LOCUS       NM_001106243            2699 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase
            kinase 1 (Map4k1), mRNA.
ACCESSION   NM_001106243 XM_001074916 XM_214883
VERSION     NM_001106243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J,
            Abbruzzese JL, Tan TH and Wang H.
  TITLE     The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8)
            ubiquitin ligase promotes degradation of hematopoietic progenitor
            kinase 1
  JOURNAL   J Biol Chem 289 (7), 4009-4017 (2014)
   PUBMED   24362026
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Li T, Yu XJ and Zhang GY.
  TITLE     Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic
            brain injury in rat hippocampal CA1 region
  JOURNAL   FEBS Lett 582 (13), 1894-1900 (2008)
   PUBMED   18498770
  REMARK    GeneRIF: The tyrosine phosphorylation of HPK1 promotes ischemic
            brain injury by activated Src via N-methyl-d-aspartate receptor
            and, ultimately, the activation of the MLK3-MKK7-JNK3 pathway after
            cerebral ischemia.
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Li T, Han D, Chen J, Yu XJ and Zhang GY.
  TITLE     Neuroprotection against ischemic brain injury by knockdown of
            hematopietic progenitor kinase 1 expression
  JOURNAL   Neuroreport 19 (6), 647-651 (2008)
   PUBMED   18382279
  REMARK    GeneRIF: knockdown of hematopietic progenitor kinase 1 expression
            provides neuroprotection
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Leung IW and Lassam N.
  TITLE     The kinase activation loop is the key to mixed lineage kinase-3
            activation via both autophosphorylation and hematopoietic
            progenitor kinase 1 phosphorylation
  JOURNAL   J Biol Chem 276 (3), 1961-1967 (2001)
   PUBMED   11053428
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N,
            Pawson T, Woodgett JR and Iscove NN.
  TITLE     HPK1, a hematopoietic protein kinase activating the SAPK/JNK
            pathway
  JOURNAL   EMBO J 15 (24), 7013-7025 (1996)
   PUBMED   9003777
REFERENCE   7  (bases 1 to 2699)
  AUTHORS   Hu MC, Qiu WR, Wang X, Meyer CF and Tan TH.
  TITLE     Human HPK1, a novel human hematopoietic progenitor kinase that
            activates the JNK/SAPK kinase cascade
  JOURNAL   Genes Dev 10 (18), 2251-2264 (1996)
   PUBMED   8824585
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214883.4, XM_001074916.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2699
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /note="mitogen activated protein kinase kinase kinase
                     kinase 1"
                     /db_xref="GeneID:292763"
                     /db_xref="RGD:1305463"
     exon            1..204
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2589
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /EC_number="2.7.11.1"
                     /note="hematopoietic progenitor kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 1"
                     /protein_id="NP_001099713.1"
                     /db_xref="GeneID:292763"
                     /db_xref="RGD:1305463"
                     /translation="MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVA
                     LKMVKMEPDDDVSTLQKEILMLKSCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI
                     YQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDSGEVKLADFGISA
                     QIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDV
                     HPLRVLFLMTKSGYQPPRLKEKGKWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQ
                     PGLNRGLILDLLDKMKNPGKGLPVEIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCC
                     RRHMEFQRPRCVECRSQADTVLLQPSADFRSTSPRSQLSDSDDDYDDVDIPAPSENLP
                     PPLPPKPKIRSPSDDGSGGVRDDGQLSPGVLVRCASGPPPRIPRPGPPPATRSPHLTA
                     RSDPSLWNPAAPEPGQPPLLPPRKEKMRKKMENEKRREEYTLLVKLFNGCPLQIHSTA
                     AWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTP
                     HLYSHSILGLLERKEVRTGSPIAHISPHRFLARKNMVSSKIQDTKGCRACCVAEGASS
                     GGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFALLTTPGSELPAVCIG
                     VSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTP
                     EGAPAPGLRTPEIPMTEAVEAVAMVGDRLQAFWKHGVQVWAPDSEQPLQELRDPTLTF
                     RLLCSPRPVVVETRPTDDPTAPSNLYIQE"
     exon            205..262
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..353
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..418
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..474
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..522
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..565
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..638
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..770
