LOCUS       NM_053847               2721 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 8
            (Map3k8), mRNA.
ACCESSION   NM_053847
VERSION     NM_053847.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Pyo,J.S., Park,M.J. and Kim,C.N.
  TITLE     TPL2 expression is correlated with distant metastasis and poor
            prognosis in colorectal cancer
  JOURNAL   Hum Pathol 79, 50-56 (2018)
   PUBMED   29763718
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Lai,D.W., Lin,K.H., Sheu,W.H., Lee,M.R., Chen,C.Y., Lee,W.J.,
            Hung,Y.W., Shen,C.C., Chung,T.J., Liu,S.H. and Sheu,M.L.
  TITLE     TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4
            (Activating Transcription Factor-4)/SDF1alpha (Chemokine Stromal
            Cell-Derived Factor-alpha) Axis Suppresses Diabetic Retinopathy
  JOURNAL   Circ Res 121 (6), e37-e52 (2017)
   PUBMED   28724746
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Boldrini,L., Giordano,M., Servadio,A., Niccoli,C., Bertoglio,P.,
            Lucchi,M., Melfi,F., Mussi,A. and Fontanini,G.
  TITLE     Prognostic role of TPL2 in early-stage non-small cell lung cancer
  JOURNAL   Mol Med Rep 15 (6), 3451-3458 (2017)
   PUBMED   28393206
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Kannan,Y., Perez-Lloret,J., Li,Y., Entwistle,L.J., Khoury,H.,
            Papoutsopoulou,S., Mahmood,R., Mansour,N.R., Ching-Cheng Huang,S.,
            Pearce,E.J., Pedro S de Carvalho,L., Ley,S.C. and Wilson,M.S.
  TITLE     TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation
            to Control TH2-Mediated Immunopathology
  JOURNAL   PLoS Pathog 12 (8), e1005783 (2016)
   PUBMED   27487182
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Li,X., Liu,C., Ip,B.C., Hu,K.Q., Smith,D.E., Greenberg,A.S. and
            Wang,X.D.
  TITLE     Tumor progression locus 2 ablation suppressed hepatocellular
            carcinoma development by inhibiting hepatic inflammation and
            steatosis in mice
  JOURNAL   J Exp Clin Cancer Res 34, 138 (2015)
   PUBMED   26560698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2721)
  AUTHORS   Belich,M.P., Salmeron,A., Johnston,L.H. and Ley,S.C.
  TITLE     TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory
            protein NF-kappaB1 p105
  JOURNAL   Nature 397 (6717), 363-368 (1999)
   PUBMED   9950430
REFERENCE   7  (bases 1 to 2721)
  AUTHORS   Kim,S.O., Irwin,P., Katz,S. and Pelech,S.L.
  TITLE     Expression of mitogen-activated protein kinase pathways during
            postnatal development of rat heart
  JOURNAL   J Cell Biochem 71 (2), 286-301 (1998)
   PUBMED   9779826
REFERENCE   8  (bases 1 to 2721)
  AUTHORS   Salmeron,A., Ahmad,T.B., Carlile,G.W., Pappin,D., Narsimhan,R.P.
            and Ley,S.C.
  TITLE     Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel
            MAP kinase kinase kinase
  JOURNAL   EMBO J 15 (4), 817-826 (1996)
   PUBMED   8631303
REFERENCE   9  (bases 1 to 2721)
  AUTHORS   Makris,A., Patriotis,C., Bear,S.E. and Tsichlis,P.N.
  TITLE     Genomic organization and expression of Tpl-2 in normal cells and
            Moloney murine leukemia virus-induced rat T-cell lymphomas:
            activation by provirus insertion
  JOURNAL   J Virol 67 (7), 4283-4289 (1993)
   PUBMED   8510223
REFERENCE   10 (bases 1 to 2721)
  AUTHORS   Patriotis,C., Makris,A., Bear,S.E. and Tsichlis,P.N.
