LOCUS       NM_001107920            4540 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase 7
            (Map3k7), mRNA.
ACCESSION   NM_001107920 XM_001062961 XM_232855
VERSION     NM_001107920.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4540)
  AUTHORS   Zhao,J., Chen,C., Ge,L., Jiang,Z., Hu,Z. and Yin,L.
  TITLE     TAK1 inhibition mitigates intracerebral hemorrhage-induced brain
            injury through reduction of oxidative stress and neuronal
            pyroptosis via the NRF2 signaling pathway
  JOURNAL   Front Immunol 15, 1386780 (2024)
   PUBMED   38756773
  REMARK    GeneRIF: TAK1 inhibition mitigates intracerebral hemorrhage-induced
            brain injury through reduction of oxidative stress and neuronal
            pyroptosis via the NRF2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4540)
  AUTHORS   Zhang,Y., Su,Y., Wang,Z., Li,T., Wang,L., Ma,D. and Zhou,M.
  TITLE     TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve
            Neuroinflammation and Cognitive Dysfunction in Aged Rats
  JOURNAL   Neurochem Res 48 (10), 3073-3083 (2023)
   PUBMED   37329446
  REMARK    GeneRIF: TAK1 Reduces Surgery-induced Overactivation of RIPK1 to
            Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats.
REFERENCE   3  (bases 1 to 4540)
  AUTHORS   Liao,C., Zhou,H., Chen,H., Cheng,G., Li,S., Ma,F., Yang,X., Xie,B.
            and Zhang,W.
  TITLE     DUSP8/TAK1 signaling mediates neuropathic pain through regulating
            neuroinflammation and neuron death in a spinal nerve ligation (SNL)
            rat model
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109284 (2022)
   PUBMED   36279673
  REMARK    GeneRIF: DUSP8/TAK1 signaling mediates neuropathic pain through
            regulating neuroinflammation and neuron death in a spinal nerve
            ligation (SNL) rat model.
REFERENCE   4  (bases 1 to 4540)
  AUTHORS   Sun,X., Li,X., Zhou,Y., Wang,Y. and Liu,X.
  TITLE     Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and
            Neuropathic Pain Induced by Sciatic Nerve Injury Through
            Inactivating NF-kappaB and JNK
  JOURNAL   Neurochem Res 47 (10), 3167-3177 (2022)
   PUBMED   35842555
  REMARK    GeneRIF: Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and
            Neuropathic Pain Induced by Sciatic Nerve Injury Through
            Inactivating NF-kappaB and JNK.
REFERENCE   5  (bases 1 to 4540)
  AUTHORS   Yu,M., Wu,X., Wang,J., He,M., Han,H., Hu,S., Xu,J., Yang,M.,
            Tan,Q., Wang,Y., Wang,H., Xie,W. and Kong,H.
  TITLE     Paeoniflorin attenuates monocrotaline-induced pulmonary arterial
            hypertension in rats by suppressing TAK1-MAPK/NF-kappaB pathways
  JOURNAL   Int J Med Sci 19 (4), 681-694 (2022)
   PUBMED   35582418
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4540)
  AUTHORS   Zhang,D., Gaussin,V., Taffet,G.E., Belaguli,N.S., Yamada,M.,
            Schwartz,R.J., Michael,L.H., Overbeek,P.A. and Schneider,M.D.
  TITLE     TAK1 is activated in the myocardium after pressure overload and is
            sufficient to provoke heart failure in transgenic mice
  JOURNAL   Nat Med 6 (5), 556-563 (2000)
   PUBMED   10802712
REFERENCE   7  (bases 1 to 4540)
  AUTHORS   Kishimoto,K., Matsumoto,K. and Ninomiya-Tsuji,J.
  TITLE     TAK1 mitogen-activated protein kinase kinase kinase is activated by
            autophosphorylation within its activation loop
  JOURNAL   J Biol Chem 275 (10), 7359-7364 (2000)
   PUBMED   10702308
REFERENCE   8  (bases 1 to 4540)
  AUTHORS   Ninomiya-Tsuji,J., Kishimoto,K., Hiyama,A., Inoue,J., Cao,Z. and
            Matsumoto,K.
