LOCUS       NM_001100872            3638 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 9
            (Map3k9), mRNA.
ACCESSION   NM_001100872 XM_002726763 XM_003750194 XM_003750195 XM_576071
VERSION     NM_001100872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3638)
  AUTHORS   Hao,K., Lin,P., Li,J., Hu,J., Wang,J. and Li,F.
  TITLE     IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate
            the progression of shoulder arthritis
  JOURNAL   Aging (Albany NY) 16 (9), 7915-7927 (2024)
   PUBMED   38728237
  REMARK    GeneRIF: IL21 inhibits miR-361-5p to promote MAP3K9 and further
            aggravate the progression of shoulder arthritis.
REFERENCE   2  (bases 1 to 3638)
  AUTHORS   Liu,S., Li,L., Li,M. and Zhang,J.
  TITLE     Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced
            ovarian granulosa cell injury by targeting MAP3K9
  JOURNAL   In Vitro Cell Dev Biol Anim 56 (3), 213-221 (2020)
   PUBMED   32185607
  REMARK    GeneRIF: Effect of miR-26b-5p on cis-diamine
            dichloroplatinum-induced ovarian granulosa cell injury by targeting
            MAP3K9.
REFERENCE   3  (bases 1 to 3638)
  AUTHORS   Johnson,G.L. and Nakamura,K.
  TITLE     The c-jun kinase/stress-activated pathway: regulation, function and
            role in human disease
  JOURNAL   Biochim Biophys Acta 1773 (8), 1341-1348 (2007)
   PUBMED   17306896
  REMARK    Review article
REFERENCE   4  (bases 1 to 3638)
  AUTHORS   Durkin,J.T., Holskin,B.P., Kopec,K.K., Reed,M.S., Spais,C.M.,
            Steffy,B.M., Gessner,G., Angeles,T.S., Pohl,J., Ator,M.A. and
            Meyer,S.L.
  TITLE     Phosphoregulation of mixed-lineage kinase 1 activity by multiple
            phosphorylation in the activation loop
  JOURNAL   Biochemistry 43 (51), 16348-16355 (2004)
   PUBMED   15610029
REFERENCE   5  (bases 1 to 3638)
  AUTHORS   Kim,K.Y., Kim,B.C., Xu,Z. and Kim,S.J.
  TITLE     Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates
            transforming growth factor-beta-induced apoptosis in hepatoma cells
  JOURNAL   J Biol Chem 279 (28), 29478-29484 (2004)
   PUBMED   15069087
REFERENCE   6  (bases 1 to 3638)
  AUTHORS   Ganguly,A., Oo,T.F., Rzhetskaya,M., Pratt,R., Yarygina,O.,
            Momoi,T., Kholodilov,N. and Burke,R.E.
  TITLE     CEP11004, a novel inhibitor of the mixed lineage kinases,
            suppresses apoptotic death in dopamine neurons of the substantia
            nigra induced by 6-hydroxydopamine
  JOURNAL   J Neurochem 88 (2), 469-480 (2004)
   PUBMED   14690535
REFERENCE   7  (bases 1 to 3638)
  AUTHORS   Xu,Z., Maroney,A.C., Dobrzanski,P., Kukekov,N.V. and Greene,L.A.
