LOCUS       NM_001419954            5721 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus microtubule-associated protein 4 (Map4),
            transcript variant 1, mRNA.
ACCESSION   NM_001419954 XM_006243822
VERSION     NM_001419954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5721)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   2  (bases 1 to 5721)
  AUTHORS   Hu,J., Chu,Z., Han,J., Zhang,Q., Zhang,D., Dang,Y., Ren,J.,
            Chan,H.C., Zhang,J. and Huang,Y.
  TITLE     Phosphorylation-dependent mitochondrial translocation of MAP4 is an
            early step in hypoxia-induced apoptosis in cardiomyocytes
  JOURNAL   Cell Death Dis 5 (9), e1424 (2014)
   PUBMED   25232678
  REMARK    GeneRIF: When targeted to mitochondria, MAP4 was found to lead to
            mPTP opening and induce apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5721)
  AUTHORS   Ghossoub,R., Hu,Q., Failler,M., Rouyez,M.C., Spitzbarth,B.,
            Mostowy,S., Wolfrum,U., Saunier,S., Cossart,P., Jamesnelson,W. and
            Benmerah,A.
  TITLE     Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the
            primary cilium and control ciliary length
  JOURNAL   J Cell Sci 126 (Pt 12), 2583-2594 (2013)
   PUBMED   23572511
REFERENCE   4  (bases 1 to 5721)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 5721)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 5721)
  AUTHORS   Samora,C.P., Mogessie,B., Conway,L., Ross,J.L., Straube,A. and
            McAinsh,A.D.
  TITLE     MAP4 and CLASP1 operate as a safety mechanism to maintain a stable
            spindle position in mitosis
  JOURNAL   Nat Cell Biol 13 (9), 1040-1050 (2011)
   PUBMED   21822276
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5721)
  AUTHORS   Fang,Y.D., Xu,X., Dang,Y.M., Zhang,Y.M., Zhang,J.P., Hu,J.Y.,
            Zhang,Q., Dai,X., Teng,M., Zhang,D.X. and Huang,Y.S.
  TITLE     MAP4 mechanism that stabilizes mitochondrial permeability
            transition in hypoxia: microtubule enhancement and DYNLT1
            interaction with VDAC1
  JOURNAL   PLoS One 6 (12), e28052 (2011)
   PUBMED   22164227
  REMARK    GeneRIF: there are two possible mechanisms triggered by MAP4:
            stabilization of MT networks; DYNLT1 modulation, which is connected
            with VDAC1, and inhibition of hypoxia-induced mitochondrial
            permeabilization
REFERENCE   8  (bases 1 to 5721)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   9  (bases 1 to 5721)
  AUTHORS   Ebneth,A., Drewes,G., Mandelkow,E.M. and Mandelkow,E.
  TITLE     Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the
            destabilization of microtubules in cells
  JOURNAL   Cell Motil Cytoskeleton 44 (3), 209-224 (1999)
   PUBMED   10542369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 24, 2023 this sequence version replaced XM_006243822.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.47710.1,
                                           SRR26643289.24294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000008.1  118804066-118804184
            120-361             JAXUCZ010000008.1  118852314-118852555
            362-430             JAXUCZ010000008.1  118869560-118869628
            431-553             JAXUCZ010000008.1  118893840-118893962
            554-667             JAXUCZ010000008.1  118895286-118895399
            668-802             JAXUCZ010000008.1  118897703-118897837
            803-1939            JAXUCZ010000008.1  118899008-118900144
            1940-2053           JAXUCZ010000008.1  118900963-118901076
            2054-2160           JAXUCZ010000008.1  118922481-118922587
            2161-2382           JAXUCZ010000008.1  118923546-118923767
            2383-2566           JAXUCZ010000008.1  118926812-118926995