  TITLE     The kinase TAK1 can activate the NIK-I kappaB as well as the MAP
            kinase cascade in the IL-1 signalling pathway
  JOURNAL   Nature 398 (6724), 252-256 (1999)
   PUBMED   10094049
REFERENCE   9  (bases 1 to 4540)
  AUTHORS   Shirakabe,K., Yamaguchi,K., Shibuya,H., Irie,K., Matsuda,S.,
            Moriguchi,T., Gotoh,Y., Matsumoto,K. and Nishida,E.
  TITLE     TAK1 mediates the ceramide signaling to stress-activated protein
            kinase/c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 272 (13), 8141-8144 (1997)
   PUBMED   9079627
REFERENCE   10 (bases 1 to 4540)
  AUTHORS   Moriguchi,T., Kuroyanagi,N., Yamaguchi,K., Gotoh,Y., Irie,K.,
            Kano,T., Shirakabe,K., Muro,Y., Shibuya,H., Matsumoto,K.,
            Nishida,E. and Hagiwara,M.
  TITLE     A novel kinase cascade mediated by mitogen-activated protein kinase
            kinase 6 and MKK3
  JOURNAL   J Biol Chem 271 (23), 13675-13679 (1996)
   PUBMED   8663074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 23, 2009 this sequence version replaced NM_001107920.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12893.1,
                                           SRR26643297.18460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000005.1  51154352-51154627
            277-387             JAXUCZ010000005.1  51167494-51167604
            388-453             JAXUCZ010000005.1  51169875-51169940
            454-499             JAXUCZ010000005.1  51170926-51170971
            500-638             JAXUCZ010000005.1  51172479-51172617
            639-763             JAXUCZ010000005.1  51174142-51174266
            764-892             JAXUCZ010000005.1  51176830-51176958
            893-1023            JAXUCZ010000005.1  51179373-51179503
            1024-1105           JAXUCZ010000005.1  51180766-51180847
            1106-1236           JAXUCZ010000005.1  51182772-51182902
            1237-1366           JAXUCZ010000005.1  51183442-51183571
            1367-1447           JAXUCZ010000005.1  51185920-51186000
            1448-1512           JAXUCZ010000005.1  51191464-51191528
            1513-1618           JAXUCZ010000005.1  51199719-51199824
            1619-1680           JAXUCZ010000005.1  51205132-51205193
            1681-1796           JAXUCZ010000005.1  51206826-51206941
            1797-4540           JAXUCZ010000005.1  51209269-51212012
FEATURES             Location/Qualifiers
     source          1..4540
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4540
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /note="mitogen activated protein kinase kinase kinase 7"
                     /db_xref="GeneID:313121"
                     /db_xref="RGD:1309438"
     exon            1..276
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1977
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /EC_number="2.7.11.25"
                     /note="TGF-beta activated kinase 1; mitogen-activated
                     protein kinase kinase kinase 7-like"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     7"
                     /protein_id="NP_001101390.2"
                     /db_xref="GeneID:313121"
                     /db_xref="RGD:1309438"
                     /translation="MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGR
                     GAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCL
                     VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPP
                     NLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGII
                     LWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS
