LOCUS       NM_133407               4109 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase
            kinase 3 (Map4k3), mRNA.
ACCESSION   NM_133407 XM_001055154 XM_001057874 XM_001057927 XM_343006
VERSION     NM_133407.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Guo,C.Y., Yu,M.X., Dai,J.M., Pan,S.N., Lu,Z.T., Qiu,X.S. and
            Zhuang,S.Q.
  TITLE     Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3
            (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and
            Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation
            Regulation
  JOURNAL   Med Sci Monit 23, 3562-3570 (2017)
   PUBMED   28731988
  REMARK    GeneRIF: MAP4K3 positively regulates preterm skeletal muscle
            satellite cell myogenesis, but may not regulate mTORC1 activity.
            MAP4K3 may play a role in mTORC1 full activation in response to
            leucine.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Zhang,M., Zhang,J., Lu,L., Qiu,Z.Y., Zhang,X., Yu,S.B., Wu,Y.P. and
            Wang,M.Q.
  TITLE     Enhancement of chondrocyte autophagy is an early response in the
            degenerative cartilage of the temporomandibular joint to
            biomechanical dental stimulation
  JOURNAL   Apoptosis 18 (4), 423-434 (2013)
   PUBMED   23386193
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Ramjaun,A.R., Angers,A., Legendre-Guillemin,V., Tong,X.K. and
            McPherson,P.S.
  TITLE     Endophilin regulates JNK activation through its interaction with
            the germinal center kinase-like kinase
  JOURNAL   J Biol Chem 276 (31), 28913-28919 (2001)
   PUBMED   11384986
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Diener,K., Wang,X.S., Chen,C., Meyer,C.F., Keesler,G., Zukowski,M.,
            Tan,T.H. and Yao,Z.
  TITLE     Activation of the c-Jun N-terminal kinase pathway by a novel
            protein kinase related to human germinal center kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9687-9692 (1997)
   PUBMED   9275185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI502900.1, AF312224.1, CK474868.1, DV716943.1 and AA819812.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_001057874.1, XM_001057927.1, XM_343006.3, XM_001055154.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132272
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               AI502900.1         1-418
            419-2757            AF312224.1         251-2589
            2758-3399           CK474868.1         16-657
            3400-4078           DV716943.1         75-753
            4079-4109           AA819812.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4109
                     /gene="Map4k3"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 3"
                     /db_xref="GeneID:170920"
                     /db_xref="RGD:621280"
     exon            1..231
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2757
                     /gene="Map4k3"
                     /EC_number="2.7.11.1"
                     /note="GLK; MEKKK 3; MEK kinase kinase 3; MAPK/ERK kinase
                     kinase kinase 3; germinal center kinase-related protein
                     kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 3"
                     /protein_id="NP_596898.1"
                     /db_xref="GeneID:170920"
                     /db_xref="RGD:621280"
                     /translation="MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAI
                     KVIKLEPGEDFAVVQQEIIMMKDCKHANIVAYFGSYLRRDKLWICMEFCGGGSLQDIY
                     HVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQ
                     ITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLH
                     PMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQP
                     LTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIPSTSRNVREEKTRSEINFG
                     QVKFDPPLRKETEPHHELDLQLEYGQGHQSNYFLGGNKSLLKSVEEELHQRGHVAHLE
