LOCUS       XM_008772674            5935 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus mitogen-activated protein kinase
            kinase kinase 21 (Map3k21), transcript variant X1, mRNA.
ACCESSION   XM_008772674
VERSION     XM_008772674.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051354.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008772674.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008772674.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5935
                     /gene="Map3k21"
                     /note="mitogen-activated protein kinase kinase kinase 21;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 11 ESTs, 14 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 13 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:307950"
                     /db_xref="RGD:1306091"
     CDS             472..3462
                     /gene="Map3k21"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     21 isoform X1"
                     /protein_id="XP_008770896.3"
                     /db_xref="GeneID:307950"
                     /db_xref="RGD:1306091"
                     /translation="MALPVAEGTAGTSLSPVRDDSGSSSSGMWAALYDYEARGEDELS
                     LKRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCSSVSPPSPPPPRPCSP
                     VHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARL
                     FAMLRHPNIIQLRGVCLQQPHLCLVLEFARGGALNRALAAAAPDPRVPGPRRARRIPP
                     HVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL
                     AREWHRTTRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL
                     AVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILKQLTAIEEAVLTD
                     LPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQ
                     LAEREIDVLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKIT
                     VQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNVVFRQEDFEVV
                     KRNFKRKGCTWGPSSIQTKGRPEGRERVRPLSDGNSPWSSLLIKSQKTTPLASLFVDQ
                     PGSCEEQKLVPDGLEHKKPKQTKSPGQAYVGLPLCKDSQREDSLEAESREEGPSKGSP
                     VNSVGAPFLKKKTESALCECGVLLASMALGLDVRKLHGAQVPTKPSPKDEKKGEGAVQ
                     LVSRCQTSSSPLLRQPSAGRAPSDGSTLLLSATSLLSKSSLSMKCLLQAGEEEAPLGN
                     TQVSCGPTTITPDPSSAAPESTLTPGLRLKADCGVLRSVPPAILEQTGERLPGCSTAG
                     DKECHRVQMGSNEIPLRPQSAPGDYGPPHSPSPGPQTDLASQDSPVQPQVVLGKCQAC
                     PAPPQRPQTASLRTTPPAAWACDKDHAVPAFACFLGAQERSRCQVLDTSLEGQNKDRA
                     MPLCRVKSVMCQPSIYALEKDFLT"
ORIGIN      
        1 cgtgtcgggg ccaggagact caggttcagg ttagactcag acgcgagctc caggggttaa
       61 agaacctgga gggcgggacc agcactaggg cgggactaat ggaaggtgga acccagggat
      121 aacgaaccca gcggggccag ggctagtgcc aaggggaagg gacctggagg gcggagtggc
      181 caaggaggag gggctgggcg tgggggcgac tgcaggggag cgcgcgtaag tccaagcagg
      241 tccagcacca ccaccggtcg tctgcgctag cggccgcggg gaagaactag ccaaactgga
      301 ggcagagcag aggccggagc ccccgggcag tggtcgtaac ctctgtagtc ccgctccagc
      361 cctgcaccct tccctgttag cttggaccga tgatacacgt cgctggagac ccgggaagct
      421 gaggttgtgg ctgtcgcact cggtccacta gcgacctctc aaatcgcccc tatggcgctg
      481 cctgtagccg agggcacggc tggcacctcg ctgtccccgg tccgggacga ctcggggagc
      541 tcctcctccg ggatgtgggc cgcgctttat gattacgaag cgcgcggtga ggacgagctg