  TITLE     The MLK family mediates c-Jun N-terminal kinase activation in
            neuronal apoptosis
  JOURNAL   Mol Cell Biol 21 (14), 4713-4724 (2001)
   PUBMED   11416147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Sep 7, 2012 this sequence version replaced
            XM_003750194.1, XM_003750195.1, XM_576071.4, XM_002726763.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1411436.1,
                                           SRR22582416.108190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               JAXUCZ010000006.1  107219643-107220061 c
            420-833             JAXUCZ010000006.1  107211009-107211422 c
            834-1014            JAXUCZ010000006.1  107181044-107181224 c
            1015-1163           JAXUCZ010000006.1  107175095-107175243 c
            1164-1339           JAXUCZ010000006.1  107174147-107174322 c
            1340-1580           JAXUCZ010000006.1  107172019-107172259 c
            1581-1703           JAXUCZ010000006.1  107170578-107170700 c
            1704-1857           JAXUCZ010000006.1  107169366-107169519 c
            1858-1970           JAXUCZ010000006.1  107165525-107165637 c
            1971-2783           JAXUCZ010000006.1  107163810-107164622 c
            2784-3638           JAXUCZ010000006.1  107161534-107162388 c
FEATURES             Location/Qualifiers
     source          1..3638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3638
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /note="mitogen-activated protein kinase kinase kinase 9"
                     /db_xref="GeneID:500690"
                     /db_xref="RGD:1562149"
     exon            1..419
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3268
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /EC_number="2.7.1.-"
                     /note="mixed-lineage kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     9"
                     /protein_id="NP_001094342.1"
                     /db_xref="GeneID:500690"
                     /db_xref="RGD:1562149"
                     /translation="MESSRSLLGCLASAAAAPPGEDATGAGAEEEEDEEEAAAELGSH
                     ATLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSN
                     YVTPRSAFSSRCQPGTEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWVGDE
                     VAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG
                     GPLNRVLSGKRVPPDILVNWAVQIARGMNYLHDEAIVPVIHRDLKSSNILILQKVENG
                     DLSNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWE
                     LLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFSSI
                     LDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQ
                     QKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDG
                     NRISLPSDFQHKFTVQASPTMDKRKSLISNRSSPPASPTIIPRLRAIQLTPGESSKTW
                     GRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELTSGDEGLKSLVDGYKQWSSSAP
                     NLGKGPRSSPALPGFTSLMEIEDEDSEGPGSGENHLQHSPNQSYLCIPFPRGEDGDGP
                     SSDGIHEEPTPVNSATSTPQLTPTNSLKRSGTHHRRCEVALLGCGAVLAATGLGFDLL
                     EAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLGDP
                     SASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTQNPLVNVRVE
                     RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPASVPPALGSRSPSSNGVSPGP
                     GAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSA
                     NRQRLDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQA
                     GPLPPAERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS"
     exon            420..833
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1014
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1163
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1339
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1580
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1703
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1857
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1970
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2783
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3638
                     /gene="Map3k9"
                     /gene_synonym="RGD1562149"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgccc cgcaccctat ggaccggccg ctccatggag tcctccagat cgcttctcgg
       61 ctgcctggcg agcgccgctg cggccccgcc gggggaggat gccaccggtg ctggggccga
