LOCUS       NM_001277694            4146 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 5
            (Map3k5), mRNA.
ACCESSION   NM_001277694 XR_145729 XR_146724
VERSION     NM_001277694.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4146)
  AUTHORS   Zou,M., Chen,W., Li,J., Qi,X., Wang,X., Liu,F., Hu,J. and Zhang,Q.
  TITLE     Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell
            Senescence and Apoptosis to Regulate Intervertebral Disc
            Degeneration
  JOURNAL   Am J Pathol 194 (9), 1737-1751 (2024)
   PUBMED   38879082
  REMARK    GeneRIF: Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus
            Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral
            Disc Degeneration.
REFERENCE   2  (bases 1 to 4146)
  AUTHORS   Shen,M., Wu,Y., Li,L., Zhang,L., Liu,G. and Wang,R.
  TITLE     CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic
            cardiomyopathy by regulating miR-22-3p/DAPK2 Axis
  JOURNAL   J Diabetes 16 (1), e13471 (2024)
   PUBMED   37735821
  REMARK    GeneRIF: CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic
            cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
REFERENCE   3  (bases 1 to 4146)
  AUTHORS   Lai,J., Li,A., Yue,L., Zhong,H., Xu,S. and Liu,X.
  TITLE     Participation of ASK-1 in the cardiomyocyte-protective role of
            mechanical ventilation in a rat model of myocardial infarction
  JOURNAL   Exp Biol Med (Maywood) 248 (18), 1579-1587 (2023)
   PUBMED   37786374
  REMARK    GeneRIF: Participation of ASK-1 in the cardiomyocyte-protective
            role of mechanical ventilation in a rat model of myocardial
            infarction.
REFERENCE   4  (bases 1 to 4146)
  AUTHORS   Li,X., Hu,X., Chen,Q. and Jiang,T.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes carrying E3
            ubiquitin ligase ITCH attenuated cardiomyocyte apoptosis by
            mediating apoptosis signal-regulated kinase-1
  JOURNAL   Pharmacogenet Genomics 33 (6), 117-125 (2023)
   PUBMED   37306338
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes
            carrying E3 ubiquitin ligase ITCH attenuated cardiomyocyte
            apoptosis by mediating apoptosis signal-regulated kinase-1.
REFERENCE   5  (bases 1 to 4146)
  AUTHORS   Vinay,P., Karen,C., Balamurugan,K. and Rajan,K.E.
  TITLE     Cronobacter sakazakii Infection in Early Postnatal Rats Impaired
            Contextual-Associated Learning: a Putative Role of C5a-Mediated
            NF-kappabeta and ASK1 Pathways
  JOURNAL   J Mol Neurosci 71 (1), 28-41 (2021)
   PUBMED   32567007
  REMARK    GeneRIF: Cronobacter sakazakii Infection in Early Postnatal Rats
            Impaired Contextual-Associated Learning: a Putative Role of
            C5a-Mediated NF-kappabeta and ASK1 Pathways.
REFERENCE   6  (bases 1 to 4146)
  AUTHORS   Tobiume,K., Saitoh,M. and Ichijo,H.
  TITLE     Activation of apoptosis signal-regulating kinase 1 by the
            stress-induced activating phosphorylation of pre-formed oligomer
  JOURNAL   J Cell Physiol 191 (1), 95-104 (2002)
   PUBMED   11920685
REFERENCE   7  (bases 1 to 4146)
  AUTHORS   Ko,Y.G., Kim,E.Y., Kim,T., Park,H., Park,H.S., Choi,E.J. and Kim,S.
  TITLE     Glutamine-dependent antiapoptotic interaction of human
            glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase
            1
  JOURNAL   J Biol Chem 276 (8), 6030-6036 (2001)
   PUBMED   11096076
REFERENCE   8  (bases 1 to 4146)
  AUTHORS   Nakahara,S., Yone,K., Sakou,T., Wada,S., Nagamine,T., Niiyama,T.
            and Ichijo,H.
  TITLE     Induction of apoptosis signal regulating kinase 1 (ASK1) after
            spinal cord injury in rats: possible involvement of ASK1-JNK and
            -p38 pathways in neuronal apoptosis
  JOURNAL   J Neuropathol Exp Neurol 58 (5), 442-450 (1999)
   PUBMED   10331432
REFERENCE   9  (bases 1 to 4146)
  AUTHORS   Chang,H.Y., Nishitoh,H., Yang,X., Ichijo,H. and Baltimore,D.
