagctcttc agggtccagc aactcaggat cccagcctgg
     2521 ctcccatcct gggtctcaga gtggctctgg tgaacgcttc agagtgagat catcatccaa
     2581 gtctgaaggt tctccatctc agcgccttga aaatgcagcc aaaaaacctg aagataagaa
     2641 agaagtattt cgacctctca aacctgctgg agaagtggac ttgactgcgt tggccaaaga
     2701 gcttcgagca gtggaagatg tgcggccacc tcacaaagtg acagactatt cctcctccag
     2761 tgaggagtct gggaccacgg atgaggagga ggaggatgtg gaacaggagg gggctgatga
     2821 ttccacctcg gggccagagg acaccagagc agcgtcgtct ctgaatctga gcaacggtga
     2881 gacagaatct gtgaaaacaa tgattgttca tgatgacgta gaaagtgaac cagccatgac
     2941 cccatccaag gagggcaccc taatcgtccg ccagactcag tccgctagta gcacactcca
     3001 gaaacacaaa tcttcctcct cctttacacc ttttatagac cccaggttac tacagatctc
     3061 tccatctagt ggaacaacag ttacttccgt tgtgggattt tcctgtgatg ggctgagacc
     3121 agaagccata aggcaagatc ctactcggaa aggctcagtg gtcaatgtga accccacgaa
     3181 cactaggcca cagagtgata cccccgagat tcgtaaatac aagaagagat ttaactcaga
     3241 gatcctgtgt gctgccttat ggggagtgaa tttgctagtt ggcacagaga gtggcctgat
     3301 gctcttggac agaagtggcc aagggaaagt gtaccctctg atcagccgga gacggttcca
     3361 gcaaatggat gtacttgagg gcctgaatgt cctggtgaca atatctggca aaaaggataa
     3421 gttacgcgtc tactatttat cctggttaag aaataaaata cttcataatg atccggaagt
     3481 tgagaagaag caggggtgga ccaccgtggg cgacctggaa gggtgcgtgc actataaagt
     3541 cgtaaaatat gaaagaatca agtttctggt aatcgctttg aagagttctg tggaagtcta
     3601 tgcatgggca ccgaagccat atcacaaatt tatggccttt aagtcatttg gagaactggt
     3661 acataagcca ttactggtgg atctcactgt cgaggaaggc cagaggttga aagtgatcta
     3721 tggatcctgt gctggattcc atgctgttga tgtggattcc ggctcagtct atgacattta
     3781 tctaccaaca cacattcagt gtaccatcaa accccatgca atcattatcc tccccaacac
     3841 ggatggaatg gagcttctgg tgtgctacga agatgaaggg gtttatgtga acacgtacgg
     3901 aagaatcacc aaggacgtgg ttctgcagtg gggagagatg ccaacatctg tagcatacat
     3961 ccggtcgaat cagacaatgg gctggggaga gaaggcaata gagatacgct ctgtggaaac
     4021 tggtcatttg gacggtgtgt ttatgcacaa aagggctcag agactaaagt tcctgtgtga
     4081 acgtaatgac aaggtgttct ttgcttccgt ccgctctggc ggcagcagcc aggtctactt
     4141 catgacctta ggcaggactt cccttctgag ctggtagagg cagtgtgagc cgggatcact
     4201 gacctctgga gtcggcaaga ccccaagaac ttggaattcc ttgcaactgg agctcagagc
     4261 tgtgccggtg cagccatgac agctgtctat gcaggcctct tgtggcgtgg cgtgtcgggt
     4321 cgggtcctct cccctccctc ctacactttc tgccagttta ttcccattct ctcctcctcc
     4381 tttctcaaaa aaataaacca aggctgcatt gcagctggtg ctgttcagac tctaccatcg
     4441 gtgctaggaa tgcttgggga tgaacacatc agaccgggaa gagcgccttt cctacagctc
     4501 caggattcct cgtctccgag ccactgtccc gtgggcgtct gctggttgtg acgattgcgc
     4561 cacccgacgt tggcggcagg cacagagagg tgaaaagttg gtgtaagaag ccgcttgctg
     4621 aagcagagaa cagagttaat atagtaacat taacaatgta tttaattgac atttctctct
     4681 ttttgtaatg tgacagtatg tggacaaaga agaaggtgca ggtctaagag gttaatattt
     4741 ataaaatgtg aaagacacag ttactaggat aacttttttt gtgggtgggg cttggggtgg
     4801 ggcagggcgg gttaaagggt cccattttgt ttctttgaaa gctttttgga gagggttgtc
     4861 ctggccaaga actcagtcat ttttctgtgt accaagtttt gcctaaattg tgcagatggt
     4921 tcttaaaaaa gaaaggaaag gaaaaggaaa tgtgtgcgtc ttgttggagg gccagaagtt
     4981 ttgttgtgta acagtattag caaggcctgg gctaagggtt taatgtccgt taagcctaaa
     5041 gtgcggcagc agctccacca cggtctgcat gcaccatagg aaaggccagc tttcctgtgg
     5101 gttctcattt cgtttcgttt tgttttttgc ctacctcatt gttcttaatg cattgagagg
     5161 tgacttagct taatggtttt ggcagaaaac atttaatgtt taatttaacc ttaataccaa
     5221 aactatctga ttaaagtttg actgactttg tcacaagtct aatcaggtac aaaaaaaaaa
     5281 ggaaaagaaa agagaaagaa agaaagaaag ctgtctatga tggtgggagc agcctcagca
     5341 ctcagacgct ctgctctcac caagttcacc attggagggt gacaggcagc ggagtcacct
     5401 gtcctgacaa gagatctcac tgttcgcagt tacaggcttt ggaagcaggc aggggtcaca
     5461 ctaggagtca cacagactat tcattcatgt tgcaggaact ttttcttggg agcgagggtg
     5521 tgtccctttt cttaaaaaaa aacaaaaagc aaaaaaaaca aaaaaaaccc cgcaatgcac
     5581 taaaactatt ttaagaatgt agttactcct acttcttcat agacggcacc tccctgcctg
     5641 tgtttcaggt gtaagactga cgctctggct tttcctgttt ctcacgtgct ctcttgtttg
     5701 ttctctctct ctttttttta aaaactaatt tttctttatg aatatgtctg tgacatttgt
     5761 aataaatgtc ttgtaataat ttgc
//
