LOCUS       NM_138503               2524 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitogen activated protein kinase kinase kinase 2
            (Map3k2), mRNA.
ACCESSION   NM_138503 XM_001059840 XM_001067270
VERSION     NM_138503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Wang,A.D., Dai,L.F., Yang,L., Wang,Y.S., Hao,X.H., Liu,Z.C. and
            Chen,P.L.
  TITLE     Upregulation of miR-335 reduces myocardial injury following
            myocardial infarction via targeting MAP3K2
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (1), 344-352 (2021)
   PUBMED   33506923
  REMARK    GeneRIF: Upregulation of miR-335 reduces myocardial injury
            following myocardial infarction via targeting MAP3K2.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Smith,A.J., Karpova,Y., D'Agostino,R. Jr., Willingham,M. and
            Kulik,G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Enomoto,A., Kido,N., Ito,M., Morita,A., Matsumoto,Y., Takamatsu,N.,
            Hosoi,Y. and Miyagawa,K.
  TITLE     Negative regulation of MEKK1/2 signaling by serine-threonine kinase
            38 (STK38)
  JOURNAL   Oncogene 27 (13), 1930-1938 (2008)
   PUBMED   17906693
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Johnson,G.L. and Nakamura,K.
  TITLE     The c-jun kinase/stress-activated pathway: regulation, function and
            role in human disease
  JOURNAL   Biochim Biophys Acta 1773 (8), 1341-1348 (2007)
   PUBMED   17306896
  REMARK    Review article
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Wang,Y., Su,B. and Xia,Z.
  TITLE     Brain-derived neurotrophic factor activates ERK5 in cortical
            neurons via a Rap1-MEKK2 signaling cascade
  JOURNAL   J Biol Chem 281 (47), 35965-35974 (2006)
   PUBMED   17003042
  REMARK    GeneRIF: Rap1 and MEKK2 are critical upstream signaling molecules
            mediating BDNF stimulation of ERK5 in central nervous system
            neurons
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Wei,X., Sun,W., Fan,R., Hahn,J., Joetham,A., Li,G., Webb,S.,
            Garrington,T., Dakhama,A., Lucas,J., Johnson,G.L. and Gelfand,E.W.
  TITLE     MEF2C regulates c-Jun but not TNF-alpha gene expression in
            stimulated mast cells
  JOURNAL   Eur J Immunol 33 (10), 2903-2909 (2003)
   PUBMED   14515274
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Lenz,G., Goncalves,D., Luo,Z., Avruch,J., Rodnight,R. and
            Neary,J.T.
  TITLE     Extracellular ATP stimulates an inhibitory pathway towards growth
            factor-induced cRaf-1 and MEKK activation in astrocyte cultures
  JOURNAL   J Neurochem 77 (4), 1001-1009 (2001)
   PUBMED   11359865
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Gruppuso,P.A. and Boylan,J.M.
  TITLE     Hepatic epidermal growth factor-regulated mitogen-activated protein
            kinase kinase kinase activity in the rat: lack of identity with
            known forms of raf and MEKK
  JOURNAL   FEBS Lett 466 (1), 200-204 (2000)
   PUBMED   10648842
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Fanger,G.R., Johnson,N.L. and Johnson,G.L.
  TITLE     MEK kinases are regulated by EGF and selectively interact with
            Rac/Cdc42
  JOURNAL   EMBO J 16 (16), 4961-4972 (1997)
   PUBMED   9305638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001059840.1, XM_001067270.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.26831.1,
                                           SRR22582419.652713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               JAXUCZ010000018.1  24081444-24081885
            443-512             JAXUCZ010000018.1  24112145-24112214
            513-631             JAXUCZ010000018.1  24116370-24116488
            632-672             JAXUCZ010000018.1  24117602-24117642
            673-772             JAXUCZ010000018.1  24119085-24119184
            773-886             JAXUCZ010000018.1  24122144-24122257
            887-974             JAXUCZ010000018.1  24122984-24123071
            975-1105            JAXUCZ010000018.1  24126256-24126386
            1106-1185           JAXUCZ010000018.1  24127602-24127681
            1186-1253           JAXUCZ010000018.1  24128554-24128621
            1254-1346           JAXUCZ010000018.1  24128769-24128861
            1347-1553           JAXUCZ010000018.1  24130895-24131101
            1554-1702           JAXUCZ010000018.1  24136214-24136362
            1703-1834           JAXUCZ010000018.1  24137294-24137425
            1835-1964           JAXUCZ010000018.1  24139165-24139294
            1965-2142           JAXUCZ010000018.1  24143633-24143810
            2143-2524           JAXUCZ010000018.1  24145270-24145651
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2524
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /note="mitogen activated protein kinase kinase kinase 2"
                     /db_xref="GeneID:171492"
                     /db_xref="RGD:620967"
     exon            1..442
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..512
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..2368
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /EC_number="2.7.11.25"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     2"
