LOCUS       NM_001107909            4339 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 6
            (Map3k6), mRNA.
ACCESSION   NM_001107909 XM_001064938 XM_232732
VERSION     NM_001107909.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4339)
  AUTHORS   Wang XS, Diener K, Tan TH and Yao Z.
  TITLE     MAPKKK6, a novel mitogen-activated protein kinase kinase kinase,
            that associates with MAPKKK5
  JOURNAL   Biochem Biophys Res Commun 253 (1), 33-37 (1998)
   PUBMED   9875215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232732.4, XM_001064938.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4339
                     /gene="Map3k6"
                     /note="mitogen-activated protein kinase kinase kinase 6"
                     /db_xref="GeneID:313022"
                     /db_xref="RGD:1304625"
     exon            1..614
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..4150
                     /gene="Map3k6"
                     /EC_number="2.7.1.-"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     6"
                     /protein_id="NP_001101379.1"
                     /db_xref="GeneID:313022"
                     /db_xref="RGD:1304625"
                     /translation="MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVAGRGCARSR
                     PLSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREACAQLQSTRPPPQLRSLPFATLAL
                     GDTAALDSFYNADVVVLEVSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQAL
                     REDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLV
                     GRLVRLLEATPTDSCGYFRETIRQDIRKARERFSGQQLRQELARLQRRLDSVELLSPD
                     IIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDREK
                     ALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFFSSSFQSTGHLEQAYHWYRKAFDVEPS
                     LHSGINAAVLLIAAGKHFDDSEELQLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQI
                     LANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPSGGPVLRAHFWLHF
                     LLQSCQPFKATPPQEDQCLVLVLEINKVLLPARLEIQGADPMSAVTLSLLEPETQDDP
                     SSWTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVERCRWFCSQIQVLVMNP
                     DSSAPTEEAEGTREVLEFDYEYSETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPE
                     RDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWG
                     PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRL
                     AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWPPFHELGSP
                     QAAMFQVGMYKVHPPVPSSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSR
                     SPGSPRHTPRPSGTPSSTSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQL
                     RVPEESAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPILAENLLDQEQDSRLS
                     RNHVELLLRCLGAQIHTPNRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQI
                     LRRRQIRPHWMFVLDSLLSRAVRAALAVLDAEAEKKAVSPKSEEWSQGESQQKPLESQ
                     PPLQSQLPPEQEPPSLMIQLGLLRAETDRLRDILAEKERECQALVQQALHRVHAETRT
                     YALASETPATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTLLTCATQDDLVYTRI
                     RGGMVCRIWRAILAQRAGATSVTPGPRDAE"
     exon            615..754
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            755..778
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            779..969
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1138
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1245
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1416
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1529
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1689
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1852
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1960
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2010
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2106
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2194
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2328
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2456
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2593
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2699
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2857
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3050
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3189
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3346
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3523
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3629
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3795
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3908
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..3982
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4059
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4339
                     /gene="Map3k6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagggtgta gcacgctgcc ggttgaattc ccaggatcct tctgtgacct gtgagccgag
       61 gattactggg taccccagat tcccagaacc cagtcctgga ttgcagatct ctaaggaccg
      121 tgaaagatta agcaaagatt tctctctgga tttaagattt ccggaacagg acgtccagcc
