LOCUS       NM_001108301            4206 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 14
            (Map3k14), mRNA.
ACCESSION   NM_001108301 XM_001081534 XM_340918
VERSION     NM_001108301.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4206)
  AUTHORS   Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P
            and Rice CM.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. PMID: 26153858]
REFERENCE   2  (bases 1 to 4206)
  AUTHORS   Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M and Kulik G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4206)
  AUTHORS   Wang X, Qin ZH, Shi H, Savitz SI, Qin AP, Jiang Y and Zhang HL.
  TITLE     Protective effect of Ginkgolids (A+B) is associated with inhibition
            of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of
            permanent focal cerebral ischemia
  JOURNAL   Brain Res 1234, 8-15 (2008)
   PUBMED   18722355
REFERENCE   4  (bases 1 to 4206)
  AUTHORS   Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ,
            Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J,
            Utsunomiya A, Watanabe T, Masuda T, Yamamoto N and Yamaoka S.
  TITLE     Overexpressed NF-kappaB-inducing kinase contributes to the
            tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg
            cells
  JOURNAL   Blood 111 (10), 5118-5129 (2008)
   PUBMED   18305221
  REMARK    GeneRIF: deregulated expression of NIK plays a critical role in
            constitutive NF-kappaB activation in ATL and H-RS cells
REFERENCE   5  (bases 1 to 4206)
  AUTHORS   Hayden MS and Ghosh S.
  TITLE     Shared principles in NF-kappaB signaling
  JOURNAL   Cell 132 (3), 344-362 (2008)
   PUBMED   18267068
  REMARK    Review article
REFERENCE   6  (bases 1 to 4206)
  AUTHORS   Lee EJ, Seo SR, Um JW, Park J, Oh Y and Chung KC.
  TITLE     NF-kappaB-inducing kinase phosphorylates and blocks the degradation
            of Down syndrome candidate region 1
  JOURNAL   J Biol Chem 283 (6), 3392-3400 (2008)
   PUBMED   18056702
  REMARK    GeneRIF: NF-kappaB-inducing kinase phosphorylates and blocks the
            degradation of Down syndrome candidate region 1
REFERENCE   7  (bases 1 to 4206)
  AUTHORS   Xu LG, Li LY and Shu HB.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
REFERENCE   8  (bases 1 to 4206)
  AUTHORS   Xiao G, Harhaj EW and Sun SC.
  TITLE     NF-kappaB-inducing kinase regulates the processing of NF-kappaB2
            p100
  JOURNAL   Mol Cell 7 (2), 401-409 (2001)
   PUBMED   11239468
REFERENCE   9  (bases 1 to 4206)
  AUTHORS   Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z and
            Matsumoto K.
  TITLE     The kinase TAK1 can activate the NIK-I kappaB as well as the MAP
            kinase cascade in the IL-1 signalling pathway
  JOURNAL   Nature 398 (6724), 252-256 (1999)
   PUBMED   10094049
REFERENCE   10 (bases 1 to 4206)
  AUTHORS   Ling L, Cao Z and Goeddel DV.
  TITLE     NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of
            Ser-176
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3792-3797 (1998)
   PUBMED   9520446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081534.1, XM_340918.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4206
                     /gene="Map3k14"
                     /note="mitogen-activated protein kinase kinase kinase 14"
                     /db_xref="GeneID:360640"
                     /db_xref="RGD:1310487"
     exon            1..66
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            67..341
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2914
                     /gene="Map3k14"
                     /EC_number="2.7.11.25"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     14"
                     /protein_id="NP_001101771.1"
                     /db_xref="GeneID:360640"
