LOCUS       NM_001013978            3451 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitogen-activated protein kinase kinase kinase 13
            (Map3k13), mRNA.
ACCESSION   NM_001013978 XM_001058114 XM_221319
VERSION     NM_001013978.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Hao,D., He,S., Harada,K., Pizzi,M.P., Lu,Y., Guan,P., Chen,L.,
            Wang,R., Zhang,S., Sewastjanow-Silva,M., Abdelhakeem,A.,
            Shanbhag,N., Bhutani,M., Han,G., Lee,J.H., Zhao,S., Weston,B., Blum
            Murphy,M., Waters,R., Estrella,J.S., Roy-Chowdhuri,S., Gan,Q.,
            Lee,J.S., Peng,G., Hanash,S.M., Calin,G.A., Song,X., Zhang,J.,
            Song,S., Wang,L. and Ajani,J.A.
  TITLE     Integrated genomic profiling and modelling for risk stratification
            in patients with advanced oesophagogastric adenocarcinoma
  JOURNAL   Gut 70 (11), 2055-2065 (2021)
   PUBMED   33334899
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Chen,M., Geoffroy,C.G., Wong,H.N., Tress,O., Nguyen,M.T.,
            Holzman,L.B., Jin,Y. and Zheng,B.
  TITLE     Leucine Zipper-bearing Kinase promotes axon growth in mammalian
            central nervous system neurons
  JOURNAL   Sci Rep 6, 31482 (2016)
   PUBMED   27511108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   Ganguly,A., Oo,T.F., Rzhetskaya,M., Pratt,R., Yarygina,O.,
            Momoi,T., Kholodilov,N. and Burke,R.E.
  TITLE     CEP11004, a novel inhibitor of the mixed lineage kinases,
            suppresses apoptotic death in dopamine neurons of the substantia
            nigra induced by 6-hydroxydopamine
  JOURNAL   J Neurochem 88 (2), 469-480 (2004)
   PUBMED   14690535
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   Masaki,M., Ikeda,A., Shiraki,E., Oka,S. and Kawasaki,T.
  TITLE     Mixed lineage kinase LZK and antioxidant protein-1 activate
            NF-kappaB synergistically
  JOURNAL   Eur J Biochem 270 (1), 76-83 (2003)
   PUBMED   12492477
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Ikeda,A., Hasegawa,K., Masaki,M., Moriguchi,T., Nishida,E.,
            Kozutsumi,Y., Oka,S. and Kawasaki,T.
  TITLE     Mixed lineage kinase LZK forms a functional signaling complex with
            JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase
            pathway
  JOURNAL   J Biochem 130 (6), 773-781 (2001)
   PUBMED   11726277
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Ikeda,A., Masaki,M., Kozutsumi,Y., Oka,S. and Kawasaki,T.
  TITLE     Identification and characterization of functional domains in a
            mixed lineage kinase LZK
  JOURNAL   FEBS Lett 488 (3), 190-195 (2001)
   PUBMED   11163770
REFERENCE   7  (bases 1 to 3451)
  AUTHORS   Sakuma,H., Ikeda,A., Oka,S., Kozutsumi,Y., Zanetta,J.P. and
            Kawasaki,T.