      181 catctccgga tcccggctgg atccacacct tcagcctcgt gccctgtccc gggtctcccg
      241 cgcccggcgt cccgcgcttg agcgcccccg catggcgggg ccgtgtcccg gggccggggt
      301 tctagaacgg gcgggcagct gctggcagga ccctctggcg gaggcgctga gccggggccg
      361 ctcgtctcct gcggtcgccg gtcggggctg cgcgcggagc cggcctctca gtgtggtcta
      421 cgtgttgacc cgcgagcctg gacccggggt ggagcccggg tcgggaaccg aggcagagcc
      481 gctgccgctg cgatgcctgc gcgaggcctg tgctcagctc cagagcacgc ggccaccccc
      541 gcaactgcgc agcctgccct ttgcgacgct ggcgctaggc gacaccgctg cgctagactc
      601 cttctacaac gcggacgtag tggtgctgga ggtgagcaac tccctggcac agccttcctt
      661 gttctaccac ctcggcgtgc gtgagagctt cagcatgacc aacaatgtgc tcctctgttc
      721 ccaggcagag ctccctgacc tgcaggccct tcgtgaggat gttttccaga agaactcgga
      781 ttgcgttggc agctacacac tgattcctta tgttgtgaca gccactggcc gggtcttatg
      841 tggcgatgca ggcctcctga ggggcatagc cgatgggcta gtacaggctg gggtgggcac
      901 tgaggccctc ctcacgcccc tggtgggccg gcttgtccgt ctcttggagg ccacacccac
      961 agactcttgc ggctacttcc gggagaccat tcgtcaagat atccggaagg cacgggagcg
     1021 gttcagcggg cagcagctga ggcaggagct ggctcgcctg cagcggaggc tggacagcgt
     1081 agagctgttg agccccgaca tcatcatgaa tctgcttctg tcataccgcg acgtccagga
     1141 ctactccgcc atcattgagc tggtggagac gctgcaggct ttgcccacct gtgatgtggc
     1201 cgaacagcac aatgtctgct tccactacac gtttgccctc aacaggagga acaggcctgg
     1261 ggaccgtgag aaggccctgg ctgtccttct gccattggtg aagcatgaag gccccgtggc
     1321 tccagacctg tactgcatgt gtggtcgtat ctacaaggac atgttcttca gctccagctt
     1381 ccaaagtact gggcacctgg agcaggccta tcactggtac cgcaaggcat ttgatgtgga
     1441 gcccagccta cactcgggca tcaatgcagc tgtgctgctc attgcagctg ggaaacactt
     1501 tgacgactct gaggagctcc agctgatagg catgaagctg ggctgcctgt tagcccgcaa
     1561 aggctgtgtg gagaagatgc agtattactg ggacgtgggg ttctacctgg gagcccagat
     1621 tcttgccaac gaccccatcc aggtggtgct ggctgcagaa caactataca agctcaatgc
     1681 ccccatatgg tacttggtgt cagtgatgga gaccttctta ctgtaccagc atttcagacc
     1741 cacaccagag ccctcgggag gacccgtgct gcgagctcac ttttggctcc atttcttgct
     1801 acaatcctgc cagcctttca aggcgacccc tcctcaggag gaccagtgcc tggtactggt
     1861 gctggagata aacaaggttc tgctgcctgc cagacttgag attcagggag ccgaccccat
     1921 gagcgcagtg accctaagct tgctggagcc agagactcag gatgatcctt ccagctggac
     1981 cttcccagtc acctccatct gtgggatcag cgcctccaag ctggaccagc gctgctgctt
     2041 cctgtacgca cttcctccgg cccaggacgt ccagctgtgc tttcccagcg tagagcgctg
     2101 ccggtggttc tgtagccaaa ttcaggtctt ggtgatgaat ccagattcct cggcgcccac
     2161 tgaggaggca gaaggcacaa gggaggtgct ggagtttgat tatgaatatt cggagacggg
     2221 tgagcggctg gtgctgggca aaggcacgta cggggtggtg tatgctggcc gcgacaggca
     2281 cacgagggta cgaatcgcca tcaaagagat cccagagaga gatagcagat tctctcagcc
     2341 tctgcacgag gagatcgctc tccacaaacg ccttcgccac aagaatatag tgcgctattt
     2401 gggctcagcc agccagggcg gctacctcaa gatcttcatg gaggaagtgc ctggaggcag
     2461 cctgtcctcc ttgcttaggt cagtgtgggg acccctaaag gacaacgaga gtactattag
     2521 cttctacacg cgtcagatcc tgcaaggact tagctacctg catgagaacc gcattgttca
     2581 ccgagacatc aagggggaca atgtactgat caacaccttc agtgggctgc tcaagatttc
     2641 tgactttggc acctccaagc ggctggcagg catcacaccc tgcacggaga ctttcacagg
     2701 gaccctgcag tatatggccc cagaaatcat tgaccagggc ccacgaggat atggaaaggc
     2761 ggctgacatc tggtctctgg gctgcactgt gattgagatg gccacaggtt ggccgccctt
     2821 tcacgaacta gggagcccgc aggctgccat gtttcaggtg ggcatgtaca aggtacatcc
     2881 accagtgcca agttccctgt cagctgaggc ccaagccttc ctcctccgaa cttttgagcc
     2941 agatccccgc ctccgagcca gtgcccaaga gctgttggga gaccccttcc tgcaaccagg
     3001 gaagaggagc cgcagccctg gctctcctcg gcacactccc cggccctcag gcaccccttc
     3061 cagtacttcc agtccttcag ctgactcagc cacacagtct cagacattcc caaggcccca
     3121 ggcaccctct cagcacccac ccagccctcc gaagcgctgc cttagttatg gggacaccag
     3181 tcagctccgt gtgcccgagg aatccgctgc cgaggaaccc gcgtccccag aagagagttc
     3241 aggcctgagc ctgctgcacc aggagagcaa gcgccgagcc atgctggctg cagtgctgga
     3301 acaggaggtg cccatactag cagagaatct cctggatcag gaacaggatt ctcgactcag
     3361 caggaatcat gtggaacttc tgcttcggtg cctcggggca caaatccata ctcctaaccg
     3421 ccggcagctg gcccaggagc tgcgggccct gcaagctcaa ctgcgggccc agagcctgag
     3481 ccctgcgctt ttgaaggggc cgctcttcgc ctttccagac gcggtgaagc agatcctccg
     3541 cagacgccag atccgcccac actggatgtt cgtgttggac tcgctgctca gccgggcagt
     3601 ccgggcggcg ctggccgtac tggacgcgga ggcagagaag aaagcggtct caccgaagtc
     3661 agaggagtgg agtcaagggg agtcccagca gaaaccgctg gagagccagc cgccgctgca
     3721 gagtcagctc ccaccagagc aggaacctcc atccctgatg atacagctgg gtctcttgcg
     3781 agctgagact gacaggcttc gggacattct ggctgagaag gaacgtgagt gccaggccct
     3841 cgtgcaacag gccctgcatc gggtgcacgc agagaccagg acgtatgccc tggcttcaga
     3901 gaccccggcc actctcccaa aggaccagaa actggtgcag tggctacagg acctgagtgt
     3961 agatccaacc actatccaaa cgctcctgag ccatagcttt acccttcaaa ccctgctcac
     4021 ctgtgccact caggatgacc tcgtctacac cagaatcagg ggagggatgg tatgcagaat
     4081 ttggagagcc atcttggcac agcgagcagg agccacgtcg gtcacccctg gaccccggga
     4141 tgctgagtga tgacatcaag ggacacagac atggatggat gaacagagga gacacaagca
     4201 gcttttgacg cacccgtccc agaacctagg agcaaactgc agggcccagg acgaacccca
     4261 atgggtggaa ctaactaggg aggcacccaa aagacactac atacgaccaa agactattaa
     4321 acagaacact tgctaccat
//