  TITLE     Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved
            in the progression of rodent T-cell lymphomas and in T-cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2251-2255 (1993)
   PUBMED   7681591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053847.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94454.1, SRR26643290.50002.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000017.1  58078175-58078468
            295-653             JAXUCZ010000017.1  58082185-58082543
            654-821             JAXUCZ010000017.1  58088122-58088289
            822-1083            JAXUCZ010000017.1  58089422-58089683
            1084-1190           JAXUCZ010000017.1  58090553-58090659
            1191-1343           JAXUCZ010000017.1  58095413-58095565
            1344-1590           JAXUCZ010000017.1  58096083-58096329
            1591-2721           JAXUCZ010000017.1  58097325-58098455
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..2721
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /note="mitogen-activated protein kinase kinase kinase 8"
                     /db_xref="GeneID:116596"
                     /db_xref="RGD:620969"
     exon            1..294
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..653
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1721
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /EC_number="2.7.11.25"
                     /note="tumor progression locus 2; serine/threonine kinase
                     (Tpl-2)"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     8"
                     /protein_id="NP_446299.2"
                     /db_xref="GeneID:116596"
                     /db_xref="RGD:620969"
                     /translation="MEYMSTGSDEKEEIDLLINHLNVSEVLDIMENLYASEEPAVYEP
                     SLMTMCPDSNQNKEHSESLLRSGQEVPWLSSVRYGTVEDLLAFANHISNTTKHFYGCR
                     PQESGILLNMVISPQNGRYQIDSDVLLVPWKLTYRSIGSGFVPRGAFGKVYLAQDMKT
                     KKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEK
                     LESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQ
                     MTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRS
                     AYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPR
                     EDQPRCQSLDSALFDRKRLLSRKELELPENIADSSCTGSTEESEVLRRQRSLYIDLGA
                     LAGYFNIVRGPPTLEYG"
     exon            654..821
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1083
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1190
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1343
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1590
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2721
                     /gene="Map3k8"
                     /gene_synonym="D17TPL2; Tpl-2; Tpl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatttccc atcgcggggg ctcgggtgtc ctgggccagc cggcaggccc tttctgttta
       61 cggagagaaa ggggaaatgg aaaaggcggg gaggacgctg gcgtcggcta cgccgccccg
      121 gggccagttc agacgccgag agtccggggc tgcagcgtac cgctcctccc gctgcggatc
      181 gcccggcctt tggtcggccg ccggtcgtcc ggacgcccgt acgtctggct cccgctggca
      241 agccacccgc tgcccaccaa gcccgagctc cgggcgggca cacggaacac tcagactccc
      301 cagcaggcac cacagtgatg gagtacatga gcaccggaag cgacgagaaa gaagagattg
      361 atttattaat taaccattta aacgtgtcgg aagtcctgga catcatggag aacctttatg
      421 caagtgaaga gcctgcagtg tatgagccca gtctgatgac catgtgtcca gacagcaatc
      481 aaaacaagga acattcagag tcgctgcttc ggagtggcca ggaggtgccc tggttgtcgt
      541 ctgtcagata tgggactgtg gaggatctgc ttgcatttgc aaaccatatc tcgaatacga
      601 caaagcattt ttacggatgt cggccccaag aatctgggat tttattaaat atggtaatca
      661 gtccccagaa tggtcgctac caaatcgact cggatgttct ccttgtcccg tggaagctga
      721 cgtacaggag cattggttct ggtttcgttc ctcggggggc ctttggaaaa gtgtacttag
      781 cacaagacat gaagacaaag aaaagaatgg catgtaaact gatccctgta gatcagttta
      841 agccatcaga tgtggaaatc caggcctgct tccggcacga gaacattgct gagttatacg
      901 gtgcggtcct atggggcgac actgtccatc tcttcatgga agctggcgag ggagggtctg
      961 tcctggagaa gctggagagc tgtgggccca tgagagaatt tgaaattatc tgggtgacaa
     1021 agcacgttct caagggactt gattttctgc actccaagaa agtcatccac cacgatatca
     1081 aacctagcaa cattgtattc atgtctacga aagctgtgtt ggtagatttt ggcctgagtg
     1141 ttcaaatgac agaagatgtc tatctcccca aggacctccg gggaacagag atctacatga
     1201 gccctgaggt gattctgtgc aggggccatt ccacaaaagc agacatctac agccttggag
     1261 ccacgctcat tcacatgcag acaggcaccc caccctgggt gaagcgctac cctcgatcgg
     1321 cctatccctc ctacctgtac ataatccaca agcaggcacc tcccctggaa gatattgctg
     1381 gtgactgcag tccaggcatg agggagctga tagaagccgc cctggagagg aaccccaacc
     1441 accgcccaaa agcagcagac ctactgaaac acgaagccct gaatccccca agagaggacc
     1501 agccacggtg tcagagtctg gactctgccc tctttgaccg gaagaggctg ctgagcagga
     1561 aggagctaga acttcctgag aacattgctg attcatcatg cacaggaagc accgaggagt
     1621 ctgaagtgct caggagacag cgttccctct acattgatct cggagctctg gctggctact
     1681 tcaatattgt tcgtggtcca ccaaccctgg aatatggctg atggatgact ctattggcaa
     1741 cagtagggcg gatatttctc tcctggatgt tggtttcaca gaccctacac agcagctctg
     1801 gatagtgaat tttacccaat ttttttagga agcagggagg aggtctctag tgacacagga
     1861 atgtcaaagc cctggccccc tttgtgaagc tcctctggca tgttccagag cccaaggttc
     1921 tcatttctca ggtggtggga ctggacaaaa gggagtggtg agctcaggaa agaatcattt
     1981 ctgatgacaa ttctattcac tttgcacttt aatggacatt aaaaaaatag ctctcacaag
     2041 atagtaacct aaaatacctg ttcttggttc ttatataacc atgggttctt cattcaactc
     2101 agaagacctg atctgtgtat atatttgtgt gtattatatg gtaactcttt gtaccttggt
     2161 tggtagagtc tagtataagt ttagttaata gtattttggg tggatagagc aactctaata
     2221 ttacagcaat tcactggact agtgtctcac aaatgactga tttactcaga gccattaagc
     2281 agcaggccac tagtgagagt ttctgttatg ttcctatgga aacactgtgt attgtacgtg
     2341 ctatgcttaa aacatttaaa acacaatgtt ttaaatgtgg acagaactgt gtaaaccaca
     2401 taatttctgt acatcccaaa ggatgagaaa tgtgaccttc aagaaaatgg aaacatttgt
     2461 aaattctttg tagtgatacc tttgtaatta atgaaactat ttttctttaa agtgtttcta
     2521 tattaaaaat agcatactgt gtatgtttta ttccaaaatt ccttcatgaa tctttcatat
     2581 atatatgtgt atatatttta acattgtaaa gtatgagtat tcttatttaa agtatatttt
     2641 tacattatgc aaatgaactt caacgtttta gtccaatgtg actggtcaaa taaaccaaat
     2701 aaactgagta ttttgtctta a
//