            2567-2626           JAXUCZ010000008.1  118927721-118927780
            2627-2919           JAXUCZ010000008.1  118927892-118928184
            2920-3033           JAXUCZ010000008.1  118930022-118930135
            3034-3126           JAXUCZ010000008.1  118931572-118931664
            3127-3208           JAXUCZ010000008.1  118936643-118936724
            3209-3321           JAXUCZ010000008.1  118938491-118938603
            3322-3511           JAXUCZ010000008.1  118940282-118940471
            3512-5721           JAXUCZ010000008.1  118940596-118942805
FEATURES             Location/Qualifiers
     source          1..5721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5721
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /note="microtubule-associated protein 4"
                     /db_xref="GeneID:367171"
                     /db_xref="RGD:1564359"
     exon            1..119
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            120..361
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3519
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 1"
                     /protein_id="NP_001406883.1"
                     /db_xref="GeneID:367171"
                     /db_xref="RGD:1564359"
                     /translation="MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEK
                     TEFIPLLDGDEKSGNSESKRKPCVDTSQVEDIPSSKPTLLANGDHGVEGNNTTGSPTD
                     FLVENVDYEDYQNSQSWPEDASFCFQPQQVLDTNQADPFNVHHDDGLADLLFVSSGPT
                     NASAFIEENNPLEDSYGVLPCDSFAPTAVVSQEWSVGAPDSPHSEPCVSPEVTIETAQ
                     PATELSKAVDLESVKEQLPAKALEMMAGQTTDAVPSKESEGSPDTDAAPGPDTDVTLT
                     KDIEESSSPDVISANVTQPFTESDMFLTQEMELLIGTEAAQVKDTMSSVEPDISSAKN
                     TAPPTEEETVPGKDMTFPKEAETALPIEMDLAPPEDVALPKETELELAPAAGTAPLSE
                     TEVALAKDEEPSTGIPAAQEMLLSSETEVVLPSDSIMTLTKEVTVPLEAAGPLVSDMT
                     AILETEMTLGGGTATPTETKLGKVKDMAPLPESEVALGKDVVTLPETKVTEFNNVTPL
                     SEEEVASIKDVSPSPETETAKNADLHSGTELTLDNSMTPPSDPALPLETKVATVQIKD
                     KETVQTQEELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKSTLPVDEGSPLEKLE
                     QKETSGSQPPELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPLATTQPA
                     KTSTSKAKIQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTL
                     PARDLKPKPITETKVAEKRTSPSKPSSAPALRPGPKTTPTISKATSPSTLVSTGSSSR
                     SPSTTLPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPPA
                     GMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVG
                     STENMKHQPGGGRAKVEKKTEAATTAGNPEPNAVTKAASSISSAPKPPAGKVQIVSKK
                     VSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKI
                     ESQKLNFKEKAQAKVGSLDNVGHLPAGGTVKTEGGGSEAPPCPGPPAGEEPAIPEAAP
                     DAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI"
     exon            362..430
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            431..553
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            554..667
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            668..802
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1939
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2053
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2160
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2382
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2566
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2626
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2919
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3033
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3126
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3208