                     MEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTN
                     MEQVPATNDTIKRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPTSEGKRMSADM
                     SEIEARIVATTAYTKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEP
                     GQVSSRSSSPSVRMITTSGPTSEKPARSLPWTPDDSTDTNGSDNSIPMAYLTLDHQLQ
                     PLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSR
                     LVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS"
     exon            277..387
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..453
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..499
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..638
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..763
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..892
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1023
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1105
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1236
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1366
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1447
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1512
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1618
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1680
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1796
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..4540
                     /gene="Map3k7"
                     /gene_synonym="Tak1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggaaagc gctgaggagc cgaagccggg actcggcggt ggcccgggtc ggtcccgcgc
       61 cacggagcgc cgggcggctg ggctgctggg ctccgggctg aagggcggtg tgcgggccgg
      121 tgggcgggcg cggccccccg ggcgccgcgg gagatcatgt cgacagcatc cgccgcctcg
      181 tcctcctcct cgtcttctgc cagtgagatg atcgaagcgc catcgcaggt ccttaacttc
      241 gaagagatcg actacaagga gatcgaggtg gaagaggttg ttgggagagg agcttttgga
      301 gtggtttgca aagctaagtg gagagcaaaa gatgttgcaa ttaaacagat tgaaagtgaa
      361 tctgagagga aggctttcat cgtggagctc cggcagttgt cccgtgtgaa ccatcctaat
      421 attgtaaagt tgtatggagc ctgcttgaat ccagtctgtc ttgtgatgga gtatgctgaa
      481 ggaggctcgt tgtataatgt gctgcacggt gctgaaccat tgccttatta cactgctgct
      541 catgccatga gctggtgtct acagtgttcc caaggagtgg cctacctgca cagcatgcag
      601 cccaaagctc tcattcatag ggacctcaag cctccaaact tgctgctggt tgcaggaggg
      661 acagttctaa aaatctgcga ttttggtaca gcttgtgaca tccagacaca catgaccaat
      721 aataaaggga gtgctgcttg gatggcaccc gaagtgttcg aaggtagcaa ttacagtgaa
      781 aagtgtgatg tcttcagctg gggtattatc ctttgggagg tgataacacg ccggaaaccc
      841 tttgatgaga tcggtggccc agctttcaga atcatgtggg ctgttcataa tggtactcga
      901 ccaccactga tcaaaaactt gcctaagccc attgagagct tgatgacccg ctgttggtct
      961 aaggaccctt ctcagcgccc ttcaatggag gaaattgtga aaataatgac tcacttgatg
     1021 cggtactttc caggagctga tgagccgtta cagtacccct gtcagtactc tgatgaaggg
     1081 cagagcaact cagccaccag cacaggctca tttatggaca tcgcttctac aaataccagt
     1141 aataaaagtg acacaaatat ggaacaagtc cctgccacaa acgacactat taaacgcttg
     1201 gagtcaaaac tgttgaaaaa ccaggcaaag caacagagtg actctggacg cctgagtttg
     1261 ggagcctctc gagggagcag tgtggagagc ttgcccccga cttctgaggg caagaggatg
     1321 agtgctgaca tgtctgaaat agaagcgagg atcgtggcga ctacagccta taccaagcct
     1381 aaacggggcc accgtaaaac cgcttcattt ggcaacattc tggatgtccc tgagatcgtc
     1441 atatcaggca acgggcaacc aaggcgtaga tccatccaag acttgactgt tactgggaca
     1501 gaacctggtc aggtgagcag caggtcatcc agccctagtg tcagaatgat cactacctca
     1561 ggaccaacct cagagaagcc agctcgcagt cttccttgga cccctgatga ttccacagat
     1621 accaatggct cggataactc catcccaatg gcgtatctta cactggatca ccagctgcag