  TITLE     Molecular cloning and functional expression of a cDNA encoding a
            new member of mixed lineage protein kinase from human brain
  JOURNAL   J Biol Chem 272 (45), 28622-28629 (1997)
   PUBMED   9353328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Sep 10, 2008 this sequence version replaced
            XM_221319.2, XM_001058114.1, NM_001013978.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132264
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3451
                     /gene="Map3k13"
                     /note="mitogen-activated protein kinase kinase kinase 13"
                     /db_xref="GeneID:303823"
                     /db_xref="RGD:1561227"
     exon            1..95
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            96..224
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            225..784
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..3186
                     /gene="Map3k13"
                     /EC_number="2.7.11.25"
                     /note="leucine zipper-bearing kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     13"
                     /protein_id="NP_001014000.2"
                     /db_xref="GeneID:303823"
                     /db_xref="RGD:1561227"
                     /translation="MANPQEHLSCSSLPHLPLTENKISGGRNELAAMGNHPSPKFPED
                     SQERVVAIQSELTEITGSPVSTTVLTSVSEDSRSQFENSVLQLREQDESEVTVSPGNS
                     NTVDGENTNGPEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDT
                     WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIA
                     FKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKII
                     HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV
                     DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS
                     KPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRL
                     DEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVE
                     KKYPGTYKRHPVRPIIHPNAMEKLMKRKVVSHKAGVQTKRPDLLRSEGIPSTEAVPTA
                     SPLSGSPKMSTGSSRSRYRSKPRHRRGNSRGSHSDFAAILKTQPAQENSPHPTYLQHT
                     QAQCPSAYQHNLPQQQVPPPLPQSRHPRLNAHGQDIATCANNLRYFGPAAALRSPLSN
                     HAQRQMPGSSPDLISTAMAADCWRNSELDQDQVGPWGCCQAEPYDPCFQCRPEHSGSL
                     DVPTTEPVGRSPDPSSSPAHNPLSGNAQGSERTEANGFNGCQSGISHQFTPPLLPQKP
                     RPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCISSYQSYSTFSSENFSVSDGEEGNTS
                     DHSNSPDESANRRQDRLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMSL
                     GKLCAEERGYENPVQFADSDRDSSEGDCSDATVRTSKNYSSATW"
     exon            785..968
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1160
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1319
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1478
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1587
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1697
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1814
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1952
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2718
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2786
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3084
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3451
                     /gene="Map3k13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttgcgc tgggtcgggt gtccagcgct gtcgcaggag cgccttgaga aagcttgcgg
       61 tcgtgcgaac tcggcttcgg gccgagaact tagaattttg cagaaccctg ctgctaccta
      121 tgcagtctgc catggatacc gtgtaaagaa accctggatg cagtaacgga caaaacatga
      181 gtcaatttgt gttgtggccc tcagatccta acacaccggg agaggttttg gagtcctctc
      241 ttgcatcaaa cctgtgtctc cgtagtcctc tgaccgtcat ctcgggacct gggtcaccct
      301 catggcacaa tggccaaccc tcaggagcac ctgagctgct cctctttgcc acacttgccc