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3321
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3511
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..5721
                     /gene="Map4"
                     /gene_synonym="Mtap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctgtgccc cgcccctccg gctagctctg tggcttctgc ggctcctccc ggctgctccg
       61 ggctcctctc tgccctctcc cggctttctg cggctccagc ttgggctcgg cggcggcggg
      121 cagtcgcagt ggtaaagaat ggcggacctc agccttgtgg atgcattgac agagccacct
      181 ccagaaattg aaggagagat aaagcgagac tttatggctg cgctggaggc agagccctat
      241 gatgacattg tgggagaaac tgtggagaag actgagttta ttcctctcct ggatggtgat
      301 gagaaatctg ggaactcaga gtccaaaagg aaaccatgtg tagacactag ccaggttgaa
      361 gatatcccat cttctaaacc aacacttcta gccaatggtg atcatggagt ggaggggaat
      421 aacactacag ggtctccaac tgacttcctc gtagagaacg tggactatga ggactatcag
      481 aacagccaga gctggccgga agatgcaagc ttttgtttcc agcctcagca agtgctggac
      541 actaaccagg ctgatccctt taacgtgcac catgatgatg gtcttgcaga tctgctcttt
      601 gtctccagtg gacccacaaa tgcttctgca tttatagagg aaaacaatcc tttggaagac
      661 agttatggtg tgcttccctg tgactcgttt gctcccacgg ctgttgtatc tcaggagtgg
      721 tctgtgggag ccccagactc tccacactca gagccctgcg tttccccaga ggttactata
      781 gaaactgcac agccagcaac agagctatcc aaggcagtcg acttggagtc agtaaaagag
      841 cagctgccag ctaaagcatt ggaaatgatg gcaggacaaa ccactgatgc ggtgccatct
      901 aaagaatcag agggctctcc agacacagat gcagcaccag gtccagacac agacgtgaca
      961 ctgactaaag acatagaaga gagcagcagt ccagatgtga tatcggcaaa tgtcacacag
     1021 ccattcactg aatcagatat gttcctgacc caggaaatgg aactactcat aggaacagag
     1081 gcagcccagg ttaaagacac catgtcgtct gtagaaccag atatatcttc agccaagaac
     1141 acagcaccgc ctacagaaga agaaacggtc ccaggcaagg atatgacatt ccccaaagaa
     1201 gcagagacag cacttccaat agaaatggat ttggcaccac ctgaggatgt ggcacttccc
     1261 aaagaaacag agctagaact agccccagcc gcgggcacgg ctccactctc agaaacagaa
     1321 gtggccctgg caaaggatga ggagccttct acaggaatac ctgcggctca ggagatgctc
     1381 ttgtcctcag aaacagaggt ggtactgccc tcagattcca taatgacact gacaaaggaa
     1441 gtgacagtac ccttagaagc agctggaccc ctggtgtcgg acatgactgc aattctggaa
     1501 acagaaatga ccctaggcgg ggggacagct acacccacag aaacaaaatt gggcaaggtc
     1561 aaagacatgg ctccactccc agaatcagaa gtggctctgg gcaaggacgt ggtcacactt
     1621 ccagaaacaa aggttactga atttaacaat gtgactccac tttcagaaga agaggtagcc
     1681 tcaatcaagg acgtatctcc gtctccagaa acagagacgg ctaagaatgc tgatctgcac
     1741 tcaggaacag agttgactct agacaacagc atgactcccc cctcggatcc tgcactgccc
     1801 ctggaaacaa aagtagccac agttcaaatt aaagacaaag aaactgtgca gacccaagaa
     1861 gagctaagtg aagactccca gttagagtct gtgcagctcg agggacagtc agcagtacct
     1921 ccttgcacga tttccccaga accagtgaaa gctgcagacc aaaagtctac tttgccagta
     1981 gatgaaggtt ctccattaga gaaattagag cagaaggaaa catctggcag tcagcctcct
     2041 gagctttgct caggagtatc ccggcaagaa gaaggaaagg ctgctgttgg tctgactgga
     2101 aatgacatcg ccactccacc aaacaaggag ctaccaccaa gcccagaaaa gaaagcaaag
     2161 cctttggcca ccactcaacc tgcaaagact tcaacatcga aagccaaaat acagcccact
     2221 tctctcccta agcaaccagc tcccaccacc tctggtgggt tgaataaaaa acccatgagc
     2281 ctcgcttcag gctcagttcc agctgcccca cacaaacgcc ctgctgctgc cactgctact
     2341 gccaggcctt ccaccctacc tgcaagagac ctgaagccaa agccaattac agaaactaag
     2401 gttgctgaaa agcggacctc gccatccaag ccttcatctg cccccgccct cagacctgga
     2461 cctaaaacca ccccaaccat ttctaaagcc acatctccct caactcttgt ttccactgga
     2521 tcaagtagta gaagtccatc tacgactctg cctaagaggc ctaccaccac caagactgag
     2581 ggaaaacctg ctgatgtcaa aaggatgact gctaagtctg ccacagctga cttgagtcgc
     2641 tcaaagacca cctctgccag ttctgtgaag agaaacacca ctcccactgg ggcaacaccc
     2701 ccagcaggga tggcttccac tcgagtcaag cccatgtctg caccttgccg gtcttctgtg