     1681 cctctagcac catgcccaaa ctccaaagaa tccatggcag tgttcgaaca gcattgtaaa
     1741 atggcacagg aatatatgaa agttcaaacc gaaatcgcat tgttactaca gaggaagcaa
     1801 gaactagttg cagaattgga ccaggatgaa aaggaccagc aaaatacatc tcgcctggta
     1861 caggaacata aaaagctttt agacgaaaac aaaagccttt ctacttatta ccagcaatgc
     1921 aaaaaacaac tagaggtcat cagaagccag cagcagaaac gacaaggcac ttcatgattc
     1981 tctgggaccg ttaaatttta aaataggcaa agaccttttt taagaaaaga caaaccatta
     2041 taacagttga tgagtgttag ctttttggcg tgttctgaat gccaaatgcc tctttgctgc
     2101 attcgttatg tcagttattt cttcttaggg tggatatcaa atccactgtc tcgctgcatc
     2161 agatgatagc acccgcggct tgggaaggca ggcattctca gcttcagagc acaggaagtg
     2221 aacgtagctg tacgtgcgtg ctccggtgtg cgctgcctga caggtgggca tcaccggcta
     2281 ctgtgtgcag gcatcgacct ttctctgtaa tacaaagtgg gacctcaagg attctcttca
     2341 tagcactcat ctcaaaaaac ctgctatttt tatcccaatg gatggcatgc accaacgtaa
     2401 agacagggta ttaaaataat tggtggtaca ttacggaggg acaggacctt gaggctaact
     2461 aagtccaaag acagggtttt gtgccgacac atcctggatc aatactaagt gtagtcccac
     2521 ctgttaatat taaaggtaag tggtggcagc tgtgtctaat gagagcaagt ttactgattt
     2581 tcataaggtt gagcatcgtc tgagatactg agtaacatgc tcttttttta cgccctaaga
     2641 attttcaatt ctgtgtgaaa gcaggagctt ttctgacttt taatattagt agaaatgaaa
     2701 ttgaaagatc atgatgtagc ttcagtgatc cttcgtgcaa cagttactga attgttttat
     2761 gatatatttg aagaaaattg aaaaataata ataattggcc cagctaaaaa aggcttgagc
     2821 ttagatgtct gtgtattata ccaaacaagg aacaatgcag gcaggtcagc agaggcgaat
     2881 gaggaagata atggagtaga atcaagcgca cttttcgtag atgtttagag ggtttggctc
     2941 ccctgaagcc atttctggga ctcctgctgc ctcccttgct tctgagagac tgagcactta
     3001 cacagagagt agtcacattg ttaacagtga gtttactacc aaccgtcaaa gtaacttaaa
     3061 ggaaacaata aaacaccatc gaaaactccc taagatctat tttttcagtc catgttgaca
     3121 cattttgata ccagtacata aatgcctttt aaatcggact ccatcagctt cgcttttata
     3181 gtgttggtgt ttgtgaagag gacgtttgga actgaaagcg tggttgctat ggtccttaga
     3241 tgtgatctag catgtcctgc tctgctccag atgagcacag gaagctttcg aaggttcttc
     3301 aaggctaaaa cagataacct tttttccatt gactttttcc cctgtgagtt ttgtaatgaa
     3361 tcccttctgt atgcagtaag attatgttcc caaattctat taggtgacat gaatgttgag
     3421 ctcagcgtta gtagtgaaat aaaactggca cagaagatat agctgtagac tgagacggcg
     3481 accacagcgc cctgccgccg ctgcctgtgc gcacagctgt ccctcggcag aagggcgctg
     3541 gtctctgagt gcagcatgtt gaaagcctct tgactttcca ggattccaca tcacatggat
     3601 gcaagatcct cctgcagcta aaaggaagtt ttgttgtcgt cgtcatgtgc agtcacttgg
     3661 tgaaaatgct cacaggcaaa tggaaggaaa tgtcaaaagg tcgttagcag gtagttgctt
     3721 gtgtatgctc gatactgtag tcctggacag ccttaagtgc attgcaacac ccacatgtac
     3781 ctttaaagct ccagctctcc ctgaaggtga gcacaccagc catacttgaa atccataccg
     3841 tttcctcagt gtctctacct ataacacctt caaatagcca acatgccagg agccagatgt
     3901 ccactgactg gtctacaatg tctacaatgg aggtagaaag ttgatgtcca agagccagac
     3961 agtccctgca cagacatcag tggcattttg ttttcgcttc tacagaagga agcaaggctg
     4021 tgtaaggtgg acggaagtcg tcctcagcaa tgaagccgtg ctctgggttg aagaaaagtc
     4081 agttaaaaac gttactttac agtcgcctgc catactgaaa acatctgctt aaagttagta
     4141 caactggtcg actgttttca ctgaagtatt ttttaagtag tgttaagtag tctttttcct
     4201 tcaaatttct gtcatgctca attccacctc ctcctgcagt cagaagttac aggtggtttt
     4261 gtttcttcct ccctccctcc ctctggtgag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4321 tgtgtgtgtg tgtgtgtggt gtgtgtgtga gtgagtgtgt gtatgtggcc tttaacaccc
     4381 aactcctctc atcacaagct agtaagttct ccttttactc ctgtcattca agcattgttt
     4441 gtaagatgat gtgatacaga aattcttgtg catactatgt aactgaagga ggcttttttg
     4501 atttattttt gtttttaata aaattgagat tgttatttca
//