      121 agaggaggaa gacgaagagg aggcggcggc cgagctggga tctcatgcca cgctgcccta
      181 ctggacggct gtgttcgagt acgaggcggc aggagaggac gagctgaccc tgcggctggg
      241 cgatgtggta gaggtgctgt ccaaggactc tcaggtgtcc ggcgatgagg gctggtggac
      301 cggacagctg aaccagcggg tgggcatctt ccccagcaac tacgtgaccc cgcgcagcgc
      361 cttctccagt cgctgccagc cgggcacgga ggaccccagc tgctacccgc ccattcagct
      421 gttggagatt gattttgcgg agctaaccct ggaggagatc atcggcattg gaggctttgg
      481 gaaagtctat cgtgctttct gggtaggtga cgaggtggcc gtgaaagcag ctcgccacga
      541 ccctgatgag gacatcagcc agaccataga gaatgttcgc caagaggcca agctctttgc
      601 catgctgaaa cacccgaaca tcattgccct cagaggggtg tgcctgaagg aacccaacct
      661 ctgcttggtc atggagttcg ctcgtggagg gcctctgaac agagtgttgt ctgggaagag
      721 ggttcccccg gacatcctgg tgaactgggc cgtgcagatc gccagaggga tgaactacct
      781 acatgatgag gcgatcgtgc ccgtcatcca ccgagacctt aagtccagca acatactgat
      841 cctgcagaaa gtggagaatg gagacctgag taacaagact ctgaagatca ctgacttcgg
      901 gctggcacgg gaatggcacc ggaccaccaa gatgagtgcg gcggggacat acgcttggat
      961 ggcgcctgaa gtcatccgcg cttccatgtt ttccaagggc agcgatgtgt ggagctatgg
     1021 agtactgctc tgggaactgt tgactggcga ggtgcccttc cggggcattg atggcttagc
     1081 agtggcttac ggtgtggcaa tgaacaagct cgcccttcct atcccttcta cctgcccaga
     1141 gccttttgcc aaactcatgg aagactgctg gaatcctgac ccccactcac gtccatcttt
     1201 ctctagtatc ctggaccagc taacgactat agaagagtct ggtttctttg agatgcccaa
     1261 ggactccttc cactgcctgc aggatgactg gaaacatgag attcaggaga tgtttgacca
     1321 actcagggcc aaagaaaagg agcttcgaac ctgggaagaa gagctgaccc gggctgcgct
     1381 ccagcagaag aatcaggagg agctgcttcg gcgtagggag caggagctgg ctgagcggga
     1441 gatcgacatc ctggaacgag agctcaacat catcatccac cagctgtgcc aggaaaagcc
     1501 ccgggtgaag aaacgcaagg gcaagttcag gaagagccga ctgaagctca aggacggcaa
     1561 ccgcatcagc cttccctcgg atttccagca caagttcacg gtgcaggcct ccccgaccat
     1621 ggataaaagg aagagtttga tcagcaaccg atcgagtcct cctgcaagcc ccaccatcat
     1681 ccctcgcctt cgagccattc agttgacacc aggtgaaagt agtaaaacct ggggccggag
     1741 ctcagttgtt ccaaaagagg aaggggaaga agaggagaag agggccccaa agaagaaagg
     1801 ccggacgtgg ggaccaggga cgcttggaca gaaggagctc acgtcaggag atgaaggcct
     1861 caagtccctg gtagacggat acaagcagtg gtcatccagt gcccccaacc tggggaaggg
     1921 cccgaggagt agccctgccc tgcccgggtt caccagcctt atggagatag aggatgagga
     1981 tagtgaaggc ccaggaagcg gagagaatca tctacagcat tcacccaacc agtcctacct
     2041 ctgtatccca tttcctcgtg gggaggatgg ggatggcccc tccagtgatg gaattcatga
     2101 ggaacccacc ccagtcaact cagctaccag tacccctcag ctgacgccaa ctaacagcct
     2161 caagcgcagc gggacccacc accggcgctg cgaggtcgct ctgctcggat gtggagctgt
     2221 tctggcagcc acaggcctgg ggtttgactt gctggaagct ggcaagtgcc agttgcttcc
     2281 cccagaggaa cctgagccac cagcccggga ggaaaagaag aggcgagagg gtcttttcca
     2341 aagggccagt cgccctcgtc ggagtaccag cccgccctcc cgaaagctct ttaagaagga
     2401 agagccgatg acgttgctag gagacccctc tgcctccttg acactgctgt ctctctcctc
     2461 catctctgaa tgcaactcta ctcgctccct actgcgctct gacagtgatg agatcgtggt
     2521 gtatgaaatg ccagtcagcc cagttgaagc tccaccccta acccagtgca cccagaaccc
     2581 cctggttaat gtccgagtgg agcgcttcaa gagagacccc aaccagtccc tgactcccac
     2641 ccacgtcacc ctcacagccc ccacacagcc tagtggtcac aggcggactc cttctgatgg
     2701 ggcacttaaa ccagcatcag tgcccccagc cctgggcagc agaagcccct ccagcaatgg
     2761 agtgagccct ggtcctggag caggcatgtt gaaaaccccc agtcccagcc gagacccagg
     2821 cgaatttccc cgtctccctg accccaacgt ggtctttccc ccaactccga ggcgctggaa
     2881 cacacagcga gactctacct tagagagacc caagacgctg gagtttctgc ctcggccacg
     2941 tccttctgcc aaccggcagc ggctggaccc ttggtggttt gtgtccccca gccatgcccg
     3001 cagcgcctcc ccagctaata gctccagcac agagacaccc agcaacctgg actcctgctt
     3061 tgccagcagc agcagcactg tggaagagcg gcctggactc ccagccctgc tccccttaca
     3121 ggcagggcca ctgccccctg ctgagcggac acttctggac ctggacgctg aggggcagag
     3181 ccaggatagc actgtgcccc tgtgcagagc tgaactgaat gcacatgggc cttctccata
     3241 tgagatccaa caggagttct ggtcttagtg aaaaagggtc agggtgggca agggagaagt
     3301 cggaggaggc agagggagct ggctggcaca gcccggtctc agttaggccc cctgggatcc
     3361 agacctcctc cttgcactga aaatgcactt tgaagacgga agggatagca gcagggccac
     3421 cggagagtct cctggcctgc agtatctttc ctccatgttc actagagggg ctgtgtcagc
     3481 tctagctgtg tgcatatgtc cccaccctct ggtcttcctc gcctttaggg tgacacaact
     3541 gcctcttctc agccaactag agttgtcccg ggttcccttt gtcagccctg agtcctacct
     3601 gttcacacag cgctactgat gttctgtgat tgatctga
//