      361 ttgactgaga acaaaatctc tggtggacga aatgagcttg cggctatggg gaaccaccct
      421 tcccccaagt tccctgagga ctcgcaggag agggtggtgg ctatacagtc agagctgacg
      481 gagatcacgg gcagcccggt ctccacaaca gtgctgacca gtgtaagcga agattccagg
      541 agccagtttg agaacagtgt ccttcagcta agggaacagg acgaatcaga ggtgaccgta
      601 tctccaggga acagcaacac cgtggatgga gagaacacga acggacctga agacatcaag
      661 atccagttca gcaggtcagg cagcggcagc ggtgggtttc tcgaaggact ctttggttgc
      721 ctcaggcccg tgtggaacat catcgggaag gcgtactcca cggattacaa actgcagcag
      781 caagacactt gggaagtgcc gtttgaggaa atctcagagc tgcagtggct gggtagtgga
      841 gcccagggag ccgtcttcct gggcaaattc cgagcagagg aggtggccat caagaaggtg
      901 agagagcaga atgagacgga catcaagcat ctgaggaagc tgaagcaccc taacatcatc
      961 gccttcaagg gcgtttgcac tcaggccccg tgctactgca tcatcatgga gtactgtgcc
     1021 cacggacagc tgtacgaggt cctgagggcc ggcaggaaga tcacgccccg gctgctcgtg
     1081 gactggtcca cggggatcgc cagtggaatg aattacctcc atctccataa gattatacat
     1141 cgagatctca agtcgcccaa tgttttagtg actcacacag atgcagtgaa aatttcagac
     1201 tttggcacat ctaaggaact cagtgataaa agcaccaaga tgtcctttgc tggcaccgtt
     1261 gcgtggatgg cacctgaggt gatccggaat gagcctgtct ctgagaaggt tgacatatgg
     1321 tcgtttggag tcgtgctttg ggagctgctg acaggggaga tcccctacaa ggacgtggac
     1381 tcatcagcca tcatttgggg tgttggcagc aatagcttgc acctcccggt tccttccact
     1441 tgcccagacg gattcaaaat ccttatgaaa cagacgtggc agagtaagcc tcgaaaccgg
     1501 ccttctttcc ggcagacact catgcatctg gacattgcct ctgcagatgt gcttgccacc
     1561 cctcaagaaa cgtacttcaa gtctcaggct gaatggagag aagaagtgaa aaaacatttc
     1621 gagaaaatca aaagtgaagg gacctgtatt catcgattag atgaagaact gattcgtcgc
     1681 cgcagggagg agctcaggca tgccctggat attcgagagc actatgagag gaagctcgag
     1741 cgggctaaca atctgtacat ggagctgagc gccatcatgc tgcagctgga gatgcgggag
     1801 aaggagctcc tcaagcgaga gcaagcagtg gaaaagaagt atcctgggac ctacaagcga
     1861 caccctgtcc gtccaatcat ccaccccaat gccatggaga agctcatgaa aaggaaggtt
     1921 gtgtctcaca aggctggtgt acagactaag cggccagacc tgttgcgatc cgaaggcatc
     1981 cctagtacag aagcagttcc cactgcatcc cctctgtctg gaagtcccaa aatgtccacc
     2041 ggaagcagca ggagccggta ccgaagcaaa ccacgtcacc gccgagggaa cagtagaggc
     2101 agccatagtg acttcgcagc aatcttgaaa acccagcctg cccaggaaaa ttcaccccac
     2161 cccacctacc tacagcacac tcaggctcag tgcccttctg cctatcaaca taatcttccc
     2221 cagcagcaag tccctcctcc cctgcctcag agccgccatc ccagactcaa tgcgcatggg
     2281 caggacattg cgacctgcgc caataacctg aggtacttcg gcccagcagc agccctgcgg
     2341 agtccactca gcaaccacgc tcaaagacag atgcctggct ctagtcccga cctcatctcc
     2401 acagccatgg cagcagattg ttggagaaat tctgaacttg accaagacca agtcggaccc
     2461 tggggctgtt gtcaggctga accctatgat ccctgtttcc agtgcaggcc agaacattct
     2521 gggtccttag atgttcccac cactgagcca gtggggagga gcccagaccc ttccagttca
     2581 ccagcacaca atcctctttc aggaaatgcc caaggctctg agagaacgga ggcaaatgga
     2641 ttcaatggct gtcagtctgg tatttctcat caattcacac ccccattgct acctcaaaag
     2701 ccacggcccc ttcagaagag tggagatgac tcctcagaag aggaaggaga agtggacagt
     2761 gaagtagaat ttcctcgacg acagaggcct caccgttgca ttagtagtta ccagtcgtac
     2821 tcaaccttta gctccgagaa cttctctgtg tctgatggag aggagggtaa cactagcgac
     2881 cactccaaca gtccggatga gtcggccaac agacggcagg accgcctggc agagacgctg
     2941 gacgacctgc tgtcccagac accagaggcc cccatcgaga tctcctccca ctcggatggg
     3001 ctgtctgaca aggagtgtgc cgtacggcgt gtgaagacac agatgtccct tggcaagctg
     3061 tgtgctgagg agcgcggcta cgagaacccc gtgcagtttg cagactcgga ccgcgactct
     3121 tcagaggggg actgctctga tgccacagtt aggaccagca agaactacag ctctgccacc
     3181 tggtgaccac agctcactcg gctccagcaa tagacccctc cctcgttcat ccgtctggga
     3241 ggcgtggcag gaacatgaga ctcgtcaaac ctctgggaaa acacccagaa gacactgcgt
     3301 ctcacggagc atttcaatca agaatggcag ggatctattg tactgagtac gccaactact
     3361 gtaacattga tatttatttt tgttggacat tttaacactt tgtattgtaa agagtgaact
     3421 atatatgata cagacacaat aatttcttta c
//