  TITLE     Activation of apoptosis signal-regulating kinase 1 (ASK1) by the
            adapter protein Daxx
  JOURNAL   Science 281 (5384), 1860-1863 (1998)
   PUBMED   9743501
REFERENCE   10 (bases 1 to 4146)
  AUTHORS   Funato,N., Moriyama,K., Saitoh,M., Baba,Y., Ichijo,H. and Kuroda,T.
  TITLE     Evidence for apoptosis signal-regulating kinase 1 in the
            regenerating palatal epithelium upon acute injury
  JOURNAL   Lab Invest 78 (4), 477-483 (1998)
   PUBMED   9564892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 14, 2013 this sequence version replaced
            XR_145729.1, XR_146724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               JAXUCZ010000001.1  16505964-16506432
            470-609             JAXUCZ010000001.1  16568113-16568252
            610-633             JAXUCZ010000001.1  16577420-16577443
            634-827             JAXUCZ010000001.1  16581567-16581760
            828-996             JAXUCZ010000001.1  16583346-16583514
            997-1103            JAXUCZ010000001.1  16584980-16585086
            1104-1274           JAXUCZ010000001.1  16587776-16587946
            1275-1387           JAXUCZ010000001.1  16607622-16607734
            1388-1547           JAXUCZ010000001.1  16617189-16617348
            1548-1701           JAXUCZ010000001.1  16619663-16619816
            1702-1809           JAXUCZ010000001.1  16642765-16642872
            1810-1859           JAXUCZ010000001.1  16652572-16652621
            1860-1955           JAXUCZ010000001.1  16655113-16655208
            1956-2037           JAXUCZ010000001.1  16658594-16658675
            2038-2171           JAXUCZ010000001.1  16670356-16670489
            2172-2299           JAXUCZ010000001.1  16674349-16674476
            2300-2436           JAXUCZ010000001.1  16674892-16675028
            2437-2542           JAXUCZ010000001.1  16685134-16685239
            2543-2700           JAXUCZ010000001.1  16688945-16689102
            2701-2899           JAXUCZ010000001.1  16691220-16691418
            2900-3077           JAXUCZ010000001.1  16699054-16699231
            3078-3246           JAXUCZ010000001.1  16699325-16699493
            3247-3432           JAXUCZ010000001.1  16707560-16707745
            3433-3538           JAXUCZ010000001.1  16710334-16710439
            3539-3782           JAXUCZ010000001.1  16714446-16714689
            3783-3895           JAXUCZ010000001.1  16718934-16719046
            3896-4008           JAXUCZ010000001.1  16720044-16720156
            4009-4085           JAXUCZ010000001.1  16722187-16722263
            4086-4146           JAXUCZ010000001.1  16723158-16723218
FEATURES             Location/Qualifiers
     source          1..4146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..4146
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /note="mitogen-activated protein kinase kinase kinase 5"
                     /db_xref="GeneID:365057"
                     /db_xref="RGD:1306565"
     CDS             1..4146
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /EC_number="2.7.11.25"
                     /note="apoptosis signal regulating kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     5"
                     /protein_id="NP_001264623.1"
                     /db_xref="GeneID:365057"
                     /db_xref="RGD:1306565"
                     /translation="MGTEAGEGITFSVPPILSAGFCPIPEGGSCRRGGGAATAAEGEP
                     SLQPLLMPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAY
                     VINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAV
                     VEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYT
                     FIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSS
                     QYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDY
                     DSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQV
                     ASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAG
                     HQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKL
                     FRLKTPAWYLKSIVETILIYKHFVKLTTEQPTAKQELVDFWMDFLVEATKTDVTVVRF