                     /protein_id="NP_612512.1"
                     /db_xref="GeneID:171492"
                     /db_xref="RGD:620967"
                     /translation="MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDV
                     RVKFEHRGEKRILQVTRPVKLEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKA
                     VELLDRSIHMKSLKILLVLNGSTQATNLEPSPSPDDLNNTPLGAERKKRLSVVGPPNR
                     DRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCP
                     SLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQE
                     YNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYEDSRIRRRGSDID
                     NPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPD
                     SPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLK
                     AYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRL
                     QTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEA
                     MAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH"
     exon            513..631
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..672
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..772
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..886
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..974
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1105
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1185
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1253
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1346
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1553
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1702
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1834
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1964
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2142
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2524
                     /gene="Map3k2"
                     /gene_synonym="Mekk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacatcacg ggtctgtgtg tagtggcggc ccggctgtcc tcagccgcat cgcctggcga
       61 gggtggcgcg gcgttcctgg gttgcgggac cggcgacaaa gaggaccgac agagaacgat
      121 ctggtcgcag agtcgccgct tccgcttagc tgcttctccg gtcacccgcg acgcgggccc
      181 ggggcttcct cctcgtcggc ccagtttact cggcgggccc cggggctgca tctacccaga
      241 agcagcgaag aggccccggg ctgcgcgccc gctgtcccat gtgaagcagg ttgggcctgg
      301 tttctgctgc ggcccttcag gcctcgggga ccccgcgagg cgctgctcct ggggggcgcg
      361 gtgacaggcc gtgcgggggc ggaggggtca gctccgtggc ctcctctcgg ccctccgctc
      421 cacgatcccc gcccagaggc cgggcaataa agaatgttga tgggagaact gttttcctaa
      481 ttttaaaatt attgagctgg acgccataat ggatgatcag caagctttga attcaatcat
      541 gcaagatttg gctgtccttc ataaggccag tcggccagca ttatctttac aagaaaccag
      601 aaaagcaaaa ccctcttcac caaaaaaaca gaatgatgtc cgagtcaaat ttgaacatag
      661 aggagaaaaa agaatcttgc aggttactag accagttaaa ctagaagatc tgaggtctaa
      721 gtctaaaatt gcctttggac agtctatgga tctacactat accaacaacg agttggtaat
      781 tccgttaact acccaagatg acttggacaa agctgtggaa ctgctggatc gcagtatcca
      841 catgaagagt ctcaagatat tacttgttct aaatgggagt acacaggcta ctaatttaga
      901 gccgtcacca tcaccagacg atctgaataa tacaccactc ggtgcggaga ggaaaaagcg
      961 gctatctgta gtaggtcccc ctaataggga tagaagttct ccacccccag gatacattcc
     1021 agatgaactg caccagattg cccggaacgg gtctttcacc agcatcaaca gtgaaggaga
     1081 gttcatccca gagagcatgg accaaatgct ggatccactg tctttaagca gccctgaaaa
     1141 ctctggctca ggaagctgcc cgtcactgga tagtcctttg gatggagaaa gctacccaaa
     1201 atcacggatg cctagggcac agagctaccc agataatcat caggagtttt cagactatga
     1261 taaccccatt tttgagaaat ttggaaaagg aggaacatat ccaagaaggt atcatgtttc
     1321 ataccatcat caagagtata atgatggtcg gaagactttt ccaagagcca gaaggaccca
     1381 gggcaccagt ttccggtctc ctgtgagttt cagtcctact gatcactcct taagcactag
     1441 tagtgggagc agcatcttta ccccagagta tgaagacagt cggataagaa gacgggggag
     1501 tgacatagac aatcctactt tgactgtcac agacatcagc ccacccagcc gttcacctcg
     1561 agctccaacc aactggagat tgggcaaact gcttggccaa ggagcttttg gaagggtcta
     1621 cctctgttat gatgttgata ccggacgaga actggctgtt aaacaagttc agtttaaccc
     1681 tgacagcccc gagaccagca aggaagtaaa tgcacttgag tgtgaaattc agttgttgaa
     1741 aaacttgttg catgagcgaa ttgttcagta ttatggctgt ctgagggatc ctcaggagaa
     1801 aacactttcc atctttatgg agtacatgcc agggggctca attaaggacc aactcaaagc
     1861 atatggagcc cttactgaga atgtgacgag gaaatacacc cgtcagattc tggagggggt
     1921 ccattacctg catagtaata tgattgtcca tagagacatc aaaggagcga atatcttaag
     1981 ggattccacg ggcaatatca agctaggaga ctttggagct agcaaacgac ttcagaccat
     2041 ctgtctctca ggcacaggga tgaagtctgt cacaggcacg ccatattgga tgagtcctga
     2101 ggtcattagt ggagaaggct atggcagaaa agcagatatc tggagcgtag catgtacggt
     2161 ggtggagatg ctaactgaaa agccaccttg ggctgaattt gaagcaatgg ctgccatctt
     2221 taagatcgcc actcagccaa caaacccaaa gctgccacct catgtctcag actatactcg
     2281 ggactttctc aaacggattt ttgtagaggc caaactccga ccttcagccg aggagctcct
     2341 gcggcacctg ttcgtgcatt gccactagca gccagcgtcc tccacccgcc cgccgccacc
     2401 gccaccttct ctcttactgc actttccttt tttataaaaa gagagatggg gagaaaaaga
     2461 caagagggaa aaatatttct cttgattctt ggttaaattt gtttaataat aatagtaaac
     2521 taaa
//