                     DDEGDDDDSKHSTLKAKVPPPLPPKPKSISIPQDTHSSEDSNQGTIKRCPSSGSPAKP
                     SHVPPRPPPPRLPPQKPAVLGNGVSSFQLNGERDGSVHQQQSEQRGTNLSRKEKKDVP
                     KPISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFGAEEGIYTLN
                     LNELHETSMEQLFPRRCTWLYVMNNCLLSVSGKASQLYSHNLPGLFDYARQMQKLPVA
                     IPAHKLPDRILPRKFAVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVE
                     PMQKFMLIKHIEFPMPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNS
                     TSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQ
                     IESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDN
                     PTANSNLYILAGHENSY"
     exon            232..289
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            290..380
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..445
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            446..501
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..549
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..592
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..665
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..797
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            798..860
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..942
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1053
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1132
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1191
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1250
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1289
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1343
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1386
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1546
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1659
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1701
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1786
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1866
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1927
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2045
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2104
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2208
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2380
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2449
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2542
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2613
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2669
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..4092
                     /gene="Map4k3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc gtgcagccgg gcgattgtga ccggcggcgg agccgggccg gccgcgggcg
       61 ctccctccgt gcggcccccc tgagcgcccc ccctccccgg gccgggaggg aggcgggggg
      121 cacccggggc ccgccatgaa cccgggcttc gacctgtccc gccggaaccc gcaggaggac
      181 ttcgagctga tccaacgcat aggcagcggc acctacggcg acgtctacaa ggcacggaat
      241 gtcaacactg gagaattagc cgcaattaaa gtgataaaat tggaaccagg agaagacttc
      301 gcggttgtac agcaagaaat cattatgatg aaagactgca aacatgcaaa catcgttgct
      361 tattttggaa gttatctcag gcgagataaa ctttggattt gcatggaatt ttgtggaggt
      421 ggctctttac aggacatcta tcatgtaact ggcccccttt cagagctgca gattgcatac
      481 gttagcaggg aaacactcca gggattgtat taccttcaca gtaaaggaaa aatgcacaga
      541 gatataaagg gcgctaacat cctactaacg gataacggtc atgtgaaatt agctgatttt
      601 ggagtttccg cacagataac agctacaatt gccaaacgga agtccttcat tggtacccca
      661 tattggatgg ccccagaagt cgcggctgtt gagcggaaag gagggtacaa tcagctgtgt
      721 gacctctggg ctgtgggcat cactgccatc gagctggcgg agctccagcc acccatgttt
      781 gaccttcacc caatgagggc attgtttcta atgacaaaaa gcaatttcca gcctcctaaa
      841 ttaaaagata agttgaagtg gtcaaatagt ttccatcatt ttgtgaagat ggctcttacc
      901 aaaaatccaa aaaaaagacc cactgcagaa aagctgctac agcatccctt tgtcacacag
      961 cctctgacga ggtctttggc aatcgagttg ctggacaagg tgaataatcc agatcattcc