                     PVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFNASSVRGVSISKF
                     EERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEEGDCEGDSLEYDY
                     EHDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLK
                     HKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGL
                     KYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPE
                     IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESM
                     SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSGMWLHGEEYLRSI
                     SLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKTRAKSCGEKDGKGIRTLFLGIPDE
                     NFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGPEEPK
                     LKWEHITTLISSLREFVRSTDRKIIATTLSRLKLELDFDSHGISQVQVVLFGFQDAVN
                     KVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVDDE
                     HEESPSNQTARRPQPVAEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKMETNRL
                     LEELVRKEKELQALLHQAIEEKDQEIKHLRLKSQPIDTPGFPVCHLNAPGTAIEDSEL
                     TGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRN
                     KGA"
     exon            1..469
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            470..609
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            610..633
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            634..827
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            828..996
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1103
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1274
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1387
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1547
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1701
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1809
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1859
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1955
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2037
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2171
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2299
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2436
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2542
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2700
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2899
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3077
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3246
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3432
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3538
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3782
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3895
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4008
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4085
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4146
                     /gene="Map3k5"
                     /gene_synonym="Ask1; RGD1306565"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcaccg aagccggcga gggcatcact ttctccgtgc cgcccatttt gtccgcgggt
       61 ttctgcccca tcccggaggg cggcagctgc cggaggggag gaggagcggc gacggcggcg
      121 gagggcgagc cgagcctgca gcccttgctt atgccgccgc cgccaccacc gccgggcagt
      181 ttctggaacg tggagagcgc ggcggctcct ggcaccagct gccctaccac cgcccccggg
      241 agcagcgcca cccgaggccg gggcaactct ggcagcgggg gcggccggcg taccaccgtg
      301 gcgtatgtga tcaacgaggc gagccagggg cagctggtgg tggcggagag cgaggccctg
      361 cagagcctgc gggaggcgtg cgaggcggtg ggcgccaccc tggagaccct gcatttcggg
      421 aagctggact ttggggaaac caccgtgctg gaccgttttt acaacgctga catcgccgtg
      481 gtagagatga gtgacgcctt ccggcagcct tccctgtttt atcatctcgg agtgagagag
      541 agcttcagca tggccaacaa catcatcctc tactgcgata ctaattcaga ctcgcttcag
      601 tccctgaagg aaatcatttg ccagaagaac acagtgtgca ctgggaacta caccttcatc
      661 ccctacatgg tgacaccaca caacaaggtc tactgctgtg acagcagctt catgaagggc
      721 ctgaccgagc tcatgcagcc caacttcgag ctcctgctgg ggccgatctg cttacctctc
      781 gtggaccgtt tcgttcagct cctgaaggtg gcgcaagcca gttccagcca gtacttccgg
      841 gaatctatac tcaacgacat caggaaagct cggaatctgt acactggtaa agagttggcg
