LOCUS       NM_001415830            4646 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase
            kinase 2 (Map4k2), transcript variant 1, mRNA.
ACCESSION   NM_001415830 XM_006230753
VERSION     NM_001415830.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4646)
  AUTHORS   Zhong,J. and Kyriakis,J.M.
  TITLE     Dissection of a signaling pathway by which pathogen-associated
            molecular patterns recruit the JNK and p38 MAPKs and trigger
            cytokine release
  JOURNAL   J Biol Chem 282 (33), 24246-24254 (2007)
   PUBMED   17584736
REFERENCE   2  (bases 1 to 4646)
  AUTHORS   Chadee,D.N., Yuasa,T. and Kyriakis,J.M.
  TITLE     Direct activation of mitogen-activated protein kinase kinase kinase
            MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2
  JOURNAL   Mol Cell Biol 22 (3), 737-749 (2002)
   PUBMED   11784851
REFERENCE   3  (bases 1 to 4646)
  AUTHORS   Ren,M., Zeng,J., De Lemos-Chiarandini,C., Rosenfeld,M., Adesnik,M.
            and Sabatini,D.D.
  TITLE     In its active form, the GTP-binding protein rab8 interacts with a
            stress-activated protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 5151-5155 (1996)
   PUBMED   8643544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 3, 2023 this sequence version replaced XM_006230753.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.953454.1,
                                           SRR26360172.1021490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000001.1  213074400-213074576
            178-235             JAXUCZ010000001.1  213074698-213074755
            236-326             JAXUCZ010000001.1  213074979-213075069
            327-391             JAXUCZ010000001.1  213075147-213075211
            392-447             JAXUCZ010000001.1  213075499-213075554
            448-495             JAXUCZ010000001.1  213075854-213075901
            496-538             JAXUCZ010000001.1  213075996-213076038
            539-611             JAXUCZ010000001.1  213076391-213076463
            612-743             JAXUCZ010000001.1  213076545-213076676
            744-806             JAXUCZ010000001.1  213076751-213076813
            807-888             JAXUCZ010000001.1  213077074-213077155
            889-996             JAXUCZ010000001.1  213077246-213077353
            997-1075            JAXUCZ010000001.1  213077696-213077774
            1076-1134           JAXUCZ010000001.1  213077879-213077937
            1135-1178           JAXUCZ010000001.1  213078601-213078644
            1179-1217           JAXUCZ010000001.1  213078724-213078762
            1218-1251           JAXUCZ010000001.1  213078865-213078898
            1252-1360           JAXUCZ010000001.1  213079016-213079124
            1361-1449           JAXUCZ010000001.1  213079204-213079292
            1450-1491           JAXUCZ010000001.1  213079372-213079413
            1492-1576           JAXUCZ010000001.1  213079497-213079581
            1577-1656           JAXUCZ010000001.1  213079677-213079756
            1657-1717           JAXUCZ010000001.1  213079835-213079895
            1718-1835           JAXUCZ010000001.1  213079979-213080096
            1836-1894           JAXUCZ010000001.1  213085017-213085075
            1895-1998           JAXUCZ010000001.1  213085154-213085257
            1999-2176           JAXUCZ010000001.1  213085334-213085511
            2177-2245           JAXUCZ010000001.1  213086992-213087060
            2246-2332           JAXUCZ010000001.1  213087187-213087273
            2333-2403           JAXUCZ010000001.1  213087516-213087586
            2404-2459           JAXUCZ010000001.1  213087679-213087734
            2460-4646           JAXUCZ010000001.1  213087856-213090042
FEATURES             Location/Qualifiers
     source          1..4646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4646
                     /gene="Map4k2"
                     /note="mitogen activated protein kinase kinase kinase
                     kinase 2"
                     /db_xref="GeneID:293694"
                     /db_xref="RGD:1308199"
     exon            1..177
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2547
                     /gene="Map4k2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 2 isoform 1"
                     /protein_id="NP_001402759.1"
                     /db_xref="GeneID:293694"
                     /db_xref="RGD:1308199"
