LOCUS       NM_001107058            4614 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase 3
            (Map3k3), mRNA.
ACCESSION   NM_001107058 XM_001081582 XM_221034
VERSION     NM_001107058.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   2  (bases 1 to 4614)
  AUTHORS   Cuenda,A. and Rousseau,S.
  TITLE     p38 MAP-kinases pathway regulation, function and role in human
            diseases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1358-1375 (2007)
   PUBMED   17481747
  REMARK    Review article
REFERENCE   3  (bases 1 to 4614)
  AUTHORS   Johnson,G.L. and Nakamura,K.
  TITLE     The c-jun kinase/stress-activated pathway: regulation, function and
            role in human disease
  JOURNAL   Biochim Biophys Acta 1773 (8), 1341-1348 (2007)
   PUBMED   17306896
  REMARK    Review article
REFERENCE   4  (bases 1 to 4614)
  AUTHORS   Wang,X. and Tournier,C.
  TITLE     Regulation of cellular functions by the ERK5 signalling pathway
  JOURNAL   Cell Signal 18 (6), 753-760 (2006)
   PUBMED   16376520
  REMARK    Review article
REFERENCE   5  (bases 1 to 4614)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
REFERENCE   6  (bases 1 to 4614)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 4614)
  AUTHORS   Yang,J., Boerm,M., McCarty,M., Bucana,C., Fidler,I.J., Zhuang,Y.
            and Su,B.
  TITLE     Mekk3 is essential for early embryonic cardiovascular development
  JOURNAL   Nat Genet 24 (3), 309-313 (2000)
   PUBMED   10700190
REFERENCE   8  (bases 1 to 4614)
  AUTHORS   Fanger,G.R., Johnson,N.L. and Johnson,G.L.
  TITLE     MEK kinases are regulated by EGF and selectively interact with
            Rac/Cdc42
  JOURNAL   EMBO J 16 (16), 4961-4972 (1997)
   PUBMED   9305638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001107058.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168979.1, SRR26643299.46110.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               JAXUCZ010000010.1  91519976-91520268
            294-415             JAXUCZ010000010.1  91531972-91532093
            416-456             JAXUCZ010000010.1  91547095-91547135
            457-556             JAXUCZ010000010.1  91550852-91550951
            557-670             JAXUCZ010000010.1  91553750-91553863
            671-791             JAXUCZ010000010.1  91560022-91560142
            792-925             JAXUCZ010000010.1  91575321-91575454
            926-999             JAXUCZ010000010.1  91577773-91577846
            1000-1067           JAXUCZ010000010.1  91580095-91580162
            1068-1160           JAXUCZ010000010.1  91580370-91580462
            1161-1352           JAXUCZ010000010.1  91581095-91581286
            1353-1501           JAXUCZ010000010.1  91582516-91582664
            1502-1633           JAXUCZ010000010.1  91583200-91583331
            1634-1763           JAXUCZ010000010.1  91583817-91583946
            1764-1941           JAXUCZ010000010.1  91584390-91584567
            1942-4614           JAXUCZ010000010.1  91585979-91588651
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4614
                     /gene="Map3k3"
                     /note="mitogen activated protein kinase kinase kinase 3"
                     /db_xref="GeneID:303604"
                     /db_xref="RGD:1304575"
     exon            1..293
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..2170
                     /gene="Map3k3"
                     /EC_number="2.7.11.25"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     3"
                     /protein_id="NP_001100528.1"
                     /db_xref="GeneID:303604"
                     /db_xref="RGD:1304575"
                     /translation="MDEQEALDSIMKDLVALQMSRRPRVSGYETMKNKDTGHPNRQSD
                     VRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDK
                     AIDILDRSASMKSLRILLLSQDRNHTSSSPHSGVSRQVRVKPSQSAGDINTIYQAPEP
                     RSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLS
                     SAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYP
                     RRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGAAVQYLDPRGR
                     LRSADSENALTVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
                     VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGS
                     VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDF
                     GASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP
                     WAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQL
                     VY"
     exon            294..415
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            416..456
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..556
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..670
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..791
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            792..925
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..999
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1067
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1160
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1352
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1501
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1633
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1763
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1941
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..4614
                     /gene="Map3k3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctggact tcaagactgg caggcgggcc agccgagtgg cgccgccgag gccgggttgg
       61 gccgagcctg ggagcgccgg ggatgtagcg ggccaccctg ctcatgccac agcgcccggc
      121 ccgggccgga gccggagcct ggggaggcgg cgggggcccc gagcgcagcc cacggccccc
      181 gcgcggagcc aggcctgccg ccgtccccgc cgcctgctcc cccggcatgc agccccggct
      241 gcggaggtga cacttctggg ctgataccgc tgccgccgcc atcgccacca tggatgaaca
      301 agaggcatta gactcaatca tgaaggacct ggtggccctc cagatgagcc gacgtccccg
      361 ggtgtctgga tatgagacca tgaagaacaa ggacacaggt cacccaaaca ggcagagtga
      421 cgtcagaatc aagtttgaac acaatgggga gagacgaatt atagcattca gccggcctgt
      481 gagatatgaa gatgtggaac acaaggtgac aacggtcttt gggcagcctc ttgatttgca
      541 ttatatgaat aatgagctct ccatcctgtt gaaaaaccaa gatgatctcg ataaagcaat
      601 tgacattttg gatagaagcg cgagtatgaa aagccttagg atactactgt tatcccaaga
      661 cagaaaccat actagttcct ctccccactc tggagtgtcc aggcaggttc gggtcaagcc
      721 ttcccagtct gcaggggata taaataccat ctaccaagct cctgagccca gaagcaggca
      781 cctctctgtc agctcccaga accctggccg aagctctcct ccccctggtt atgtacctga
      841 gcgacaacag cacattgccc ggcagggatc atatacgagc atcaatagtg aaggtgaatt
      901 catcccagag accagcgagc agtgcatgct agatcccctg agcagtgccg aaaattcctt
      961 gtcaggaagc tgccaatcct tggacaggtc agcagacagc ccatctttca ggaaatcaca
     1021 aatgtcccga gcccggagct tcccagacaa cagaaaggaa tgctcggatc gggagaccca
     1081 gctctatgat aaaggagtta aaggcggaac ctatcccagg cgttaccatg tatctgtgca
     1141 tcataaagac tacaatgatg gcagaagaac gtttccccga atacgacggc accagggcaa
     1201 cctattcact ctggtgccct caagtcgctc cttgagcaca aatggcgaga acatgggtgc
     1261 cgctgtgcag tacttggacc cccgcgggcg cctacggagt gcagacagtg aaaatgccct
     1321 cactgtgcag gaaagaagtg tgccaaccaa gtctcctagt gctcccatca attggcgtcg
     1381 ggggaagctc ctgggtcaag gtgccttcgg cagggtctac ttatgctatg atgtggacac
     1441 aggacgtgaa cttgcttcta agcaggttca gtttgaccca gatagtcctg agactagcaa
     1501 ggaggtgagt gctctggagt gcgagatcca gttgctgaag aacttgcagc atgagcgcat
     1561 cgtgcagtac tatggctgcc tgcgggaccg tgctgagaag atcctcacca tctttatgga