      601 agcctgaagc gcggtcagct ggtggaggta ctgtcccagg acgccgcggt gtcaggagac
      661 gaaggctggt gggccggcca agtgcagcgg cgcctgggca tcttcccggc cagctacgtg
      721 gcgccgtgta gctcggtgtc gccaccctcg ccacccccac cgcgaccctg ctcgcctgtg
      781 cacgtagact tcgagcgcct ggagctcaag gagctgatcg gcgccggcgg cttcggacag
      841 gtgtatcgcg ccacctggca gggccaggag gtggcggtga aggcggcgcg ccgggacccg
      901 gagcaagacg ccgcggcggc ggccgagagc gtacggcgcg aggcgcggct cttcgctatg
      961 ctgcggcacc ccaacatcat ccagctgcgg ggcgtgtgcc tgcagcagcc gcacctctgc
     1021 ctagtgctgg agttcgcgcg cggcggggcg ctcaaccgtg cgctggcggc cgccgcaccg
     1081 gatccccgag tccccggccc tcgccgcgcg cgccgcatcc cgccgcacgt tctagtcaac
     1141 tgggccgtgc agatcgcccg cggcatgctg tacctgcacg aggaggcggt agtgcccatc
     1201 ctgcaccgtg acctcaagtc cagcaacatt ttgctgctgg agaagataga gcacgatgac
     1261 atttgcaaca agaccctgaa gatcacggac ttcgggttgg cgagggaatg gcacaggacc
     1321 accaggatga gcgcagcagg aacctacgcc tggatggctc ctgaggtcat caggtcctcc
     1381 ctgttctcca agggcagcga catctggagc tatggagtgc tgttgtggga gctgctcacg
     1441 ggtgaggtcc cataccgggg catcgatgga ctggctgtgg catacggggt ggccgtcaac
     1501 aagctcacgc tgcccattcc ctccacctgc cctgaaccat ttgcaaaact catgaaagag
     1561 tgctgggaac aagaccctca tatccgcccc tcgtttgcct tgattcttaa acagctgact
     1621 gcgatcgaag aggcagtgct gaccgacttg ccccaggagt ccttccattc catgcaggaa
     1681 gactggaaac tggagattca gcaaatgttc agtgagcttc gaaccaagga gaaggagctg
     1741 cgttcccgag aggaagagct aagtcgagct gccttgcaac agaaatcgca ggaactgctg
     1801 ctcagacgcc gggagcagca gctcgcagag cgtgagatcg acgtgctgga gcgcgagctg
     1861 aacgtgctca tcttccaact gagccaggag gcgccgcacg tgaagaagag gaaggggagg
     1921 ttcaggaggg gccggctcag gctcaaagac ggccaccgca tcagcctgcc ttcagatttc
     1981 cagcacaaga tcacagtgca ggcttcccca accctggaca agcgccggag ctcagacagc
     2041 ggactgtgca gcccacccgg cagccccctg atgctccccc gcctccgggc gattcagtta
     2101 acttcagatg agaacaataa aacccgggga aggaacgtgg tcttccgaca agaagacttt
     2161 gaagtcgtga aaaggaattt caagagaaaa ggttgtacgt ggggaccaag ctccatccaa
     2221 acgaagggaa gaccagaagg gcgagagcgg gtcagacctc tctcagatgg caacagccct
     2281 tggtcgtctc ttttaataaa aagccagaaa accacaccct tggcttcact gtttgtggac
     2341 cagccaggat cctgtgaaga gcagaaactt gtccctgatg gattagaaca taaaaaacca
     2401 aagcaaacga agtcccctgg ccaggcctat gttggtctac ctctttgcaa agacagccag
     2461 agagaagact cattagaggc tgagagtcgg gaggagggac cctctaaagg gtccccggtg
     2521 aacagtgtgg gcgcaccctt cctgaaaaag aaaacggagt cagctctgtg tgagtgtggg
     2581 gtgctgctgg catcaatggc tttgggacta gatgtcagga aactacatgg agcccaggtc
     2641 cccacaaaac catcacccaa ggatgaaaag aagggagagg gcgctgtcca actggtctcc
     2701 aggtgccaaa caagttccag tccacttctg aggcagccat ctgcgggcag ggcacccagt
     2761 gatggctcca ctctcctgct gagtgccaca agtctcctct caaagtcctc tctctccatg
     2821 aagtgtttgc tgcaggctgg cgaagaggag gcaccattgg ggaacactca ggtctcctgt
     2881 ggtcccacaa cgatcacccc agatcctagt tctgctgcgc cagagagcac cctaacccct
     2941 ggactgagac ttaaggctga ctgtggcgtg ttgagaagcg tcccgcctgc catcctggag
     3001 cagacagggg agagactgcc aggctgttcc actgcagggg acaaagaatg ccaccgtgtg
     3061 cagatgggat ctaatgaaat tcctctccgg ccccaaagtg ctcctggaga ctatgggcca
     3121 ccacactctc cctcccctgg acctcaaaca gacctggcca gccaggactc tcctgtgcaa
     3181 cctcaagttg ttctgggcaa gtgccaggca tgccctgccc cgccacaaag gccacagact
     3241 gcttcattga ggacaacacc tccagctgcc tgggcctgtg acaaggacca tgcggtgcca