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..833
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..915
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1029
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1108
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1167
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1211
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1256
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1299
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1462
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1545
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1569
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1654
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1731
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1792
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1901
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1960
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2064
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2239
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2302
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2392
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2463
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2519
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2699
                     /gene="Map4k1"
                     /gene_synonym="Hpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaaggcg ggcccaggac ttgtggagac agagggtaat accaaagctt gagccctgag
       61 gccctgttgg cccactgggc actggcccag ccccggcctc cagggatggc ccttgtggac
      121 cctgacatct ttaataagga ccctcgagaa cactatgatc tactgcagcg actgggtggt
      181 ggaacgtatg gagaagtgtt caaggctcgc gacaaggtgt ctaaggacct agtggctttg
      241 aagatggtga agatggagcc tgatgatgac gtctctaccc ttcagaagga gattctcatg
      301 ctgaaatctt gccggcacgc caacatcgtg gcttaccatg gcagttacct ctggcttcag
      361 aagctatgga tctgcatgga attttgtgga gccggttccc tccaggacat ctaccaagtg
      421 accggctctc tgtccgagct ccagatcagc tatgtgtgcc gggaagtgct gcagggactg
      481 gcctacctgc attcacagaa gaagatacat cgagacatca agggagccaa catcctcatc
      541 aatgactccg gggaggttaa actggctgac tttgggatct cagcccagat tggggcaaca
      601 ctggcccgac gcctgtcttt cattggaaca ccatactgga tggctccaga ggtggcagct
      661 gtggccctga aaggtggata caatgagctg tgtgacatct ggtctcttgg catcacagcc
      721 atcgagctgg ccgagcttca gccccctctc tttgatgtgc accccctcag ggttctcttc
      781 ctcatgacca agagcggcta ccagcctccg cggctaaagg aaaagggcaa atggtcctct
      841 tccttccaca actttgtcaa agtcaccctc actaagaact ccaagaaacg ccccagtgcc
      901 accaagatgc tcagtcatca gctggtgtcc cagccaggac tgaacagagg cctgatcttg
      961 gatcttcttg acaaaatgaa gaatcctggg aaagggctgc ccgttgagat tgaagatgag
     1021 gagcctgagc ctccccctgc catccctcgg cggatcagat ctacctaccg ggccagctcg
     1081 ctggggattc cagacgcaga ttgctgtcgg cggcacatgg agttccagag gcccagatgt
     1141 gtggaatgca gatctcaggc tgacactgtt ctcttacagc cctctgcaga cttcaggagc
     1201 accagtccca ggagccaact ctcagactct gatgacgact atgatgatgt ggacattcct
     1261 gccccttcag agaacctacc tcctcccctg ccccccaagc ccaaaattcg gtctccatca
     1321 gatgatggtt ctggaggagt tagggacgac gggcaactga gcccaggggt gctggtccgg
     1381 tgcgccagtg ggcctcctcc acgtattccc cgtcctggac ctcccccagc cacccgcagc
     1441 cctcatctca cagcccgttc agatccctcg ctatggaacc cagctgcccc ggagccaggc
     1501 cagcccccac tcctaccccc taggaaggaa aagatgagga aaaagatgga gaacgagaag
     1561 cgccgagagg aatacaccct tcttgtgaaa ttgttcaacg gctgtcccct ccagatccac
     1621 agtacggctg cctggacaca tccctcgacg aaagaccagc atctgctcct gggtgcagag
     1681 gaaggcattt tcatactgaa ccggaatgat caggaggcca cgctggaaat gatctttcct
     1741 ggccgcacaa cctggctgta ctgcatcaac aacctcctca tgtctctctc agggaagaca
     1801 ccccacctgt attctcatag tatcctgggc cttctggaaa gaaaagaggt cagaacagga
     1861 agccccatcg ctcacatcag ccctcaccgg ttcctggcaa gaaagaacat ggtctccagt
     1921 aagatccagg acaccaaagg ctgccgggct tgttgtgtgg ccgagggtgc cagctctggg
     1981 ggcccattcc tgtgtggagc attggagacc tctgtggttc tgctccagtg gtaccagcca
     2041 atgaacaaat tcttgcttgt ccggcaggtg ttgttcccgc tgcccacgcc actgccggtg
     2101 ttcgcgctgc tgacaacgcc cggctccgag ctgccggctg tgtgcatcgg cgtgagcccg
     2161 gggcaagcgg caaagtcggt actcttccac accgtgcgct tcggtgcctt gtcctgctgg
     2221 ctggacgact ccagcaccga gcacaaggga ccagtgcagg tgatccaagt aaaggaagac
     2281 atggtgatgg tgttgatgga tggctctctg aagctagtga ccccggaggg ggcaccagct
     2341 cccgggcttc gcacccctga gatccccatg acagaagcgg tcgaggctgt ggcaatggtt
     2401 ggagatcgac tccaggcctt ctggaagcac ggagttcagg tgtgggctcc agactcggaa
     2461 cagccgctgc aggagctgag agatcccacc ctcaccttcc gtctgctctg ctccccgagg
     2521 cctgtagtgg tggaaacacg gcccacggat gaccctaccg cccccagcaa cctctacatc
     2581 caggaatgaa ccattgagag ggcattgaga aacggacacc tgcagaccct aagggacaca
     2641 ctagtggtca caacatgtcc ttatctccca ataaacttga ctttagtctt gtcatcttg
//