     2761 gctctttccg tggacaagaa gcccacctcc actaagccta gctcctctgc tcccagggtg
     2821 agccgtttgg ccacaactgt ttctgcccct gatctgaaga gtgtccgctc caaggtcggc
     2881 tccacagaga acatgaagca ccagccagga ggaggccggg ccaaagtaga gaaaaaaaca
     2941 gaggcagcta ccacagctgg aaatcctgag cctaatgcag tcactaaagc agccagctcc
     3001 atttcgagtg caccgaagcc ccctgccggg aaagtccaga tagtctccaa aaaagtgagc
     3061 tacagccata ttcaatccaa gtgtgggtcc aaggacaata ttaagcatgt ccctggaggt
     3121 ggcaatgttc agattcagaa caagaaagtg gacatatcca aggtctcctc caagtgtggg
     3181 tccaaagcta atatcaaaca caagcctggt ggaggagatg tcaagatcga aagtcagaag
     3241 ttgaatttca aggagaaggc tcaagccaaa gtggggtccc ttgataacgt tggccacttg
     3301 cctgcaggag gaaccgtgaa gactgagggc ggtggcagtg aggcccctcc gtgtccaggc
     3361 ccccccgctg gggaggagcc agccatccct gaggctgcgc ctgacgctgg cgcccctact
     3421 tcagccagtg gcctcagtgg ccacaccacc ctgtcagggg gtggtgacca aagggagccc
     3481 cagaccttgg acagccagat ccaggagaca agcatctaat gatgacattc tggtctcgtc
     3541 ttccatctcc cctgtgttcc ctctcttgtc tccccccttg ttgccctctc ccatccctcc
     3601 tcacgtgtca ctgcagattg agacctacag gctgacgttc cgggcaaatg ccagggcccg
     3661 caccgaccat ggggctgaca ttgtctcccg gcctccccac ttccctggtg gcccaagctt
     3721 ggggtctcgg gccctgggct ccttttcccg ggctgtctac tagacttgta agctcttggg
     3781 tgctgggcag cccctttagg cctccttccc tcctgtctcg cttgctcaag gcagccgcag
     3841 ccctgctgcc ttcacacctc cttccaccct ttctgggccc agctccaact tcactatcgc
     3901 acccttcact gctctatgga gaaaggtggg agggggtggg agtctaatgg gatctctgtg
     3961 ggatctaggg gtgaggggct ggattccagc cttggccgtt tggttttttt ggaccaaacc
     4021 caaaagaaac tgacaaaccc tccctctctt ccctggctca ccctcgagag actagtaaag
     4081 gtgaactccg agtggagacc agcaccgacc gaaccccctg gaacccaaac tactgcctct
     4141 ccttgacccc atgctagagg ccaccatgga ggtgtcacca ggcccttttg ctgccctgcc
     4201 tcaagttagt caaggttcag tcctccttgt ccccactgct tattgtacct gaatagctgc
     4261 tgtctcactt ttttccttct tttccccttc ccaataacct atgaactggt ggtgtagttt
     4321 gcaggttgaa gctatgtcta aaagagagtt ctcagtaggt ggtgaaggaa gcagaggagg
     4381 agatcctgag tctccactga ggaggctgtc aggcattggg gtctgcccta ctctgggcag
     4441 cttggatcct gtgggaagaa gtggactatt gcctagtgga gttggacagc caggtggtca
     4501 gcgtgatggc tgtgttgtgt atatttgctg cttttctaac aagaggctgg ttttggcatc
     4561 tatctcattc cctgggaatc cggtggttaa tgtgtgatac aaaaccaggg ctggagaaac
     4621 agaaatgaag gtcaaagtcc ctggtctgta cctgcaggcc atggcaccca aatcctcata
     4681 tctaggggag cctgagatgt ccagaatgct tgtgaacagt ggggaatcag gtgtgaaaat
     4741 ttaaaactaa aatgcatgag actgaggcca tcccactttt cttctggtgt gactggagag
     4801 gaggagcagg agaggccagc cgtggaggtg cagccatccc agtgtggtct gctcatggat
     4861 gggatggctg caatattgag aaaatcccgg gaattgtatc aacacaagat tcttattgca
     4921 cttgtatttt ttgtattaaa gtttgcatgg tttctaataa agaattcaaa cctaagtttg
     4981 tattgaaatg gcctgggagt gtctaagggc tcctctggta gggcattttc tgctgggcag
     5041 atttgcctct caggaggctg acccagactt gacccccccc aggccctcct tctaacacag
     5101 cctcgcctct gcttgggtgt gtttttgagc aggtagaggt cttcactatc tctctgccaa
     5161 gggagggtat ccctgggctt gaaggtcctc tccatttatg aggtagcagt tactttataa
     5221 tcttgacatg gaatccctag ctctctaagc acacacaaag aattattgcg gtctgtagaa
     5281 aaaaggactg ccagaactat gcttggagcc tgcattgtat tttgcagcaa gaagggggcc
     5341 tgatggagct gggaaggacg cagtagggat cagggtagtg atggctgagg gcataaaggt
     5401 acttgctacc ctccttgatg ttaatcttgg ggccttgaag atgctgatga aattgtcaag
     5461 aaacaagtcc attggccaag gattagagaa aggaaggcag cccaagctct ccaggtagct
     5521 ccccgaaagg atgccacaag ccagagaacc tgagaaggct ggtctagcag attgggacca
     5581 caggccatgt ggtgtgcata cttcgaaatg tttgggaata agatcttttc tgtactttac
     5641 agtttgctca tggcttagcc atttcctgtg tctgtaattg ttgtactgat ttaaacaata
     5701 aagctgcctg acatcccacc a
//