                     /translation="MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAV
                     KIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY
                     HATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGE
                     LTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLH
                     PMRALMLMSKSSFQPPKLRDKTRWTQTFHHFLKLALTKNPKKRPTAEKLLQHPFTTQP
                     LPPALLTQLLDKASDPHLGTLSPEDSELETHDMFPDTIHSRGHHGPAERTPSEIQFHQ
                     VKFGAPRRKETDPLSEPWEEEWTFLGKEELSRSLLQSVQEALEERSLTIRPAIELQEL
                     DSPDDAIGTIKRAPFMGLPHTESTSDDNAQSCSPGTLSAPPAGPSSPPLLPTAWATLK
                     QREDHERSSCHGLPPTPKVHMGACFSKVFNGCPLQIHAAVTWVHPVTRDQFLVVGAEE
                     GIYTLNLHELHEDTLEKLISHRCIWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQ
                     HQAPLSIPTNRITQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGSTFLLAALPASLL
                     LLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFH
                     VLPLETGLTPDILIPPEGIPGSAQQVIQVDRDTVLVSFERCVRIVNLQGEPTAALAPE
                     LTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILE
                     SIPTGNPGAHSNLYILTGHQSSY"
     exon            178..235
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..326
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..391
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..447
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..495
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..538
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..611
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..743
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..806
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..888
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..996
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1075
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1134
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1178
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1217
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1251
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1360
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1449
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1491
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1576
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1656
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1717
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1835
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1894
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1998
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2176
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2245
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2332
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2403
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2459
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..4646
                     /gene="Map4k2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcctcg ccccgccccg ccccgcgccg ctccgcgccg gctccgcagc ttgcgcccgc
       61 cggcgggtcc ggcgccgggc catggcgctg ttgcgggacg tgtcgttgca ggatccgcgg
      121 gaccgcttcg agctgctgca gcgtgttggg gccgggacct atggcgacgt ttacaaggcc
      181 cgtgacaccg tcacgtccga actggccgcg gtgaagatcg tcaagctaga cccaggagac
      241 gacatcagct ctcttcagca ggaaatcacc atcctccgtg aatgccgcca ccccaatgtt
      301 gtggcctaca ttggcagcta cctcaggaat gaccgcttgt ggatatgtat ggagttctgt
      361 ggaggagggt cactgcagga gatttaccac gccaccgggc ccctggaaga acggcagatt
      421 gcctatgttt gccgggaggc actgaagggg ctccaccacc tgcattctca ggggaaaatt
      481 caccgagaca ttaagggtgc caatcttctg ctcactctgc agggtgatgt caagctagcg
      541 gactttggag tgtcaggcga gttgacagca tctgtggcca agaggcggtc tttcattggc
      601 actccatact ggatggcacc agaggttgct gctgtggaac gcaagggtgg ctacaatgag
      661 ctgtgtgacg tctgggccct gggcatcact gccattgagc tgggcgagct gcaaccaccg
      721 ctgttccacc tccaccccat gagggccttg atgctcatgt cgaaaagcag cttccaacca
      781 cccaagctga gagacaagac acgatggacc cagactttcc accacttcct caagctagcc
      841 ctaaccaaga accccaagaa gaggcctaca gctgagaagc ttctgcagca cccattcaca
      901 acccagccac tccctccagc cctccttacc cagctcctcg acaaggccag cgacccccac
      961 ttgggaaccc tctcccctga agacagtgaa ctggagaccc acgatatgtt tccagacacc
     1021 atccattccc ggggccatca tggtccagct gagaggaccc cctccgagat ccaatttcac
     1081 caagtgaaat ttggtgctcc tcgccggaaa gagacagacc ctctcagtga accgtgggag