     3301 gcctttgcct gttttcttgg tgctcaagag agaagcaggt gccaggttct ggacaccagc
     3361 ttagaaggtc aaaacaagga ccgtgccatg cccttgtgtc gagtgaagag cgtgatgtgt
     3421 caaccgtcca tctacgccct ggagaaagac tttctgacct gatgacctct gccttcccgc
     3481 cattatcatt tgatgcggtc acacggaggc accgcgtgcc ttgtgctatg tttcggacgc
     3541 gtggcctatg atgctagagg cggatgctga cacagtggct tcaaatacac agaggtccga
     3601 atgactatcc gcggaggtgg ggtcatccga gccagtttct ctgcttcagt ctttcctgtg
     3661 ccctgcccgt gagcgggcac gcacacggca aaactgcagt gactggtctt ttcttcctgc
     3721 cttcatcttt tctctctttt tcttgtcctt ttggggtttt atttgttgtc tgcttttaca
     3781 cagcagaaag ccaagacata gctactcact tctcagctgt aacaatgtga tgataaaagc
     3841 aagcgtttat ttacggaggg gggcgggaaa ggtcctactg tctgggggta atgcagagtc
     3901 ctatttaaac tgcccagagg aaatagtagc cttgtaatgt ggaagtgtat ccagttgact
     3961 cctgaggtac acaaggatag ccctcttcca ggaggatata acctataaac gctttattga
     4021 ggctcgaaga gatggctcaa cactgacgca tgcatctagc tcttttggag gacccaggtt
     4081 caattcctgg cacccatgtc agacggcaca cacacacaca cacacacaca cacacacaca
     4141 cacacacaca cacacacaaa cttaaaagtt gaaatatttt aaaggtttta ttgaatgtaa
     4201 ctatattgtc attttttgta tcaggcaacc aaaatgccct agaacaactt aaagggagga
     4261 actatttact ttgctcgtgg tttcagaggg atcagtgcaa ccgtgggaag ggcctgttgg
     4321 ggtgtcttct catcatggtg ggcaggaagc gggagaaaag aagaaattag ggcaagctac
     4381 agccccgggg cacatcctca ctgaacttgt tctcctgttt ctataacctc ccaaagcagc
     4441 actcctatgt gaagaccaaa caaatagagc ccggatgtct cagattcaga ccttagcagt
     4501 aactgctgag catcactgat accaggcact aatagttggc accctgcaca aggccgcttt
     4561 actggtttcc ctgcagaaat ggctcagtag tagccagaag tggggagttt cttcatgttc
     4621 tagaagcctt taaacattta atgatccatg gccagctatc tttgaagagc ccacgcacca
     4681 tgaacataca tgttgtgtgg tcttatctct ccctgaacca gcagttttgc caacactaac
     4741 aatactacct gtgcaagaga cagcaggacc atcagggttt ccagtcagct tttcacactc
     4801 catctaaccc tgagccagcg gggtcatctg tgggggtgag tgggcatggc gggaagacgc
     4861 aggtgacttc tggaagtgac tttggatagc agatgggatt ggaaccaact taaagctatt
     4921 cgtgaatcac ttccataact tcacagagag ggcgccgtat cgctgggact gggtgactct
     4981 tcaggagctc agtgtccttg tctgggcttc ttgagtactg tgatcccctt ctgtcaccag
     5041 aatgtagtta tctgtgaggc agatagtaaa tacttaaagt cccagacagt aggaaactaa
     5101 attaccagta gcccttcatg ttttagttaa cattgtatct tggttgaccg ataatagcgg
     5161 aagttcaaag gggattcaat caggtatgat gacatctaag tcacttacag gtttgtctgc
     5221 gggtgacctg agaggaggac cttactgcct gctctaggca ggtttcagac gcttggagca
     5281 aaacctcagg ctttcaccag acttcctgtg ttgtttccag tctgcgattc tgcctcactt
     5341 cagtagccat taagtggtgt gacagggata tagtttgctc aacattggtc acatcggaca
     5401 gactgcttgg cctcttcttt ccaagagaag ctaaaagtaa agggcatgac ccaaataccc
     5461 tgtgcacgga aggaacatat actgtgttca gttttgcttc tgtcgcactc tggtggaatg
     5521 tgtgcatgac agagatggtg aaatcagacg tgtctgtcta tccgtcatgt cctctctcgc
     5581 tctgtgtccc agcctccctt ctcttcgttt tgccaaactg tgataaattt agaaaggaag
     5641 ccatgctaca atgataacta caccagaagg agccaatctt acccacggct gctgcaggtc
     5701 ttcatgaagg ttttcactga gaccccagat tttctgtgtg tgctaacaca cctagcagaa
     5761 cctgaatatt cattttctgt agacccggtt cctgtgtaat ccatactctg ctttttctgc
     5821 ccaccgcaga gactagcagc tggagcccgg atggatgtgc tatactcaga agcctgtggc
     5881 tgacaaaaat gtttacgtat gttgtctagc tttttaataa actttttaaa aacag
//