                     /db_xref="RGD:1310487"
                     /translation="MAVMEVACPGTPGSAVGQQKEFAKAKEKTQSPGKKQSCIFQLEA
                     VEKSPVFCGKWEILNDVITKGTAKEGSEGGPPAISIIAQAECENSQEFSPTFSERIFI
                     AGSQQYSQSESLDQIPNNVAHATEGKMARVCRKGKRHSKARKKRRKRRSKSLAQAGVA
                     LAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLKGPGLGHLCFKKQDEGLR
                     PVLPRPELHKLISPLQCLNHVWKLHHPQATGPLPHPTHPFPFSRMPHPFPFYPLEPWR
                     PYTLNPAFLDKLAAVSGQRPLPGPPHLSKPAYRDSQKPLPGPHLESSCLSREALEKVP
                     AEEYLVHALQGSVSSGQAHSLASLAKTWSSGSSKLQRFSPETEDNEGVLLTEKLKPVD
                     YEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRAEELIACAGLS
                     SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQKGCLPEDRALYYLGQALEGLEYL
                     HTHRVLHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMA
                     PEVVLGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPVREIPPSC
                     TPLTAQAIQEGLRKEPIHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQA
                     PCPQTLHTLPRENPPAKANTDGAPERQPPLPPEPPEPNKAPALNLSKEESGTWEPLPL
                     SSLDPAPAKGPSLPDRRATFPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSL
                     SLSEDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSCSMALARGRPTDIPSYFNGV
                     KVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSG
                     IDLQCTLAPDGSFAWAWRVKHGQLENRP"
     exon            342..411
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            412..622
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1243
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1381
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1511
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1643
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1748
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1912
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2063
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2396
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2503
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2648
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2749
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..4206
                     /gene="Map3k14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgagcg atcgctggcc agcgaagcgc cacactcgct tgtttgagga gaacggcgct
       61 ccgccggtga gcacaagcct aggagatggc cgtgatggaa gtggcctgcc caggcactcc
      121 tgggtcggca gtcgggcagc agaaggagtt cgccaaagcc aaggagaaga cacagtcacc
      181 agggaagaag cagagctgca tcttccagct cgaggcggtg gagaagagcc ctgtgttctg
      241 tgggaagtgg gagatcctca acgatgtgat caccaaaggc acagccaagg aaggttccga
      301 gggcgggccc cccgccatct ccatcatcgc ccaggctgaa tgtgagaata gccaagagtt
      361 cagccccacc ttctcagagc gcattttcat cgcggggtca cagcagtaca gccagtctga
      421 gagtcttgat caaatcccca acaatgtggc ccatgcaact gaaggcaaaa tggcccgagt
      481 gtgccggaag gggaagcgtc acagcaaagc ccgaaaaaaa cgtaggaaga ggaggtcgaa
      541 gtcactggcc caggcaggag tggccttggc caagcccctg cccagaaccc ctgagcaaga
      601 gagctgtacc atcccagtgc aggaagatga gtctccacta ggcaacctct atgccagaaa
      661 tgtctcccag ttcaccaagc ctctgaaggg accaggcctt ggccacctgt gctttaagaa
      721 acaagatgaa ggcctgcgac cagtgctgcc tcgaccagaa ctccacaaac tgatcagccc
      781 cctgcaatgt ctaaaccacg tgtggaaact ccaccacccg caggccacag gccccctgcc
      841 ccaccccact cacccgttcc ccttcagcag aatgccccat cctttcccat tctaccccct
      901 ggagccctgg agaccctata cactgaaccc ggccttcctg gacaaactag ccgctgtaag
      961 tggccagcgg cctctgcctg gcccaccaca cctaagcaaa ccggcctaca gagacagtca
     1021 gaagcccctg cctggcccac atctggagtc cagctgcctg tcccgagagg ccctagaaaa
     1081 ggtccctgcc gaggaatacc tggtgcacgc gctacaagga agtgtgagct caggccaggc
     1141 ccacagcctg gctagcctgg ctaagacatg gtcatcaggg agctccaagc tgcagaggtt