     1021 acataccacg actttgacga tgatgaccca gagcctcttg ttgctgtacc acatagaatt
     1081 ccttcaacta gtaggaatgt gagagaagaa aagacacgct cagagataaa ctttggtcag
     1141 gtaaaatttg acccgccctt aaggaaggag acagagccgc atcatgaact tgatctacaa
     1201 ttagagtacg ggcaaggaca ccaaagtaat tactttttag gtggaaacaa gagtcttctg
     1261 aagtctgttg aagaggagct gcaccagcga ggacacgtgg cacacttaga agatgacgaa
     1321 ggggacgatg acgactctaa acattcaacc ttgaaagcaa aagtcccacc tcctctgcca
     1381 ccaaagccta aatccatctc cataccacag gatacacatt cttctgagga cagtaatcaa
     1441 ggcacaatca agagatgtcc ctcatcaggg agcccagcaa agccatccca cgttcctcct
     1501 agaccaccac cccccaggct acccccgcag aagcctgctg ttttaggcaa tggggtgagc
     1561 tccttccagc tcaatggtga acgggacggg tcggtgcatc agcagcagag tgagcagaga
     1621 ggcacgaacc tctccagaaa agagaagaag gacgtgccaa agccaattag taatggcctt
     1681 cccccaacac ctaaagtgca tatgggagca tgtttttcaa aggtttttaa tggatgtccc
     1741 ttgaaaatcc actgtgccac atcttggata aatccggaca cgagagacca gtacttgata
     1801 tttggcgctg aagagggcat ttataccctt aatctcaatg aacttcatga aacatcaatg
     1861 gaacagctgt tcccccgcag gtgtacgtgg ttgtatgtaa tgaacaactg cttactgtcc
     1921 gtatccggca aagcctctca gctttattcc cacaatttac cagggctttt cgattatgca
     1981 agacagatgc agaagttacc tgtagccatc ccagcacaca agctcccgga tcgaatactg
     2041 cccaggaaat ttgctgtatc agcaaagatt cctgaaacca agtggtgtca gaagtgctgc
     2101 gtggtgagaa atccttacac gggccataag tacctgtgcg gagcacttca gactagcatt
     2161 gttctattag aatgggttga gccaatgcag aagtttatgt taattaagca catagagttt
     2221 ccaatgccgt gtccgctccg gatgttcgag atgctggtgg tgccagagca ggagtaccct
     2281 ctggtctgtg ttggcgtcag tagagggcga gacttcaacc aagtggtgcg atttgagacc
     2341 gtcaatccaa attctacctc gtcatggttc acagagtcag ataccccgca gacaaacgtc
     2401 acccatgtga cccagctgga gagagacacc atcctcgtgt gcttggattg ttgtataaaa
     2461 atagtgaatc tccaaggaag attgaaatcc agcagaaaat tatcttcaga gctcaccttc
     2521 gatttccaga tagaatccat agtttgtcta caagacagtg tgctagcttt ctggaaacac
     2581 gggatgcaag gtagaagttt tagatctaac gaggtaacac aagaaatttc agataacaca
     2641 agaatcttca gacttcttgg atctgacagg gttgtggttt tggaaagtag accaactgac
     2701 aacccaacag caaatagcaa tttatacatc ctggcgggcc acgaaaacag ctactgacac
     2761 tggtgtcgtg acagtgacct gtggagacag ggggccacag ccgctgcaac cttagtggat
     2821 ccgcgaagct atgcgggcgc tgcaggaacc tggctctgtt ccttatagtt tactgtggcg
     2881 aggcagatgg gagaaggctt tgttttaagt ggtatggatc tgtttagcat attgaacaca
     2941 caagtgcttc agccattgtt atgtaatctt tgtacataga agcagtattt ttctgtgaga
     3001 cttcatattg ctgaaggcat acactaagga ttgatgtaga taatgtactt tcatgagatg
     3061 taaaagtgtc ttatctgtac agatgtaaat gtggattaaa atgcagctgg gttaatattt
     3121 taagaattct tagtaaattc ttgggtgtgg tcatattaca gaatgggatg ctggtaatga
     3181 aacaagacat ttaacactat cgtattttta ttatatgtaa tttagtaata tggacataaa
     3241 tcttgtaact tttaaaatgg taacgagctg taatcatttt ataatcctgt ttttaatttg
     3301 aatgcacgtg cactggtgtt tctcctgcac agagtattgc cacgtgatgt gctgtcacag
     3361 agaggctgtg acgccagccg tgactacgca tttggtccta caacatcttt tctacgtgta
     3421 tttggattgt tttctacgtg aaacaaagcc gttaaccacc tactgtagta actgatcttt
     3481 tcctatcaag cagaatcgtg tgcgatagct tgtctgtgct taggacacac ctttgcaaaa
     3541 cgtaaatcac agaatggcgg taccgtggta gaacactgca gctgtcgcca gggcgacagt
     3601 gtgcacagga gagactggca ctgctgagga ctccacacta gacatttcag tcacactgaa
     3661 gagccgtcac attccacagt gacatggtcg cgtttttcat ggacttttac ttctgttggc
     3721 cttattttat tatgacttcc atatttcttt ttatttagag tattaataca tggccaaaat
     3781 aatttagtta ctacctcata cagacatcat aatggttact acagatcaca ggaagttagt
     3841 ttggttaaaa tcattattga tgggtttttc caatggagtg tatctgtctt accaagatcg
     3901 atggcaaggt gtagcgaagc gcacgcctct gactctggta tacgttcatg tgttctttat
     3961 attttgatgt gagtatgtat acactaagaa caagctaaat tgtggtttat gcttcattta
     4021 ttttaactga taatggtttt aaatacgttc ctgattgtac atactgtaaa ataaacatgt
     4081 tttttaacat gcaaaaaaaa aaaaaaaaa
//