      901 gctgagctgg cgaggatccg gcagcgggta gacaatattg aagttctgac ggcagacatt
      961 gttatcaacc tgttgctttc ctacagagat atccaggact atgactccat agtgaagctg
     1021 gtagagacct tagaaaaact accgaccttc gatctggcct cgcaccacca cgtgaagttt
     1081 cattatgcct ttgcactgaa caggagaaat ctccctggag acagagcaaa agctcttgac
     1141 atcatgatcc ccatggtgca aagtgaagag caagttgctt cggatatgta ctgtctcgtt
     1201 ggccgaatct acaaagacat gtttttggat tcaaatttca ctgacaccga aagcagggac
     1261 catggagcat cttggttcaa aaaggcgttt gagtctgagc caacactaca gtcaggaatt
     1321 aattacgcag tcctcttgct ggcggctggg caccagtttg aatcttcttt tgagcttcgg
     1381 aaagttggag ttaaactgag cagccttctg ggtaaaaagg ggaacttgga gaaactccag
     1441 agctactggg aagtcggatt ttttctggga gccagcgtcc tggccaacga ccatctgagg
     1501 gtcattcagg catctgagaa actgttcaga ctgaagacgc cagcgtggta cctcaagtct
     1561 attgtggaga ccattttgat atataagcat tttgtgaaac tgaccacaga gcagcccaca
     1621 gccaagcagg agctcgtgga cttctggatg gatttcctgg tggaggccac aaagacagat
     1681 gttactgtcg ttagatttcc agtgttaata ttagagccaa cgaaaatcta tcagccttct
     1741 tacctgtcga tcaacaatga agtcgaggag aagacgatct ctatttggca tgtcctccct
     1801 gacgacaaga agggtatcca tgagtggaac tttaacgctt cctctgtcag gggggtgagt
     1861 atctccaagt ttgaagaacg atgctgtttc ctttatgtac ttcacaattc cgacgacttc
     1921 caaatctact tctgcacaga actgcactgt aaaaggtttt tcgaaatggt gaacaccatc
     1981 accgaagaga aggggagagg cgcggaggaa ggagactgtg aaggtgactc cctagagtat
     2041 gactacgaac acgatgaaaa tggagacaga gttgtgctag gaaaggggac ttacgggata
     2101 gtctacgcag gccgagacct gagcaaccag gtcagaattg ctattaagga aatcccagag
     2161 agagacagca gatactctca gcccctgcat gaggaaattg ccttacacaa gcatctgaag
     2221 cacaagaaca ttgtccagta tctgggctcc ttcagtgaga acggcttcat caaaatcttc
     2281 atggagcaag tcccaggagg aagtctctct gctctcctcc gttcaaaatg gggcccacta
     2341 aaagacaatg agcagacgat tggcttctat acgaagcaaa tattggaagg attaaaatat
     2401 cttcatgaca atcagatagt ccaccgggat ataaagggtg acaatgtatt gattaatacc
     2461 tacagtggcg tgctcaagat ctctgacttt gggacatcca agaggcttgc tggcataaac
     2521 ccgtgcaccg aaacctttac aggtaccctt cagtatatgg cgccagaaat catcgataaa
     2581 ggaccacgag gctatggaaa ggccgccgac atttggtcac tgggctgtac gatcatcgaa
     2641 atggctactg gaaaaccacc gttttatgaa ctaggagagc cccaggcagc catgttcaag
     2701 gtggggatgt ttaaggtcca ccccgagatc ccagagtcca tgtctgccga ggccaaggcg
     2761 ttcatactga agtgttttga accagaccct gacaagagag cctgtgctaa tgacctgctt
     2821 gttgatgagt tcctaaaagt ttccagcaaa aagaagaaga cacagcccaa actctcgggt
     2881 atgtggttgc acggagagga gtatcttaga agcatctcgc tgccggtccc tgtcctggta
     2941 gaagacacca gcagcagcag cgagtatggc tccgtttctc cggacacaga gctgaaggcc
     3001 gaccccttct ccttcaaaac cagagctaag tcctgtggag aaaaggacgg gaaagggatc
     3061 cggacgctgt tcctgggcat tccggatgaa aactttgaag atcacagtgc gcccccgtcc
     3121 cctgaagaga aagactccgg cttttttatg ctgagaaagg atagcgaaag gcgggcgacc
     3181 cttcacagga tcctgacaga agaccaggac aaggttgtga ggaacctaat ggagtctctg
     3241 gcccagggtc ctgaagagcc taaactcaag tgggaacaca tcacaactct catctcaagc
     3301 ctcagagagt ttgtgaggtc cactgaccgg aaaatcatag ccactacact gtccaggctc
     3361 aagctggagc tggacttcga cagccatggc atcagccagg tgcaggtggt cctctttggc
     3421 ttccaggatg cggtcaataa agttctccgg aatcataaca tcaagccaca ctggatgttt
     3481 gccttggaca gtatcattcg gaaggctgtg cagacagcta tcaccatcct ggttccagag
     3541 ttgaggccac atttcagcct cgcgtcggag agcgacacgg cggatccgga agacttggat
     3601 gtcgacgatg aacacgagga atcgccttcg aatcaaaccg cgcggaggcc ccaacccgtc
     3661 gcggaggatg ccgtggctac ctcaggggtg agcacgctca gctccaccgt atcccatgat
     3721 tcccagaatg cacaccgctc gctgaatgtg cagcttggga ggatgaagat ggaaactaac
     3781 agattacttg aagagttggt tcggaaagag aaagagttgc aggcactcct tcatcaagcc
     3841 attgaagaaa aggaccaaga aattaagcac ctgagactta agtcccaacc catagatacc
     3901 cctgggtttc ccgtgtgcca cctgaacgct cctggtacag ccattgaaga ctctgaactt
     3961 actggctggc tgagggaaaa tggagctgac gaagacacta taagtcggtt tctggctgag
     4021 gattacacgc tggtggatgt cctttactac gtcacgcgtg acgacttgaa gtgcctccga
     4081 ctaaggggag ggatgctgtg cacgctgtgg aaggccatca ttgactttcg gaacaaaggg
     4141 gcctga
//