     1141 gaggagtgga cattcctggg gaaagaagaa ctgagtagga gcttgctgca gtcagtccag
     1201 gaggccctgg aggaaaggag cctgactatc cggccagcca tagaactcca ggagctggac
     1261 tccccagatg atgccattgg aactatcaaa cgggccccat ttatgggact gccccacact
     1321 gagtcaacat ctgatgacaa tgcccagtct tgctccccag gaaccctgtc agcacctcca
     1381 gctggcccta gcagcccccc actgctgcca actgcctggg cgactctgaa gcaacgggag
     1441 gatcatgagc gatcatcctg ccatggtctt cctcccaccc ccaaggtgca catgggtgcc
     1501 tgcttctcca aggtcttcaa tggctgcccc ctgcagatcc atgctgctgt cacttgggtt
     1561 caccctgtga ctcgagacca gttcctggtg gtaggggctg aggaaggcat ctacaccctc
     1621 aaccttcatg aactgcatga ggatacgctg gagaagctca tctcccatcg ctgcatctgg
     1681 ctctactgtg tgaataatgt gttgctgtca ctctcaggga aatccacaca tatctgggcg
     1741 catgacctcc caggcctgtt tgagcagcgg agactgcagc accaggcacc cctctccatc
     1801 cctaccaacc gcatcactca gcgcatcatc cccagacgct ttgccctgtc taccaagatt
     1861 cctgacacca aaggctgctt gcagtgccgt gtggttcgca acccctatac cggcagtacc
     1921 ttcctgctgg ccgccctgcc tgccagcctg cttctgctgc agtggtatga gccactgcag
     1981 aaattcctgc tgctgaagaa cttttccagc cccttgccca gcccggcagg gatgctggag
     2041 ccgctggtgc tcgacgggaa ggagctgcca caggtgtgcg tgggcgctga gggacctgag
     2101 ggacccggct gcagagtcct gttccatgtc ttgcccctgg agactggcct gactccagac
     2161 atcctcatcc ctcctgaggg gatcccaggt tctgcacagc aggtgatcca ggtggacagg
     2221 gacacagtgc tggtcagctt tgaacgctgt gtgaggatcg ttaacctgca gggagagccc
     2281 acggctgcgc ttgcccctga gctaaccttt gacttcccta ttgagactgt ggtatgtctg
     2341 caggatagcg tgctggcgtt ctggagtcat ggcatgcagg gtcgaagcct tgacaccaac
     2401 gaggtgaccc aggagattac agatgagacc aggatcttcc gagtgctggg ggcccacagg
     2461 gacatcatcc tggaaagcat tcccactggc aaccctgggg cacacagcaa cctctatatc
     2521 ctcacaggtc accagagcag ctactgagct atccccctga tgtcacccag gcctcggttg
     2581 ccacctccag cctctgctgg ggtcccagag agcagaccta gttctgagaa gtgtttgggg
     2641 gcagagagga gaggtagccc acccacttca gcaataaccc caaccagtgg gagctgtgag
     2701 cacctaccct ccctggagag ttgtccccgt acaggagacc ctgggcagga tgggctgcct
     2761 ggccgatcca ttccactttc tcacttttcc ttcccattct ttctgccaag agcctgtccc
     2821 aggttttatc ctgggcaaca tgtatttaag agagaattat attggtatta aagctggttg
     2881 gtcttatccc actagtccct ctgaggtgaa ggagttgaac cctcaccttc tgtcccttct
     2941 ctccttcctc tttctttccc tctttcctgc aggacacttt tctttaagta cttggttggt
     3001 ctcaggcatg caccatggaa gggccagtcc actggtgctc tgtggagtct aagctcaggt
     3061 gacataaacc attgtccctg gtccagcagc tctcactcag ttgtgtagat tgagtcctct
     3121 gctataatct ggcaccttat ggacatgtgc agggcagcca agcaccaaat aggatcttgc
     3181 ctgtggtctg tgggaggatg ctggaaacta gctaccatgt ttataacatt tctgagatgt
     3241 acgctctgcc cctgccatct actgcagtat ccgtgacaag catgtaacaa ttcagtgggc
     3301 atcggcttag accaggaaga tgatgtgggc tcctttagtg ttcagtcact cattccaaga
     3361 tacagctcac cacctaggaa actcattggc acgaatctcc ctgtggctta ttgtatttgt
     3421 cctctcttag tttccttccc tgtggtccca gacactggct gaagatccac tgaaggacgg
     3481 cagggtacac agaaaaggcc tggcctagga gggttaaggg agcgtgtgga gcaaaggtcc
     3541 agctcactct caccctcctg acatttagaa cacatgttgg caaaaggtgc ctggtatgct
     3601 ggctgcaagt acttgccagt cagtgaatca atgggtgggt gggggtgggt aggtgacagt
     3661 tcatgtgtgg ctcttgtggc agttactgtc cctgtgacta ccctcttcca agctctgatt
     3721 ggtttccagt gaccaagagg tttgcttggc taaataggaa gccagaggag gaaaaggaca
     3781 cagtatttgt cctcagtgag acagtcccag agtcagctga ggggccaggg gagacagggc
     3841 tacagagtaa atacctagct tcctatctcc cagacttctg gggtgcgggg tgccggtgat
     3901 aggtgtgaga ggtgttcacc acccagctca caacacttga tcccaggtgc cctggacgaa
     3961 ctggccctca gactttagag cagtaggctg caggcagtga cacctggtgg caggagtcca
     4021 tctgaaaagg tttaggggta tagcatgcca aggtgagggg cctgtgaaag gcaagatcca
     4081 ctgataatgt ttgctcccag caaaggtggg tgccacaagc caaagacggg gcaagccagg
     4141 aatatgcact gaaagatgta attttattta tgtatttgtt tatagatagc cttttaaaaa
     4201 agaaaataga ttctaggtta gactgtggtg aatgcctgtg aacccagtac tcaggaggca
     4261 gaggcaggac cgtgtgaatt gtagtccagc ctggtccaca tagtgaattc caggccagcc
     4321 aaagttatat gtagacaggg ctgcgtcaaa aataaataaa acttgccttc tcatttatcc
     4381 tccagttcct tctagaagta tttatgatat ttaaacaatt tgacatattt ttattcacat
     4441 ggaaatattc tatatatctt tctggctttt tgaaaataca ttctggagat ctttacgtta
     4501 acaacctggc atttttttgt atagctagag cagggtttta tgcatttagg tgactaatgt
     4561 taacagaaag atctttattg atggaatgta tttctacttt aatatcacaa accacactgc
     4621 aataaataac tcctgtgtca aagcca
//