     1201 cagccctgaa actgaggaca acgagggggt cctgcttact gagaaactca aaccagtgga
     1261 ttatgagtac cgggaagagg tccactggat gacacaccag cctcgggtgg gcagagggtc
     1321 cttcggcgaa gtccacagaa tgaaggacaa gcagacaggc ttccagtgtg ctgtcaaaaa
     1381 ggtacggctt gaggtatttc gggcagagga actgatagcc tgtgccggac tgagctcgcc
     1441 caggatcgtc cctctctacg gagctgtaag agaaggcccg tgggtgaaca tcttcatgga
     1501 gctgctagaa ggtggctctc taggccagct cataaagcag aagggctgtc tgccagaaga
     1561 ccgagccctt tactacctgg gccaggccct ggaggggctg gaatacctcc atacacacag
     1621 ggttctgcat ggcgacgtca aagctgacaa cgtgctcctg tccagtgatg gaagccgagc
     1681 tgccctctgt gacttcggcc atgccttgtg cctacaacct gatggcctag gaaaatcctt
     1741 gctcacaggg gactacattc ctggcacaga gacccacatg gccccagaag tggtgctggg
     1801 gaagccctgt gatgccaagg tcgacatctg gagcagctgt tgcatgatgc tccacatgct
     1861 caatggctgc cacccctgga ctcagtactt ccgaggcccg ctctgtctca agattgccag
     1921 cgagcctcca cctgtcaggg agattccacc ttcctgcaca cccctcacag cccaggccat
     1981 ccaagagggg ctgaggaaag agcccatcca ccgagcatct gccatggaac ttcggaggaa
     2041 agtgggcaag gcgttacagg aagtgggagg tctgaaaagc ccttggaaag gagaatataa
     2101 agagccaaga cctccacccc aagaccaagc cccctgcccc cagaccttac ataccctgcc
     2161 aagagagaac ccaccagcca aggccaacac agacggggcc cctgagcgtc agcctcctct
     2221 gccgcctgaa ccaccggaac cgaacaaagc accagccctg aacctgagca aggaggagtc
     2281 tggcacctgg gaacccctgc ctctgtcctc cctggaccca gcccctgcca aaggccccag
     2341 cttgccagac cggagggcaa ccttcccgga gctggagcta caacagctgg agatagaact
     2401 gttcctaaac agcctgtccc agccgttttc tctggaggaa caggaacaga ttctctcctg
     2461 cctcagcatc gacagcctct cactgtcaga ggacagtgaa aagaacccat ctaaggcctc
     2521 tcagagctca cgtgataccc tgagttccgg cgtgcactct tggagcagcc aagcagaggc
     2581 cagaagctcc agctgcagca tggcgctggc ccggggacgg cccactgaca tcccgagcta
     2641 cttcaacggt gtcaaggtcc agatacagtc tctcaatggc gagcacctgc acatccggga
     2701 attccaccgg gtcaaggtgg gagacattgc aaccggcatc agcagccaga tcccggccac
     2761 agctttcagc ttggtgacca aagatggaca gcctgtttgc tatgacatgg aggtgccaga
     2821 ctcaggcatc gacctgcagt gcaccctagc ccctgatggc agcttcgctt gggcctggag
     2881 ggtcaagcac ggccagctgg agaaccggcc ctagccctgt cttccagcac cagctctact
     2941 ctggccacag caggcttcct ttgaatctca gtactcagtg gcgctctgag atgctggatg
     3001 agtctgctca ggcccctgcc agtccccggc tgggcataag accggggctg tcgagcagca
     3061 agcggaggag cagagtaaaa cgcctcccag gacttgcctg cctcctgctg ctggctcctg
     3121 gcaggagaaa ctcttccctc atgagaagac aaggaggaag acaggggtct catcccccag
     3181 agagagagcc agcgctttct gtgatgctcc aaatgaggta gccagaccca catgggtcag
     3241 tcagcacttg ccagcagttg gggagcagct tctagcctgg gcacgaagag caggcacccc
     3301 tgaggagggc aggagagtgt ctggggttcc tgcccagctt gttacagggc aggcagtagg
     3361 tgtacctgcc cagggacttg tggagtcctt gaccccgtgt gaggtggacg aggcaggaag
     3421 gacacgagaa tgcacggagc cttcaggtta gtgcaaccca ggtcctgagt tgagctcctc
     3481 gatcaaccaa ggaccctaga agatgctgag agaagagact ctcccgcctc aagtgtccgg
     3541 ctgctggaca gcactcctca gagcaccagc cccactggct ccctggcact ctagtccctc
     3601 agctgtggaa atgaaggatg acaggagacc cacctgacag gaatggtctg caaatgatag
     3661 atgctcaaga aagccacaga agcaggactc gccaccctct ggggcgcagt cagtcgccag
     3721 catgccagcc tcatggtggc aagacactgc cagcagcact ttgcactctg atgacctcaa
     3781 agcactttcc tggctgcctt ccagcagggc actggctctg catggtcaca agcaagccag
     3841 gggatgggga agggactgtc tcgacccatc atccacacag gcttgagccc ctcaagcttc
     3901 tttcagatgt aaaatgagca cccccaaccc cattgcccta gctggggctt ctcctggtgg
     3961 gacttggaaa tggctgctta ggactgactc attgtagcat taagttaact gtgaatcatt
     4021 gtagggaggg gcagagactt ctcctgtaga gaagctcatt cccccgccct cactcgacag
     4081 ccaggatacc gtccgtccct atatttgcgt ggatccagac tgctcctggc cccagtacat
     4141 gaaccgcagc catggtgctg catttggggt atatcgaggt ctgtacacaa taaaatttgg
     4201 aatgaa
//