     1621 gtatatgcca gggggctctg taaaagacca gttgaaggcc tacggagctc tgacggagag
     1681 tgtgacccgc aagtatacac ggcagatcct ggagggcatg tcctacctgc acagcaacat
     1741 gatcgtgcat cgtgacatca agggagccaa tatcctccga gactcggctg ggaatgtgaa
     1801 gcttggggat tttggggcca gcaaacgcct gcaaaccatc tgcatgtcag ggacaggcat
     1861 gcgctctgtc actggcacac cctactggat gagtcctgaa gtcatcagtg gcgagggcta
     1921 tggaagaaag gcagatgtgt ggagcctggg ctgtaccgtg gtggagatgc tgacagagaa
     1981 accaccttgg gcagagtatg aagctatggc tgccattttc aagattgcca cccagcctac
     2041 caatcctcag ctgccctctc acatctcaga acacggcagg gacttcctga ggcgcatatt
     2101 tgtggaagct cgtcagagac cctcggctga ggagctgctc acacaccact ttgcacagct
     2161 agtgtactga gctctcaagg ctatgctgct gccagctgcc acctgctgag caggcgaggg
     2221 gctgctgtcc ggcgcagtga agttgctgct tctcccaggc aaggctatgg accagtggag
     2281 tgtcccagcc attgtctgtc tgtgccccat ctgccgctgg gactcaaagc caggatctgg
     2341 catcaagact gggagctcca gcctgtaaga cccaagagct ttgacatcct aagctcagtg
     2401 tggcaggaag ggctgggacc agtatgtaag actgccatgg gtcctgcctg ccctcagatg
     2461 tgtcctaaca ctgcagacag cactgaagtc aagagggact aggcacagga cctactcaag
     2521 ggtatgaata gtgttacttc atccagagtg ttactttgtt tctctcccaa tgtttggaga
     2581 ccaccagaga atctctgggc tgcatgagcc cacacaagcc tgaggtaaag cccagcgtcc
     2641 cccagcaaca ggaggtagag gtttgggctg ccccactaag cttccaggta tgctgtgtca
     2701 gtcctgtctt accaaagatg aatgaagcaa acgctatgct gccttatcct gggaaggagg
     2761 agctacccca ataagcaggg cctgagaagc ggggctgcct ccagtaactg gggagaccca
     2821 gtcttgtcaa tgcaattgtc tctgttttac aggttggagt cactcttatg ctgttcccag
     2881 ttttgaaact ggagactttg ccctctgagc tctggagacc catgtgggct taggccttgg
     2941 actggatggg aaagagctga tggcctccac ccctggcctg ccatctgttc cctcactgga
     3001 gcagagaaag tagacaacac aagttagggc acctggctct gggcaactca gcaaagtgca
     3061 ggggggtctc tcaggctatc tacatctcaa atctgtcagg cctgagccca ctccatgggg
     3121 cagaaagtcc ttgtgctgcc acaaccatgt ccaaaaccac cagctgtgtt ccttagccct
     3181 ccttgtccac ttgtcatcag cctcatttcc ttgttcctcc cacaggggag gatgccagca
     3241 ggggttaggg aaaaagttat ctccgagcag cttagagttg gccatattta cctcagcctg
     3301 ggtgctggtc ctttcttcca gcccctttct tcccctccaa atgtgcctat tgctagagct
     3361 cctccctcct gattcccaag tttcttggga attatcatta aagaaaaaaa aaaaaagcca
     3421 gtgcccaggt gggcatctcc agggagctgg ggatcagtgc caggcatctc tttgccagcc
     3481 atgcccacgt ccccatgggc acagaacaag ccaaagcctt cgttgtctgt tgacgatgca
     3541 cttttatgaa tgtagttcct atcgctgttt ttagcctttt cccatcatgt aatgtgaggc
     3601 cttgtacttg ttaatttata tctcagatcc atatttgatg gtttttatat atatcaattc
     3661 tagactgtta ccggtgatgg actcctgaag agagaacaga aattgaaagc agctggtttt
     3721 gcagatatgt gtgttgcacg gtgccaattg ggcctgggcc cctttgtttt atttcctttc
     3781 ccttgggggt ctgttaggcc actctctaac tgctctgaag ccagtgagca aagtcctgct
     3841 tccacctcag cctttgccca aagtagggac tggccccctc ttctagacca aagctgccaa
     3901 aaggcagctc ggcctctcca tgaccccatc ctgctggcta tgtagcaccc cttagcctat
     3961 ccctatccac acccccaaac ctagaggaaa tagagcttgg tgggctgaca agatgttaga
     4021 tgagacaact ctgcttgtca caggttcagg ctctcacaga gctcctcccc cattcctccc
     4081 cttgggggag cttattacct catagggaat gtttctaaag tgaacttaaa agtaagtcaa
     4141 caaatcctgc actccaaagg aaaaaaaaaa agaccctttt tttttgtgcc aaaaactgtg
     4201 gacatgctgg ttcagcatcc tcaggaccaa agctattaat ttattttctc ttattaacaa
     4261 atttaaaaga gaattgtggg cctccaggat ggcctggacc caaaggttat gaaggacagt
     4321 ttcctagcag cccttggctt gctgtgcaaa gattctgtgc caccatttgt tcttcattcc
     4381 atggggttta tctgcctttg ccaaccccat atggaagggc caggcctggg tcaggtgcat
     4441 gccgcccgcc accctcctgc ccctcccact cacccagctc tgtgtgcgtc tgaattgtgg
     4501 attgtgcaga agaacctgca ggcatagtta ttgactatat cgtgactgag ggcttgcagt
     4561 gcaaagccag gccagtgcat tacttaacaa taaaagggat catttatatc agaa
//
